Incidental Mutation 'R8207:Farp2'
ID 635942
Institutional Source Beutler Lab
Gene Symbol Farp2
Ensembl Gene ENSMUSG00000034066
Gene Name FERM, RhoGEF and pleckstrin domain protein 2
Synonyms Fir, D030026M03Rik
MMRRC Submission 067630-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8207 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 93439826-93549698 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 93548965 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 1024 (R1024G)
Ref Sequence ENSEMBL: ENSMUSP00000112725 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027498] [ENSMUST00000120301] [ENSMUST00000133769]
AlphaFold Q91VS8
PDB Structure Crystal strucure of the DH domain of FARP2 [X-RAY DIFFRACTION]
Crystal strucure of the DH-PH-PH domain of FARP2 [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000027498
SMART Domains Protein: ENSMUSP00000027498
Gene: ENSMUSG00000026277

DomainStartEndE-ValueType
S_TKc 20 270 2.92e-98 SMART
low complexity region 292 314 N/A INTRINSIC
PDB:3W8H|B 355 426 8e-43 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000120301
AA Change: R1024G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000112725
Gene: ENSMUSG00000034066
AA Change: R1024G

DomainStartEndE-ValueType
B41 40 234 1.48e-66 SMART
FERM_C 238 328 3.29e-35 SMART
FA 332 378 1.13e-15 SMART
low complexity region 409 421 N/A INTRINSIC
low complexity region 440 459 N/A INTRINSIC
low complexity region 462 473 N/A INTRINSIC
low complexity region 478 492 N/A INTRINSIC
RhoGEF 542 728 1.57e-56 SMART
PH 759 857 1.45e-19 SMART
low complexity region 879 890 N/A INTRINSIC
PH 931 1029 2.62e-17 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000133769
SMART Domains Protein: ENSMUSP00000117765
Gene: ENSMUSG00000026277

DomainStartEndE-ValueType
Pfam:Pkinase 20 233 1.7e-63 PFAM
Pfam:Pkinase_Tyr 20 233 2.1e-47 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (49/49)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit slight increase in bone volumetrics and reduced osteoclast differentiation from BMDMs cultured with M-CSF and RANKL [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aen G A 7: 78,552,491 (GRCm39) M150I possibly damaging Het
Arhgef11 A G 3: 87,606,082 (GRCm39) N279S possibly damaging Het
Arid3a T C 10: 79,786,760 (GRCm39) probably null Het
Casp8ap2 A G 4: 32,646,446 (GRCm39) T1840A possibly damaging Het
Ccdc14 T A 16: 34,525,413 (GRCm39) N235K possibly damaging Het
Cdh20 T C 1: 109,922,076 (GRCm39) V56A probably damaging Het
Clec16a G A 16: 10,512,574 (GRCm39) R837H probably damaging Het
Clec16a A G 16: 10,445,312 (GRCm39) N518S probably benign Het
Cog7 T C 7: 121,576,515 (GRCm39) D137G possibly damaging Het
Cpt1b T C 15: 89,303,018 (GRCm39) T649A probably damaging Het
Efcab8 C G 2: 153,631,145 (GRCm39) L192V probably damaging Het
Flvcr2 GTAGTGTATA GTA 12: 85,849,922 (GRCm39) probably null Het
Fmo1 T A 1: 162,677,676 (GRCm39) T147S probably benign Het
Fryl A C 5: 73,257,843 (GRCm39) probably null Het
Galnt13 A C 2: 54,770,122 (GRCm39) I305L probably benign Het
Guca2a A G 4: 119,494,951 (GRCm39) N2D unknown Het
Iqcd C T 5: 120,740,514 (GRCm39) R282W probably damaging Het
Lamc1 A C 1: 153,126,268 (GRCm39) C475G probably damaging Het
Map3k5 AAAAGAAAAAGA AA 10: 19,986,612 (GRCm39) probably null Het
