Incidental Mutation 'R8191:Zfp607a'
ID 635157
Institutional Source Beutler Lab
Gene Symbol Zfp607a
Ensembl Gene ENSMUSG00000020420
Gene Name zinc finger protein 607A
Synonyms Zfp607, 4732475C15Rik
MMRRC Submission 067614-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R8191 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 27556952-27580250 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27578868 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 646 (E646G)
Ref Sequence ENSEMBL: ENSMUSP00000146261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053722] [ENSMUST00000205534] [ENSMUST00000205715]
AlphaFold Q3TQG9
Predicted Effect possibly damaging
Transcript: ENSMUST00000053722
AA Change: E646G

PolyPhen 2 Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000051496
Gene: ENSMUSG00000020420
AA Change: E646G

DomainStartEndE-ValueType
KRAB 14 75 8.48e-36 SMART
ZnF_C2H2 173 195 2.91e-2 SMART
ZnF_C2H2 201 223 3.44e-4 SMART
ZnF_C2H2 229 251 3.83e-2 SMART
ZnF_C2H2 257 279 4.87e-4 SMART
ZnF_C2H2 285 307 1.38e-3 SMART
ZnF_C2H2 313 335 4.17e-3 SMART
ZnF_C2H2 341 363 2.86e-1 SMART
ZnF_C2H2 369 391 5.14e-3 SMART
ZnF_C2H2 397 419 1.2e-3 SMART
ZnF_C2H2 425 447 4.47e-3 SMART
ZnF_C2H2 453 475 1.1e-2 SMART
ZnF_C2H2 481 503 1.45e-2 SMART
ZnF_C2H2 509 531 1.12e-3 SMART
ZnF_C2H2 537 559 1.5e-4 SMART
ZnF_C2H2 565 587 8.34e-3 SMART
ZnF_C2H2 593 615 1.12e-3 SMART
ZnF_C2H2 621 643 6.42e-4 SMART
ZnF_C2H2 649 671 6.23e-2 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000205534
AA Change: E646G

PolyPhen 2 Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000205715
AA Change: E646G

