|Institutional Source||Beutler Lab|
|Gene Name||interleukin 18 receptor accessory protein|
|Synonyms||AcPL accessory protein-like)|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8201 (G1)|
|Chromosomal Location||40515362-40551705 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to T at 40539269 bp|
|Amino Acid Change||Arginine to Isoleucine at position 280 (R280I)|
|Ref Sequence||ENSEMBL: ENSMUSP00000027237 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027237]|
|Predicted Effect||possibly damaging
AA Change: R280I
PolyPhen 2 Score 0.751 (Sensitivity: 0.85; Specificity: 0.92)
AA Change: R280I
|Meta Mutation Damage Score||0.1712|
|Coding Region Coverage||
FUNCTION: Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014]
PHENOTYPE: Homozygous null mice exhibit defective IL-18-mediated immune responses such as the inability of splenocytes, T helper 1 cells and neutrophils to produce cytokines in response to IL-18. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il18rap||
(F):5'- TGGCTATTCCTGGTACCCAC -3'
(R):5'- TGAGAAATGGAGTGCCTCTG -3'
(F):5'- TGGTACCCACTTGACGGACAC -3'
(R):5'- TAGACAGACAGACAGATAGTGTTTAC -3'