Incidental Mutation 'R8196:Zfp52'
ID 635467
Institutional Source Beutler Lab
Gene Symbol Zfp52
Ensembl Gene ENSMUSG00000051341
Gene Name zinc finger protein 52
Synonyms Zfp-52, KRAB11, Zfp76, zfec29
MMRRC Submission 067619-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R8196 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 21755801-21782863 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21782156 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 668 (N668S)
Ref Sequence ENSEMBL: ENSMUSP00000078233 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079242]
AlphaFold Q8BJ45
Predicted Effect possibly damaging
Transcript: ENSMUST00000079242
AA Change: N668S

PolyPhen 2 Score 0.454 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000078233
Gene: ENSMUSG00000051341
AA Change: N668S

DomainStartEndE-ValueType
KRAB 13 73 3.79e-24 SMART
ZnF_C2H2 186 208 1.79e-2 SMART
ZnF_C2H2 214 236 5.07e0 SMART
ZnF_C2H2 242 264 2.29e1 SMART
ZnF_C2H2 270 292 2.36e-2 SMART
ZnF_C2H2 298 320 4.72e-2 SMART
ZnF_C2H2 326 348 1.77e1 SMART
ZnF_C2H2 382 404 1.12e-3 SMART
ZnF_C2H2 410 432 1.34e2 SMART
ZnF_C2H2 438 460 1.06e-4 SMART
ZnF_C2H2 466 488 6.99e-5 SMART
ZnF_C2H2 494 516 4.17e-3 SMART
ZnF_C2H2 522 544 5.5e-3 SMART
ZnF_C2H2 550 572 8.47e-4 SMART
ZnF_C2H2 578 600 1.01e-1 SMART
ZnF_C2H2 606 628 9.73e-4 SMART
ZnF_C2H2 634 656 4.17e-3 SMART
ZnF_C2H2 662 684 6.32e-3 SMART
ZnF_C2H2 690 712 1.69e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd17b T A 19: 21,656,024 (GRCm39) V102D probably damaging Het
Adam6b T A 12: 113,454,087 (GRCm39) D301E probably benign Het
Adnp A C 2: 168,025,092 (GRCm39) D734E probably benign Het
Ank2 T A 3: 126,723,532 (GRCm39) T932S probably damaging Het
Arhgap20 C A 9: 51,760,277 (GRCm39) D709E possibly damaging Het
Atoh1 A G 6: 64,707,226 (GRCm39) D307G probably benign Het
Aven C T 2: 112,390,120 (GRCm39) R8W probably benign Het
B3galt1 A G 2: 67,948,530 (GRCm39) I82V probably benign Het
Chd2 T C 7: 73,118,285 (GRCm39) D1111G probably benign Het
Csmd1 T C 8: 16,059,468 (GRCm39) D2089G probably benign Het
Dach1 T A 14: 98,256,370 (GRCm39) H296L probably damaging Het
Dennd4b T G 3: 90,178,904 (GRCm39) L556R probably damaging Het
Dop1a T A 9: 86,405,151 (GRCm39) S326T probably benign Het
Eif2b5 T A 16: 20,321,306 (GRCm39) H286Q probably damaging Het
Fcnb C T 2: 27,968,330 (GRCm39) S209N possibly damaging Het
Fn3k T A 11: 121,341,222 (GRCm39) F292L probably damaging Het
Gm1123 G A 9: 98,905,309 (GRCm39) A67V probably benign Het
Hey2 C T 10: 30,710,273 (GRCm39) C160Y probably benign Het
Jph2 T A 2: 163,180,621 (GRCm39) probably null Het
Lars1 A G 18: 42,343,166 (GRCm39) S1084P possibly damaging Het
Macf1 T C 4: 123,276,497 (GRCm39) D6084G probably damaging Het
Mdfic G T 6: 15,740,989 (GRCm39) A115S probably benign Het
Mki67 T C 7: 135,297,237 (GRCm39) E2599G probably damaging Het
Mtus1 A G 8: 41,509,689 (GRCm39) S131P probably benign Het
Muc16 G T 9: 18,556,630 (GRCm39) T3221K unknown Het
Or1q1 T A 2: 36,886,873 (GRCm39) I17N possibly damaging Het
Or8b3 A G 9: 38,314,904 (GRCm39) S245G probably damaging Het
Or8b54 G A 9: 38,686,577 (GRCm39) V9M noncoding transcript Het
Pdgfc A G 3: 80,944,811 (GRCm39) E23G possibly damaging Het
