Mutagenetix > Incidental Mutation

Incidental Mutation 'R8195:Vmn2r111'

635425

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r111

Ensembl Gene

ENSMUSG00000095093

Gene Name

vomeronasal 2, receptor 111

Synonyms

EG210876

MMRRC Submission

067618-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R8195 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

22547941-22573273 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22559051 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 549 (N549S)

Ref Sequence

ENSEMBL: ENSMUSP00000090148 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092491]

AlphaFold

K7N674

Predicted Effect

possibly damaging
Transcript: ENSMUST00000092491
AA Change: N549S

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000090148
Gene: ENSMUSG00000095093
AA Change: N549S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.5e-29	PFAM
Pfam:NCD3G	512	565	1.1e-20	PFAM
Pfam:7tm_3	595	833	5.6e-54	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.2%

Validation Efficiency

100% (53/53)

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	G	A	11: 9,274,735 (GRCm38)	G483R	probably benign	Het
Abca9	T	C	11: 110,138,329 (GRCm38)	D801G	probably benign	Het
Aldob	T	C	4: 49,538,822 (GRCm38)	N232S	probably damaging	Het
Ankhd1	T	C	18: 36,654,177 (GRCm38)	V322A		Het
Arfgef1	T	C	1: 10,173,253 (GRCm38)	K1024E	probably damaging	Het
Arhgef40	T	A	14: 51,988,769 (GRCm38)	V90E	probably damaging	Het
Cblc	A	T	7: 19,785,337 (GRCm38)	S399R	possibly damaging	Het
Ccdc17	T	A	4: 116,599,014 (GRCm38)	I368K	possibly damaging	Het
Ccdc17	T	A	4: 116,599,016 (GRCm38)	W369R	probably damaging	Het
Cd276	G	A	9: 58,537,472 (GRCm38)	T72I	probably damaging	Het
Cdk14	C	T	5: 5,227,159 (GRCm38)		probably null	Het
Cfap61	C	T	2: 145,947,175 (GRCm38)	S33L	probably benign	Het
Cmtm2a	A	G	8: 104,293,038 (GRCm38)	F7L	probably benign	Het
Eif2ak4	T	C	2: 118,450,338 (GRCm38)	I1062T	possibly damaging	Het
Fcnb	C	T	2: 28,078,318 (GRCm38)	S209N	possibly damaging	Het
Fxr1	A	T	3: 34,047,729 (GRCm38)	E204V	probably damaging	Het
Fzd6	T	A	15: 39,031,564 (GRCm38)	L375Q	probably damaging	Het
Ggta1	T	A	2: 35,422,267 (GRCm38)	E33V	probably damaging	Het
Gnb1l	T	A	16: 18,544,215 (GRCm38)	I119N	probably benign	Het
Gpsm1	A	G	2: 26,324,917 (GRCm38)		probably null	Het
Hecw1	A	G	13: 14,306,107 (GRCm38)	I885T	probably damaging	Het
Itgb8	T	C	12: 119,168,170 (GRCm38)	D580G	probably damaging	Het
Kbtbd12	T	A	6: 88,617,931 (GRCm38)	T306S	possibly damaging	Het
Kctd1	C	T	18: 15,063,243 (GRCm38)	E108K	unknown	Het
Lrrc36	A	G	8: 105,452,085 (GRCm38)	D304G	possibly damaging	Het
Lrrn2	A	G	1: 132,937,344 (GRCm38)	E49G	probably damaging	Het
Lysmd2	C	A	9: 75,626,028 (GRCm38)	Y88*	probably null	Het
Lzts3	A	G	2: 130,635,185 (GRCm38)	S448P	probably benign	Het
Meioc	T	A	11: 102,675,067 (GRCm38)	L447*	probably null	Het
Mybpc1	A	G	10: 88,558,691 (GRCm38)	I244T	possibly damaging	Het
Necab3	G	A	2: 154,547,443 (GRCm38)	A160V	probably benign	Het
Nek8	G	T	11: 78,170,761 (GRCm38)	P314Q	possibly damaging	Het
Nlrp5	A	G	7: 23,413,337 (GRCm38)	T140A	probably benign	Het
Olfr655	A	T	7: 104,596,926 (GRCm38)	F85Y	probably damaging	Het
Olfr763	T	C	10: 129,011,575 (GRCm38)	C97R	probably damaging	Het
Olfr860	A	T	9: 19,846,484 (GRCm38)	I45N	probably damaging	Het
Olfr921	G	A	9: 38,775,281 (GRCm38)	V9M	noncoding transcript	Het
Pgm3	G	A	9: 86,570,321 (GRCm38)	R29W	probably damaging	Het
Ppp2r3a	A	G	9: 101,213,032 (GRCm38)	C31R	probably damaging	Het
Prom1	C	T	5: 44,037,428 (GRCm38)	S334N	possibly damaging	Het
Rai14	C	T	15: 10,575,216 (GRCm38)	S581N	probably benign	Het
Rbm46	C	T	3: 82,865,468 (GRCm38)	R119Q	probably benign	Het
Rgs16	T	C	1: 153,740,943 (GRCm38)	F42S	probably benign	Het
Slc2a6	T	G	2: 27,027,826 (GRCm38)	E27A	probably benign	Het
Slc38a1	G	A	15: 96,592,566 (GRCm38)	S110L	probably benign	Het
Sox30	C	T	11: 45,991,765 (GRCm38)	R541C	probably benign	Het
Sptbn4	C	A	7: 27,408,889 (GRCm38)	E703*	probably null	Het
Tjp1	A	T	7: 65,343,722 (GRCm38)	F34L	probably damaging	Het
Trim65	T	C	11: 116,126,211 (GRCm38)	Q475R	probably benign	Het
Ttc38	A	T	15: 85,844,515 (GRCm38)	R223*	probably null	Het
Tulp1	T	C	17: 28,364,326 (GRCm38)	Q80R	probably benign	Het
Utp23	T	C	15: 51,882,202 (GRCm38)	F139L	possibly damaging	Het
Vmn1r121	A	T	7: 21,098,303 (GRCm38)	F71I	probably damaging	Het
Zdbf2	T	C	1: 63,304,066 (GRCm38)	S535P	possibly damaging	Het
Zfp788	T	G	7: 41,649,377 (GRCm38)	M479R	probably benign	Het

