Mutagenetix > Incidental Mutation

Incidental Mutation 'R8201:Gm7168'

635689

Institutional Source

Beutler Lab

Gene Symbol

Gm7168

Ensembl Gene

ENSMUSG00000067941

Gene Name

predicted gene 7168

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.100) question?

Stock #

R8201 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

13948373-13950678 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 13949780 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 470 (C470R)

Ref Sequence

ENSEMBL: ENSMUSP00000094997 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088809]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000088809
AA Change: C470R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000094997
Gene: ENSMUSG00000067941
AA Change: C470R

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
S_TKc	28	276	5.25e-91	SMART
UBA	296	333	4.39e-2	SMART
low complexity region	436	451	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 97.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	T	C	3: 124,401,397	E543G	probably benign	Het
2210408I21Rik	T	A	13: 77,193,159	N302K	possibly damaging	Het
Apbb2	T	C	5: 66,309,115	N609S	probably benign	Het
Atp10a	G	T	7: 58,819,676	G1092*	probably null	Het
Ccdc150	A	G	1: 54,329,487	N618S	probably benign	Het
Cct4	T	A	11: 22,999,115	V287E	probably damaging	Het
Cyp2j7	A	T	4: 96,195,327	I462N	probably damaging	Het
Dnajc6	C	T	4: 101,618,763	A611V	probably benign	Het
Dusp10	C	A	1: 184,037,005	A56E	possibly damaging	Het
Fam189b	T	C	3: 89,185,808	V291A	probably damaging	Het
Fat3	A	C	9: 15,997,477	C2410G	possibly damaging	Het
Fcgrt	T	A	7: 45,095,210	Q274L	possibly damaging	Het
Fdxacb1	G	T	9: 50,770,155		probably benign	Het
Fubp1	T	A	3: 152,222,186	I424N	probably damaging	Het
Gm5114	T	A	7: 39,410,949	T159S	probably damaging	Het
Hebp1	A	G	6: 135,137,908	V185A	possibly damaging	Het
Il18rap	G	T	1: 40,539,269	R280I	possibly damaging	Het
Mamdc4	T	C	2: 25,566,081	N771S	probably damaging	Het
Ndufaf4	A	G	4: 24,898,197	N11D	possibly damaging	Het
Nkiras1	T	C	14: 18,276,908		probably benign	Het
Noct	T	C	3: 51,248,023	S135P	probably benign	Het
Olfr18	T	C	9: 20,314,612	M103V	probably benign	Het
Olfr317	A	C	11: 58,733,114	F17C	probably damaging	Het
Olfr330	A	T	11: 58,529,039	*316R	noncoding transcript	Het
Olfr382	T	A	11: 73,517,073	N42I	probably damaging	Het
Olfr873	G	T	9: 20,301,021	G271C	probably damaging	Het
Pcdhac1	A	T	18: 37,090,839	H235L	probably benign	Het
Pcdhb22	G	T	18: 37,518,465		probably benign	Het
Pdlim1	A	T	19: 40,230,514	D224E	probably benign	Het
Plpp3	G	T	4: 105,219,358	G223W	probably damaging	Het
Rcan3	A	G	4: 135,420,373	F81S	probably damaging	Het
Sel1l2	A	C	2: 140,266,392	Y191D	probably damaging	Het
Supt16	A	G	14: 52,170,990	F833L	probably damaging	Het
Tchh	T	C	3: 93,443,474	F74L	probably damaging	Het
Tgfbr3	T	C	5: 107,130,565	D725G	probably benign	Het
Tmem14c	C	T	13: 41,017,710	P10S	probably benign	Het
Ubb	G	A	11: 62,552,227	A28T	probably benign	Het
Vars2	A	T	17: 35,658,310	V833E	probably benign	Het
Zfyve9	T	C	4: 108,650,277	D528G	possibly damaging	Het

Other mutations in Gm7168

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01298:Gm7168	APN	17	13949858	missense	probably benign	0.00
IGL01392:Gm7168	APN	17	13948907	missense	probably benign
IGL01577:Gm7168	APN	17	13949387	missense	probably damaging	0.99
IGL01691:Gm7168	APN	17	13948878	missense	probably damaging	0.96
R0064:Gm7168	UTSW	17	13949859	missense	probably benign	0.21
R0611:Gm7168	UTSW	17	13949535	missense	probably benign
R0737:Gm7168	UTSW	17	13948983	missense	probably damaging	1.00
R1789:Gm7168	UTSW	17	13949584	missense	probably benign	0.03
R2864:Gm7168	UTSW	17	13949855	missense	probably benign	0.42
R2865:Gm7168	UTSW	17	13949855	missense	probably benign	0.42
R4179:Gm7168	UTSW	17	13949003	missense	probably benign	0.00
R4652:Gm7168	UTSW	17	13949807	missense	possibly damaging	0.88
R5174:Gm7168	UTSW	17	13948455	missense	probably damaging	1.00
R5722:Gm7168	UTSW	17	13949562	missense	probably benign
R6180:Gm7168	UTSW	17	13948596	missense	probably damaging	0.98
R7195:Gm7168	UTSW	17	13949360	missense	probably benign	0.01
R7366:Gm7168	UTSW	17	13949885	missense	probably damaging	1.00
R7490:Gm7168	UTSW	17	13949013	missense	probably benign	0.01
R7748:Gm7168	UTSW	17	13948652	missense	probably benign	0.03
R8113:Gm7168	UTSW	17	13948976	nonsense	probably null
R9197:Gm7168	UTSW	17	13949227	missense	probably benign	0.13
R9260:Gm7168	UTSW	17	13949226	missense	probably benign	0.01
R9520:Gm7168	UTSW	17	13949244	missense	probably benign
X0020:Gm7168	UTSW	17	13949736	missense	probably benign	0.04
Z1177:Gm7168	UTSW	17	13949082	missense	probably damaging	1.00
Z1177:Gm7168	UTSW	17	13949670	missense	probably damaging	1.00
Z1177:Gm7168	UTSW	17	13949757	missense	probably benign	0.22

Predicted Primers

Posted On

2020-07-13