Incidental Mutation 'R8181:Vmn2r74'
| ID |
634618 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r74
|
| Ensembl Gene |
ENSMUSG00000090774 |
| Gene Name |
vomeronasal 2, receptor 74 |
| Synonyms |
EG546980 |
| MMRRC Submission |
067605-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.105)
|
| Stock # |
R8181 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85601075-85610690 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 85605324 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 441
(F441L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126917
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166355]
|
| AlphaFold |
E9PW21 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166355
AA Change: F441L
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: F441L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
467 |
7.3e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
4.7e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.3e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.6329 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.3%
|
| Validation Efficiency |
100% (73/73) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
G |
A |
3: 137,774,156 (GRCm39) |
S1115N |
probably damaging |
Het |
| Abca1 |
A |
G |
4: 53,059,303 (GRCm39) |
V1551A |
probably benign |
Het |
| Adam30 |
T |
C |
3: 98,070,291 (GRCm39) |
I708T |
probably benign |
Het |
| Aknad1 |
T |
A |
3: 108,659,328 (GRCm39) |
L114H |
possibly damaging |
Het |
| Akr1c18 |
G |
A |
13: 4,185,262 (GRCm39) |
S290L |
probably benign |
Het |
| Aldh18a1 |
G |
T |
19: 40,545,881 (GRCm39) |
D635E |
probably benign |
Het |
| Bax |
G |
T |
7: 45,115,698 (GRCm39) |
P23Q |
probably null |
Het |
| Bhlha15 |
A |
T |
5: 144,128,244 (GRCm39) |
N119Y |
probably damaging |
Het |
| Boll |
T |
A |
1: 55,402,478 (GRCm39) |
M1L |
probably benign |
Het |
| C2cd2 |
A |
T |
16: 97,693,502 (GRCm39) |
I123N |
probably benign |
Het |
| Cacnb4 |
A |
C |
2: 52,364,997 (GRCm39) |
S89A |
probably benign |
Het |
| Calca |
A |
G |
7: 114,234,387 (GRCm39) |
C21R |
probably benign |
Het |
| Calcr |
T |
C |
6: 3,693,899 (GRCm39) |
I325M |
probably benign |
Het |
| Card14 |
T |
A |
11: 119,212,718 (GRCm39) |
F94Y |
probably damaging |
Het |
| Chil3 |
A |
C |
3: 106,057,203 (GRCm39) |
I247S |
probably damaging |
Het |
| Clca3b |
T |
C |
3: 144,544,898 (GRCm39) |
N363S |
probably benign |
Het |
| Cnksr3 |
A |
G |
10: 7,070,475 (GRCm39) |
V494A |
possibly damaging |
Het |
| Cog4 |
A |
G |
8: 111,578,717 (GRCm39) |
|
probably null |
Het |
| Crybg1 |
T |
A |
10: 43,862,322 (GRCm39) |
Y1484F |
probably damaging |
Het |
| Dglucy |
A |
G |
12: 100,816,370 (GRCm39) |
|
probably null |
Het |
| Dmp1 |
T |
A |
5: 104,359,380 (GRCm39) |
|
probably null |
Het |
| Dscaml1 |
T |
A |
9: 45,658,140 (GRCm39) |
I1637N |
possibly damaging |
Het |
| Ercc6 |
T |
A |
14: 32,279,905 (GRCm39) |
I640N |
probably damaging |
Het |
| Esp16 |
G |
T |
17: 39,850,707 (GRCm39) |
E29* |
probably null |
Het |
| Fam149a |
T |
C |
8: 45,834,755 (GRCm39) |
I15V |
possibly damaging |
Het |
| Flt4 |
T |
A |
11: 49,525,723 (GRCm39) |
I724N |
probably damaging |
Het |
| Glb1 |
C |
T |
9: 114,259,429 (GRCm39) |
R202C |
probably damaging |
Het |
| Gmpr2 |
C |
A |
14: 55,910,441 (GRCm39) |
S41* |
probably null |
Het |
| Golgb1 |
T |
A |
16: 36,737,192 (GRCm39) |
D2187E |
probably damaging |
Het |
| Gpsm2 |
A |
G |
3: 108,597,080 (GRCm39) |
|
probably null |
Het |
| Helz |
A |
G |
11: 107,563,399 (GRCm39) |
D1613G |
unknown |
Het |
| Hemgn |
A |
C |
4: 46,396,504 (GRCm39) |
M244R |
possibly damaging |
Het |
| Hsd3b1 |
A |
T |
3: 98,763,453 (GRCm39) |
V56E |
probably damaging |
Het |
| Jup |
A |
T |
11: 100,267,751 (GRCm39) |
I524N |
probably damaging |
Het |
| Kdm1b |
G |
T |
13: 47,205,377 (GRCm39) |
|
probably null |
Het |
| Kif11 |
A |
T |
19: 37,379,095 (GRCm39) |
|
probably null |
Het |
| Lars1 |
A |
T |
18: 42,361,835 (GRCm39) |
W591R |
probably damaging |
Het |
| Lrtm1 |
T |
A |
14: 28,743,894 (GRCm39) |
S121T |
probably damaging |
Het |
| Med12l |
A |
C |
3: 59,169,389 (GRCm39) |
D1593A |
probably damaging |
Het |
| Med17 |
A |
T |
9: 15,188,928 (GRCm39) |
D112E |
possibly damaging |
