Incidental Mutation 'R8188:Gm7298'
ID 634974
Institutional Source Beutler Lab
Gene Symbol Gm7298
Ensembl Gene ENSMUSG00000108022
Gene Name predicted gene 7298
Synonyms
MMRRC Submission 067611-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.235) question?
Stock # R8188 (G1)
Quality Score 161.009
Status Validated
Chromosome 6
Chromosomal Location 121711454-121761598 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to G at 121763537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145242 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000204124] [ENSMUST00000204124] [ENSMUST00000204124]
AlphaFold A0A0N4SVU1
Predicted Effect probably null
Transcript: ENSMUST00000204124
SMART Domains Protein: ENSMUSP00000145242
Gene: ENSMUSG00000108022

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:A2M_N 128 221 4e-18 PFAM
A2M_N_2 449 599 1e-45 SMART
A2M 740 830 2.1e-39 SMART
Pfam:Thiol-ester_cl 963 992 1.9e-15 PFAM
Pfam:A2M_comp 1012 1268 1.6e-90 PFAM
A2M_recep 1378 1465 4.3e-42 SMART
Predicted Effect probably null
Transcript: ENSMUST00000204124
SMART Domains Protein: ENSMUSP00000145242
Gene: ENSMUSG00000108022

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:A2M_N 128 221 4e-18 PFAM
A2M_N_2 449 599 1e-45 SMART
A2M 740 830 2.1e-39 SMART
Pfam:Thiol-ester_cl 963 992 1.9e-15 PFAM
Pfam:A2M_comp 1012 1268 1.6e-90 PFAM
A2M_recep 1378 1465 4.3e-42 SMART
Predicted Effect probably null
Transcript: ENSMUST00000204124
SMART Domains Protein: ENSMUSP00000145242
Gene: ENSMUSG00000108022

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:A2M_N 128 221 4e-18 PFAM
A2M_N_2 449 599 1e-45 SMART
A2M 740 830 2.1e-39 SMART
Pfam:Thiol-ester_cl 963 992 1.9e-15 PFAM
Pfam:A2M_comp 1012 1268 1.6e-90 PFAM
A2M_recep 1378 1465 4.3e-42 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aco1 C G 4: 40,180,284 (GRCm39) A395G probably benign Het
Adgrf5 G A 17: 43,741,503 (GRCm39) C380Y probably damaging Het
Astn2 T C 4: 65,977,418 (GRCm39) T422A unknown Het
Baz1b G T 5: 135,233,916 (GRCm39) V148F probably benign Het
Bicd1 A C 6: 149,451,854 (GRCm39) S823R probably damaging Het
Bltp3b C T 10: 89,647,928 (GRCm39) T1330M possibly damaging Het
Blvra A C 2: 126,937,047 (GRCm39) S167R probably damaging Het
Camsap2 G T 1: 136,225,132 (GRCm39) probably null Het
Card14 T C 11: 119,228,623 (GRCm39) S650P probably damaging Het
Ccdc121rt2 A G 5: 112,597,993 (GRCm39) D180G possibly damaging Het
Cdh2 A G 18: 16,781,593 (GRCm39) I166T probably damaging Het
Cdnf T C 2: 3,514,228 (GRCm39) V22A probably benign Het
Cfhr4 T A 1: 139,625,868 (GRCm39) I869F probably damaging Het
Chd2 T A 7: 73,079,504 (GRCm39) K1799* probably null Het
Col20a1 G A 2: 180,658,126 (GRCm39) probably null Het
Cyp4a31 T C 4: 115,426,943 (GRCm39) I182T probably benign Het
Dap3 A T 3: 88,843,543 (GRCm39) F25L probably benign Het
Dcc T A 18: 71,943,928 (GRCm39) Y241F probably benign Het