PolyPhen 2 Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700037C18Rik G A 16: 3,724,918 (GRCm39) R49W probably damaging Het
Adamts4 T C 1: 171,080,292 (GRCm39) S282P Het
Aqp4 A G 18: 15,531,222 (GRCm39) S180P probably benign Het
Armc2 T G 10: 41,839,747 (GRCm39) E406A probably benign Het
Atp13a3 A T 16: 30,168,598 (GRCm39) Y464N probably damaging Het
B3gnt3 C A 8: 72,146,122 (GRCm39) V136L probably benign Het
Cacna1s C T 1: 136,035,893 (GRCm39) H1378Y probably damaging Het
Ccnk A T 12: 108,159,933 (GRCm39) E138D probably benign Het
Cenpe A G 3: 134,957,375 (GRCm39) K1878E probably benign Het
Cep57l1 T A 10: 41,616,955 (GRCm39) I111L probably damaging Het
Cfap298 G T 16: 90,727,889 (GRCm39) N100K probably damaging Het
Copg2 T C 6: 30,790,665 (GRCm39) I509V probably benign Het
Cux2 T A 5: 122,012,217 (GRCm39) D406V probably benign Het
Cyp2a12 G T 7: 26,730,529 (GRCm39) A165S probably benign Het
Dnaaf5 T G 5: 139,167,250 (GRCm39) S719A probably benign Het
Dnah7c A G 1: 46,646,618 (GRCm39) I1220V possibly damaging Het
Dnai3 G T 3: 145,800,066 (GRCm39) P158H probably damaging Het
Dnajb8 C T 6: 88,199,940 (GRCm39) R159C possibly damaging Het
Dusp10 T A 1: 183,769,749 (GRCm39) D238E possibly damaging Het
Dync1li1 C A 9: 114,538,253 (GRCm39) D203E probably benign Het
Ecpas A T 4: 58,872,587 (GRCm39) probably null Het
Eif5b T C 1: 38,075,283 (GRCm39) S587P probably damaging Het
Ephb2 G A 4: 136,386,256 (GRCm39) T832I probably damaging Het
Exoc1 T A 5: 76,707,674 (GRCm39) probably null Het
Fam193a T A 5: 34,597,917 (GRCm39) N571K probably damaging Het
Fem1a T A 17: 56,565,356 (GRCm39) I483N probably damaging Het
Fgf20 C A 8: 40,761,361 (GRCm39) probably benign Het
Fkbp1a C T 2: 151,399,356 (GRCm39) P98S Het
Gpsm3 A T 17: 34,809,451 (GRCm39) D19V probably benign Het
Ido2 C A 8: 25,023,696 (GRCm39) G381W probably damaging Het
Ifi204 T C 1: 173,579,226 (GRCm39) T540A possibly damaging Het
Isl1 A T 13: 116,441,954 (GRCm39) M93K probably benign Het
Map3k10 T A 7: 27,362,671 (GRCm39) S472C probably damaging Het
Mcrs1 A T 15: 99,141,206 (GRCm39) V432E probably damaging Het
Metap2 A G 10: 93,701,267 (GRCm39) probably null Het
Muc5b A G 7: 141,421,421 (GRCm39) S4304G probably benign Het
Myef2l G T 3: 10,153,914 (GRCm39) V228F probably damaging Het
Nell1 T C 7: 50,098,622 (GRCm39) V308A unknown Het
Or10g1b A G 14: 52,627,987 (GRCm39) V81A probably benign Het
Or4d5 A T 9: 40,012,767 (GRCm39) H6Q probably benign Het
Plxna4 C A 6: 32,493,885 (GRCm39) V244F possibly damaging Het
Pnpla6 T C 8: 3,592,382 (GRCm39) S1224P probably benign Het
Ripk4 A G 16: 97,564,726 (GRCm39) probably benign Het
Rnpep T C 1: 135,200,172 (GRCm39) E261G possibly damaging Het
Robo1 C A 16: 72,730,142 (GRCm39) S194R probably damaging Het
Rpusd1 C G 17: 25,947,611 (GRCm39) Y99* probably null Het
Scarf1 T C 11: 75,413,065 (GRCm39) M437T probably benign Het
Sh3tc2 G T 18: 62,106,429 (GRCm39) D153Y probably damaging Het
Siglec1 T C 2: 130,927,599 (GRCm39) Y69C probably damaging Het
Slc25a34 T C 4: 141,347,895 (GRCm39) Y262C probably damaging Het
Srrm2 T A 17: 24,039,219 (GRCm39) N1954K probably damaging Het
St6galnac2 T C 11: 116,572,748 (GRCm39) Y236C probably damaging Het
Stac3 T A 10: 127,344,068 (GRCm39) I322N probably damaging Het
Tcaf1 T C 6: 42,652,190 (GRCm39) Q764R probably damaging Het
Tcf20 G A 15: 82,737,606 (GRCm39) R1282* probably null Het
Tlr2 T A 3: 83,743,821 (GRCm39) K754M probably damaging Het
Tlr2 T G 3: 83,743,822 (GRCm39) K754Q probably damaging Het
Tnn C T 1: 159,953,088 (GRCm39) V651M probably damaging Het
Ttn T C 2: 76,701,083 (GRCm39) H9622R unknown Het
