Incidental Mutation 'R8174:Ppp2r3d'
ID 634236
Institutional Source Beutler Lab
Gene Symbol Ppp2r3d
Ensembl Gene ENSMUSG00000093803
Gene Name protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta
Synonyms Ppp2r3, PR59, Ppp2r3a
MMRRC Submission 067599-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.361) question?
Stock # R8174 (G1)
Quality Score 120.133
Status Validated
Chromosome 9
Chromosomal Location 124195827-124204759 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to C at 101090501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000075327 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075941]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000075941
SMART Domains Protein: ENSMUSP00000075327
Gene: ENSMUSG00000043154

DomainStartEndE-ValueType
low complexity region 248 266 N/A INTRINSIC
Blast:EFh 760 789 1e-9 BLAST
Pfam:EF-hand_7 902 1000 2.5e-17 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 A G 7: 75,378,617 (GRCm39) N2090S possibly damaging Het
Asxl3 T C 18: 22,650,800 (GRCm39) S930P probably benign Het
Cachd1 T A 4: 100,823,466 (GRCm39) I506N probably damaging Het
Calm1 G T 12: 100,171,967 (GRCm39) V140L probably benign Het
Cdsn A T 17: 35,866,529 (GRCm39) K353* probably null Het
Cldn11 T C 3: 31,208,210 (GRCm39) V125A probably benign Het
Ddx60 G A 8: 62,470,284 (GRCm39) probably null Het
Dlg2 A G 7: 91,589,248 (GRCm39) I216V probably benign Het
Dnah5 A G 15: 28,311,279 (GRCm39) probably null Het
Dnajc28 G A 16: 91,413,795 (GRCm39) R150* probably null Het
Erap1 A T 13: 74,794,683 (GRCm39) Y114F probably benign Het
Gm14443 G A 2: 175,011,468 (GRCm39) P326L probably damaging Het
Gm2042 T A 12: 87,926,928 (GRCm39) L415Q probably damaging Het
Gm8797 T C 3: 5,816,094 (GRCm39) I44T probably benign Het
Matn2 C A 15: 34,422,555 (GRCm39) F547L probably benign Het
Mpc2 T A 1: 165,308,458 (GRCm39) probably null Het
Or5b12b A G 19: 12,861,268 (GRCm39) T8A probably benign Het
Or7d10 A C 9: 19,832,020 (GRCm39) T172P probably damaging Het
Pcnx4 T A 12: 72,603,687 (GRCm39) L536Q probably damaging Het
Phlpp2 G A 8: 110,595,321 (GRCm39) R24H unknown Het
Pkmyt1 A T 17: 23,952,813 (GRCm39) D123V probably damaging Het
Polg A T 7: 79,106,466 (GRCm39) M668K probably benign Het
Ppp1r12a G T 10: 108,107,598 (GRCm39) A974S probably benign Het
Rabl3 T C 16: 37,377,225 (GRCm39) Y61H probably damaging Het
Rap2a T A 14: 120,716,269 (GRCm39) I44N probably damaging Het
Rev3l T C 10: 39,735,111 (GRCm39) V2779A probably damaging Het
Rnf43 G T 11: 87,622,057 (GRCm39) R259L probably benign Het
Rspry1 T A 8: 95,376,450 (GRCm39) L448Q probably damaging Het
Slc43a2 T G 11: 75,434,193 (GRCm39) probably null Het
Slc6a5 A G 7: 49,598,057 (GRCm39) I640M probably benign Het
Sp140l1 T G 1: 85,077,261 (GRCm39) S102R probably damaging Het
Srrm2 C T 17: 24,034,297 (GRCm39) P314S unknown Het
Strn4 C T 7: 16,562,733 (GRCm39) R291C probably damaging Het
Syt4 T A 18: 31,577,230 (GRCm39) R41S probably benign Het
Tfb1m T C 17: 3,569,855 (GRCm39) D337G probably benign Het