Ddx46 A G 13: 55,814,029 (GRCm39) I662V possibly damaging Het
Dzip3 T C 16: 48,772,499 (GRCm39) D390G probably damaging Het
Eif1 A G 11: 100,211,624 (GRCm39) D55G probably benign Het
Exosc5 T A 7: 25,358,790 (GRCm39) S44T probably damaging Het
Fat2 A G 11: 55,163,997 (GRCm39) V3086A probably damaging Het
Fcamr T A 1: 130,730,665 (GRCm39) probably null Het
Gcg T C 2: 62,309,004 (GRCm39) D50G probably damaging Het
Hfe A G 13: 23,892,175 (GRCm39) V63A probably damaging Het
Hoxd11 T A 2: 74,514,298 (GRCm39) I276N probably damaging Het
Htt T C 5: 34,919,287 (GRCm39) S13P probably benign Het
Il12a T A 3: 68,598,872 (GRCm39) C18S unknown Het
Itk G T 11: 46,222,776 (GRCm39) Y564* probably null Het
Lrrc46 A T 11: 96,931,705 (GRCm39) L39Q probably damaging Het
Myom3 T A 4: 135,507,231 (GRCm39) L537Q probably damaging Het
Nrap A C 19: 56,325,010 (GRCm39) Y1234* probably null Het
Or51q1 T C 7: 103,628,743 (GRCm39) S121P probably damaging Het
Or8b9 A T 9: 37,766,407 (GRCm39) M98L probably benign Het
Parn T C 16: 13,359,020 (GRCm39) D574G probably benign Het
Pbrm1 A G 14: 30,789,773 (GRCm39) I807V probably damaging Het
Pclo T A 5: 14,725,193 (GRCm39) S1350R unknown Het
Pira13 T C 7: 3,826,126 (GRCm39) H289R unknown Het
Plaa T C 4: 94,474,586 (GRCm39) Q272R probably damaging Het
Rfx6 T A 10: 51,594,292 (GRCm39) I174N probably benign Het
Ripk2 T A 4: 16,139,218 (GRCm39) K226N probably damaging Het
Scgb1b2 T C 7: 30,990,946 (GRCm39) D54G possibly damaging Het
Slc45a4 T C 15: 73,456,383 (GRCm39) Y599C probably benign Het
Slc7a13 T C 4: 19,819,082 (GRCm39) V94A probably benign Het
Slc7a8 A G 14: 54,972,579 (GRCm39) F281L probably benign Het
Slco4c1 T A 1: 96,772,261 (GRCm39) T243S probably damaging Het
Smim30 C T 6: 13,870,541 (GRCm39) G57E probably damaging Het
Stat5b A G 11: 100,692,262 (GRCm39) I174T probably damaging Het
Styk1 C A 6: 131,281,848 (GRCm39) V257L probably benign Het
Tmem268 T C 4: 63,498,209 (GRCm39) F210L probably damaging Het
Ugt2b35 T A 5: 87,149,302 (GRCm39) S184R probably damaging Het
Vps50 T A 6: 3,562,297 (GRCm39) L464* probably null Het
Zfhx2 A T 14: 55,301,898 (GRCm39) S2029T probably benign Het
Zfp235 T A 7: 23,841,296 (GRCm39) F572I probably damaging Het
Zfp280d T C 9: 72,267,615 (GRCm39) I766T probably benign Het
Zfr T G 15: 12,171,904 (GRCm39) C933W probably damaging Het
Other mutations in Gm7298
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0030:Gm7298 UTSW 6 121,751,009 (GRCm39) missense probably benign
R4978:Gm7298 UTSW 6 121,710,076 (GRCm39) critical splice donor site probably null
R4980:Gm7298 UTSW 6 121,736,198 (GRCm39) splice site probably null
R6000:Gm7298 UTSW 6 121,742,038 (GRCm39) missense possibly damaging 0.91
R6160:Gm7298 UTSW 6 121,741,886 (GRCm39) missense probably benign 0.28
R6180:Gm7298 UTSW 6 121,737,782 (GRCm39) missense probably benign 0.01
R6243:Gm7298 UTSW 6 121,756,096 (GRCm39) missense possibly damaging 0.88