Het |
| Mettl2 |
T |
A |
11: 105,019,866 (GRCm39) |
F168I |
probably benign |
Het |
| Mmp9 |
A |
T |
2: 164,792,365 (GRCm39) |
D323V |
probably damaging |
Het |
| Mpzl2 |
C |
T |
9: 44,961,006 (GRCm39) |
T214I |
probably benign |
Het |
| Ms4a15 |
T |
C |
19: 10,958,670 (GRCm39) |
H134R |
probably benign |
Het |
| Ms4a6d |
T |
A |
19: 11,580,653 (GRCm39) |
I2F |
probably damaging |
Het |
| Muc3a |
G |
A |
5: 137,244,535 (GRCm39) |
P206S |
unknown |
Het |
| Nectin2 |
C |
A |
7: 19,458,733 (GRCm39) |
L359F |
probably damaging |
Het |
| Or2y6 |
C |
A |
11: 52,104,096 (GRCm39) |
C240F |
probably damaging |
Het |
| Or4f53 |
T |
A |
2: 111,087,918 (GRCm39) |
F153I |
probably benign |
Het |
| Pgm2 |
G |
T |
5: 64,269,467 (GRCm39) |
C518F |
possibly damaging |
Het |
| Plppr4 |
A |
G |
3: 117,116,114 (GRCm39) |
V581A |
probably damaging |
Het |
| Prkra |
G |
C |
2: 76,469,634 (GRCm39) |
L142V |
probably damaging |
Het |
| Prpf38a |
G |
A |
4: 108,434,195 (GRCm39) |
T74I |
probably benign |
Het |
| Ptprs |
T |
A |
17: 56,736,064 (GRCm39) |
N635I |
probably damaging |
Het |
| Rxfp2 |
A |
G |
5: 149,987,201 (GRCm39) |
N361D |
probably benign |
Het |
| Ryr3 |
T |
G |
2: 112,608,588 (GRCm39) |
I2351L |
probably damaging |
Het |
| Sfmbt2 |
A |
T |
2: 10,580,190 (GRCm39) |
T618S |
probably benign |
Het |
| Six6 |
A |
G |
12: 72,986,906 (GRCm39) |
D26G |
probably damaging |
Het |
| Slc20a1 |
T |
C |
2: 129,051,047 (GRCm39) |
L568P |
probably damaging |
Het |
| Slx4ip |
T |
A |
2: 136,842,104 (GRCm39) |
C10S |
probably damaging |
Het |
| Sox13 |
G |
T |
1: 133,311,498 (GRCm39) |
T578K |
probably benign |
Het |
| Spire2 |
A |
T |
8: 124,088,042 (GRCm39) |
S509C |
probably damaging |
Het |
| Sptbn4 |
T |
C |
7: 27,074,808 (GRCm39) |
D1521G |
possibly damaging |
Het |
| Sult2a7 |
T |
C |
7: 14,204,098 (GRCm39) |
T207A |
probably benign |
Het |
| Sun2 |
A |
G |
15: 79,609,721 (GRCm39) |
I708T |
probably damaging |
Het |
| Supt5 |
T |
C |
7: 28,030,899 (GRCm39) |
E44G |
unknown |
Het |
| Thsd1 |
A |
G |
8: 22,733,022 (GRCm39) |
E23G |
probably damaging |
Het |
| Ticrr |
T |
C |
7: 79,310,728 (GRCm39) |
V214A |
possibly damaging |
Het |
| Zfp30 |
A |
G |
7: 29,493,080 (GRCm39) |
T526A |
probably benign |
Het |
| Zfp518a |
G |
T |
19: 40,902,415 (GRCm39) |
Q781H |
probably damaging |
Het |
| Zmynd11 |
A |
G |
13: 9,739,687 (GRCm39) |
V434A |
probably benign |
Het |
| Zranb1 |
A |
G |
7: 132,585,508 (GRCm39) |
D652G |
probably damaging |
Het |
|
| Other mutations in Vmn2r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00899:Vmn2r74
|
APN |
7 |
85,606,338 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00904:Vmn2r74
|
APN |
7 |
85,606,788 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01285:Vmn2r74
|
APN |
7 |
85,606,692 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01300:Vmn2r74
|
APN |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01410:Vmn2r74
|
APN |
7 |
85,610,500 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01827:Vmn2r74
|
APN |
7 |
85,606,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02094:Vmn2r74
|
APN |
7 |
85,610,669 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02252:Vmn2r74
|
APN |
7 |
85,606,531 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02349:Vmn2r74
|
APN |
7 |
85,601,724 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02438:Vmn2r74
|
APN |
7 |
85,601,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02554:Vmn2r74
|
APN |
7 |
85,606,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03036:Vmn2r74
|
APN |
7 |
85,601,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL03370:Vmn2r74
|
APN |
7 |
85,607,265 (GRCm39) |
missense |
probably benign |
|
|
R0115:Vmn2r74
|
UTSW |
7 |
85,606,564 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0333:Vmn2r74
|
UTSW |
7 |
85,601,491 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0415:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Vmn2r74
|
UTSW |
7 |
85,601,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Vmn2r74
|
UTSW |
7 |
85,610,517 (GRCm39) |
nonsense |
probably null |
|
|
R0659:Vmn2r74
|
UTSW |
7 |
85,605,122 (GRCm39) |
splice site |
probably benign |
|
|
R1202:Vmn2r74
|
UTSW |
7 |