Med13 A T 11: 86,194,375 (GRCm39) D789E probably damaging Het
Mn1 A G 5: 111,569,651 (GRCm39) Y1207C probably damaging Het
Mroh2b A G 15: 4,967,892 (GRCm39) D977G possibly damaging Het
Mrpl53 A T 6: 83,086,169 (GRCm39) N26I probably damaging Het
Nell1 A T 7: 49,869,760 (GRCm39) probably null Het
Ogdh T G 11: 6,299,329 (GRCm39) F743V probably benign Het
Or4d10b A T 19: 12,036,222 (GRCm39) M298K possibly damaging Het
Or4n4 C T 14: 50,519,036 (GRCm39) V225I probably benign Het
Or6c3 A G 10: 129,308,953 (GRCm39) T131A probably benign Het
Plscr1l1 T A 9: 92,233,061 (GRCm39) F61L probably benign Het
Pmvk A G 3: 89,375,899 (GRCm39) E174G probably benign Het
Pou6f2 T C 13: 18,414,158 (GRCm39) N206D Het
Prelid3a A T 18: 67,606,018 (GRCm39) S42C probably benign Het
Riok1 T A 13: 38,236,296 (GRCm39) H347Q probably damaging Het
Ryr1 A G 7: 28,789,650 (GRCm39) L1488P probably damaging Het
Shkbp1 A G 7: 27,052,109 (GRCm39) V158A probably benign Het
Slc9c1 A G 16: 45,360,076 (GRCm39) I43M possibly damaging Het
Smarca2 A G 19: 26,654,080 (GRCm39) N755S possibly damaging Het
Tcof1 G C 18: 60,962,123 (GRCm39) A702G possibly damaging Het
Tfb2m G A 1: 179,373,668 (GRCm39) P10L probably benign Het
Trim30c T C 7: 104,032,703 (GRCm39) M252V probably benign Het
Ttll1 A G 15: 83,384,279 (GRCm39) L116P probably damaging Het
Tubd1 C T 11: 86,440,248 (GRCm39) H91Y possibly damaging Het
Vgll4 A G 6: 114,839,786 (GRCm39) S175P probably damaging Het
Vmn1r79 A G 7: 11,910,415 (GRCm39) Y99C possibly damaging Het
Vmn2r80 C T 10: 79,030,150 (GRCm39) Q659* probably null Het
Zfp382 A G 7: 29,833,840 (GRCm39) D497G possibly damaging Het
Zfp41 A G 15: 75,490,384 (GRCm39) E112G probably damaging Het
Zfyve26 A G 12: 79,307,605 (GRCm39) S1754P probably damaging Het
Other mutations in Farp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00598:Farp2 APN 1 93,531,103 (GRCm39) missense probably benign 0.00
IGL00953:Farp2 APN 1 93,488,896 (GRCm39) missense possibly damaging 0.92
IGL00961:Farp2 APN 1 93,549,035 (GRCm39) missense possibly damaging 0.81
IGL00970:Farp2 APN 1 93,488,049 (GRCm39) missense probably benign 0.00
IGL01377:Farp2 APN 1 93,531,181 (GRCm39) missense possibly damaging 0.74
IGL01408:Farp2 APN 1 93,546,702 (GRCm39) missense probably benign 0.19
IGL01919:Farp2 APN 1 93,504,155 (GRCm39) missense probably damaging 1.00
IGL01985:Farp2 APN 1 93,535,324 (GRCm39) missense probably damaging 1.00
IGL02375:Farp2 APN 1 93,504,185 (GRCm39) missense probably damaging 1.00
IGL02392:Farp2 APN 1 93,505,372 (GRCm39) missense probably damaging 1.00
IGL02815:Farp2 APN 1 93,488,007 (GRCm39) missense probably damaging 1.00
IGL03003:Farp2 APN 1 93,495,140 (GRCm39) missense probably damaging 1.00
IGL03074:Farp2 APN 1 93,488,049 (GRCm39) missense probably benign 0.00
IGL03223:Farp2 APN 1 93,545,324 (GRCm39) nonsense probably null
IGL03379:Farp2 APN 1 93,535,160 (GRCm39) missense probably benign 0.08
IGL02802:Farp2 UTSW 1 93,456,332 (GRCm39) missense probably damaging 1.00
PIT4468001:Farp2 UTSW 1 93,456,499 (GRCm39) nonsense probably null
PIT4494001:Farp2 UTSW 1 93,545,316 (GRCm39) missense probably damaging 1.00
R0207:Farp2 UTSW 1 93,496,809 (GRCm39) missense probably damaging 0.96
R0521:Farp2 UTSW 1 93,504,543 (GRCm39) critical splice acceptor site probably null
