Incidental Mutation 'R8181:Gmpr2'
ID 634643
Institutional Source Beutler Lab
Gene Symbol Gmpr2
Ensembl Gene ENSMUSG00000002326
Gene Name guanosine monophosphate reductase 2
Synonyms 5730544D12Rik, 1810008P16Rik
MMRRC Submission 067605-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.323) question?
Stock # R8181 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 55909398-55916657 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 55910441 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Stop codon at position 41 (S41*)
Ref Sequence ENSEMBL: ENSMUSP00000002397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002397] [ENSMUST00000010520] [ENSMUST00000163750]
AlphaFold Q99L27
Predicted Effect probably null
Transcript: ENSMUST00000002397
AA Change: S41*
SMART Domains Protein: ENSMUSP00000002397
Gene: ENSMUSG00000002326
AA Change: S41*

DomainStartEndE-ValueType
IMPDH 8 347 7.5e-147 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000010520
SMART Domains Protein: ENSMUSP00000010520
Gene: ENSMUSG00000010376

DomainStartEndE-ValueType
UBQ 1 72 3.94e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163750
SMART Domains Protein: ENSMUSP00000130492
Gene: ENSMUSG00000010376

DomainStartEndE-ValueType
UBQ 1 72 3.94e-26 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 100% (73/73)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik G A 3: 137,774,156 (GRCm39) S1115N probably damaging Het
Abca1 A G 4: 53,059,303 (GRCm39) V1551A probably benign Het
Adam30 T C 3: 98,070,291 (GRCm39) I708T probably benign Het
Aknad1 T A 3: 108,659,328 (GRCm39) L114H possibly damaging Het
Akr1c18 G A 13: 4,185,262 (GRCm39) S290L probably benign Het
Aldh18a1 G T 19: 40,545,881 (GRCm39) D635E probably benign Het
Bax G T 7: 45,115,698 (GRCm39) P23Q probably null Het
Bhlha15 A T 5: 144,128,244 (GRCm39) N119Y probably damaging Het
Boll T A 1: 55,402,478 (GRCm39) M1L probably benign Het
C2cd2 A T 16: 97,693,502 (GRCm39) I123N probably benign Het
Cacnb4 A C 2: 52,364,997 (GRCm39) S89A probably benign Het
Calca A G 7: 114,234,387 (GRCm39) C21R probably benign Het
Calcr T C 6: 3,693,899 (GRCm39) I325M probably benign Het
Card14 T A 11: 119,212,718 (GRCm39) F94Y probably damaging Het
Chil3 A C 3: 106,057,203 (GRCm39) I247S probably damaging Het
Clca3b T C 3: 144,544,898 (GRCm39) N363S probably benign Het
Cnksr3 A G 10: 7,070,475 (GRCm39) V494A possibly damaging Het
Cog4 A G 8: 111,578,717 (GRCm39) probably null Het
Crybg1 T A 10: 43,862,322 (GRCm39) Y1484F probably damaging Het
Dglucy A G 12: 100,816,370 (GRCm39) probably null Het
Dmp1 T A 5: 104,359,380 (GRCm39) probably null Het
Dscaml1 T A 9: 45,658,140 (GRCm39) I1637N possibly damaging Het
Ercc6 T A 14: 32,279,905 (GRCm39) I640N probably damaging Het
Esp16 G T 17: 39,850,707 (GRCm39) E29* probably null Het
Fam149a T C 8: 45,834,755 (GRCm39) I15V possibly damaging Het
Flt4 T A 11: 49,525,723 (GRCm39) I724N probably damaging Het
Glb1 C T 9: 114,259,429 (GRCm39) R202C probably damaging Het
Golgb1 T A 16: 36,737,192 (GRCm39) D2187E probably damaging Het
Gpsm2 A G 3: 108,597,080 (GRCm39) probably null Het
Helz A G 11: 107,563,399 (GRCm39) D1613G unknown Het
Hemgn A C 4: 46,396,504 (GRCm39) M244R possibly damaging Het
Hsd3b1 A T 3: 98,763,453 (GRCm39) V56E probably damaging Het
Jup A T 11: 100,267,751 (GRCm39) I524N probably damaging Het
Kdm1b G T 13: 47,205,377 (GRCm39) probably null Het
Kif11 A T 19: 37,379,095 (GRCm39) probably null Het
Lars1 A T 18: 42,361,835 (GRCm39) W591R probably damaging Het
Lrtm1 T A 14: 28,743,894 (GRCm39) S121T probably damaging Het
Med12l A C 3: 59,169,389 (GRCm39) D1593A probably damaging Het
Med17 A T 9: 15,188,928 (GRCm39) D112E possibly damaging Het