Togaram1 G T 12: 65,029,465 (GRCm39) D963Y possibly damaging Het
Tpsg1 T C 17: 25,591,564 (GRCm39) C55R probably damaging Het
Tram1l1 A G 3: 124,115,911 (GRCm39) K357R probably benign Het
Veph1 A G 3: 66,171,316 (GRCm39) I42T probably damaging Het
Vps13b C G 15: 35,709,456 (GRCm39) S1801* probably null Het
Zcwpw1 G A 5: 137,817,839 (GRCm39) probably null Het
Zfp266 G A 9: 20,418,110 (GRCm39) probably benign Het
Zmym5 T A 14: 57,031,918 (GRCm39) R397* probably null Het
Other mutations in Ppp2r3d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00792:Ppp2r3d APN 9 101,088,500 (GRCm39) missense possibly damaging 0.50
IGL01122:Ppp2r3d APN 9 101,088,844 (GRCm39) missense probably benign 0.30
IGL02332:Ppp2r3d APN 9 101,057,602 (GRCm39) missense possibly damaging 0.78
IGL02653:Ppp2r3d APN 9 101,088,892 (GRCm39) missense probably benign 0.13
IGL03329:Ppp2r3d APN 9 101,003,630 (GRCm39) splice site probably benign
IGL03351:Ppp2r3d APN 9 101,088,391 (GRCm39) missense probably benign 0.00
lank UTSW 9 101,075,829 (GRCm39) critical splice donor site probably null
PIT4480001:Ppp2r3d UTSW 9 101,003,576 (GRCm39) missense possibly damaging 0.95
PIT4687001:Ppp2r3d UTSW 9 101,021,579 (GRCm39) missense probably benign 0.00
R0243:Ppp2r3d UTSW 9 101,089,483 (GRCm39) missense probably damaging 1.00
R1004:Ppp2r3d UTSW 9 101,075,829 (GRCm39) critical splice donor site probably null
R1086:Ppp2r3d UTSW 9 101,031,021 (GRCm39) missense possibly damaging 0.67
R1215:Ppp2r3d UTSW 9 101,089,883 (GRCm39) missense probably benign 0.02
R1245:Ppp2r3d UTSW 9 101,071,593 (GRCm39) missense probably damaging 0.99
R1458:Ppp2r3d UTSW 9 101,088,511 (GRCm39) missense probably damaging 1.00
R1682:Ppp2r3d UTSW 9 101,089,505 (GRCm39) missense probably benign 0.00
R1857:Ppp2r3d UTSW 9 101,090,092 (GRCm39) missense probably damaging 0.96
R1972:Ppp2r3d UTSW 9 101,088,976 (GRCm39) missense probably benign 0.00
R2029:Ppp2r3d UTSW 9 101,022,680 (GRCm39) missense probably damaging 1.00
R2076:Ppp2r3d UTSW 9 101,021,570 (GRCm39) missense possibly damaging 0.83
R2135:Ppp2r3d UTSW 9 101,088,757 (GRCm39) missense probably damaging 0.99
R2180:Ppp2r3d UTSW 9 101,004,214 (GRCm39) nonsense probably null
R3155:Ppp2r3d UTSW 9 101,089,559 (GRCm39) missense possibly damaging 0.56
R4190:Ppp2r3d UTSW 9 124,424,123 (GRCm38) unclassified probably benign
R4657:Ppp2r3d UTSW 9 124,476,821 (GRCm38) missense unknown
R4797:Ppp2r3d UTSW 9 101,089,179 (GRCm39) missense probably benign 0.01
R4829:Ppp2r3d UTSW 9 101,089,709 (GRCm39) missense possibly damaging 0.67
R5269:Ppp2r3d UTSW 9 101,031,064 (GRCm39) missense probably damaging 0.98
R5498:Ppp2r3d UTSW 9 124,439,123 (GRCm38) unclassified probably benign
R5820:Ppp2r3d UTSW 9 124,422,765 (GRCm38) missense possibly damaging 0.90
R5917:Ppp2r3d UTSW 9 101,089,183 (GRCm39) missense probably benign 0.10
R5939:Ppp2r3d UTSW 9 101,089,824 (GRCm39) missense probably benign 0.37
R6089:Ppp2r3d UTSW 9 101,088,835 (GRCm39) missense probably benign 0.00
