Incidental Mutation 'V1662:Adgra1'
ID 63485
Institutional Source Beutler Lab
Gene Symbol Adgra1
Ensembl Gene ENSMUSG00000025475
Gene Name adhesion G protein-coupled receptor A1
Synonyms Gpr123, D7Ertd680e, 2900059M17Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # V1662 () of strain 633
Quality Score 176
Status Not validated
Chromosome 7
Chromosomal Location 139834174-139878088 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 139852579 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 111 (I111T)
Ref Sequence ENSEMBL: ENSMUSP00000026548 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026548]
AlphaFold Q8C4G9
Predicted Effect probably damaging
Transcript: ENSMUST00000026548
AA Change: I111T

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000026548
Gene: ENSMUSG00000025475
AA Change: I111T

DomainStartEndE-ValueType
Pfam:7tm_2 19 307 1.4e-16 PFAM
low complexity region 407 419 N/A INTRINSIC
low complexity region 423 434 N/A INTRINSIC
low complexity region 469 481 N/A INTRINSIC
Meta Mutation Damage Score 0.7014 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb G C 5: 114,238,708 G1951R probably damaging Het
Adamts12 T A 15: 11,071,808 L146Q probably benign Het
Amph G A 13: 19,139,370 V601M probably benign Het
Arfgef1 T C 1: 10,173,253 K1024E probably damaging Het
Arhgef2 G A 3: 88,633,329 R154Q probably damaging Het
Bank1 T A 3: 136,054,418 D782V probably damaging Het
Bhlha9 G T 11: 76,673,036 R163L probably benign Het
Cacna1h T C 17: 25,377,309 N1913D possibly damaging Het
Cd7 T C 11: 121,037,126 I184V probably benign Het
Cdk2ap1 T A 5: 124,348,676 I68F possibly damaging Het
Cfap44 C A 16: 44,449,138 Y1168* probably null Het
D6Ertd527e T C 6: 87,111,892 S346P unknown Het
Daam2 A G 17: 49,464,601 L839P possibly damaging Het
Fam198a A G 9: 121,965,025 R82G probably damaging Het
Gm7030 A G 17: 36,128,931 Y104H probably benign Het
Golgb1 A G 16: 36,898,542 H270R probably benign Het
Itgav C T 2: 83,783,854 R519W possibly damaging Het
Lrp1b A T 2: 41,122,932 I2001K probably damaging Het
Lrrc40 T A 3: 158,052,789 I277K probably damaging Het
Olfr1025-ps1 C A 2: 85,918,594 T223K probably benign Het
Olfr1350 A T 7: 6,570,819 Y276F probably damaging Het
Olfr1373 T C 11: 52,145,177 M118V probably damaging Het
Olfr524 C T 7: 140,201,958 D271N possibly damaging Het
Pyroxd1 G A 6: 142,358,443 G307S probably damaging Het
Rp1 T A 1: 4,349,560 Y443F probably damaging Het
Rpusd4 C A 9: 35,272,761 S237R probably benign Het
Sdk2 A C 11: 113,834,908 W1172G probably damaging Het
Utrn A G 10: 12,421,640 Y675H probably damaging Het
Vmn1r193 A G 13: 22,219,075 I249T possibly damaging Het
Other mutations in Adgra1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00484:Adgra1 APN 7 139875944 missense probably benign 0.01
IGL01014:Adgra1 APN 7 139875660 missense probably benign 0.05
IGL01014:Adgra1 APN 7 139875661 missense probably damaging 1.00
IGL01068:Adgra1 APN 7 139845625 missense probably damaging 0.96
IGL01095:Adgra1 APN 7 139845654 missense possibly damaging 0.79
IGL02717:Adgra1 APN 7 139876178 missense probably damaging 0.98
adaga UTSW 7 139875280 missense probably damaging 1.00
I2288:Adgra1 UTSW 7 139852579 missense probably damaging 0.98
R0630:Adgra1 UTSW 7 139852584 nonsense probably null
R0653:Adgra1 UTSW 7 139876147 missense probably damaging 0.98
R1388:Adgra1 UTSW 7 139874003 missense probably damaging 0.97
R1462:Adgra1 UTSW 7 139875829 missense probably damaging 1.00
R1462:Adgra1 UTSW 7 139875829 missense probably damaging 1.00
R1667:Adgra1 UTSW 7 139845648 missense possibly damaging 0.95
R1770:Adgra1 UTSW 7 139874031 nonsense probably null
R2083:Adgra1 UTSW 7 139875631 missense probably damaging 0.99
R2967:Adgra1 UTSW 7 139875685 missense possibly damaging 0.68
R3410:Adgra1 UTSW 7 139847703 missense possibly damaging 0.94
R3411:Adgra1 UTSW 7 139847703 missense possibly damaging 0.94
R3687:Adgra1 UTSW 7 139852590 missense probably damaging 1.00
R3804:Adgra1 UTSW 7 139845594 missense probably benign 0.01
R3912:Adgra1 UTSW 7 139845714 critical splice donor site probably null
R4452:Adgra1 UTSW 7 139852521 missense probably benign 0.02
R4466:Adgra1 UTSW 7 139840836 intron probably benign
R4469:Adgra1 UTSW 7 139876061 missense probably damaging 0.96
R4675:Adgra1 UTSW 7 139876186 missense probably damaging 1.00
R4724:Adgra1 UTSW 7 139875589 missense probably benign
R5220:Adgra1 UTSW 7 139875596 missense probably benign 0.06
R5846:Adgra1 UTSW 7 139875280 missense probably damaging 1.00
R5972:Adgra1 UTSW 7 139845667 missense probably damaging 1.00
R6453:Adgra1 UTSW 7 139875427 missense probably benign 0.09
R7242:Adgra1 UTSW 7 139847657 critical splice acceptor site probably null
R7343:Adgra1 UTSW 7 139876142 missense probably damaging 1.00
R7774:Adgra1 UTSW 7 139847712 missense possibly damaging 0.79
R8190:Adgra1 UTSW 7 139876118 missense probably benign
R8355:Adgra1 UTSW 7 139875651 nonsense probably null
R8455:Adgra1 UTSW 7 139875651 nonsense probably null
R8905:Adgra1 UTSW 7 139875847 missense probably damaging 1.00
R9045:Adgra1 UTSW 7 139852650 missense possibly damaging 0.64
R9056:Adgra1 UTSW 7 139852576 missense probably damaging 1.00
R9183:Adgra1 UTSW 7 139875800 missense probably benign 0.24
R9438:Adgra1 UTSW 7 139852609 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCTGGGACAGGTGGCTGGA -3'
(R):5'- TGGTGAAGAAGGTTTACAGGACACATGA -3'

Sequencing Primer
(F):5'- acaggtggctggaggagg -3'
(R):5'- TTTACAGGACACATGAAAGGTATG -3'
Posted On 2013-07-30