Mutagenetix > Incidental Mutation

Incidental Mutation 'R0722:Zfp267'

63550

Institutional Source

Beutler Lab

Gene Symbol

Zfp267

Ensembl Gene

ENSMUSG00000033883

Gene Name

zinc finger protein 267

Synonyms

D3Ertd254e

MMRRC Submission

038904-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

R0722 (G1)

Quality Score

132

Status

Validated

Chromosome

Chromosomal Location

36205233-36224491 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 36219218 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Tyrosine at position 414 (H414Y)

Ref Sequence

ENSEMBL: ENSMUSP00000142829 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165956] [ENSMUST00000197653] [ENSMUST00000205077]

AlphaFold

A0A0G2JEM5

Predicted Effect

probably benign
Transcript: ENSMUST00000165956
AA Change: H413Y

PolyPhen 2 Score 0.347 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000131779
Gene: ENSMUSG00000033883
AA Change: H413Y

Domain	Start	End	E-Value	Type
KRAB	3	63	2.91e-34	SMART
ZnF_C2H2	342	364	1.08e-1	SMART
ZnF_C2H2	395	417	1.56e-2	SMART
ZnF_C2H2	423	445	3.11e-2	SMART
ZnF_C2H2	451	473	5.9e-3	SMART
ZnF_C2H2	479	501	1.82e-3	SMART
ZnF_C2H2	507	529	5.21e-4	SMART
ZnF_C2H2	535	557	1.84e-4	SMART
ZnF_C2H2	563	585	1.95e-3	SMART
ZnF_C2H2	591	613	2.05e-2	SMART
ZnF_C2H2	619	641	1.6e-4	SMART
ZnF_C2H2	647	669	5.21e-4	SMART
ZnF_C2H2	675	697	1.69e-3	SMART
ZnF_C2H2	703	725	2.61e-4	SMART
ZnF_C2H2	731	753	1.12e-3	SMART
ZnF_C2H2	759	779	3.85e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000197653
AA Change: H414Y

PolyPhen 2 Score 0.347 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000142829
Gene: ENSMUSG00000033883
AA Change: H414Y

Domain	Start	End	E-Value	Type
KRAB	4	64	1.2e-36	SMART
ZnF_C2H2	343	365	4.4e-4	SMART
ZnF_C2H2	396	418	6.7e-5	SMART
ZnF_C2H2	424	446	1.3e-4	SMART
ZnF_C2H2	452	474	2.5e-5	SMART
ZnF_C2H2	480	502	7.9e-6	SMART
ZnF_C2H2	508	530	2.2e-6	SMART
ZnF_C2H2	536	558	7.7e-7	SMART
ZnF_C2H2	564	586	8e-6	SMART
ZnF_C2H2	592	614	8.9e-5	SMART
ZnF_C2H2	620	642	6.6e-7	SMART
ZnF_C2H2	648	670	2.2e-6	SMART
ZnF_C2H2	676	698	7.1e-6	SMART
ZnF_C2H2	704	726	1.1e-6	SMART
ZnF_C2H2	732	754	4.8e-6	SMART
ZnF_C2H2	760	780	1.6e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000205077

Meta Mutation Damage Score

0.6964

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.5%
20x: 91.7%

Validation Efficiency

97% (63/65)

