Incidental Mutation 'R8205:Ptgfr'
ID 635854
Institutional Source Beutler Lab
Gene Symbol Ptgfr
Ensembl Gene ENSMUSG00000028036
Gene Name prostaglandin F receptor
Synonyms FP, PGF
MMRRC Submission 067628-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R8205 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 151504247-151543165 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 151541418 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 30 (V30A)
Ref Sequence ENSEMBL: ENSMUSP00000029670 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029670] [ENSMUST00000106126]
AlphaFold P43117
Predicted Effect probably benign
Transcript: ENSMUST00000029670
AA Change: V30A

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000029670
Gene: ENSMUSG00000028036
AA Change: V30A

DomainStartEndE-ValueType
Pfam:7tm_1 23 304 6.8e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106126
AA Change: V30A

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000101732
Gene: ENSMUSG00000028036
AA Change: V30A

DomainStartEndE-ValueType
Pfam:7tm_1 43 304 7.6e-26 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Pregnant females homozygous for a targeted null mutation are unable to deliver their offspring due to lack of induction of the oxytocin receptor and fail to show the normal decline of serum progesterone levels preceding parturition. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam39 T C 8: 41,278,080 (GRCm39) V157A probably benign Het
Adamtsl1 A G 4: 86,117,650 (GRCm39) *204W probably null Het
Add2 A G 6: 86,063,899 (GRCm39) E66G probably damaging Het
Adgrd1 A G 5: 129,192,175 (GRCm39) T114A possibly damaging Het
Aldh7a1 A T 18: 56,678,070 (GRCm39) I247N probably damaging Het
Ankrd13d A T 19: 4,331,009 (GRCm39) M166K probably damaging Het
Brd7 A G 8: 89,070,243 (GRCm39) F388L probably damaging Het
Cap2 G A 13: 46,768,739 (GRCm39) V182M probably damaging Het
Col22a1 A T 15: 71,732,918 (GRCm39) V1100E unknown Het
Cracdl T C 1: 37,664,047 (GRCm39) D617G probably benign Het
Crisp2 T C 17: 41,095,969 (GRCm39) E63G possibly damaging Het
Dst T G 1: 34,253,685 (GRCm39) W2304G probably damaging Het
Eif2a A C 3: 58,456,156 (GRCm39) N385T probably damaging Het
Eif4ebp2 A T 10: 61,270,704 (GRCm39) H108Q probably benign Het
Fgd3 T C 13: 49,449,823 (GRCm39) D142G probably benign Het
Gbp8 T A 5: 105,198,846 (GRCm39) H23L probably benign Het
Glt1d1 A G 5: 127,768,080 (GRCm39) E229G probably benign Het
Gpatch8 T C 11: 102,371,213 (GRCm39) D775G unknown Het
Heatr1 T C 13: 12,430,928 (GRCm39) Y1008H probably benign Het
Heatr5a T A 12: 52,005,792 (GRCm39) N61I probably benign Het
Hydin A T 8: 111,319,270 (GRCm39) H4391L possibly damaging Het
Ifi206 T C 1: 173,309,450 (GRCm39) E182G Het
Mbtps1 A G 8: 120,247,077 (GRCm39) S789P probably damaging Het
Mex3a T C 3: 88,444,159 (GRCm39) S412P possibly damaging Het
Msantd5f1 G A 4: 73,605,542 (GRCm39) V318I possibly damaging Het
Mup2 T A 4: 60,137,659 (GRCm39) D128V probably benign Het
Ndufaf7 G A 17: 79,254,461 (GRCm39) C418Y probably benign Het
Nlrp4a A G 7: 26,150,219 (GRCm39) S609G probably benign Het
Obscn T A 11: 58,898,697 (GRCm39) Y6554F unknown Het
Odf2l A G 3: 144,856,495 (GRCm39) probably benign Het
Or14j2 A T 17: 37,885,892 (GRCm39) C141S probably damaging Het
Or1o11 T C 17: 37,757,180 (GRCm39) V245A probably damaging Het
