Incidental Mutation 'R8191:Ido2'
ID 635162
Institutional Source Beutler Lab
Gene Symbol Ido2
Ensembl Gene ENSMUSG00000031549
Gene Name indoleamine 2,3-dioxygenase 2
Synonyms Ido2, C230043N17Rik, Indol1
MMRRC Submission 067614-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8191 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 25021908-25066349 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 25023696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Tryptophan at position 381 (G381W)
Ref Sequence ENSEMBL: ENSMUSP00000113979 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121992]
AlphaFold Q8R0V5
Predicted Effect probably damaging
Transcript: ENSMUST00000121992
AA Change: G381W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113979
Gene: ENSMUSG00000031549
AA Change: G381W

DomainStartEndE-ValueType
Pfam:IDO 15 399 1.4e-124 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired T cell function and decreased susceptibility to type IV hypersensitivity reaction. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700037C18Rik G A 16: 3,724,918 (GRCm39) R49W probably damaging Het
Adamts4 T C 1: 171,080,292 (GRCm39) S282P Het
Aqp4 A G 18: 15,531,222 (GRCm39) S180P probably benign Het
Armc2 T G 10: 41,839,747 (GRCm39) E406A probably benign Het
Atp13a3 A T 16: 30,168,598 (GRCm39) Y464N probably damaging Het
B3gnt3 C A 8: 72,146,122 (GRCm39) V136L probably benign Het
Cacna1s C T 1: 136,035,893 (GRCm39) H1378Y probably damaging Het
Ccnk A T 12: 108,159,933 (GRCm39) E138D probably benign Het
Cenpe A G 3: 134,957,375 (GRCm39) K1878E probably benign Het
Cep57l1 T A 10: 41,616,955 (GRCm39) I111L probably damaging Het
Cfap298 G T 16: 90,727,889 (GRCm39) N100K probably damaging Het
Copg2 T C 6: 30,790,665 (GRCm39) I509V probably benign Het
Cux2 T A 5: 122,012,217 (GRCm39) D406V probably benign Het
Cyp2a12 G T 7: 26,730,529 (GRCm39) A165S probably benign Het
Dnaaf5 T G 5: 139,167,250 (GRCm39) S719A probably benign Het
Dnah7c A G 1: 46,646,618 (GRCm39) I1220V possibly damaging Het
Dnai3 G T 3: 145,800,066 (GRCm39) P158H probably damaging Het
Dnajb8 C T 6: 88,199,940 (GRCm39) R159C possibly damaging Het
Dusp10 T A 1: 183,769,749 (GRCm39) D238E possibly damaging Het
Dync1li1 C A 9: 114,538,253 (GRCm39) D203E probably benign Het
Ecpas A T 4: 58,872,587 (GRCm39) probably null Het
Eif5b T C 1: 38,075,283 (GRCm39) S587P probably damaging Het
Ephb2 G A 4: 136,386,256 (GRCm39) T832I probably damaging Het
Exoc1 T A 5: 76,707,674 (GRCm39) probably null Het
Fam193a T A 5: 34,597,917 (GRCm39) N571K probably damaging Het
Fem1a T A 17: 56,565,356 (GRCm39) I483N probably damaging Het
Fgf20 C A 8: 40,761,361 (GRCm39) probably benign Het
Fkbp1a C T 2: 151,399,356 (GRCm39) P98S Het
Gpsm3 A T 17: 34,809,451 (GRCm39) D19V probably benign Het
Ifi204 T C 1: 173,579,226 (GRCm39) T540A possibly damaging Het
Isl1 A T 13: 116,441,954 (GRCm39) M93K probably benign Het
Map3k10 T A 7: 27,362,671 (GRCm39) S472C probably damaging Het
Mcrs1 A T 15: 99,141,206 (GRCm39) V432E probably damaging Het
Metap2 A G 10: 93,701,267 (GRCm39) probably null Het
Muc5b A G 7: 141,421,421 (GRCm39) S4304G probably benign Het
Myef2l G T 3: 10,153,914 (GRCm39) V228F probably damaging Het
Nell1 T C 7: 50,098,622 (GRCm39) V308A unknown Het
Or10g1b A G 14: 52,627,987 (GRCm39) V81A probably benign Het
Or4d5 A T 9: 40,012,767 (GRCm39) H6Q probably benign Het
Plxna4 C A 6: 32,493,885 (GRCm39) V244F possibly damaging Het
Pnpla6 T C 8: 3,592,382 (GRCm39) S1224P probably benign Het
Ripk4 A G 16: 97,564,726 (GRCm39) probably benign Het
Rnpep T C 1: 135,200,172 (GRCm39) E261G possibly damaging Het
Robo1 C A 16: 72,730,142 (GRCm39) S194R probably damaging Het
Rpusd1 C G 17: 25,947,611 (GRCm39) Y99* probably null Het
Scarf1 T C 11: 75,413,065 (GRCm39) M437T probably benign Het
Sh3tc2 G T 18: 62,106,429 (GRCm39) D153Y probably damaging Het
Siglec1 T C 2: 130,927,599 (GRCm39) Y69C probably damaging Het