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adap2	T	C	11: 80,047,810 (GRCm39)	F89L	possibly damaging	Het
Akr1c13	A	G	13: 4,247,931 (GRCm39)		probably null	Het
Atp10a	A	G	7: 58,465,931 (GRCm39)	I1053V	possibly damaging	Het
Bmper	G	T	9: 23,285,224 (GRCm39)	V258L	probably benign	Het
Brd4	T	C	17: 32,431,956 (GRCm39)	H636R	possibly damaging	Het
Cacna2d4	C	T	6: 119,284,247 (GRCm39)	R745W	probably damaging	Het
Ccbe1	C	T	18: 66,217,877 (GRCm39)	C112Y	probably damaging	Het
Ccdc28b	T	A	4: 129,514,945 (GRCm39)		probably null	Het
Cd320	T	C	17: 34,065,004 (GRCm39)	S46P	possibly damaging	Het
Cfap251	T	A	5: 123,394,248 (GRCm39)	V379E	probably damaging	Het
Cfap44	G	A	16: 44,225,039 (GRCm39)	E95K	possibly damaging	Het
Clpp	T	C	17: 57,299,901 (GRCm39)	V144A	probably damaging	Het
Crtam	A	T	9: 40,903,912 (GRCm39)	C96S	probably damaging	Het
Dcst1	C	T	3: 89,261,112 (GRCm39)	R480H	probably benign	Het
Dock2	A	T	11: 34,414,970 (GRCm39)		probably benign	Het
Ermard	A	G	17: 15,242,390 (GRCm39)	T189A	probably benign	Het
Gm10840	A	G	11: 106,051,902 (GRCm39)		probably benign	Het
Gm4845	T	A	1: 141,184,598 (GRCm39)		noncoding transcript	Het
Heatr1	A	G	13: 12,420,918 (GRCm39)	E403G	probably benign	Het
Herc4	A	G	10: 63,121,844 (GRCm39)	I399V	probably null	Het
Htr1f	A	G	16: 64,746,254 (GRCm39)	I346T	probably damaging	Het
Igf2r	T	C	17: 12,934,382 (GRCm39)		probably null	Het
Jmy	G	A	13: 93,589,325 (GRCm39)	T644I	probably benign	Het
Kcnn2	T	C	18: 45,692,543 (GRCm39)	C40R	possibly damaging	Het
Krt13	T	G	11: 100,009,979 (GRCm39)	K297T	probably damaging	Het
Lrba	T	C	3: 86,513,296 (GRCm39)		probably null	Het
Lrrc8b	T	C	5: 105,627,978 (GRCm39)	V108A	possibly damaging	Het
Lrrc8c	T	A	5: 105,727,414 (GRCm39)	V26E	probably damaging	Het
Or10g6	A	G	9: 39,934,295 (GRCm39)	D202G	probably damaging	Het
Or5p6	A	G	7: 107,631,541 (GRCm39)	F3S	probably benign	Het
Pcna	A	G	2: 132,093,155 (GRCm39)		probably benign	Het
Pgm2	A	T	5: 64,265,022 (GRCm39)	R348*	probably null	Het
Pikfyve	T	G	1: 65,292,682 (GRCm39)	S1378A	probably damaging	Het
Pkp2	T	C	16: 16,064,892 (GRCm39)	V472A	probably benign	Het
Pld5	A	G	1: 175,803,081 (GRCm39)	F395L	probably benign	Het
Plekhb1	A	T	7: 100,294,810 (GRCm39)	Y169N	probably damaging	Het
Polr2c	T	A	8: 95,589,265 (GRCm39)	Y186N	probably damaging	Het
Ppp1r16a	C	T	15: 76,577,869 (GRCm39)	Q328*	probably null	Het
Prr5l	A	G	2: 101,547,819 (GRCm39)		probably benign	Het
Ptbp2	C	T	3: 119,514,570 (GRCm39)	R419Q	possibly damaging	Het
Ralgapa2	A	G	2: 146,230,451 (GRCm39)	V1038A	probably damaging	Het
Rassf2	A	G	2: 131,844,830 (GRCm39)	V204A	probably damaging	Het
Slc22a22	T	C	15: 57,119,949 (GRCm39)		probably null	Het
Slit1	T	C	19: 41,596,874 (GRCm39)	Y1075C	probably damaging	Het
Smc5	C	A	19: 23,186,291 (GRCm39)	L1055F	probably damaging	Het
Spidr	A	G	16: 15,730,645 (GRCm39)	F620S	probably damaging	Het
Susd1	A	G	4: 59,379,749 (GRCm39)	S293P	possibly damaging	Het
Tepsin	A	G	11: 119,986,163 (GRCm39)		probably benign	Het
Vmn2r68	A	T	7: 84,870,794 (GRCm39)	L830I	possibly damaging	Het
Vtn	A	G	11: 78,391,680 (GRCm39)		probably benign	Het
Zfp280d	T	G	9: 72,219,383 (GRCm39)	S162A	possibly damaging	Het
Zfp608	T	G	18: 55,033,306 (GRCm39)	K409T	probably damaging	Het
Zfp738	A	T	13: 67,819,643 (GRCm39)	M116K	probably benign	Het