Or4c104 A T 2: 88,587,016 (GRCm39) M1K probably null Het
Plod2 G T 9: 92,424,371 (GRCm39) probably benign Het
Pxdn T G 12: 30,056,566 (GRCm39) L1259R probably damaging Het
Rnf6 A G 5: 146,147,714 (GRCm39) S435P probably damaging Het
Sacm1l G A 9: 123,415,724 (GRCm39) probably null Het
Scgb2b26 T C 7: 33,643,833 (GRCm39) T36A probably benign Het
Slc1a7 A G 4: 107,865,508 (GRCm39) N332S probably benign Het
Slfn5 T C 11: 82,851,544 (GRCm39) F614L probably benign Het
Smad7 C A 18: 75,527,119 (GRCm39) Q322K probably damaging Het
Smap1 T C 1: 23,888,507 (GRCm39) T253A probably benign Het
Socs5 G T 17: 87,441,138 (GRCm39) R26L probably benign Het
Steap4 A T 5: 8,026,795 (GRCm39) I253F possibly damaging Het
Tacc1 G A 8: 25,672,803 (GRCm39) H142Y probably benign Het
Tent5c A G 3: 100,380,138 (GRCm39) F206S probably benign Het
Tmem117 G A 15: 94,992,679 (GRCm39) M446I probably benign Het
Trav7-6 G A 14: 53,954,550 (GRCm39) D47N probably benign Het
Trim2 C A 3: 84,100,646 (GRCm39) A162S probably damaging Het
Ttc28 A G 5: 111,373,596 (GRCm39) I1011V possibly damaging Het
Vmn2r98 T C 17: 19,301,425 (GRCm39) V809A probably damaging Het
Wfikkn1 T A 17: 26,097,071 (GRCm39) T418S probably benign Het
Zbtb41 T A 1: 139,356,919 (GRCm39) D391E possibly damaging Het
Zfp109 G A 7: 23,928,635 (GRCm39) S266F probably damaging Het
Other mutations in Ptgfr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01322:Ptgfr APN 3 151,541,323 (GRCm39) missense probably benign 0.43
IGL02085:Ptgfr APN 3 151,541,437 (GRCm39) missense probably benign 0.00
IGL02110:Ptgfr APN 3 151,541,097 (GRCm39) missense probably damaging 0.97
IGL02971:Ptgfr APN 3 151,540,963 (GRCm39) missense probably benign 0.00
IGL03263:Ptgfr APN 3 151,541,500 (GRCm39) missense probably benign 0.00
R0048:Ptgfr UTSW 3 151,540,728 (GRCm39) missense possibly damaging 0.51
R0048:Ptgfr UTSW 3 151,540,728 (GRCm39) missense possibly damaging 0.51
R0602:Ptgfr UTSW 3 151,540,839 (GRCm39) missense probably damaging 1.00
R0624:Ptgfr UTSW 3 151,540,839 (GRCm39) missense probably damaging 1.00
R0633:Ptgfr UTSW 3 151,507,400 (GRCm39) missense probably benign 0.00
R1614:Ptgfr UTSW 3 151,507,416 (GRCm39) missense probably benign 0.44
R1930:Ptgfr UTSW 3 151,540,831 (GRCm39) missense probably benign 0.16
R1931:Ptgfr UTSW 3 151,540,831 (GRCm39) missense probably benign 0.16
R1989:Ptgfr UTSW 3 151,540,976 (GRCm39) nonsense probably null
R4596:Ptgfr UTSW 3 151,507,430 (GRCm39) missense probably damaging 1.00
R5899:Ptgfr UTSW 3 151,540,738 (GRCm39) missense probably damaging 0.96
R6295:Ptgfr UTSW 3 151,540,926 (GRCm39) missense probably benign 0.00
R6907:Ptgfr UTSW 3 151,540,938 (GRCm39) missense possibly damaging 0.95
R7047:Ptgfr UTSW 3 151,541,178 (GRCm39) missense possibly damaging 0.74
R7320:Ptgfr UTSW 3 151,541,034 (GRCm39) missense probably benign 0.22
R8420:Ptgfr UTSW 3 151,541,053 (GRCm39) missense possibly damaging 0.49
R9049:Ptgfr UTSW 3 151,541,404 (GRCm39) missense probably benign 0.24
R9352:Ptgfr UTSW 3 151,541,160 (GRCm39) missense probably damaging 1.00
R9537:Ptgfr UTSW 3 151,541,445 (GRCm39) missense possibly damaging 0.91
Z1176:Ptgfr UTSW 3 151,541,278 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCTCCGTTGATAAGGTGG -3'
(R):5'- AGGCACTTGGTTCTAAATGTCAG -3'

Sequencing Primer
(F):5'- TGGCCAAAGAAGTCTGTGATCAC -3'
(R):5'- CAGATGACTGACTGGTAATTAGGTC -3'
Posted On 2020-07-13