Mettl2 T A 11: 105,019,866 (GRCm39) F168I probably benign Het
Mmp9 A T 2: 164,792,365 (GRCm39) D323V probably damaging Het
Mpzl2 C T 9: 44,961,006 (GRCm39) T214I probably benign Het
Ms4a15 T C 19: 10,958,670 (GRCm39) H134R probably benign Het
Ms4a6d T A 19: 11,580,653 (GRCm39) I2F probably damaging Het
Muc3a G A 5: 137,244,535 (GRCm39) P206S unknown Het
Nectin2 C A 7: 19,458,733 (GRCm39) L359F probably damaging Het
Or2y6 C A 11: 52,104,096 (GRCm39) C240F probably damaging Het
Or4f53 T A 2: 111,087,918 (GRCm39) F153I probably benign Het
Pgm2 G T 5: 64,269,467 (GRCm39) C518F possibly damaging Het
Plppr4 A G 3: 117,116,114 (GRCm39) V581A probably damaging Het
Prkra G C 2: 76,469,634 (GRCm39) L142V probably damaging Het
Prpf38a G A 4: 108,434,195 (GRCm39) T74I probably benign Het
Ptprs T A 17: 56,736,064 (GRCm39) N635I probably damaging Het
Rxfp2 A G 5: 149,987,201 (GRCm39) N361D probably benign Het
Ryr3 T G 2: 112,608,588 (GRCm39) I2351L probably damaging Het
Sfmbt2 A T 2: 10,580,190 (GRCm39) T618S probably benign Het
Six6 A G 12: 72,986,906 (GRCm39) D26G probably damaging Het
Slc20a1 T C 2: 129,051,047 (GRCm39) L568P probably damaging Het
Slx4ip T A 2: 136,842,104 (GRCm39) C10S probably damaging Het
Sox13 G T 1: 133,311,498 (GRCm39) T578K probably benign Het
Spire2 A T 8: 124,088,042 (GRCm39) S509C probably damaging Het
Sptbn4 T C 7: 27,074,808 (GRCm39) D1521G possibly damaging Het
Sult2a7 T C 7: 14,204,098 (GRCm39) T207A probably benign Het
Sun2 A G 15: 79,609,721 (GRCm39) I708T probably damaging Het
Supt5 T C 7: 28,030,899 (GRCm39) E44G unknown Het
Thsd1 A G 8: 22,733,022 (GRCm39) E23G probably damaging Het
Ticrr T C 7: 79,310,728 (GRCm39) V214A possibly damaging Het
Vmn2r74 A T 7: 85,605,324 (GRCm39) F441L probably damaging Het
Zfp30 A G 7: 29,493,080 (GRCm39) T526A probably benign Het
Zfp518a G T 19: 40,902,415 (GRCm39) Q781H probably damaging Het
Zmynd11 A G 13: 9,739,687 (GRCm39) V434A probably benign Het
Zranb1 A G 7: 132,585,508 (GRCm39) D652G probably damaging Het
Other mutations in Gmpr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00235:Gmpr2 APN 14 55,913,171 (GRCm39) missense probably damaging 0.98
IGL00949:Gmpr2 APN 14 55,914,207 (GRCm39) splice site probably benign
IGL02348:Gmpr2 APN 14 55,915,758 (GRCm39) missense probably damaging 1.00
R0092:Gmpr2 UTSW 14 55,915,402 (GRCm39) missense probably benign 0.36
R0197:Gmpr2 UTSW 14 55,910,192 (GRCm39) missense possibly damaging 0.83
R0323:Gmpr2 UTSW 14 55,910,203 (GRCm39) missense probably damaging 0.99
R0594:Gmpr2 UTSW 14 55,915,445 (GRCm39) missense probably damaging 1.00
R1366:Gmpr2 UTSW 14 55,914,200 (GRCm39) splice site probably benign
R2904:Gmpr2 UTSW 14 55,910,215 (GRCm39) missense probably damaging 1.00
R4996:Gmpr2 UTSW 14 55,914,252 (GRCm39) missense probably damaging 0.99
R5407:Gmpr2 UTSW 14 55,915,733 (GRCm39) missense possibly damaging 0.72
R5695:Gmpr2 UTSW 14 55,914,691 (GRCm39) missense possibly damaging 0.77
R6721:Gmpr2 UTSW 14 55,910,191 (GRCm39) missense probably damaging 1.00
R7414:Gmpr2 UTSW 14 55,910,259 (GRCm39) critical splice donor site probably null
R7623:Gmpr2 UTSW 14 55,910,491 (GRCm39) missense probably damaging 0.99
R8944:Gmpr2 UTSW 14 55,913,149 (GRCm39) missense possibly damaging 0.70
R9487:Gmpr2 UTSW 14 55,915,778 (GRCm39) missense probably damaging 0.98
X0025:Gmpr2 UTSW 14 55,912,847 (GRCm39) missense probably benign
Z1176:Gmpr2 UTSW 14 55,910,200 (GRCm39) missense probably benign 0.32
Predicted Primers PCR Primer
(F):5'- AAACGCAGCACTCTTAAGTCTCG -3'
(R):5'- CACAACATTCTGTTAATTGCCAGAG -3'

Sequencing Primer
(F):5'- GCAGCACTCTTAAGTCTCGAAGTG -3'
(R):5'- GACTGGGAATACAGATGCAATTCCTC -3'
Posted On 2020-07-13