Incidental Mutation 'R8196:Or8b54'
ID 635453
Institutional Source Beutler Lab
Gene Symbol Or8b54
Ensembl Gene ENSMUSG00000049926
Gene Name olfactory receptor family 8 subfamily B member 54
Synonyms MOR165-8, GA_x6K02T2PVTD-32478047-32478988, Olfr921
MMRRC Submission 067619-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R8196 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38684384-38687650 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38686577 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 9 (V9M)
Gene Model predicted gene model for transcript(s):
AlphaFold Q7TRC0
Predicted Effect noncoding transcript
Transcript: ENSMUST00000062124
AA Change: V9M
SMART Domains Protein: ENSMUSP00000051879
Gene: ENSMUSG00000049926
AA Change: V9M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.8e-48 PFAM
Pfam:7tm_1 41 290 6.3e-23 PFAM
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd17b T A 19: 21,656,024 (GRCm39) V102D probably damaging Het
Adam6b T A 12: 113,454,087 (GRCm39) D301E probably benign Het
Adnp A C 2: 168,025,092 (GRCm39) D734E probably benign Het
Ank2 T A 3: 126,723,532 (GRCm39) T932S probably damaging Het
Arhgap20 C A 9: 51,760,277 (GRCm39) D709E possibly damaging Het
Atoh1 A G 6: 64,707,226 (GRCm39) D307G probably benign Het
Aven C T 2: 112,390,120 (GRCm39) R8W probably benign Het
B3galt1 A G 2: 67,948,530 (GRCm39) I82V probably benign Het
Chd2 T C 7: 73,118,285 (GRCm39) D1111G probably benign Het
Csmd1 T C 8: 16,059,468 (GRCm39) D2089G probably benign Het
Dach1 T A 14: 98,256,370 (GRCm39) H296L probably damaging Het
Dennd4b T G 3: 90,178,904 (GRCm39) L556R probably damaging Het
Dop1a T A 9: 86,405,151 (GRCm39) S326T probably benign Het
Eif2b5 T A 16: 20,321,306 (GRCm39) H286Q probably damaging Het
Fcnb C T 2: 27,968,330 (GRCm39) S209N possibly damaging Het
Fn3k T A 11: 121,341,222 (GRCm39) F292L probably damaging Het
Gm1123 G A 9: 98,905,309 (GRCm39) A67V probably benign Het
Hey2 C T 10: 30,710,273 (GRCm39) C160Y probably benign Het
Jph2 T A 2: 163,180,621 (GRCm39) probably null Het
Lars1 A G 18: 42,343,166 (GRCm39) S1084P possibly damaging Het
Macf1 T C 4: 123,276,497 (GRCm39) D6084G probably damaging Het
Mdfic G T 6: 15,740,989 (GRCm39) A115S probably benign Het
Mki67 T C 7: 135,297,237 (GRCm39) E2599G probably damaging Het
Mtus1 A G 8: 41,509,689 (GRCm39) S131P probably benign Het
Muc16 G T 9: 18,556,630 (GRCm39) T3221K unknown Het
Or1q1 T A 2: 36,886,873 (GRCm39) I17N possibly damaging Het
Or8b3 A G 9: 38,314,904 (GRCm39) S245G probably damaging Het
Pdgfc A G 3: 80,944,811 (GRCm39) E23G possibly damaging Het
Pfkp T C 13: 6,655,698 (GRCm39) T312A probably benign Het
Pxn A G 5: 115,683,768 (GRCm39) E200G probably damaging Het
Rai1 C T 11: 60,076,796 (GRCm39) H287Y probably damaging Het
Rap1gap G A 4: 137,445,275 (GRCm39) V319I probably benign Het
Rbm46 C T 3: 82,772,775 (GRCm39) R119Q probably benign Het
Selp A T 1: 163,961,490 (GRCm39) D401V possibly damaging Het
Sh3bp5 A G 14: 31,139,399 (GRCm39) V58A probably benign Het
Shpk A T 11: 73,094,775 (GRCm39) I64F probably benign Het
Slmap A G 14: 26,189,646 (GRCm39) Y171H probably damaging Het
Tmem67 T C 4: 12,075,661 (GRCm39) T183A probably benign Het
Tyw1 G T 5: 130,328,862 (GRCm39) L549F probably damaging Het
Uhrf2 T A 19: 30,051,329 (GRCm39) M301K probably benign Het
Uvssa G A 5: 33,568,311 (GRCm39) V532I probably benign Het
Vmn2r113 A T 17: 23,176,938 (GRCm39) K574I probably damaging Het
Zfp52 A G 17: 21,782,156 (GRCm39) N668S possibly damaging Het
Other mutations in Or8b54
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Or8b54 APN 9 38,687,108 (GRCm39) nonsense probably null
IGL01016:Or8b54 APN 9 38,686,737 (GRCm39) missense probably damaging 0.99
IGL01391:Or8b54 APN 9 38,686,826 (GRCm39) missense probably damaging 1.00
IGL01451:Or8b54 APN 9 38,687,225 (GRCm39) missense probably benign 0.04
IGL02250:Or8b54 APN 9 38,686,850 (GRCm39) missense probably damaging 1.00
R0026:Or8b54 UTSW 9 38,686,892 (GRCm39) missense probably benign 0.01
R0334:Or8b54 UTSW 9 38,686,535 (GRCm39) critical splice acceptor site probably null
R0655:Or8b54 UTSW 9 38,686,850 (GRCm39) nonsense probably null
R1024:Or8b54 UTSW 9 38,686,631 (GRCm39) missense probably damaging 0.97
R3522:Or8b54 UTSW 9 38,687,016 (GRCm39) missense possibly damaging 0.67
R3967:Or8b54 UTSW 9 38,686,664 (GRCm39) missense probably benign 0.09
R3968:Or8b54 UTSW 9 38,686,664 (GRCm39) missense probably benign 0.09
R3969:Or8b54 UTSW 9 38,686,664 (GRCm39) missense probably benign 0.09
R4761:Or8b54 UTSW 9 38,687,133 (GRCm39) missense probably benign 0.05
R4796:Or8b54 UTSW 9 38,686,670 (GRCm39) missense probably benign 0.15
R4880:Or8b54 UTSW 9 38,686,843 (GRCm39) nonsense probably null
R5237:Or8b54 UTSW 9 38,687,252 (GRCm39) missense probably damaging 1.00
R5756:Or8b54 UTSW 9 38,686,554 (GRCm39) start codon destroyed probably null 1.00
R6230:Or8b54 UTSW 9 38,687,073 (GRCm39) missense possibly damaging 0.94
R6487:Or8b54 UTSW 9 38,686,731 (GRCm39) missense probably damaging 1.00
R7514:Or8b54 UTSW 9 38,686,974 (GRCm39) missense probably damaging 1.00
R7573:Or8b54 UTSW 9 38,686,791 (GRCm39) missense probably damaging 1.00
R7755:Or8b54 UTSW 9 38,687,073 (GRCm39) missense possibly damaging 0.94
R8195:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8197:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8199:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8211:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8212:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8236:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8239:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8279:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8282:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R8283:Or8b54 UTSW 9 38,686,577 (GRCm39) missense noncoding transcript
R9207:Or8b54 UTSW 9 38,686,960 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- ACAAGCTATTCGGAAATTTCATCC -3'
(R):5'- TCATAGGCCATTGACACCAG -3'

Sequencing Primer
(F):5'- GCTATTCGGAAATTTCATCCTGAGC -3'
(R):5'- AAGTAGAGTTGGGACATACATCC -3'
Posted On 2020-07-13