|Institutional Source||Beutler Lab|
|Gene Name||5 hydroxytryptamine (serotonin) receptor 4|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8190 (G1)|
|Chromosomal Location||62324204-62467802 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 62437900 bp|
|Amino Acid Change||Glutamine to Arginine at position 342 (Q342R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000027560 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027560]|
|Predicted Effect||possibly damaging
AA Change: Q342R
PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
AA Change: Q342R
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutant mice exhibit attenuated feeding behavior following stress and novelty and show a hypersensitivity to seizures. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Htr4||
(F):5'- TAGACTACACTGTCCCCGAG -3'
(R):5'- AACAGAGCCCAAGTCCTTGC -3'
(F):5'- AGCAGGTGTGGACTGCTTTCC -3'
(R):5'- GCCCACTAATTGATTCCATGGTTAG -3'