Tubgcp6 C T 15: 89,004,843 (GRCm39) G259S probably damaging Het
Ubr5 C A 15: 38,006,751 (GRCm39) C1174F Het
Ugt2b35 T A 5: 87,149,302 (GRCm39) S184R probably damaging Het
Vit C T 17: 78,853,828 (GRCm39) H25Y probably benign Het
Vmn1r177 G A 7: 23,565,736 (GRCm39) Q47* probably null Het
Vmn2r104 A T 17: 20,250,465 (GRCm39) V602D possibly damaging Het
Vmn2r115 A G 17: 23,578,530 (GRCm39) T668A probably damaging Het
Vmn2r125 T G 4: 156,703,709 (GRCm39) C362W probably damaging Het
Vwa7 A G 17: 35,238,712 (GRCm39) T267A probably damaging Het
Xpa C A 4: 46,183,225 (GRCm39) R188L possibly damaging Het
Zfp143 C T 7: 109,676,364 (GRCm39) T249I probably damaging Het
Zfp729a A T 13: 67,769,838 (GRCm39) S130R probably benign Het
Zswim3 C A 2: 164,662,128 (GRCm39) Q203K probably damaging Het
Other mutations in Zfp607a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Zfp607a APN 7 27,577,214 (GRCm39) missense possibly damaging 0.55
IGL01019:Zfp607a APN 7 27,578,042 (GRCm39) missense probably damaging 1.00
IGL01412:Zfp607a APN 7 27,578,109 (GRCm39) missense probably damaging 0.99
IGL03206:Zfp607a APN 7 27,577,248 (GRCm39) missense possibly damaging 0.52
R0071:Zfp607a UTSW 7 27,577,694 (GRCm39) missense probably damaging 0.96
R0304:Zfp607a UTSW 7 27,578,637 (GRCm39) missense possibly damaging 0.92
R0685:Zfp607a UTSW 7 27,577,901 (GRCm39) missense probably damaging 0.97
R0726:Zfp607a UTSW 7 27,578,574 (GRCm39) missense probably benign 0.00
R1201:Zfp607a UTSW 7 27,578,736 (GRCm39) missense probably damaging 1.00
R1304:Zfp607a UTSW 7 27,565,000 (GRCm39) missense probably benign 0.00
R1648:Zfp607a UTSW 7 27,578,493 (GRCm39) missense probably benign 0.02
R1732:Zfp607a UTSW 7 27,577,884 (GRCm39) missense probably damaging 1.00
R2194:Zfp607a UTSW 7 27,578,805 (GRCm39) missense possibly damaging 0.73
R3793:Zfp607a UTSW 7 27,578,331 (GRCm39) missense probably benign 0.01
R3808:Zfp607a UTSW 7 27,578,826 (GRCm39) missense probably benign 0.01
R4296:Zfp607a UTSW 7 27,565,073 (GRCm39) missense probably damaging 1.00
R4786:Zfp607a UTSW 7 27,578,838 (GRCm39) missense probably damaging 1.00
R4792:Zfp607a UTSW 7 27,578,078 (GRCm39) missense probably benign 0.23
R4915:Zfp607a UTSW 7 27,577,985 (GRCm39) missense probably benign 0.00
R4950:Zfp607a UTSW 7 27,578,176 (GRCm39) missense probably damaging 1.00
R5123:Zfp607a UTSW 7 27,578,523 (GRCm39) missense probably damaging 1.00
R5217:Zfp607a UTSW 7 27,577,269 (GRCm39) missense probably damaging 0.97
R5270:Zfp607a UTSW 7 27,577,730 (GRCm39) nonsense probably null
R5403:Zfp607a UTSW 7 27,578,744 (GRCm39) missense possibly damaging 0.54
R6010:Zfp607a UTSW 7 27,577,254 (GRCm39) nonsense probably null
R6224:Zfp607a UTSW 7 27,578,007 (GRCm39) missense probably damaging 1.00
R6939:Zfp607a UTSW 7 27,578,473 (GRCm39) nonsense probably null
R6953:Zfp607a UTSW 7 27,577,790 (GRCm39) missense possibly damaging 0.59
R7082:Zfp607a UTSW 7 27,578,183 (GRCm39) missense probably damaging 1.00
R7781:Zfp607a UTSW 7 27,565,000 (GRCm39) missense possibly damaging 0.90
R7909:Zfp607a UTSW 7 27,578,519 (GRCm39) missense probably damaging 1.00
R8224:Zfp607a UTSW 7 27,577,536 (GRCm39) missense probably damaging 1.00
R8949:Zfp607a UTSW 7 27,577,944 (GRCm39) missense possibly damaging 0.56
R8962:Zfp607a UTSW 7 27,578,786 (GRCm39) missense possibly damaging 0.79
R9178:Zfp607a UTSW 7 27,577,382 (GRCm39) missense probably benign 0.00
R9802:Zfp607a UTSW 7 27,578,704 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGGAAAGCTTTTAATCATCGCTC -3'
(R):5'- CCAAGCTTGACTAATAGCCTTCAC -3'

Sequencing Primer
(F):5'- CATTCTGATGAGAGACCCTTTGAG -3'
(R):5'- GCTTGACTAATAGCCTTCACAAATC -3'
Posted On 2020-07-13