R6254:Ppp2r3d UTSW 9 101,025,786 (GRCm39) missense possibly damaging 0.75
R6574:Ppp2r3d UTSW 9 101,071,584 (GRCm39) missense probably benign 0.03
R6776:Ppp2r3d UTSW 9 101,090,061 (GRCm39) missense probably benign 0.00
R6823:Ppp2r3d UTSW 9 124,439,078 (GRCm38) unclassified probably benign
R6927:Ppp2r3d UTSW 9 101,052,547 (GRCm39) missense probably damaging 1.00
R6986:Ppp2r3d UTSW 9 124,439,080 (GRCm38) nonsense probably null
R7162:Ppp2r3d UTSW 9 124,439,673 (GRCm38) missense
R7189:Ppp2r3d UTSW 9 101,003,621 (GRCm39) missense possibly damaging 0.59
R7190:Ppp2r3d UTSW 9 101,089,726 (GRCm39) missense probably benign 0.11
R7288:Ppp2r3d UTSW 9 101,004,203 (GRCm39) missense probably damaging 0.98
R7292:Ppp2r3d UTSW 9 101,089,871 (GRCm39) missense probably damaging 0.96
R7512:Ppp2r3d UTSW 9 101,052,532 (GRCm39) missense possibly damaging 0.69
R7655:Ppp2r3d UTSW 9 101,088,911 (GRCm39) missense probably benign 0.30
R7656:Ppp2r3d UTSW 9 101,088,911 (GRCm39) missense probably benign 0.30
R7661:Ppp2r3d UTSW 9 124,442,696 (GRCm38) missense
R7666:Ppp2r3d UTSW 9 124,440,873 (GRCm38) missense probably damaging 1.00
R7769:Ppp2r3d UTSW 9 124,439,087 (GRCm38) missense
R8195:Ppp2r3d UTSW 9 101,090,231 (GRCm39) missense probably damaging 1.00
R8236:Ppp2r3d UTSW 9 124,440,067 (GRCm38) missense
R8344:Ppp2r3d UTSW 9 101,088,985 (GRCm39) missense probably benign 0.03
R8505:Ppp2r3d UTSW 9 124,439,084 (GRCm38) missense
R8720:Ppp2r3d UTSW 9 101,089,084 (GRCm39) missense probably damaging 1.00
R8765:Ppp2r3d UTSW 9 124,439,649 (GRCm38) missense
R8775:Ppp2r3d UTSW 9 101,004,204 (GRCm39) missense probably benign 0.00
R8775-TAIL:Ppp2r3d UTSW 9 101,004,204 (GRCm39) missense probably benign 0.00
R8853:Ppp2r3d UTSW 9 101,090,110 (GRCm39) missense probably benign 0.05
R8958:Ppp2r3d UTSW 9 101,088,634 (GRCm39) missense probably benign
R9069:Ppp2r3d UTSW 9 101,090,006 (GRCm39) missense probably benign 0.02
R9210:Ppp2r3d UTSW 9 101,063,175 (GRCm39) missense probably benign 0.09
R9212:Ppp2r3d UTSW 9 101,063,175 (GRCm39) missense probably benign 0.09
R9300:Ppp2r3d UTSW 9 124,423,977 (GRCm38) missense unknown
R9404:Ppp2r3d UTSW 9 101,025,840 (GRCm39) missense probably damaging 1.00
R9465:Ppp2r3d UTSW 9 124,442,222 (GRCm38) missense
R9477:Ppp2r3d UTSW 9 124,476,857 (GRCm38) missense
R9538:Ppp2r3d UTSW 9 124,424,007 (GRCm38) missense unknown
R9545:Ppp2r3d UTSW 9 101,089,214 (GRCm39) missense probably benign
R9639:Ppp2r3d UTSW 9 101,022,713 (GRCm39) missense probably benign
R9649:Ppp2r3d UTSW 9 124,440,831 (GRCm38) missense
X0020:Ppp2r3d UTSW 9 101,089,238 (GRCm39) missense probably benign 0.19
Z1176:Ppp2r3d UTSW 9 101,003,588 (GRCm39) missense possibly damaging 0.67
Z1177:Ppp2r3d UTSW 9 124,476,815 (GRCm38) missense unknown
Z1177:Ppp2r3d UTSW 9 124,422,692 (GRCm38) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CACAAGTCTGTAAGTTGCTGCC -3'
(R):5'- TGGGAGGACTCAGTTATCACAG -3'

Sequencing Primer
(F):5'- GTCTGTAAGTTGCTGCCATAATATC -3'
(R):5'- GGAGGACTCAGTTATCACAGTAATCC -3'
Posted On 2020-07-13