Incidental Mutation 'R8209:Or51f23b'
ID 636066
Institutional Source Beutler Lab
Gene Symbol Or51f23b
Ensembl Gene ENSMUSG00000110008
Gene Name olfactory receptor family 51 subfamily F member 23B
Synonyms GA_x6K02T2PBJ9-5470572-5469628, Olfr560, MOR14-1
MMRRC Submission 067632-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.151) question?
Stock # R8209 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102402190-102403134 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102402950 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 62 (Y62C)
Ref Sequence ENSEMBL: ENSMUSP00000148074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060187] [ENSMUST00000168007] [ENSMUST00000210453]
AlphaFold A0A1B0GSU5
Predicted Effect probably benign
Transcript: ENSMUST00000060187
SMART Domains Protein: ENSMUSP00000058085
Gene: ENSMUSG00000043366

DomainStartEndE-ValueType
Pfam:7tm_4 30 309 1.9e-111 PFAM
Pfam:7TM_GPCR_Srsx 34 252 1.4e-8 PFAM
Pfam:7tm_1 40 291 2.3e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168007
SMART Domains Protein: ENSMUSP00000133255
Gene: ENSMUSG00000043366

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 34 252 1.4e-8 PFAM
Pfam:7tm_1 40 291 1.4e-25 PFAM
Pfam:7tm_4 140 284 2.8e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210453
AA Change: Y62C

PolyPhen 2 Score 0.296 (Sensitivity: 0.91; Specificity: 0.89)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A G 10: 29,094,195 (GRCm39) N27S probably damaging Het
Akr1b1 G C 6: 34,288,867 (GRCm39) T114R probably damaging Het
Alx4 T C 2: 93,505,696 (GRCm39) M266T possibly damaging Het
Arhgap21 C T 2: 20,876,556 (GRCm39) D820N probably damaging Het
Clec4a1 A G 6: 122,907,773 (GRCm39) S154G probably damaging Het
Col11a2 T C 17: 34,266,253 (GRCm39) probably null Het
Dnaaf2 A T 12: 69,244,866 (GRCm39) V65E probably damaging Het
Dnah14 A G 1: 181,623,110 (GRCm39) E3996G possibly damaging Het
Dsg1b A G 18: 20,541,947 (GRCm39) Y818C probably benign Het
Dzip3 C T 16: 48,798,307 (GRCm39) G133S probably damaging Het
Efcab6 T C 15: 83,788,456 (GRCm39) Y946C probably benign Het
Eprs1 A G 1: 185,139,812 (GRCm39) E967G possibly damaging Het
F5 T C 1: 164,021,959 (GRCm39) V1478A probably benign Het
Fchsd2 C T 7: 100,931,679 (GRCm39) P745L probably damaging Het
Gart T C 16: 91,425,041 (GRCm39) I661V possibly damaging Het
Gm14295 T A 2: 176,502,970 (GRCm39) I820K unknown Het
Grb10 G T 11: 11,901,533 (GRCm39) L214M probably damaging Het
Gria2 A G 3: 80,616,764 (GRCm39) V396A probably benign Het
Il17rc C A 6: 113,449,771 (GRCm39) Q126K probably benign Het
Ipo8 A G 6: 148,698,176 (GRCm39) I615T possibly damaging Het
Irak4 T A 15: 94,456,244 (GRCm39) L277Q probably damaging Het
Islr T C 9: 58,065,340 (GRCm39) S56G probably damaging Het
Krt78 A T 15: 101,855,480 (GRCm39) M777K possibly damaging Het
Lrch4 A G 5: 137,637,997 (GRCm39) H93R Het
Muc21 T C 17: 35,930,599 (GRCm39) probably benign Het
Nbeal1 A T 1: 60,316,336 (GRCm39) K1846N probably damaging Het
Nedd1 T A 10: 92,527,797 (GRCm39) M466L probably benign Het
Nup107 T C 10: 117,593,836 (GRCm39) K786E probably benign Het
Or5ak25 T A 2: 85,268,981 (GRCm39) I174F probably damaging Het
Or5m12 T C 2: 85,734,547 (GRCm39) I284V probably benign Het
Phc2 T C 4: 128,603,299 (GRCm39) L143P probably benign Het
Pkhd1l1 A G 15: 44,437,803 (GRCm39) N3533D possibly damaging Het
Plpp1 A T 13: 113,003,465 (GRCm39) T230S probably benign Het
Prokr2 C A 2: 132,215,961 (GRCm39) A167S probably damaging Het
Qser1 C T 2: 104,619,070 (GRCm39) A491T probably benign Het
Rc3h2 T A 2: 37,267,001 (GRCm39) Y1040F possibly damaging Het
Rgl2 C T 17: 34,151,501 (GRCm39) L182F possibly damaging Het
Rnf130 T C 11: 49,962,097 (GRCm39) V181A probably benign Het
Scn7a T G 2: 66,531,204 (GRCm39) I558L possibly damaging Het
Shtn1 T C 19: 58,992,328 (GRCm39) I417V possibly damaging Het
Slco1a5 T G 6: 142,208,408 (GRCm39) N128H probably damaging Het
Smg5 C T 3: 88,258,838 (GRCm39) A603V probably benign Het
Svs3b T A 2: 164,098,140 (GRCm39) E60D possibly damaging Het
Thap1 CAGCATCTGCTCGGAGCA CAGCA 8: 26,650,884 (GRCm39) probably null Het
Timm44 A T 8: 4,316,844 (GRCm39) M263K probably benign Het
Tmem150b A G 7: 4,723,691 (GRCm39) L162P probably damaging Het
Tmprss11f A G 5: 86,687,566 (GRCm39) V114A probably damaging Het
Trak1 C T 9: 121,280,793 (GRCm39) T394I probably benign Het
Tram2 A C 1: 21,075,801 (GRCm39) Y206D probably damaging Het
Trhde C T 10: 114,403,133 (GRCm39) V497M probably damaging Het
Trpc2 A G 7: 101,737,482 (GRCm39) M425V possibly damaging Het
Tuba1b C T 15: 98,829,591 (GRCm39) G410S probably benign Het
Vmn2r1 A G 3: 63,997,199 (GRCm39) D285G possibly damaging Het
Zfp536 A T 7: 37,268,080 (GRCm39) S445R probably benign Het
Zfp606 A T 7: 12,227,234 (GRCm39) T452S probably benign Het
Other mutations in Or51f23b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7081:Or51f23b UTSW 7 102,402,395 (GRCm39) missense probably benign 0.18
R7094:Or51f23b UTSW 7 102,402,305 (GRCm39) missense probably benign
R7605:Or51f23b UTSW 7 102,402,952 (GRCm39) missense probably benign 0.28
R7868:Or51f23b UTSW 7 102,402,812 (GRCm39) missense possibly damaging 0.95
R8226:Or51f23b UTSW 7 102,402,950 (GRCm39) missense probably benign 0.30
R8242:Or51f23b UTSW 7 102,402,306 (GRCm39) missense probably benign 0.01
R9180:Or51f23b UTSW 7 102,402,734 (GRCm39) missense probably damaging 1.00
Z1176:Or51f23b UTSW 7 102,402,623 (GRCm39) missense possibly damaging 0.91
Z1176:Or51f23b UTSW 7 102,402,621 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GGGTTGGAGATGGCCACATAAC -3'
(R):5'- AATCTAGCATGCCAACTTTCCAG -3'

Sequencing Primer
(F):5'- GATGGCCACATAACGATCATAAG -3'
(R):5'- TTCCAGAACACCACAGCTTCTTC -3'
Posted On 2020-07-13