R6266:Gm7298 UTSW 6 121,759,663 (GRCm39) missense probably damaging 1.00
R6268:Gm7298 UTSW 6 121,756,032 (GRCm39) missense possibly damaging 0.83
R6363:Gm7298 UTSW 6 121,765,565 (GRCm39) missense probably damaging 1.00
R6364:Gm7298 UTSW 6 121,756,402 (GRCm39) missense possibly damaging 0.90
R6527:Gm7298 UTSW 6 121,746,669 (GRCm39) missense probably benign 0.01
R6538:Gm7298 UTSW 6 121,753,132 (GRCm39) missense probably damaging 0.98
R6801:Gm7298 UTSW 6 121,752,768 (GRCm39) missense probably benign 0.03
R6884:Gm7298 UTSW 6 121,737,480 (GRCm39) missense possibly damaging 0.74
R6935:Gm7298 UTSW 6 121,744,653 (GRCm39) missense probably benign 0.02
R7051:Gm7298 UTSW 6 121,751,993 (GRCm39) critical splice donor site probably null
R7144:Gm7298 UTSW 6 121,738,546 (GRCm39) missense probably damaging 0.99
R7178:Gm7298 UTSW 6 121,762,855 (GRCm39) missense probably damaging 0.98
R7398:Gm7298 UTSW 6 121,758,912 (GRCm39) missense probably benign 0.02
R7706:Gm7298 UTSW 6 121,712,570 (GRCm39) missense probably damaging 0.96
R7793:Gm7298 UTSW 6 121,737,563 (GRCm39) critical splice donor site probably null
R7829:Gm7298 UTSW 6 121,742,297 (GRCm39) missense probably damaging 1.00
R7877:Gm7298 UTSW 6 121,759,741 (GRCm39) nonsense probably null
R8010:Gm7298 UTSW 6 121,712,542 (GRCm39) missense probably benign
R8167:Gm7298 UTSW 6 121,761,414 (GRCm39) nonsense probably null
R8248:Gm7298 UTSW 6 121,764,402 (GRCm39) missense probably benign 0.02
R8669:Gm7298 UTSW 6 121,742,002 (GRCm39) missense probably benign
R8806:Gm7298 UTSW 6 121,761,641 (GRCm39) synonymous silent
R8867:Gm7298 UTSW 6 121,748,788 (GRCm39) missense probably benign
R8907:Gm7298 UTSW 6 121,741,817 (GRCm39) missense probably benign 0.10
R8930:Gm7298 UTSW 6 121,742,030 (GRCm39) missense probably benign 0.01
R8932:Gm7298 UTSW 6 121,742,030 (GRCm39) missense probably benign 0.01
R8947:Gm7298 UTSW 6 121,757,553 (GRCm39) missense possibly damaging 0.62
R9016:Gm7298 UTSW 6 121,758,800 (GRCm39) missense possibly damaging 0.96
R9040:Gm7298 UTSW 6 121,764,438 (GRCm39) missense probably benign 0.20
R9069:Gm7298 UTSW 6 121,761,393 (GRCm39) missense probably benign
R9154:Gm7298 UTSW 6 121,756,436 (GRCm39) missense probably damaging 1.00
R9273:Gm7298 UTSW 6 121,756,604 (GRCm39) intron probably benign
R9371:Gm7298 UTSW 6 121,744,541 (GRCm39) missense probably benign 0.02
R9372:Gm7298 UTSW 6 121,748,746 (GRCm39) missense probably benign 0.21
R9490:Gm7298 UTSW 6 121,751,083 (GRCm39) missense probably benign 0.00
R9649:Gm7298 UTSW 6 121,764,491 (GRCm39) missense probably damaging 1.00
Z1176:Gm7298 UTSW 6 121,741,834 (GRCm39) missense possibly damaging 0.48
Z1176:Gm7298 UTSW 6 121,741,829 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CATCAGATTATTTTCAGTTGGGCC -3'
(R):5'- ACACCTCACCTTGGCATGTATAG -3'

Sequencing Primer
(F):5'- GGCCTTTAGTAGAGTAGCATTCAC -3'
(R):5'- CCTCACCTTGGCATGTATAGGAAGG -3'
Posted On 2020-07-13