Incidental Mutation 'R8177:Vmn2r112'
| ID |
634446 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r112
|
| Ensembl Gene |
ENSMUSG00000094921 |
| Gene Name |
vomeronasal 2, receptor 112 |
| Synonyms |
EG628185 |
| MMRRC Submission |
067602-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
R8177 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
22820129-22838114 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 22822594 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 424
(N424S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094994
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000097381]
|
| AlphaFold |
L7N221 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000097381
AA Change: N424S
PolyPhen 2
Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: N424S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
471 |
2.8e-32 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
5.8e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
6.5e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9830107B12Rik |
A |
T |
17: 48,439,174 (GRCm39) |
Y127* |
probably null |
Het |
| Abcb5 |
C |
T |
12: 118,836,525 (GRCm39) |
V1129I |
possibly damaging |
Het |
| Abcc2 |
A |
G |
19: 43,795,519 (GRCm39) |
D425G |
probably damaging |
Het |
| Adamts15 |
T |
A |
9: 30,833,322 (GRCm39) |
D71V |
probably damaging |
Het |
| Add1 |
A |
G |
5: 34,774,049 (GRCm39) |
H435R |
possibly damaging |
Het |
| Akr1c19 |
A |
G |
13: 4,292,591 (GRCm39) |
N204S |
probably benign |
Het |
| Ankub1 |
C |
A |
3: 57,597,837 (GRCm39) |
R44S |
possibly damaging |
Het |
| Ano3 |
T |
A |
2: 110,496,801 (GRCm39) |
N783Y |
probably damaging |
Het |
| Bbs9 |
A |
G |
9: 22,425,359 (GRCm39) |
M138V |
probably benign |
Het |
| Ccdc18 |
G |
A |
5: 108,345,661 (GRCm39) |
E936K |
possibly damaging |
Het |
| Cit |
T |
G |
5: 116,126,218 (GRCm39) |
L1604V |
probably benign |
Het |
| Col2a1 |
T |
A |
15: 97,874,654 (GRCm39) |
S1396C |
unknown |
Het |
| Col3a1 |
G |
C |
1: 45,374,924 (GRCm39) |
G653R |
unknown |
Het |
| Col6a1 |
T |
C |
10: 76,560,863 (GRCm39) |
E45G |
probably damaging |
Het |
| Col9a3 |
T |
A |
2: 180,249,450 (GRCm39) |
F271I |
probably damaging |
Het |
| Cyp2g1 |
C |
A |
7: 26,518,578 (GRCm39) |
D364E |
probably damaging |
Het |
| Dmbt1 |
T |
A |
7: 130,708,162 (GRCm39) |
V1457D |
possibly damaging |
Het |
| Dnah17 |
A |
T |
11: 118,019,753 (GRCm39) |
I98N |
possibly damaging |
Het |
| Dyrk1b |
T |
A |
7: 27,882,601 (GRCm39) |
M222K |
possibly damaging |
Het |
| Epha8 |
T |
C |
4: 136,672,974 (GRCm39) |
D270G |
probably benign |
Het |
| Fbxw17 |
T |
C |
13: 50,579,660 (GRCm39) |
L159P |
probably damaging |
Het |
| Fgl2 |
G |
A |
5: 21,578,307 (GRCm39) |
|
probably null |
Het |
| Fmnl1 |
A |
T |
11: 103,080,785 (GRCm39) |
M309L |
probably damaging |
Het |
| Fn1 |
T |
C |
1: 71,648,746 (GRCm39) |
I1479V |
probably benign |
Het |
| Gm11939 |
A |
T |
11: 99,450,124 (GRCm39) |
S57T |
possibly damaging |
Het |
| Gm9195 |
C |
T |
14: 72,697,977 (GRCm39) |
A1268T |
possibly damaging |
Het |
| Gnpda1 |
A |
G |
18: 38,466,348 (GRCm39) |
W90R |
possibly damaging |
Het |
| Igkv5-43 |
T |
A |
6: 69,800,445 (GRCm39) |
R81W |
probably damaging |
Het |
| Mapk3 |
T |
A |
7: 126,362,937 (GRCm39) |
W230R |
probably null |
Het |
| Mplkip |
A |
G |
13: 17,870,205 (GRCm39) |
S46G |
probably benign |
Het |
| Mrs2 |
T |
C |
13: 25,188,961 (GRCm39) |
T118A |
probably benign |
Het |
| Mst1r |
T |
A |
9: 107,784,784 (GRCm39) |
H147Q |
probably damaging |
Het |
| Muc5ac |
G |
C |
7: 141,361,068 (GRCm39) |
G1460R |
probably damaging |
Het |
| Myorg |
G |
T |
4: 41,497,568 (GRCm39) |
Y687* |
probably null |
Het |
| Naip1 |
T |
C |
13: 100,563,911 (GRCm39) |
H418R |
probably benign |
Het |
| Ncapg |
A |
G |
5: 45,851,095 (GRCm39) |
T763A |
probably benign |
Het |
| Nr6a1 |
T |
C |
2: 38,619,510 (GRCm39) |
I462V |
probably benign |
Het |
| Nudcd3 |
T |
C |
11: 6,143,460 (GRCm39) |
D70G |
possibly damaging |
Het |
| Nup210 |
A |
G |
6: 90,991,470 (GRCm39) |
S1858P |
probably benign |
Het |
| Or12e13 |
T |
A |
2: 87,663,512 (GRCm39) |
I43N |
probably benign |
Het |
| Or5aq1 |
C |
A |
2: 86,966,294 (GRCm39) |
V124L |
possibly damaging |
Het |
| Or6a2 |
G |
C |
7: 106,600,663 (GRCm39) |
L135V |
probably damaging |
Het |
| Or6c205 |
A |
G |
10: 129,086,790 (GRCm39) |
H129R |
probably benign |
Het |
| Or8k33 |
T |