R0594:Farp2 UTSW 1 93,504,222 (GRCm39) missense probably damaging 1.00
R1386:Farp2 UTSW 1 93,547,873 (GRCm39) splice site probably null
R1522:Farp2 UTSW 1 93,546,275 (GRCm39) missense possibly damaging 0.79
R1589:Farp2 UTSW 1 93,507,582 (GRCm39) missense probably damaging 1.00
R1651:Farp2 UTSW 1 93,531,191 (GRCm39) critical splice donor site probably null
R1695:Farp2 UTSW 1 93,488,047 (GRCm39) missense probably damaging 0.97
R1833:Farp2 UTSW 1 93,504,086 (GRCm39) splice site probably benign
R1915:Farp2 UTSW 1 93,456,424 (GRCm39) missense probably benign 0.16
R2241:Farp2 UTSW 1 93,507,625 (GRCm39) missense probably benign 0.31
R4505:Farp2 UTSW 1 93,546,732 (GRCm39) missense probably damaging 1.00
R4518:Farp2 UTSW 1 93,548,363 (GRCm39) missense probably benign 0.04
R4551:Farp2 UTSW 1 93,546,314 (GRCm39) missense possibly damaging 0.92
R4723:Farp2 UTSW 1 93,508,621 (GRCm39) missense probably benign 0.07
R4821:Farp2 UTSW 1 93,502,192 (GRCm39) splice site probably null
R4861:Farp2 UTSW 1 93,533,141 (GRCm39) missense probably damaging 1.00
R4861:Farp2 UTSW 1 93,533,141 (GRCm39) missense probably damaging 1.00
R5221:Farp2 UTSW 1 93,504,140 (GRCm39) missense probably damaging 0.99
R5625:Farp2 UTSW 1 93,456,470 (GRCm39) missense probably damaging 1.00
R5663:Farp2 UTSW 1 93,497,735 (GRCm39) missense probably damaging 1.00
R5935:Farp2 UTSW 1 93,548,367 (GRCm39) critical splice donor site probably null
R6593:Farp2 UTSW 1 93,497,662 (GRCm39) missense possibly damaging 0.48
R6853:Farp2 UTSW 1 93,497,738 (GRCm39) missense probably damaging 1.00
R7001:Farp2 UTSW 1 93,547,952 (GRCm39) missense possibly damaging 0.94
R7001:Farp2 UTSW 1 93,547,906 (GRCm39) missense possibly damaging 0.94
R7133:Farp2 UTSW 1 93,548,956 (GRCm39) missense probably damaging 1.00
R7134:Farp2 UTSW 1 93,531,181 (GRCm39) missense probably benign 0.04
R7184:Farp2 UTSW 1 93,531,137 (GRCm39) missense probably damaging 1.00
R7219:Farp2 UTSW 1 93,488,040 (GRCm39) missense probably damaging 0.97
R7234:Farp2 UTSW 1 93,507,841 (GRCm39) missense possibly damaging 0.94
R7426:Farp2 UTSW 1 93,548,950 (GRCm39) missense possibly damaging 0.55
R7477:Farp2 UTSW 1 93,508,750 (GRCm39) splice site probably null
R7503:Farp2 UTSW 1 93,495,219 (GRCm39) missense probably benign 0.03
R7921:Farp2 UTSW 1 93,495,237 (GRCm39) critical splice donor site probably null
R7939:Farp2 UTSW 1 93,487,983 (GRCm39) missense probably damaging 1.00
R7985:Farp2 UTSW 1 93,504,246 (GRCm39) missense probably damaging 1.00
R8162:Farp2 UTSW 1 93,548,325 (GRCm39) missense probably damaging 1.00
R8292:Farp2 UTSW 1 93,456,350 (GRCm39) missense probably damaging 1.00
R8348:Farp2 UTSW 1 93,504,614 (GRCm39) critical splice donor site probably null
R8495:Farp2 UTSW 1 93,531,139 (GRCm39) missense possibly damaging 0.74
R9106:Farp2 UTSW 1 93,488,910 (GRCm39) critical splice donor site probably null
Z1176:Farp2 UTSW 1 93,508,189 (GRCm39) missense probably benign 0.00
Z1176:Farp2 UTSW 1 93,508,183 (GRCm39) missense probably benign
Z1176:Farp2 UTSW 1 93,507,858 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCTGCCTTGTTTTAGGAGACAG -3'
(R):5'- AGTGCCTGGGATGATGCTTAC -3'

Sequencing Primer
(F):5'- ACCTCCTCAGTGCTGGATTAGG -3'
(R):5'- GATGATGCTTACAGTCCCTGCAAG -3'
Posted On 2020-07-13