Other mutations in Vmn2r111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00932:Vmn2r111	APN	17	22,548,753 (GRCm38)	missense	probably benign	0.00
IGL01306:Vmn2r111	APN	17	22,568,984 (GRCm38)	missense	probably damaging	0.99
IGL01309:Vmn2r111	APN	17	22,569,016 (GRCm38)	missense	possibly damaging	0.51
IGL01457:Vmn2r111	APN	17	22,571,985 (GRCm38)	nonsense	probably null
IGL01465:Vmn2r111	APN	17	22,548,737 (GRCm38)	missense	probably benign	0.00
IGL01505:Vmn2r111	APN	17	22,548,572 (GRCm38)	missense	probably benign	0.00
IGL01571:Vmn2r111	APN	17	22,571,392 (GRCm38)	missense	probably damaging	0.99
IGL01715:Vmn2r111	APN	17	22,569,073 (GRCm38)	splice site	probably benign
IGL01962:Vmn2r111	APN	17	22,548,284 (GRCm38)	missense	possibly damaging	0.90
IGL02190:Vmn2r111	APN	17	22,570,773 (GRCm38)	missense	probably benign	0.00
IGL02496:Vmn2r111	APN	17	22,568,856 (GRCm38)	missense	probably benign
IGL02519:Vmn2r111	APN	17	22,548,339 (GRCm38)	missense	possibly damaging	0.80
IGL02616:Vmn2r111	APN	17	22,571,050 (GRCm38)	missense	possibly damaging	0.67
IGL02641:Vmn2r111	APN	17	22,573,224 (GRCm38)	missense	possibly damaging	0.82
IGL02690:Vmn2r111	APN	17	22,559,042 (GRCm38)	critical splice donor site	probably null
IGL02698:Vmn2r111	APN	17	22,571,245 (GRCm38)	missense	probably damaging	1.00
IGL03017:Vmn2r111	APN	17	22,570,858 (GRCm38)	missense	probably damaging	1.00
R0046:Vmn2r111	UTSW	17	22,548,009 (GRCm38)	missense	probably benign
R0064:Vmn2r111	UTSW	17	22,572,072 (GRCm38)	missense	probably benign	0.00
R0519:Vmn2r111	UTSW	17	22,573,121 (GRCm38)	missense	probably benign	0.02
R1439:Vmn2r111	UTSW	17	22,571,116 (GRCm38)	missense	probably benign	0.00
R1467:Vmn2r111	UTSW	17	22,571,047 (GRCm38)	missense	probably damaging	0.99
R1467:Vmn2r111	UTSW	17	22,571,047 (GRCm38)	missense	probably damaging	0.99
R1636:Vmn2r111	UTSW	17	22,571,399 (GRCm38)	missense	probably damaging	1.00
R1647:Vmn2r111	UTSW	17	22,569,061 (GRCm38)	missense	probably benign	0.03
R1648:Vmn2r111	UTSW	17	22,569,061 (GRCm38)	missense	probably benign	0.03
R1697:Vmn2r111	UTSW	17	22,548,060 (GRCm38)	missense	probably benign	0.26
R1996:Vmn2r111	UTSW	17	22,548,081 (GRCm38)	missense	probably benign	0.21
R2040:Vmn2r111	UTSW	17	22,548,414 (GRCm38)	missense	probably damaging	1.00
R2075:Vmn2r111	UTSW	17	22,559,062 (GRCm38)	missense	probably damaging	1.00
R2134:Vmn2r111	UTSW	17	22,573,104 (GRCm38)	missense	possibly damaging	0.68
R2357:Vmn2r111	UTSW	17	22,559,170 (GRCm38)	splice site	probably benign
R3700:Vmn2r111	UTSW	17	22,571,161 (GRCm38)	nonsense	probably null
R3782:Vmn2r111	UTSW	17	22,571,320 (GRCm38)	missense	possibly damaging	0.89
R4085:Vmn2r111	UTSW	17	22,559,115 (GRCm38)	missense	probably benign	0.00
R4323:Vmn2r111	UTSW	17	22,573,178 (GRCm38)	missense	probably benign	0.02
R4900:Vmn2r111	UTSW	17	22,548,656 (GRCm38)	missense	possibly damaging	0.94
R5072:Vmn2r111	UTSW	17	22,548,041 (GRCm38)	missense	probably damaging	0.99
R5123:Vmn2r111	UTSW	17	22,571,143 (GRCm38)	missense	possibly damaging	0.82
R5181:Vmn2r111	UTSW	17	22,571,020 (GRCm38)	missense	possibly damaging	0.56
R5357:Vmn2r111	UTSW	17	22,548,102 (GRCm38)	nonsense	probably null
R5398:Vmn2r111	UTSW	17	22,573,271 (GRCm38)	start codon destroyed	probably null	0.88
R5434:Vmn2r111	UTSW	17	22,548,489 (GRCm38)	missense	probably damaging	0.99
R5462:Vmn2r111	UTSW	17	22,548,257 (GRCm38)	missense	probably damaging	1.00
R6149:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6149:Vmn2r111	UTSW	17	22,548,815 (GRCm38)	missense	probably benign	0.00
R6207:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6281:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6282:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6283:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6307:Vmn2r111	UTSW	17	22,573,089 (GRCm38)	missense	probably benign	0.00
R6323:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6325:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6367:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6368:Vmn2r111	UTSW	17	22,571,908 (GRCm38)	missense	probably benign	0.38
