Incidental Mutation 'R8187:Tmem158'
ID 634927
Institutional Source Beutler Lab
Gene Symbol Tmem158
Ensembl Gene ENSMUSG00000054871
Gene Name transmembrane protein 158
Synonyms 2310037P21Rik, Ris1
MMRRC Submission 067610-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8187 (G1)
Quality Score 135.008
Status Validated
Chromosome 9
Chromosomal Location 123088118-123089829 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 123088875 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 246 (T246S)
Ref Sequence ENSEMBL: ENSMUSP00000069161 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068140]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000068140
AA Change: T246S
SMART Domains Protein: ENSMUSP00000069161
Gene: ENSMUSG00000054871
AA Change: T246S

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 48 71 N/A INTRINSIC
low complexity region 109 115 N/A INTRINSIC
transmembrane domain 214 236 N/A INTRINSIC
SCOP:d1gkub1 247 281 4e-5 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]
PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and developmentally normal, and exhibit a normal lifespan and no predisposition to spontaneous or chemically-induced tumors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110009E18Rik A T 1: 120,115,913 (GRCm39) *122L probably null Het
4930438A08Rik A G 11: 58,180,548 (GRCm39) S200G Het
Adgre1 T A 17: 57,727,349 (GRCm39) S426R probably benign Het
Adgrg1 A G 8: 95,732,446 (GRCm39) E229G probably benign Het
Arhgap45 G A 10: 79,863,706 (GRCm39) A819T probably damaging Het
Arhgef39 A T 4: 43,498,999 (GRCm39) L84Q probably damaging Het
Bpifb9a A G 2: 154,111,377 (GRCm39) I544V probably benign Het
Brwd1 A T 16: 95,803,934 (GRCm39) L2079I probably damaging Het
Ccnh T A 13: 85,337,656 (GRCm39) M1K probably null Het
Cdh16 T C 8: 105,344,870 (GRCm39) N415S probably damaging Het
Chuk T C 19: 44,079,551 (GRCm39) N317D probably benign Het
Cnot10 A T 9: 114,426,556 (GRCm39) C665* probably null Het
Csmd1 G T 8: 16,177,188 (GRCm39) H1358Q probably damaging Het
Cyp4f37 T C 17: 32,854,171 (GRCm39) V540A probably benign Het
Daam1 A G 12: 71,942,602 (GRCm39) D22G unknown Het
Dhdds A G 4: 133,727,679 (GRCm39) probably benign Het
Dnah5 T C 15: 28,384,355 (GRCm39) V3033A probably damaging Het
Dync1i2 A G 2: 71,044,865 (GRCm39) K25R probably benign Het
Efhc1 T A 1: 21,030,396 (GRCm39) S110T probably damaging Het
Emilin3 T C 2: 160,750,000 (GRCm39) N583S possibly damaging Het
Eri2 A G 7: 119,384,767 (GRCm39) V578A probably damaging Het
F2rl2 A T 13: 95,837,911 (GRCm39) I319L probably benign Het
Gjd3 A C 11: 102,691,381 (GRCm39) Y207* probably null Het
Gm19965 T A 1: 116,749,532 (GRCm39) C404* probably null Het
Gm2832 A T 14: 41,000,915 (GRCm39) H51L Het
Gpam T C 19: 55,066,269 (GRCm39) T631A probably benign Het
Hdac2 T C 10: 36,864,132 (GRCm39) S114P probably damaging Het
Hsd3b1 T A 3: 98,759,933 (GRCm39) T353S probably damaging Het
Idh1 T C 1: 65,198,700 (GRCm39) D390G probably damaging Het
Il36g T G 2: 24,082,617 (GRCm39) L131V probably damaging Het
Irs1 G T 1: 82,266,021 (GRCm39) P732T probably damaging Het
Kansl1l T A 1: 66,840,896 (GRCm39) I135F possibly damaging Het
Mcc A G 18: 44,667,327 (GRCm39) V208A possibly damaging Het
Mgrn1 A G 16: 4,738,229 (GRCm39) N261S probably benign Het
Mybpc2 T A 7: 44,161,894 (GRCm39) N519Y possibly damaging Het
Nbeal1 G C 1: 60,276,310 (GRCm39) V684L probably benign Het
Nr1h5 G T 3: 102,861,986 (GRCm39) H94Q probably benign Het
Nsmce4a A G 7: 130,144,519 (GRCm39) V128A probably benign Het
Or5w14 T G 2: 87,541,624 (GRCm39) S209R probably benign Het
Or6y1 TTGTGTG TTGTG 1: 174,276,838 (GRCm39) probably null Het
Osmr T A 15: 6,850,485 (GRCm39) Y707F probably damaging Het
Pck1 G T 2: 172,997,033 (GRCm39) R225L probably benign Het
Prom1 A T 5: 44,191,708 (GRCm39) L354Q probably damaging Het
Rev3l C A 10: 39,682,693 (GRCm39) Q300K probably benign Het
Rin3 T A 12: 102,292,066 (GRCm39) C88S unknown Het
Slc37a4 T C 9: 44,311,291 (GRCm39) V194A possibly damaging Het
Smpd4 T A 16: 17,446,999 (GRCm39) H242Q probably damaging Het
Spen T C 4: 141,200,216 (GRCm39) I2804V possibly damaging Het
Srrm4 A C 5: 116,587,680 (GRCm39) F359L unknown Het
Svs5 A G 2: 164,079,692 (GRCm39) Y72H possibly damaging Het
Ttn A G 2: 76,633,735 (GRCm39) V14038A probably benign Het
Ttn A G 2: 76,559,790 (GRCm39) I29537T probably damaging Het
Ttn A G 2: 76,626,069 (GRCm39) S14997P probably damaging Het
Vmn1r231 A T 17: 21,110,893 (GRCm39) D7E probably benign Het
Vmn2r14 A G 5: 109,368,420 (GRCm39) S191P probably benign Het
Zfp599 G T 9: 22,161,111 (GRCm39) Y351* probably null Het
Zfp729a T A 13: 67,769,918 (GRCm39) K104* probably null Het
Other mutations in Tmem158
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1709:Tmem158 UTSW 9 123,088,950 (GRCm39) missense possibly damaging 0.90
R1779:Tmem158 UTSW 9 123,088,974 (GRCm39) missense probably benign 0.14
R7248:Tmem158 UTSW 9 123,089,390 (GRCm39) missense probably damaging 0.97
R7299:Tmem158 UTSW 9 123,089,366 (GRCm39) missense probably damaging 0.96
R7301:Tmem158 UTSW 9 123,089,366 (GRCm39) missense probably damaging 0.96
R8805:Tmem158 UTSW 9 123,089,309 (GRCm39) missense probably damaging 0.96
R8875:Tmem158 UTSW 9 123,089,132 (GRCm39) missense possibly damaging 0.62
Predicted Primers PCR Primer
(F):5'- AAGAGCCGGTTTCCCTTGTG -3'
(R):5'- TTCTGCTGCCTGGACTTCAG -3'

Sequencing Primer
(F):5'- TTCAGCCCGAGAGCTTGC -3'
(R):5'- ACTTCAGCCTGGAGGAGCTG -3'
Posted On 2020-07-13