Incidental Mutation 'R8195:Or10p21'
ID 635409
Institutional Source Beutler Lab
Gene Symbol Or10p21
Ensembl Gene ENSMUSG00000063374
Gene Name olfactory receptor family 10 subfamily P member 21
Synonyms MOR269-2, GA_x6K02T2PULF-10696986-10697915, Olfr763
MMRRC Submission 067618-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R8195 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 128847156-128848085 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 128847444 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 97 (C97R)
Ref Sequence ENSEMBL: ENSMUSP00000076671 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077460]
AlphaFold Q8VGC1
Predicted Effect probably damaging
Transcript: ENSMUST00000077460
AA Change: C97R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000076671
Gene: ENSMUSG00000063374
AA Change: C97R

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.9e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.3e-10 PFAM
Pfam:7tm_1 41 290 6.9e-15 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 G A 11: 9,224,735 (GRCm39) G483R probably benign Het
Abca9 T C 11: 110,029,155 (GRCm39) D801G probably benign Het
Aldob T C 4: 49,538,822 (GRCm39) N232S probably damaging Het
Ankhd1 T C 18: 36,787,230 (GRCm39) V322A Het
Arfgef1 T C 1: 10,243,478 (GRCm39) K1024E probably damaging Het
Arhgef40 T A 14: 52,226,226 (GRCm39) V90E probably damaging Het
Cblc A T 7: 19,519,262 (GRCm39) S399R possibly damaging Het
Ccdc17 T A 4: 116,456,211 (GRCm39) I368K possibly damaging Het
Ccdc17 T A 4: 116,456,213 (GRCm39) W369R probably damaging Het
Cd276 G A 9: 58,444,755 (GRCm39) T72I probably damaging Het
Cdk14 C T 5: 5,277,159 (GRCm39) probably null Het
Cfap61 C T 2: 145,789,095 (GRCm39) S33L probably benign Het
Cmtm2a A G 8: 105,019,670 (GRCm39) F7L probably benign Het
Eif2ak4 T C 2: 118,280,819 (GRCm39) I1062T possibly damaging Het
Fcnb C T 2: 27,968,330 (GRCm39) S209N possibly damaging Het
Fxr1 A T 3: 34,101,878 (GRCm39) E204V probably damaging Het
Fzd6 T A 15: 38,894,959 (GRCm39) L375Q probably damaging Het
Ggta1 T A 2: 35,312,279 (GRCm39) E33V probably damaging Het
Gnb1l T A 16: 18,362,965 (GRCm39) I119N probably benign Het
Gpsm1 A G 2: 26,214,929 (GRCm39) probably null Het
Hecw1 A G 13: 14,480,692 (GRCm39) I885T probably damaging Het
Itgb8 T C 12: 119,131,905 (GRCm39) D580G probably damaging Het
Kbtbd12 T A 6: 88,594,913 (GRCm39) T306S possibly damaging Het
Kctd1 C T 18: 15,196,300 (GRCm39) E108K unknown Het
Lrrc36 A G 8: 106,178,717 (GRCm39) D304G possibly damaging Het
Lrrn2 A G 1: 132,865,082 (GRCm39) E49G probably damaging Het
Lysmd2 C A 9: 75,533,310 (GRCm39) Y88* probably null Het
Lzts3 A G 2: 130,477,105 (GRCm39) S448P probably benign Het
Meioc T A 11: 102,565,893 (GRCm39) L447* probably null Het
Mybpc1 A G 10: 88,394,553 (GRCm39) I244T possibly damaging Het
Necab3 G A 2: 154,389,363 (GRCm39) A160V probably benign Het
Nek8 G T 11: 78,061,587 (GRCm39) P314Q possibly damaging Het
Nlrp5 A G 7: 23,112,762 (GRCm39) T140A probably benign Het
Or52ac1 A T 7: 104,246,133 (GRCm39) F85Y probably damaging Het
Or7e169 A T 9: 19,757,780 (GRCm39) I45N probably damaging Het
Or8b54 G A 9: 38,686,577 (GRCm39) V9M noncoding transcript Het
Pgm3 G A 9: 86,452,374 (GRCm39) R29W probably damaging Het
Ppp2r3d A G 9: 101,090,231 (GRCm39) C31R probably damaging Het
Prom1 C T 5: 44,194,770 (GRCm39) S334N possibly damaging Het
Rai14 C T 15: 10,575,302 (GRCm39) S581N probably benign Het
Rbm46 C T 3: 82,772,775 (GRCm39) R119Q probably benign Het
Rgs16 T C 1: 153,616,689 (GRCm39) F42S probably benign Het
Slc2a6 T G 2: 26,917,838 (GRCm39) E27A probably benign Het
Slc38a1 G A 15: 96,490,447 (GRCm39) S110L probably benign Het
Sox30 C T 11: 45,882,592 (GRCm39) R541C probably benign Het
Sptbn4 C A 7: 27,108,314 (GRCm39) E703* probably null Het
Tjp1 A T 7: 64,993,470 (GRCm39) F34L probably damaging Het
Trim65 T C 11: 116,017,037 (GRCm39) Q475R probably benign Het
Ttc38 A T 15: 85,728,716 (GRCm39) R223* probably null Het
Tulp1 T C 17: 28,583,300 (GRCm39) Q80R probably benign Het
Utp23 T C 15: 51,745,598 (GRCm39) F139L possibly damaging Het
Vmn1r121 A T 7: 20,832,228 (GRCm39) F71I probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Zdbf2 T C 1: 63,343,225 (GRCm39) S535P possibly damaging Het
Zfp788 T G 7: 41,298,801 (GRCm39) M479R probably benign Het
Other mutations in Or10p21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Or10p21 APN 10 128,847,729 (GRCm39) missense probably damaging 1.00
IGL01571:Or10p21 APN 10 128,847,696 (GRCm39) missense probably damaging 0.99
R0189:Or10p21 UTSW 10 128,847,191 (GRCm39) missense possibly damaging 0.88
R2079:Or10p21 UTSW 10 128,847,898 (GRCm39) missense probably damaging 1.00
R5074:Or10p21 UTSW 10 128,847,213 (GRCm39) missense possibly damaging 0.55
R5363:Or10p21 UTSW 10 128,847,783 (GRCm39) missense probably damaging 1.00
R5905:Or10p21 UTSW 10 128,847,156 (GRCm39) start codon destroyed probably benign 0.01
R7943:Or10p21 UTSW 10 128,847,934 (GRCm39) missense possibly damaging 0.88
R8240:Or10p21 UTSW 10 128,847,766 (GRCm39) missense possibly damaging 0.53
R8936:Or10p21 UTSW 10 128,847,802 (GRCm39) missense probably benign 0.01
R9621:Or10p21 UTSW 10 128,847,759 (GRCm39) missense probably benign 0.04
Z1177:Or10p21 UTSW 10 128,847,040 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- CTTCAGGGCCATCTGTTCTG -3'
(R):5'- CCTGAGATGACACCTGCAAG -3'

Sequencing Primer
(F):5'- TGTTACCTTGCTGGGCAAC -3'
(R):5'- CCTGAGATGACACCTGCAAGATAAG -3'
Posted On 2020-07-13