R6369:Vmn2r111	UTSW	17	22,548,602 (GRCm38)	missense	probably damaging	1.00
R6489:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6490:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6546:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6547:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6557:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6654:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6655:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6657:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6659:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6660:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6664:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6798:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6799:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6801:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6893:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6895:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6897:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6922:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6923:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6944:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6945:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7017:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7018:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7024:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7031:Vmn2r111	UTSW	17	22,571,245 (GRCm38)	missense	probably damaging	1.00
R7039:Vmn2r111	UTSW	17	22,548,184 (GRCm38)	missense	probably damaging	1.00
R7053:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7054:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7055:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7056:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7145:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7146:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7246:Vmn2r111	UTSW	17	22,548,714 (GRCm38)	missense	probably damaging	1.00
R7259:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7260:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7327:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7401:Vmn2r111	UTSW	17	22,571,086 (GRCm38)	missense	possibly damaging	0.93
R7514:Vmn2r111	UTSW	17	22,548,399 (GRCm38)	missense	probably benign	0.05
R7651:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7781:Vmn2r111	UTSW	17	22,570,733 (GRCm38)	missense	probably benign	0.17
R7816:Vmn2r111	UTSW	17	22,573,102 (GRCm38)	missense	probably damaging	0.97
R7821:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7838:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8078:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8080:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8117:Vmn2r111	UTSW	17	22,571,488 (GRCm38)	missense	probably benign	0.12
R8171:Vmn2r111	UTSW	17	22,573,092 (GRCm38)	missense	probably benign	0.10
R8197:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8411:Vmn2r111	UTSW	17	22,548,581 (GRCm38)	missense	probably benign	0.03
R8539:Vmn2r111	UTSW	17	22,571,293 (GRCm38)	missense	probably benign	0.23
R8540:Vmn2r111	UTSW	17	22,559,043 (GRCm38)	missense	probably damaging	1.00
R8540:Vmn2r111	UTSW	17	22,559,042 (GRCm38)	critical splice donor site	probably null
R8557:Vmn2r111	UTSW	17	22,571,929 (GRCm38)	nonsense	probably null
R8720:Vmn2r111	UTSW	17	22,573,213 (GRCm38)	missense	possibly damaging	0.88
R8729:Vmn2r111	UTSW	17	22,548,258 (GRCm38)	missense	probably damaging	1.00
R8843:Vmn2r111	UTSW	17	22,548,030 (GRCm38)	missense	probably benign	0.00
R9184:Vmn2r111	UTSW	17	22,571,841 (GRCm38)	missense	probably benign
R9374:Vmn2r111	UTSW	17	22,568,878 (GRCm38)	missense	probably benign	0.17
R9452:Vmn2r111	UTSW	17	22,559,151 (GRCm38)	missense	probably damaging	1.00
X0026:Vmn2r111	UTSW	17	22,548,695 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GTAAAAGATGCAGCCCAATTTCTAC -3'
(R):5'- TCAAGGAGTTGGGAAACAATTCAAC -3'

Sequencing Primer
(F):5'- TGAGTAACTTAGGACAGAGAT -3'
(R):5'- ACAATGCACTAAATAAGGTCTGC -3'

Posted On

2020-07-13