Incidental Mutation 'R8201:Nkiras1'
ID 635687
Institutional Source Beutler Lab
Gene Symbol Nkiras1
Ensembl Gene ENSMUSG00000021772
Gene Name NFKB inhibitor interacting Ras-like protein 1
Synonyms 2400004O09Rik, KBRAS1
MMRRC Submission 067624-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # R8201 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 4185693-4198560 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to C at 18276908 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122235 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022294] [ENSMUST00000132374] [ENSMUST00000133460]
AlphaFold Q8CEC5
Predicted Effect probably benign
Transcript: ENSMUST00000022294
SMART Domains Protein: ENSMUSP00000022294
Gene: ENSMUSG00000021772

DomainStartEndE-ValueType
SCOP:d1i2ma_ 5 39 1e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132374
SMART Domains Protein: ENSMUSP00000121496
Gene: ENSMUSG00000021772

DomainStartEndE-ValueType
Pfam:Arf 1 168 7.8e-11 PFAM
Pfam:Roc 6 124 1.6e-13 PFAM
Pfam:Ras 6 170 5.2e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000133460
SMART Domains Protein: ENSMUSP00000122235
Gene: ENSMUSG00000021772

DomainStartEndE-ValueType
Pfam:Arf 4 115 1.7e-7 PFAM
Pfam:Ras 4 118 1.3e-21 PFAM
Pfam:Miro 5 97 1.7e-12 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik T C 3: 124,195,046 (GRCm39) E543G probably benign Het
2210408I21Rik T A 13: 77,341,278 (GRCm39) N302K possibly damaging Het
Apbb2 T C 5: 66,466,458 (GRCm39) N609S probably benign Het
Atp10a G T 7: 58,469,424 (GRCm39) G1092* probably null Het
Ccdc150 A G 1: 54,368,646 (GRCm39) N618S probably benign Het
Cct4 T A 11: 22,949,115 (GRCm39) V287E probably damaging Het
Cyp2j7 A T 4: 96,083,564 (GRCm39) I462N probably damaging Het
Dnajc6 C T 4: 101,475,960 (GRCm39) A611V probably benign Het
Dusp10 C A 1: 183,769,202 (GRCm39) A56E possibly damaging Het
Entrep3 T C 3: 89,093,115 (GRCm39) V291A probably damaging Het
Fat3 A C 9: 15,908,773 (GRCm39) C2410G possibly damaging Het
Fcgrt T A 7: 44,744,634 (GRCm39) Q274L possibly damaging Het
Fdxacb1 G T 9: 50,681,455 (GRCm39) probably benign Het
Fubp1 T A 3: 151,927,823 (GRCm39) I424N probably damaging Het
Gm5114 T A 7: 39,060,373 (GRCm39) T159S probably damaging Het
Gm7168 T C 17: 14,170,042 (GRCm39) C470R probably benign Het
Hebp1 A G 6: 135,114,906 (GRCm39) V185A possibly damaging Het
Il18rap G T 1: 40,578,429 (GRCm39) R280I possibly damaging Het
Mamdc4 T C 2: 25,456,093 (GRCm39) N771S probably damaging Het
Ndufaf4 A G 4: 24,898,197 (GRCm39) N11D possibly damaging Het
Noct T C 3: 51,155,444 (GRCm39) S135P probably benign Het
Or1e23 T A 11: 73,407,899 (GRCm39) N42I probably damaging Het
Or2t48 A T 11: 58,419,865 (GRCm39) *316R noncoding transcript Het
Or2w3b A C 11: 58,623,940 (GRCm39) F17C probably damaging Het
Or7e177 G T 9: 20,212,317 (GRCm39) G271C probably damaging Het
Or7e178 T C 9: 20,225,908 (GRCm39) M103V probably benign Het
Pcdhac1 A T 18: 37,223,892 (GRCm39) H235L probably benign Het
Pcdhb22 G T 18: 37,651,518 (GRCm39) probably benign Het
Pdlim1 A T 19: 40,218,958 (GRCm39) D224E probably benign Het
Plpp3 G T 4: 105,076,555 (GRCm39) G223W probably damaging Het
Rcan3 A G 4: 135,147,684 (GRCm39) F81S probably damaging Het
Sel1l2 A C 2: 140,108,312 (GRCm39) Y191D probably damaging Het
Supt16 A G 14: 52,408,447 (GRCm39) F833L probably damaging Het
Tchh T C 3: 93,350,781 (GRCm39) F74L probably damaging Het
Tgfbr3 T C 5: 107,278,431 (GRCm39) D725G probably benign Het
Tmem14c C T 13: 41,171,186 (GRCm39) P10S probably benign Het
Ubb G A 11: 62,443,053 (GRCm39) A28T probably benign Het
Vars2 A T 17: 35,969,202 (GRCm39) V833E probably benign Het
Zfyve9 T C 4: 108,507,474 (GRCm39) D528G possibly damaging Het
Other mutations in Nkiras1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00518:Nkiras1 APN 14 18,278,435 (GRCm38) missense probably benign 0.03
IGL01986:Nkiras1 APN 14 18,280,071 (GRCm38) missense probably damaging 0.99
IGL02593:Nkiras1 APN 14 18,278,475 (GRCm38) missense possibly damaging 0.49
IGL03410:Nkiras1 APN 14 18,280,073 (GRCm38) missense probably benign
R0230:Nkiras1 UTSW 14 18,280,185 (GRCm38) missense probably benign 0.01
R0508:Nkiras1 UTSW 14 18,278,524 (GRCm38) missense probably damaging 1.00
R1835:Nkiras1 UTSW 14 18,276,732 (GRCm38) missense probably damaging 1.00
R2400:Nkiras1 UTSW 14 18,280,011 (GRCm38) missense possibly damaging 0.50
R4789:Nkiras1 UTSW 14 18,276,935 (GRCm38) start gained probably benign
R7232:Nkiras1 UTSW 14 18,276,732 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTGCTGCCCTAGGAGAAGATG -3'
(R):5'- TCAGCATGCTATCTATGTCTGAAG -3'

Sequencing Primer
(F):5'- AAGGGTTGCAAGGTTGTCATTTG -3'
(R):5'- GAATATTGTCACTTGATGTTGCTACC -3'
Posted On 2020-07-13