Other mutations in Zfp267

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01524:Zfp267	APN	3	36,218,729 (GRCm39)	missense	possibly damaging	0.86
IGL02089:Zfp267	APN	3	36,218,877 (GRCm39)	missense	possibly damaging	0.53
IGL02162:Zfp267	APN	3	36,218,210 (GRCm39)	missense	probably benign	0.18
R0243:Zfp267	UTSW	3	36,219,303 (GRCm39)	missense	possibly damaging	0.47
R0512:Zfp267	UTSW	3	36,220,262 (GRCm39)	missense	probably damaging	0.96
R0762:Zfp267	UTSW	3	36,220,016 (GRCm39)	missense	possibly damaging	0.92
R0792:Zfp267	UTSW	3	36,218,711 (GRCm39)	missense	probably benign	0.01
R0894:Zfp267	UTSW	3	36,218,935 (GRCm39)	nonsense	probably null
R1731:Zfp267	UTSW	3	36,218,620 (GRCm39)	missense	probably benign	0.18
R2098:Zfp267	UTSW	3	36,220,289 (GRCm39)	missense	probably benign
R2099:Zfp267	UTSW	3	36,218,361 (GRCm39)	missense	possibly damaging	0.86
R3709:Zfp267	UTSW	3	36,213,725 (GRCm39)	missense	possibly damaging	0.71
R3808:Zfp267	UTSW	3	36,219,792 (GRCm39)	splice site	probably null
R4035:Zfp267	UTSW	3	36,218,989 (GRCm39)	missense	possibly damaging	0.53
R4288:Zfp267	UTSW	3	36,213,747 (GRCm39)	missense	possibly damaging	0.71
R4289:Zfp267	UTSW	3	36,213,747 (GRCm39)	missense	possibly damaging	0.71
R4959:Zfp267	UTSW	3	36,218,285 (GRCm39)	missense	possibly damaging	0.91
R4973:Zfp267	UTSW	3	36,218,285 (GRCm39)	missense	possibly damaging	0.91
R5102:Zfp267	UTSW	3	36,216,814 (GRCm39)	missense	possibly damaging	0.73
R5462:Zfp267	UTSW	3	36,219,969 (GRCm39)	missense	possibly damaging	0.95
R5548:Zfp267	UTSW	3	36,219,640 (GRCm39)	missense	possibly damaging	0.90
R5782:Zfp267	UTSW	3	36,219,128 (GRCm39)	missense	possibly damaging	0.73
R6153:Zfp267	UTSW	3	36,219,303 (GRCm39)	missense	possibly damaging	0.47
R6225:Zfp267	UTSW	3	36,220,352 (GRCm39)	missense	probably benign	0.18
R6602:Zfp267	UTSW	3	36,219,004 (GRCm39)	missense	possibly damaging	0.86
R6785:Zfp267	UTSW	3	36,219,601 (GRCm39)	nonsense	probably null
R7513:Zfp267	UTSW	3	36,218,792 (GRCm39)	missense	possibly damaging	0.53
R7846:Zfp267	UTSW	3	36,219,738 (GRCm39)	missense	probably benign	0.43
R8120:Zfp267	UTSW	3	36,218,640 (GRCm39)	missense	possibly damaging	0.96
R8265:Zfp267	UTSW	3	36,213,677 (GRCm39)	start gained	probably benign
R8415:Zfp267	UTSW	3	36,219,182 (GRCm39)	missense	probably damaging	0.98
R8826:Zfp267	UTSW	3	36,218,255 (GRCm39)	missense	possibly damaging	0.86
R9026:Zfp267	UTSW	3	36,219,066 (GRCm39)	missense	possibly damaging	0.96
R9159:Zfp267	UTSW	3	36,219,902 (GRCm39)	missense	possibly damaging	0.47
R9786:Zfp267	UTSW	3	36,219,853 (GRCm39)	nonsense	probably null
X0021:Zfp267	UTSW	3	36,218,340 (GRCm39)	missense	possibly damaging	0.72

Predicted Primers

Posted On

2013-07-30