A |
2: 86,383,623 (GRCm39) |
I282F |
noncoding transcript |
Het |
| Pde4dip |
T |
C |
3: 97,674,848 (GRCm39) |
T23A |
probably damaging |
Het |
| Pex6 |
A |
G |
17: 47,024,988 (GRCm39) |
Q347R |
probably benign |
Het |
| Rbm27 |
A |
G |
18: 42,457,175 (GRCm39) |
K694R |
probably damaging |
Het |
| Rnf40 |
T |
G |
7: 127,195,322 (GRCm39) |
D549E |
probably benign |
Het |
| Rpl22 |
A |
G |
4: 152,411,968 (GRCm39) |
K15E |
probably damaging |
Het |
| Rsph6a |
T |
A |
7: 18,808,164 (GRCm39) |
D697E |
unknown |
Het |
| Sec23b |
C |
T |
2: 144,427,543 (GRCm39) |
P590L |
probably benign |
Het |
| Semp2l1 |
T |
C |
1: 32,585,457 (GRCm39) |
E151G |
probably benign |
Het |
| Slc17a7 |
T |
A |
7: 44,824,356 (GRCm39) |
M524K |
probably benign |
Het |
| Slc28a1 |
G |
A |
7: 80,814,164 (GRCm39) |
D454N |
probably benign |
Het |
| Slc6a13 |
C |
T |
6: 121,301,987 (GRCm39) |
R190* |
probably null |
Het |
| Slc7a9 |
G |
A |
7: 35,155,558 (GRCm39) |
V257I |
probably benign |
Het |
| Slco1a6 |
T |
A |
6: 142,047,460 (GRCm39) |
M377L |
probably damaging |
Het |
| Slit3 |
A |
G |
11: 35,469,919 (GRCm39) |
E307G |
probably damaging |
Het |
| Smchd1 |
A |
G |
17: 71,697,448 (GRCm39) |
M1164T |
probably benign |
Het |
| Stk4 |
T |
C |
2: 163,930,777 (GRCm39) |
I126T |
probably damaging |
Het |
| Syndig1 |
A |
T |
2: 149,741,788 (GRCm39) |
S125C |
probably damaging |
Het |
| Synm |
T |
C |
7: 67,383,813 (GRCm39) |
D1283G |
probably benign |
Het |
| Tmprss6 |
T |
C |
15: 78,349,327 (GRCm39) |
M73V |
probably benign |
Het |
| Tmprss9 |
A |
G |
10: 80,730,882 (GRCm39) |
I803V |
probably benign |
Het |
| Tmx4 |
A |
T |
2: 134,485,822 (GRCm39) |
V35E |
probably damaging |
Het |
| Topbp1 |
T |
G |
9: 103,197,740 (GRCm39) |
S440A |
probably benign |
Het |
| Twf1 |
T |
C |
15: 94,482,276 (GRCm39) |
I157V |
possibly damaging |
Het |
| Vmn1r205 |
T |
C |
13: 22,776,415 (GRCm39) |
N229S |
probably benign |
Het |
| Vmn1r27 |
T |
A |
6: 58,192,759 (GRCm39) |
I82L |
probably benign |
Het |
| Vmn2r68 |
A |
T |
7: 84,871,422 (GRCm39) |
Y620* |
probably null |
Het |
| Zfp51 |
A |
G |
17: 21,684,129 (GRCm39) |
D248G |
probably benign |
Het |
|
| Other mutations in Vmn2r112 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00341:Vmn2r112
|
APN |
17 |
22,837,917 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01021:Vmn2r112
|
APN |
17 |
22,837,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01122:Vmn2r112
|
APN |
17 |
22,821,988 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01360:Vmn2r112
|
APN |
17 |
22,837,603 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01536:Vmn2r112
|
APN |
17 |
22,824,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02148:Vmn2r112
|
APN |
17 |
22,838,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vmn2r112
|
APN |
17 |
22,833,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4576001:Vmn2r112
|
UTSW |
17 |
22,833,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0278:Vmn2r112
|
UTSW |
17 |
22,821,987 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0328:Vmn2r112
|
UTSW |
17 |
22,824,251 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0583:Vmn2r112
|
UTSW |
17 |
22,837,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0831:Vmn2r112
|
UTSW |
17 |
22,833,980 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1080:Vmn2r112
|
UTSW |
17 |
22,837,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1245:Vmn2r112
|
UTSW |
17 |
22,822,228 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1321:Vmn2r112
|
UTSW |
17 |
22,837,500 (GRCm39) |
nonsense |
probably null |
|
|
R1381:Vmn2r112
|
UTSW |
17 |
22,837,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1514:Vmn2r112
|
UTSW |
17 |
22,821,825 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1519:Vmn2r112
|
UTSW |
17 |
22,837,884 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1572:Vmn2r112
|
UTSW |
17 |
22,822,125 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1590:Vmn2r112
|
UTSW |
17 |
22,833,989 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1640:Vmn2r112
|
UTSW |
17 |
22,824,097 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2221:Vmn2r112
|
UTSW |
17 |
22,820,214 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2223:Vmn2r112
|
UTSW |
17 |
