Incidental Mutation 'R0720:Eri3'
ID 63511
Institutional Source Beutler Lab
Gene Symbol Eri3
Ensembl Gene ENSMUSG00000033423
Gene Name exoribonuclease 3
Synonyms PINT1, Prnpip1
MMRRC Submission 038902-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0720 (G1)
Quality Score 110
Status Validated
Chromosome 4
Chromosomal Location 117407562-117531494 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 117410242 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117034 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037127] [ENSMUST00000144373]
AlphaFold Q8C460
Predicted Effect probably null
Transcript: ENSMUST00000037127
SMART Domains Protein: ENSMUSP00000042796
Gene: ENSMUSG00000033423

DomainStartEndE-ValueType
low complexity region 23 35 N/A INTRINSIC
low complexity region 124 135 N/A INTRINSIC
EXOIII 145 329 1.17e-42 SMART
Predicted Effect probably null
Transcript: ENSMUST00000144373
SMART Domains Protein: ENSMUSP00000117034
Gene: ENSMUSG00000033423

DomainStartEndE-ValueType
low complexity region 85 96 N/A INTRINSIC
Pfam:RNase_T 108 163 3.7e-14 PFAM
Meta Mutation Damage Score 0.9582 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.7%
  • 20x: 95.9%
Validation Efficiency 98% (44/45)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf2 A G 17: 43,024,063 (GRCm39) I136T probably damaging Het
Bbs7 T C 3: 36,646,572 (GRCm39) D416G probably damaging Het
Commd4 G T 9: 57,062,718 (GRCm39) D179E probably benign Het
Cyp3a57 T C 5: 145,327,213 (GRCm39) probably benign Het
Dnah5 A G 15: 28,314,007 (GRCm39) N1941S probably null Het
Dynap T C 18: 70,374,055 (GRCm39) D157G unknown Het
Entrep2 A G 7: 64,469,658 (GRCm39) probably benign Het
Fbxo25 A G 8: 13,985,222 (GRCm39) Y305C probably damaging Het
Flt4 C T 11: 49,527,166 (GRCm39) probably benign Het
Fxr2 A G 11: 69,530,241 (GRCm39) D36G probably benign Het
Gas2l3 T C 10: 89,249,805 (GRCm39) T438A probably benign Het
Gcm1 A T 9: 77,971,923 (GRCm39) Y288F possibly damaging Het
Gm3164 C A 14: 4,442,719 (GRCm38) S218R probably benign Het
Hipk2 C T 6: 38,675,491 (GRCm39) R1029H probably damaging Het
Htra3 T C 5: 35,811,453 (GRCm39) I392M probably damaging Het
Kansl1l T C 1: 66,840,515 (GRCm39) M262V possibly damaging Het
Lrrc47 T C 4: 154,104,344 (GRCm39) probably null Het
Macf1 A T 4: 123,326,718 (GRCm39) N4926K probably damaging Het
Mllt10 T C 2: 18,201,406 (GRCm39) S631P probably benign Het
Nlrp14 A G 7: 106,781,220 (GRCm39) H139R probably benign Het
Or1e34 T A 11: 73,778,688 (GRCm39) N170I probably benign Het
Or5w20 A T 2: 87,727,013 (GRCm39) T157S probably benign Het
Ptger2 T C 14: 45,226,590 (GRCm39) C57R probably benign Het
Rhot1 T C 11: 80,114,769 (GRCm39) V59A probably damaging Het
Rmdn2 G A 17: 79,975,458 (GRCm39) probably null Het
Rxfp2 G T 5: 149,967,584 (GRCm39) K148N probably benign Het
Sec23a G A 12: 59,018,057 (GRCm39) T623M probably damaging Het
Smcr8 T C 11: 60,669,269 (GRCm39) L139P probably damaging Het
Spag6l A T 16: 16,584,960 (GRCm39) probably benign Het
Taar1 T C 10: 23,796,971 (GRCm39) I223T probably damaging Het
Tdo2 G T 3: 81,870,065 (GRCm39) A269E probably damaging Het
Tnfsf18 A G 1: 161,331,156 (GRCm39) Y102C possibly damaging Het
Tns1 A G 1: 73,964,740 (GRCm39) L1297P probably benign Het
Txndc8 C T 4: 57,984,245 (GRCm39) probably benign Het
Ubr5 T C 15: 37,973,235 (GRCm39) N2622S probably damaging Het
Vmn2r99 T A 17: 19,599,305 (GRCm39) F330I probably benign Het
Zdhhc2 T A 8: 40,925,948 (GRCm39) probably null Het
Other mutations in Eri3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00678:Eri3 APN 4 117,422,088 (GRCm39) missense probably benign 0.00
IGL01392:Eri3 APN 4 117,446,356 (GRCm39) critical splice donor site probably null
IGL01781:Eri3 APN 4 117,421,874 (GRCm39) missense probably benign 0.00
IGL02737:Eri3 APN 4 117,422,057 (GRCm39) missense probably damaging 1.00
IGL02969:Eri3 APN 4 117,506,508 (GRCm39) missense probably damaging 1.00
chewed_out UTSW 4 117,506,604 (GRCm39) critical splice donor site probably null
PIT4280001:Eri3 UTSW 4 117,439,831 (GRCm39) missense probably damaging 1.00
R0993:Eri3 UTSW 4 117,421,860 (GRCm39) missense possibly damaging 0.85
R1331:Eri3 UTSW 4 117,422,104 (GRCm39) splice site probably benign
R1538:Eri3 UTSW 4 117,439,836 (GRCm39) missense possibly damaging 0.92
R1854:Eri3 UTSW 4 117,506,562 (GRCm39) missense probably benign 0.01
R1971:Eri3 UTSW 4 117,421,964 (GRCm39) missense probably benign 0.10
R5340:Eri3 UTSW 4 117,530,991 (GRCm39) missense probably damaging 0.99
R5511:Eri3 UTSW 4 117,472,386 (GRCm39) missense possibly damaging 0.90
R5569:Eri3 UTSW 4 117,506,553 (GRCm39) missense possibly damaging 0.90
R6052:Eri3 UTSW 4 117,421,825 (GRCm39) missense probably damaging 0.99
R7140:Eri3 UTSW 4 117,506,604 (GRCm39) critical splice donor site probably null
R7187:Eri3 UTSW 4 117,446,343 (GRCm39) missense probably benign 0.03
R7268:Eri3 UTSW 4 117,506,580 (GRCm39) missense probably benign
R8083:Eri3 UTSW 4 117,450,359 (GRCm39) missense probably damaging 1.00
R8557:Eri3 UTSW 4 117,472,520 (GRCm39) missense possibly damaging 0.73
R9430:Eri3 UTSW 4 117,439,868 (GRCm39) nonsense probably null
R9563:Eri3 UTSW 4 117,422,013 (GRCm39) missense probably benign 0.15
R9565:Eri3 UTSW 4 117,422,013 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- GTCTAGGAGTGACCACCAGTGAGAA -3'
(R):5'- TCCATAACCCTCAAGGCAAGGAACT -3'

Sequencing Primer
(F):5'- AATGTGTGTCTGTCCACAGC -3'
(R):5'- tggaaggcagaggcagg -3'
Posted On 2013-07-30