Incidental Mutation 'R8174:Or7d10'
ID 634234
Institutional Source Beutler Lab
Gene Symbol Or7d10
Ensembl Gene ENSMUSG00000051118
Gene Name olfactory receptor family 7 subfamily D member 10
Synonyms 18A, Olfr77, GA_x6K02T2PVTD-13660026-13660964, MOR143-1
MMRRC Submission 067599-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R8174 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 19828525-19833806 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 19832020 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 172 (T172P)
Ref Sequence ENSEMBL: ENSMUSP00000058810 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057596]
AlphaFold Q8VEY9
Predicted Effect probably damaging
Transcript: ENSMUST00000057596
AA Change: T172P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000058810
Gene: ENSMUSG00000051118
AA Change: T172P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3e-53 PFAM
Pfam:7tm_1 41 290 1.2e-24 PFAM
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 A G 7: 75,378,617 (GRCm39) N2090S possibly damaging Het
Asxl3 T C 18: 22,650,800 (GRCm39) S930P probably benign Het
Cachd1 T A 4: 100,823,466 (GRCm39) I506N probably damaging Het
Calm1 G T 12: 100,171,967 (GRCm39) V140L probably benign Het
Cdsn A T 17: 35,866,529 (GRCm39) K353* probably null Het
Cldn11 T C 3: 31,208,210 (GRCm39) V125A probably benign Het
Ddx60 G A 8: 62,470,284 (GRCm39) probably null Het
Dlg2 A G 7: 91,589,248 (GRCm39) I216V probably benign Het
Dnah5 A G 15: 28,311,279 (GRCm39) probably null Het
Dnajc28 G A 16: 91,413,795 (GRCm39) R150* probably null Het
Erap1 A T 13: 74,794,683 (GRCm39) Y114F probably benign Het
Gm14443 G A 2: 175,011,468 (GRCm39) P326L probably damaging Het
Gm2042 T A 12: 87,926,928 (GRCm39) L415Q probably damaging Het
Gm8797 T C 3: 5,816,094 (GRCm39) I44T probably benign Het
Matn2 C A 15: 34,422,555 (GRCm39) F547L probably benign Het
Mpc2 T A 1: 165,308,458 (GRCm39) probably null Het
Or5b12b A G 19: 12,861,268 (GRCm39) T8A probably benign Het
Pcnx4 T A 12: 72,603,687 (GRCm39) L536Q probably damaging Het
Phlpp2 G A 8: 110,595,321 (GRCm39) R24H unknown Het
Pkmyt1 A T 17: 23,952,813 (GRCm39) D123V probably damaging Het
Polg A T 7: 79,106,466 (GRCm39) M668K probably benign Het
Ppp1r12a G T 10: 108,107,598 (GRCm39) A974S probably benign Het
Ppp2r3d T C 9: 101,090,501 (GRCm39) probably benign Het
Rabl3 T C 16: 37,377,225 (GRCm39) Y61H probably damaging Het
Rap2a T A 14: 120,716,269 (GRCm39) I44N probably damaging Het
Rev3l T C 10: 39,735,111 (GRCm39) V2779A probably damaging Het
Rnf43 G T 11: 87,622,057 (GRCm39) R259L probably benign Het
Rspry1 T A 8: 95,376,450 (GRCm39) L448Q probably damaging Het
Slc43a2 T G 11: 75,434,193 (GRCm39) probably null Het
Slc6a5 A G 7: 49,598,057 (GRCm39) I640M probably benign Het
Sp140l1 T G 1: 85,077,261 (GRCm39) S102R probably damaging Het
Srrm2 C T 17: 24,034,297 (GRCm39) P314S unknown Het
Strn4 C T 7: 16,562,733 (GRCm39) R291C probably damaging Het
Syt4 T A 18: 31,577,230 (GRCm39) R41S probably benign Het