Slc25a34 T C 4: 141,347,895 (GRCm39) Y262C probably damaging Het
Srrm2 T A 17: 24,039,219 (GRCm39) N1954K probably damaging Het
St6galnac2 T C 11: 116,572,748 (GRCm39) Y236C probably damaging Het
Stac3 T A 10: 127,344,068 (GRCm39) I322N probably damaging Het
Tcaf1 T C 6: 42,652,190 (GRCm39) Q764R probably damaging Het
Tcf20 G A 15: 82,737,606 (GRCm39) R1282* probably null Het
Tlr2 T A 3: 83,743,821 (GRCm39) K754M probably damaging Het
Tlr2 T G 3: 83,743,822 (GRCm39) K754Q probably damaging Het
Tnn C T 1: 159,953,088 (GRCm39) V651M probably damaging Het
Ttn T C 2: 76,701,083 (GRCm39) H9622R unknown Het
Tubgcp6 C T 15: 89,004,843 (GRCm39) G259S probably damaging Het
Ubr5 C A 15: 38,006,751 (GRCm39) C1174F Het
Ugt2b35 T A 5: 87,149,302 (GRCm39) S184R probably damaging Het
Vit C T 17: 78,853,828 (GRCm39) H25Y probably benign Het
Vmn1r177 G A 7: 23,565,736 (GRCm39) Q47* probably null Het
Vmn2r104 A T 17: 20,250,465 (GRCm39) V602D possibly damaging Het
Vmn2r115 A G 17: 23,578,530 (GRCm39) T668A probably damaging Het
Vmn2r125 T G 4: 156,703,709 (GRCm39) C362W probably damaging Het
Vwa7 A G 17: 35,238,712 (GRCm39) T267A probably damaging Het
Xpa C A 4: 46,183,225 (GRCm39) R188L possibly damaging Het
Zfp143 C T 7: 109,676,364 (GRCm39) T249I probably damaging Het
Zfp607a A G 7: 27,578,868 (GRCm39) E646G possibly damaging Het
Zfp729a A T 13: 67,769,838 (GRCm39) S130R probably benign Het
Zswim3 C A 2: 164,662,128 (GRCm39) Q203K probably damaging Het
Other mutations in Ido2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0413:Ido2 UTSW 8 25,048,159 (GRCm39) splice site probably null
R1103:Ido2 UTSW 8 25,066,239 (GRCm39) missense probably benign 0.08
R1601:Ido2 UTSW 8 25,066,205 (GRCm39) missense possibly damaging 0.57
R1868:Ido2 UTSW 8 25,043,776 (GRCm39) missense possibly damaging 0.90
R2158:Ido2 UTSW 8 25,030,652 (GRCm39) missense probably damaging 1.00
R2266:Ido2 UTSW 8 25,025,268 (GRCm39) missense probably damaging 1.00
R2267:Ido2 UTSW 8 25,025,268 (GRCm39) missense probably damaging 1.00
R2268:Ido2 UTSW 8 25,025,268 (GRCm39) missense probably damaging 1.00
R2484:Ido2 UTSW 8 25,023,831 (GRCm39) missense probably damaging 1.00
R3151:Ido2 UTSW 8 25,023,776 (GRCm39) missense possibly damaging 0.61
R3735:Ido2 UTSW 8 25,025,209 (GRCm39) missense probably damaging 0.98
R3820:Ido2 UTSW 8 25,023,771 (GRCm39) missense probably benign 0.00
R3821:Ido2 UTSW 8 25,023,771 (GRCm39) missense probably benign 0.00
R3822:Ido2 UTSW 8 25,023,771 (GRCm39) missense probably benign 0.00
R4520:Ido2 UTSW 8 25,066,194 (GRCm39) missense probably damaging 0.99
R4824:Ido2 UTSW 8 25,023,875 (GRCm39) missense probably benign 0.12
R4949:Ido2 UTSW 8 25,023,970 (GRCm39) critical splice acceptor site probably null
R5235:Ido2 UTSW 8 25,037,202 (GRCm39) missense probably damaging 0.99
R5580:Ido2 UTSW 8 25,040,882 (GRCm39) missense possibly damaging 0.67
R5961:Ido2 UTSW 8 25,023,786 (GRCm39) missense probably damaging 1.00
R6433:Ido2 UTSW 8 25,023,939 (GRCm39) missense probably damaging 1.00
R7085:Ido2 UTSW 8 25,048,212 (GRCm39) missense probably benign 0.09
R7186:Ido2 UTSW 8 25,040,826 (GRCm39) splice site probably null
R7248:Ido2 UTSW 8 25,038,839 (GRCm39) missense probably damaging 0.97
R7248:Ido2 UTSW 8 25,030,657 (GRCm39) nonsense probably null
R7287:Ido2 UTSW 8 25,025,154 (GRCm39) splice site probably null
R7788:Ido2 UTSW 8 25,037,242 (GRCm39) missense probably damaging 0.99
R7923:Ido2 UTSW 8 25,066,209 (GRCm39) missense probably damaging 1.00
R8026:Ido2 UTSW 8 25,025,156 (GRCm39) critical splice donor site probably null
R9132:Ido2 UTSW 8 25,023,933 (GRCm39) missense probably damaging 1.00
R9429:Ido2 UTSW 8 25,037,194 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCACTAGGATGCAGGACATG -3'
(R):5'- ACTACATACTGGCCTCTGGTCC -3'

Sequencing Primer
(F):5'- ACATGACTGCTAAGCGCTG -3'
(R):5'- TCCTGGGGACTGCCTGATG -3'
Posted On 2020-07-13