85,610,545 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1473:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Vmn2r74
|
UTSW |
7 |
85,601,650 (GRCm39) |
missense |
probably benign |
|
|
R2079:Vmn2r74
|
UTSW |
7 |
85,606,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2368:Vmn2r74
|
UTSW |
7 |
85,610,522 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3782:Vmn2r74
|
UTSW |
7 |
85,605,322 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3824:Vmn2r74
|
UTSW |
7 |
85,607,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3977:Vmn2r74
|
UTSW |
7 |
85,607,345 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4182:Vmn2r74
|
UTSW |
7 |
85,606,395 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4289:Vmn2r74
|
UTSW |
7 |
85,606,562 (GRCm39) |
missense |
probably benign |
|
|
R4294:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4645:Vmn2r74
|
UTSW |
7 |
85,606,317 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r74
|
UTSW |
7 |
85,606,782 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4655:Vmn2r74
|
UTSW |
7 |
85,610,555 (GRCm39) |
missense |
probably benign |
|
|
R4901:Vmn2r74
|
UTSW |
7 |
85,605,199 (GRCm39) |
nonsense |
probably null |
|
|
R5532:Vmn2r74
|
UTSW |
7 |
85,601,197 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5642:Vmn2r74
|
UTSW |
7 |
85,606,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5913:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6170:Vmn2r74
|
UTSW |
7 |
85,606,348 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6232:Vmn2r74
|
UTSW |
7 |
85,607,498 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6238:Vmn2r74
|
UTSW |
7 |
85,601,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6255:Vmn2r74
|
UTSW |
7 |
85,601,659 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6468:Vmn2r74
|
UTSW |
7 |
85,610,599 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6732:Vmn2r74
|
UTSW |
7 |
85,606,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Vmn2r74
|
UTSW |
7 |
85,610,621 (GRCm39) |
nonsense |
probably null |
|
|
R6836:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6995:Vmn2r74
|
UTSW |
7 |
85,606,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6995:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7186:Vmn2r74
|
UTSW |
7 |
85,601,150 (GRCm39) |
nonsense |
probably null |
|
|
R7246:Vmn2r74
|
UTSW |
7 |
85,605,173 (GRCm39) |
missense |
probably benign |
|
|
R7374:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7505:Vmn2r74
|
UTSW |
7 |
85,606,279 (GRCm39) |
nonsense |
probably null |
|
|
R7525:Vmn2r74
|
UTSW |
7 |
85,610,510 (GRCm39) |
missense |
probably benign |
|
|
R7569:Vmn2r74
|
UTSW |
7 |
85,601,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r74
|
UTSW |
7 |
85,606,746 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7956:Vmn2r74
|
UTSW |
7 |
85,605,166 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8119:Vmn2r74
|
UTSW |
7 |
85,610,690 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
|
R8131:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8147:Vmn2r74
|
UTSW |
7 |
85,605,227 (GRCm39) |
nonsense |
probably null |
|
|
R8184:Vmn2r74
|
UTSW |
7 |
85,601,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8375:Vmn2r74
|
UTSW |
7 |
85,601,914 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8948:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8950:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9033:Vmn2r74
|
UTSW |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
|
|
R9342:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9578:Vmn2r74
|
UTSW |
7 |
85,606,101 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9607:Vmn2r74
|
UTSW |
7 |
85,610,619 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9776:Vmn2r74
|
UTSW |
7 |
85,605,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Z1176:Vmn2r74
|
UTSW |
7 |
85,604,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z31818:Vmn2r74
|
UTSW |
7 |
85,604,729 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATCAATATCTGTAGCCCACTCTATC -3'
(R):5'- GGTTTTAAAGCACCAAGTCCAG -3'
Sequencing Primer
(F):5'- AGCCCACTCTATCATTTCTTTAGAC -3'
(R):5'- CCAAGTCCAGAAAGAAAATTGTATTG -3'
|
| Posted On |
2020-07-13 |
Incidental Mutation