Incidental Mutation 'R8199:Or2j3'
ID 635610
Institutional Source Beutler Lab
Gene Symbol Or2j3
Ensembl Gene ENSMUSG00000054940
Gene Name olfactory receptor family 2 subfamily J member 3
Synonyms Olfr137, MOR256-18, GA_x6K02T2PSCP-2749525-2748587
MMRRC Submission 067622-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.469) question?
Stock # R8199 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 38615412-38616350 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38615444 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 303 (R303G)
Ref Sequence ENSEMBL: ENSMUSP00000051537 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057394]
AlphaFold Q8VFC2
Predicted Effect probably benign
Transcript: ENSMUST00000057394
AA Change: R303G

PolyPhen 2 Score 0.311 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000051537
Gene: ENSMUSG00000054940
AA Change: R303G

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 4e-49 PFAM
Pfam:7tm_1 42 291 4.5e-28 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik T C 7: 41,275,304 (GRCm39) Y336H probably damaging Het
4930563I02Rik A G 14: 60,333,388 (GRCm39) I42M noncoding transcript Het
Acad9 T C 3: 36,139,572 (GRCm39) S391P probably damaging Het
Aven C T 2: 112,390,120 (GRCm39) R8W probably benign Het
Cacna1c T C 6: 118,651,545 (GRCm39) T972A probably benign Het
Col25a1 G A 3: 130,345,628 (GRCm39) G406E probably damaging Het
Coro2b T G 9: 62,336,302 (GRCm39) I267L probably benign Het
Cst12 A G 2: 148,631,459 (GRCm39) N60S probably benign Het
Dnah8 A T 17: 31,090,393 (GRCm39) I4632F probably benign Het
Eif3d C T 15: 77,844,292 (GRCm39) C404Y possibly damaging Het
Elapor2 C T 5: 9,470,657 (GRCm39) T260M probably damaging Het
Fam43a A T 16: 30,419,586 (GRCm39) K57* probably null Het
Fbrs T C 7: 127,086,956 (GRCm39) probably null Het
Fcnb C T 2: 27,968,330 (GRCm39) S209N possibly damaging Het
Fggy G A 4: 95,700,381 (GRCm39) E351K probably benign Het
Gabra6 G A 11: 42,207,280 (GRCm39) S268L probably damaging Het
Gatm A G 2: 122,432,994 (GRCm39) Y223H probably damaging Het
Gli3 T A 13: 15,900,576 (GRCm39) M1321K probably benign Het
Hira G A 16: 18,766,194 (GRCm39) A669T probably benign Het
Hoxa5 T C 6: 52,181,240 (GRCm39) S31G probably benign Het
Kdm2a T A 19: 4,439,054 (GRCm39) Q25L unknown Het
Loxhd1 C A 18: 77,469,334 (GRCm39) N1000K possibly damaging Het
Mpdu1 C T 11: 69,548,069 (GRCm39) W235* probably null Het
Msantd2 G C 9: 37,400,789 (GRCm39) G57A probably benign Het
Nat1 A G 8: 67,943,650 (GRCm39) R9G probably damaging Het
Nbl1 G A 4: 138,810,880 (GRCm39) P105S probably damaging Het
Or52e4 A C 7: 104,705,852 (GRCm39) Q133P probably damaging Het
Or8b54 G A 9: 38,686,577 (GRCm39) V9M noncoding transcript Het
Pdzrn3 T C 6: 101,128,918 (GRCm39) S583G probably damaging Het
Prpf4 A G 4: 62,340,866 (GRCm39) D427G probably damaging Het
Ptpn21 T A 12: 98,644,841 (GRCm39) I1167F possibly damaging Het
Rasgrp1 T A 2: 117,124,293 (GRCm39) H303L probably damaging Het
Ros1 T A 10: 51,977,813 (GRCm39) K1499* probably null Het
Skida1 C A 2: 18,052,959 (GRCm39) L64F probably damaging Het
St3gal5 T C 6: 72,119,175 (GRCm39) Y123H probably benign Het
Syk T C 13: 52,778,768 (GRCm39) S285P probably benign Het
Syt4 T C 18: 31,577,268 (GRCm39) T29A probably benign Het
Trav7-3 A G 14: 53,681,099 (GRCm39) D47G possibly damaging Het
Trpm7 A G 2: 126,691,918 (GRCm39) F146L probably damaging Het
Utp20 A T 10: 88,634,337 (GRCm39) D786E probably benign Het
Uts2 G A 4: 151,086,115 (GRCm39) C117Y possibly damaging Het
Zfp553 T C 7: 126,835,468 (GRCm39) L341P probably damaging Het
Zfp994 T A 17: 22,419,204 (GRCm39) K582* probably null Het
Other mutations in Or2j3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02131:Or2j3 APN 17 38,615,539 (GRCm39) missense probably benign 0.03
IGL03169:Or2j3 APN 17 38,615,992 (GRCm39) missense probably damaging 1.00
IGL03392:Or2j3 APN 17 38,615,786 (GRCm39) missense probably benign 0.02
R0055:Or2j3 UTSW 17 38,615,702 (GRCm39) missense possibly damaging 0.84
R0055:Or2j3 UTSW 17 38,615,702 (GRCm39) missense possibly damaging 0.84
R0496:Or2j3 UTSW 17 38,615,549 (GRCm39) missense probably damaging 0.99
R0761:Or2j3 UTSW 17 38,616,282 (GRCm39) missense probably benign 0.00
R1126:Or2j3 UTSW 17 38,615,579 (GRCm39) missense probably damaging 0.97
R1835:Or2j3 UTSW 17 38,616,203 (GRCm39) missense probably benign 0.02
R3727:Or2j3 UTSW 17 38,616,310 (GRCm39) missense possibly damaging 0.64
R5556:Or2j3 UTSW 17 38,615,964 (GRCm39) missense possibly damaging 0.71
R5979:Or2j3 UTSW 17 38,616,083 (GRCm39) missense probably benign
R6430:Or2j3 UTSW 17 38,616,249 (GRCm39) missense probably benign 0.04
R6433:Or2j3 UTSW 17 38,616,304 (GRCm39) missense probably damaging 1.00
R7400:Or2j3 UTSW 17 38,616,222 (GRCm39) missense possibly damaging 0.91
R8053:Or2j3 UTSW 17 38,616,101 (GRCm39) missense probably benign
R8446:Or2j3 UTSW 17 38,615,638 (GRCm39) missense probably benign 0.01
R8865:Or2j3 UTSW 17 38,615,872 (GRCm39) missense probably damaging 0.97
R9116:Or2j3 UTSW 17 38,615,654 (GRCm39) missense probably benign 0.01
R9756:Or2j3 UTSW 17 38,615,971 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- TGGGAATGTCACATCCATCG -3'
(R):5'- TGGAGCCCATCTTACTGTTG -3'

Sequencing Primer
(F):5'- GGGAATGTCACATCCATCGAAAGTAC -3'
(R):5'- GGAGCCCATCTTACTGTTGTTTCTC -3'
Posted On 2020-07-13