Tfb1m T C 17: 3,569,855 (GRCm39) D337G probably benign Het
Togaram1 G T 12: 65,029,465 (GRCm39) D963Y possibly damaging Het
Tpsg1 T C 17: 25,591,564 (GRCm39) C55R probably damaging Het
Tram1l1 A G 3: 124,115,911 (GRCm39) K357R probably benign Het
Veph1 A G 3: 66,171,316 (GRCm39) I42T probably damaging Het
Vps13b C G 15: 35,709,456 (GRCm39) S1801* probably null Het
Zcwpw1 G A 5: 137,817,839 (GRCm39) probably null Het
Zfp266 G A 9: 20,418,110 (GRCm39) probably benign Het
Zmym5 T A 14: 57,031,918 (GRCm39) R397* probably null Het
Other mutations in Or7d10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Or7d10 APN 9 19,832,245 (GRCm39) missense possibly damaging 0.87
IGL01318:Or7d10 APN 9 19,832,054 (GRCm39) missense probably benign 0.44
IGL01547:Or7d10 APN 9 19,832,197 (GRCm39) missense probably benign 0.00
IGL01635:Or7d10 APN 9 19,831,780 (GRCm39) missense probably damaging 1.00
IGL02112:Or7d10 APN 9 19,831,821 (GRCm39) missense possibly damaging 0.48
IGL02858:Or7d10 APN 9 19,831,747 (GRCm39) missense probably damaging 0.99
IGL02904:Or7d10 APN 9 19,832,393 (GRCm39) missense probably damaging 1.00
IGL02956:Or7d10 APN 9 19,832,348 (GRCm39) missense possibly damaging 0.87
IGL03066:Or7d10 APN 9 19,831,667 (GRCm39) missense probably benign 0.12
R0662:Or7d10 UTSW 9 19,831,796 (GRCm39) missense probably damaging 1.00
R1222:Or7d10 UTSW 9 19,832,344 (GRCm39) missense possibly damaging 0.87
R1572:Or7d10 UTSW 9 19,832,208 (GRCm39) missense probably benign 0.35
R1761:Or7d10 UTSW 9 19,832,445 (GRCm39) makesense probably null
R2409:Or7d10 UTSW 9 19,832,077 (GRCm39) missense probably damaging 1.00
R2409:Or7d10 UTSW 9 19,832,072 (GRCm39) missense probably benign 0.31
R3621:Or7d10 UTSW 9 19,832,209 (GRCm39) missense probably damaging 0.99
R3849:Or7d10 UTSW 9 19,832,105 (GRCm39) missense probably damaging 1.00
R3850:Or7d10 UTSW 9 19,832,105 (GRCm39) missense probably damaging 1.00
R4277:Or7d10 UTSW 9 19,831,685 (GRCm39) missense possibly damaging 0.91
R4768:Or7d10 UTSW 9 19,831,841 (GRCm39) missense possibly damaging 0.56
R4979:Or7d10 UTSW 9 19,831,655 (GRCm39) missense probably benign 0.03
R5276:Or7d10 UTSW 9 19,831,917 (GRCm39) missense possibly damaging 0.87
R5503:Or7d10 UTSW 9 19,831,675 (GRCm39) missense probably benign 0.36
R5760:Or7d10 UTSW 9 19,832,050 (GRCm39) missense probably benign 0.00
R5778:Or7d10 UTSW 9 19,832,337 (GRCm39) missense probably benign 0.20
R5930:Or7d10 UTSW 9 19,832,206 (GRCm39) missense probably damaging 0.99
R6012:Or7d10 UTSW 9 19,832,237 (GRCm39) missense probably damaging 0.99
R7269:Or7d10 UTSW 9 19,831,631 (GRCm39) missense possibly damaging 0.95
R7977:Or7d10 UTSW 9 19,831,610 (GRCm39) missense possibly damaging 0.48
R7987:Or7d10 UTSW 9 19,831,610 (GRCm39) missense possibly damaging 0.48
Z1088:Or7d10 UTSW 9 19,832,008 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGAAGATATCCTACACAGAGTGCC -3'
(R):5'- GGAGGACATTTTCATTAAAGCAGAG -3'

Sequencing Primer
(F):5'- TAATTTTCTACTGACCATTATGGCC -3'
(R):5'- ACATTTTCATTAAAGCAGAGACAATG -3'
Posted On 2020-07-13