22,820,214 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2310:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2312:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2337:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2339:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2340:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2341:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2342:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2401:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2860:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2861:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2926:Vmn2r112
|
UTSW |
17 |
22,833,984 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3236:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3237:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3977:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3979:Vmn2r112
|
UTSW |
17 |
22,822,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4168:Vmn2r112
|
UTSW |
17 |
22,822,069 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4256:Vmn2r112
|
UTSW |
17 |
22,837,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4386:Vmn2r112
|
UTSW |
17 |
22,820,303 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4912:Vmn2r112
|
UTSW |
17 |
22,822,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4947:Vmn2r112
|
UTSW |
17 |
22,821,860 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5446:Vmn2r112
|
UTSW |
17 |
22,837,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5870:Vmn2r112
|
UTSW |
17 |
22,838,004 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6351:Vmn2r112
|
UTSW |
17 |
22,820,259 (GRCm39) |
missense |
probably benign |
|
|
R6384:Vmn2r112
|
UTSW |
17 |
22,824,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6390:Vmn2r112
|
UTSW |
17 |
22,824,230 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6401:Vmn2r112
|
UTSW |
17 |
22,822,532 (GRCm39) |
nonsense |
probably null |
|
|
R6405:Vmn2r112
|
UTSW |
17 |
22,837,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Vmn2r112
|
UTSW |
17 |
22,822,082 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6648:Vmn2r112
|
UTSW |
17 |
22,837,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6649:Vmn2r112
|
UTSW |
17 |
22,820,160 (GRCm39) |
missense |
probably null |
1.00 |
|
R6653:Vmn2r112
|
UTSW |
17 |
22,820,160 (GRCm39) |
missense |
probably null |
1.00 |
|
R6654:Vmn2r112
|
UTSW |
17 |
22,822,450 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6700:Vmn2r112
|
UTSW |
17 |
22,822,462 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6993:Vmn2r112
|
UTSW |
17 |
22,822,195 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7052:Vmn2r112
|
UTSW |
17 |
22,821,507 (GRCm39) |
missense |
probably benign |
|
|
R7454:Vmn2r112
|
UTSW |
17 |
22,822,288 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7763:Vmn2r112
|
UTSW |
17 |
22,822,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8032:Vmn2r112
|
UTSW |
17 |
22,822,375 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8263:Vmn2r112
|
UTSW |
17 |
22,824,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8395:Vmn2r112
|
UTSW |
17 |
22,837,587 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8492:Vmn2r112
|
UTSW |
17 |
22,821,470 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8889:Vmn2r112
|
UTSW |
17 |
22,837,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8892:Vmn2r112
|
UTSW |
17 |
22,837,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9246:Vmn2r112
|
UTSW |
17 |
22,824,088 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9269:Vmn2r112
|
UTSW |
17 |
22,820,213 (GRCm39) |
missense |
probably benign |
|
|
R9273:Vmn2r112
|
UTSW |
17 |
22,837,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9288:Vmn2r112
|
UTSW |
17 |
22,822,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9352:Vmn2r112
|
UTSW |
17 |
22,822,479 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9406:Vmn2r112
|
UTSW |
17 |
22,824,223 (GRCm39) |
nonsense |
probably null |
|
|
R9432:Vmn2r112
|
UTSW |
17 |
22,821,233 (GRCm39) |
missense |
|
|
|
R9728:Vmn2r112
|
UTSW |
17 |
22,824,108 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1088:Vmn2r112
|
UTSW |
17 |
22,824,059 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCACTGAAGAACTGCTCATC -3'
(R):5'- TGCAGGTATACAAGGACAGATTATGC -3'
Sequencing Primer
(F):5'- GCTCATCCAGTTACTCATTTGATTGG -3'
(R):5'- CAAGGACAGATTATGCCTTCTAGTC -3'
|
| Posted On |
2020-07-13 |
Incidental Mutation