Incidental Mutation 'R0696:Zfp101'
| ID |
63462 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp101
|
| Ensembl Gene |
ENSMUSG00000055240 |
| Gene Name |
zinc finger protein 101 |
| Synonyms |
|
| MMRRC Submission |
038880-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.056)
|
| Stock # |
R0696 (G1)
|
| Quality Score |
181 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
33599148-33613593 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 33600401 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 452
(A452T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132508
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167107]
[ENSMUST00000174417]
[ENSMUST00000174512]
|
| AlphaFold |
Q8BP18 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167107
AA Change: A452T
PolyPhen 2
Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000132508
Gene: ENSMUSG00000055240
AA Change: A452T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
10 |
62 |
9.34e-15 |
SMART |
|
ZnF_C2H2
|
219 |
241 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
247 |
269 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
275 |
297 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
302 |
322 |
1.65e2 |
SMART |
|
ZnF_C2H2
|
330 |
352 |
6.75e0 |
SMART |
|
ZnF_C2H2
|
358 |
380 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
386 |
408 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
414 |
436 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
470 |
492 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
4.72e-2 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
583 |
605 |
5.06e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173151
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174417
|
| SMART Domains |
Protein: ENSMUSP00000134459
Gene: ENSMUSG00000055240
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
38 |
5e-16 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174512
|
| SMART Domains |
Protein: ENSMUSP00000133873
Gene: ENSMUSG00000055240
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
10 |
62 |
9.34e-15 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183047
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.7%
- 20x: 95.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Amigo2 |
T |
C |
15: 97,143,855 (GRCm39) |
K189R |
probably benign |
Het |
| Arpp21 |
A |
T |
9: 112,012,657 (GRCm39) |
|
probably null |
Het |
| Atp6v1a |
G |
T |
16: 43,907,834 (GRCm39) |
Q603K |
probably benign |
Het |
| Bcorl1 |
C |
A |
X: 47,494,895 (GRCm39) |
P1722H |
probably damaging |
Het |
| Cd209a |
C |
A |
8: 3,798,384 (GRCm39) |
A55S |
possibly damaging |
Het |
| Cdh6 |
A |
G |
15: 13,051,418 (GRCm39) |
V405A |
probably benign |
Het |
| Cdsn |
A |
T |
17: 35,866,893 (GRCm39) |
Q474L |
possibly damaging |
Het |
| Col4a4 |
T |
A |
1: 82,470,270 (GRCm39) |
D753V |
unknown |
Het |
| Csmd3 |
T |
C |
15: 47,710,569 (GRCm39) |
T1569A |
probably benign |
Het |
| Cul7 |
C |
T |
17: 46,970,534 (GRCm39) |
P1084L |
probably damaging |
Het |
| Cyp7b1 |
T |
C |
3: 18,126,749 (GRCm39) |
T466A |
probably benign |
Het |
| Enpp2 |
C |
T |
15: 54,761,092 (GRCm39) |
W253* |
probably null |
Het |
| Igf2bp2 |
A |
T |
16: 21,898,875 (GRCm39) |
S245T |
probably benign |
Het |
| Lmnb1 |
A |
G |
18: 56,873,793 (GRCm39) |
T400A |
probably damaging |
Het |
| Mecom |
T |
C |
3: 30,010,538 (GRCm39) |
T724A |
probably benign |
Het |
| Mybl1 |
T |
C |
1: 9,743,373 (GRCm39) |
N560D |
probably damaging |
Het |
| Nav1 |
A |
G |
1: 135,460,352 (GRCm39) |
S324P |
probably damaging |
Het |
| Prrc2c |
C |
T |
1: 162,536,421 (GRCm39) |
|
probably null |
Het |
| Rgma |
T |
C |
7: 73,059,160 (GRCm39) |
V88A |
probably damaging |
Het |
| Slc7a1 |
A |
T |
5: 148,277,366 (GRCm39) |
V383E |
probably benign |
Het |
| St8sia5 |
A |
G |
18: 77,342,160 (GRCm39) |
N254S |
probably damaging |
Het |
| Stx19 |
A |
G |
16: 62,642,406 (GRCm39) |
K74R |
probably benign |
Het |
| Tmem81 |
C |
G |
1: 132,435,567 (GRCm39) |
I124M |
probably damaging |
Het |
| Uap1 |
G |
A |
1: 169,976,843 (GRCm39) |
P452L |
probably benign |
Het |
| Zfp820 |
A |
G |
17: 22,039,041 (GRCm39) |
S96P |
possibly damaging |
Het |
|
| Other mutations in Zfp101 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0189:Zfp101
|
UTSW |
17 |
33,601,213 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0254:Zfp101
|
UTSW |
17 |
33,599,952 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0448:Zfp101
|
UTSW |
17 |
33,601,295 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0834:Zfp101
|
UTSW |
17 |
33,601,418 (GRCm39) |
missense |
probably benign |
0.33 |
|
R2000:Zfp101
|
UTSW |
17 |
33,600,491 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2366:Zfp101
|
UTSW |
17 |
33,599,972 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2471:Zfp101
|
UTSW |
17 |
33,599,950 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3713:Zfp101
|
UTSW |
17 |
33,600,880 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3857:Zfp101
|
UTSW |
17 |
33,601,405 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Zfp101
|
UTSW |
17 |
33,601,466 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4712:Zfp101
|
UTSW |
17 |
33,613,457 (GRCm39) |
splice site |
probably null |
|
|
R5049:Zfp101
|
UTSW |
17 |
33,600,872 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5241:Zfp101
|
UTSW |
17 |
33,601,210 (GRCm39) |
missense |
probably benign |
|
|
R5499:Zfp101
|
UTSW |
17 |
33,601,318 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5587:Zfp101
|
UTSW |
17 |
33,600,295 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5694:Zfp101
|
UTSW |
17 |
33,599,919 (GRCm39) |
missense |
probably benign |
|
|
R5994:Zfp101
|
UTSW |
17 |
33,599,936 (GRCm39) |
missense |
probably benign |
|
|
R6193:Zfp101
|
UTSW |
17 |
33,600,720 (GRCm39) |
nonsense |
probably null |
|
|
R7331:Zfp101
|
UTSW |
17 |
33,601,559 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7393:Zfp101
|
UTSW |
17 |
33,605,674 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7434:Zfp101
|
UTSW |
17 |
33,600,564 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7922:Zfp101
|
UTSW |
17 |
33,600,511 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8087:Zfp101
|
UTSW |
17 |
33,599,977 (GRCm39) |
missense |
probably benign |
|
|
R8684:Zfp101
|
UTSW |
17 |
33,600,977 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9443:Zfp101
|
UTSW |
17 |
33,601,418 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9581:Zfp101
|
UTSW |
17 |
33,605,730 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGGATGTAGGACCCAGAAATGCT -3'
(R):5'- CCATATTCATGCACACATTGTGGGAAAG -3'
Sequencing Primer
(F):5'- cggcttctctccagtgtg -3'
(R):5'- aatgtgggaaagccttcaaac -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation