Incidental Mutation 'R8210:Slc1a6'
ID |
636127 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Slc1a6
|
Ensembl Gene |
ENSMUSG00000005357 |
Gene Name |
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
Synonyms |
EAAT4 |
MMRRC Submission |
067633-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.083)
|
Stock # |
R8210 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
10 |
Chromosomal Location |
78616330-78650599 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 78632091 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 306
(I306F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000005490
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005490]
|
AlphaFold |
O35544 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000005490
AA Change: I306F
PolyPhen 2
Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000005490 Gene: ENSMUSG00000005357 AA Change: I306F
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
Pfam:SDF
|
55 |
519 |
8.5e-129 |
PFAM |
|
Meta Mutation Damage Score |
0.0953 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.4%
|
Validation Efficiency |
100% (63/63) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for disruptions in this gene survive well and display no obvious abnormalities of behavior or brain structure. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 62 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acsbg1 |
G |
A |
9: 54,517,083 (GRCm39) |
P577S |
probably damaging |
Het |
Adal |
T |
C |
2: 120,985,236 (GRCm39) |
V269A |
possibly damaging |
Het |
Adam33 |
T |
C |
2: 130,898,250 (GRCm39) |
T155A |
probably benign |
Het |
Adgre1 |
A |
T |
17: 57,752,061 (GRCm39) |
E603V |
possibly damaging |
Het |
Adgrf4 |
T |
C |
17: 42,978,441 (GRCm39) |
T301A |
probably damaging |
Het |
Agtpbp1 |
G |
T |
13: 59,630,385 (GRCm39) |
A782E |
possibly damaging |
Het |
Ank3 |
A |
T |
10: 69,811,925 (GRCm39) |
K1197N |
possibly damaging |
Het |
Anxa9 |
A |
T |
3: 95,213,207 (GRCm39) |
D46E |
probably damaging |
Het |
Atg9a |
T |
C |
1: 75,161,927 (GRCm39) |
T540A |
probably damaging |
Het |
Atg9a |
A |
G |
1: 75,163,009 (GRCm39) |
Y364H |
probably damaging |
Het |
Bltp1 |
A |
C |
3: 37,067,030 (GRCm39) |
E73A |
|
Het |
Cd300c2 |
C |
T |
11: 114,891,634 (GRCm39) |
G80D |
possibly damaging |
Het |
Cebpz |
T |
C |
17: 79,230,685 (GRCm39) |
E844G |
probably benign |
Het |
Celsr1 |
T |
C |
15: 85,863,436 (GRCm39) |
I1199V |
probably benign |
Het |
Cftr |
A |
G |
6: 18,220,696 (GRCm39) |
N189S |
probably damaging |
Het |
Dhrs13 |
G |
T |
11: 77,924,302 (GRCm39) |
R116I |
unknown |
Het |
Dnah10 |
A |
G |
5: 124,827,858 (GRCm39) |
M735V |
probably benign |
Het |
Dnajb8 |
C |
T |
6: 88,199,940 (GRCm39) |
R159C |
possibly damaging |
Het |
E130208F15Rik |
C |
A |
7: 30,021,619 (GRCm39) |
S93* |
probably null |
Het |
E330034G19Rik |
T |
C |
14: 24,346,104 (GRCm39) |