Pfkp T C 13: 6,655,698 (GRCm39) T312A probably benign Het
Pxn A G 5: 115,683,768 (GRCm39) E200G probably damaging Het
Rai1 C T 11: 60,076,796 (GRCm39) H287Y probably damaging Het
Rap1gap G A 4: 137,445,275 (GRCm39) V319I probably benign Het
Rbm46 C T 3: 82,772,775 (GRCm39) R119Q probably benign Het
Selp A T 1: 163,961,490 (GRCm39) D401V possibly damaging Het
Sh3bp5 A G 14: 31,139,399 (GRCm39) V58A probably benign Het
Shpk A T 11: 73,094,775 (GRCm39) I64F probably benign Het
Slmap A G 14: 26,189,646 (GRCm39) Y171H probably damaging Het
Tmem67 T C 4: 12,075,661 (GRCm39) T183A probably benign Het
Tyw1 G T 5: 130,328,862 (GRCm39) L549F probably damaging Het
Uhrf2 T A 19: 30,051,329 (GRCm39) M301K probably benign Het
Uvssa G A 5: 33,568,311 (GRCm39) V532I probably benign Het
Vmn2r113 A T 17: 23,176,938 (GRCm39) K574I probably damaging Het
Other mutations in Zfp52
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01752:Zfp52 APN 17 21,780,412 (GRCm39) missense probably benign 0.12
PIT4449001:Zfp52 UTSW 17 21,777,478 (GRCm39) missense probably damaging 1.00
R0270:Zfp52 UTSW 17 21,781,564 (GRCm39) missense probably damaging 1.00
R0674:Zfp52 UTSW 17 21,782,108 (GRCm39) missense probably damaging 1.00
R1224:Zfp52 UTSW 17 21,775,324 (GRCm39) missense possibly damaging 0.70
R1248:Zfp52 UTSW 17 21,780,311 (GRCm39) missense probably damaging 1.00
R1622:Zfp52 UTSW 17 21,781,833 (GRCm39) missense probably benign 0.00
R1663:Zfp52 UTSW 17 21,782,084 (GRCm39) missense possibly damaging 0.59
R1917:Zfp52 UTSW 17 21,780,426 (GRCm39) missense probably benign
R4272:Zfp52 UTSW 17 21,780,459 (GRCm39) nonsense probably null
R4273:Zfp52 UTSW 17 21,780,459 (GRCm39) nonsense probably null
R4278:Zfp52 UTSW 17 21,782,132 (GRCm39) missense probably benign
R4683:Zfp52 UTSW 17 21,781,769 (GRCm39) missense probably benign 0.31
R4865:Zfp52 UTSW 17 21,781,505 (GRCm39) missense probably damaging 1.00
R4964:Zfp52 UTSW 17 21,780,665 (GRCm39) missense probably benign 0.04
R4966:Zfp52 UTSW 17 21,780,665 (GRCm39) missense probably benign 0.04
R5430:Zfp52 UTSW 17 21,775,329 (GRCm39) missense probably benign 0.01
R5685:Zfp52 UTSW 17 21,782,013 (GRCm39) missense probably benign 0.15
R6133:Zfp52 UTSW 17 21,780,733 (GRCm39) missense probably damaging 1.00
R6882:Zfp52 UTSW 17 21,775,309 (GRCm39) start codon destroyed probably null 1.00
R7083:Zfp52 UTSW 17 21,780,392 (GRCm39) missense possibly damaging 0.86
R7439:Zfp52 UTSW 17 21,781,132 (GRCm39) nonsense probably null
R7456:Zfp52 UTSW 17 21,781,615 (GRCm39) missense probably damaging 1.00
R7740:Zfp52 UTSW 17 21,781,252 (GRCm39) missense probably damaging 1.00
R8930:Zfp52 UTSW 17 21,780,692 (GRCm39) missense possibly damaging 0.48
R8932:Zfp52 UTSW 17 21,780,692 (GRCm39) missense possibly damaging 0.48
R9033:Zfp52 UTSW 17 21,780,655 (GRCm39) missense possibly damaging 0.67
R9510:Zfp52 UTSW 17 21,782,218 (GRCm39) missense possibly damaging 0.49
R9645:Zfp52 UTSW 17 21,781,937 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- CATACTGGAGAGAAACCTTACAAATGC -3'
(R):5'- TGATTTGCAAGCAGAGAATACCAG -3'

Sequencing Primer
(F):5'- TGCAAAGACTGTGGCATATCC -3'
(R):5'- TGCAAGCAGAGAATACCAGATATATG -3'
Posted On 2020-07-13