I92T |
|
Het |
Eef1d |
A |
T |
15: 75,768,309 (GRCm39) |
V511D |
probably damaging |
Het |
Efna1 |
T |
G |
3: 89,183,520 (GRCm39) |
E102A |
probably damaging |
Het |
H2-M11 |
C |
A |
17: 36,858,860 (GRCm39) |
F133L |
probably damaging |
Het |
Htr3b |
G |
T |
9: 48,847,343 (GRCm39) |
|
probably null |
Het |
Kcns3 |
A |
G |
12: 11,142,253 (GRCm39) |
S149P |
probably damaging |
Het |
Lhx4 |
T |
A |
1: 155,586,214 (GRCm39) |
|
probably null |
Het |
Lrp1 |
C |
T |
10: 127,412,354 (GRCm39) |
V1317M |
probably damaging |
Het |
Mphosph9 |
A |
G |
5: 124,405,174 (GRCm39) |
I799T |
probably damaging |
Het |
Muc1 |
C |
T |
3: 89,138,906 (GRCm39) |
A505V |
probably damaging |
Het |
Muc6 |
C |
A |
7: 141,235,673 (GRCm39) |
|
probably null |
Het |
Mylk |
A |
G |
16: 34,820,721 (GRCm39) |
D1891G |
probably damaging |
Het |
Nfe2l3 |
A |
T |
6: 51,428,065 (GRCm39) |
H209L |
probably benign |
Het |
Nprl2 |
A |
C |
9: 107,421,947 (GRCm39) |
Y241S |
probably damaging |
Het |
Oprm1 |
A |
T |
10: 6,780,442 (GRCm39) |
Q368L |
probably benign |
Het |
Or4g7 |
T |
A |
2: 111,309,753 (GRCm39) |
M208K |
possibly damaging |
Het |
Pcm1 |
C |
T |
8: 41,766,974 (GRCm39) |
R1593C |
probably damaging |
Het |
Pitpnm1 |
T |
C |
19: 4,162,878 (GRCm39) |
|
probably null |
Het |
Pnoc |
A |
G |
14: 65,642,521 (GRCm39) |
S81P |
probably benign |
Het |
Prkg2 |
T |
A |
5: 99,114,393 (GRCm39) |
D585V |
probably damaging |
Het |
Prpf38b |
A |
T |
3: 108,815,148 (GRCm39) |
|
probably benign |
Het |
Ranbp3l |
G |
T |
15: 9,065,059 (GRCm39) |
S482I |
probably benign |
Het |
Rapgef4 |
T |
C |
2: 72,056,364 (GRCm39) |
F651L |
probably benign |
Het |
Rasgrf1 |
A |
G |
9: 89,793,675 (GRCm39) |
T151A |
unknown |
Het |
Rnf215 |
T |
C |
11: 4,085,544 (GRCm39) |
L91P |
possibly damaging |
Het |
Rph3a |
T |
C |
5: 121,099,312 (GRCm39) |
H193R |
probably benign |
Het |
Rps17 |
C |
T |
7: 80,994,750 (GRCm39) |
V4I |
probably benign |
Het |
Sec61a2 |
A |
T |
2: 5,881,728 (GRCm39) |
F234Y |
possibly damaging |
Het |
Serpinb8 |
T |
C |
1: 107,526,736 (GRCm39) |
L92P |
probably damaging |
Het |
Slc26a11 |
T |
C |
11: 119,270,692 (GRCm39) |
V538A |
possibly damaging |
Het |
Slc27a1 |
G |
A |
8: 72,032,566 (GRCm39) |
S193N |
probably benign |
Het |
Slc9b1 |
T |
C |
3: 135,097,948 (GRCm39) |
S393P |
probably damaging |
Het |
Slfn3 |
T |
A |
11: 83,105,332 (GRCm39) |
I320K |
possibly damaging |
Het |
Spata31f1a |
T |
A |
4: 42,848,542 (GRCm39) |
M1205L |
probably benign |
Het |
Tgfbr1 |
A |
T |
4: 47,406,924 (GRCm39) |
I420F |
probably benign |
Het |
Tnik |
A |
T |
3: 28,658,482 (GRCm39) |
D589V |
possibly damaging |
Het |
Trappc8 |
A |
C |
18: 21,006,938 (GRCm39) |
|
probably null |
Het |
Ttbk1 |
A |
G |
17: 46,791,087 (GRCm39) |
S66P |
possibly damaging |
Het |
Unc13c |
A |
G |
9: 73,392,220 (GRCm39) |
V2044A |
probably benign |
Het |
Usp53 |
T |
C |
3: 122,741,045 (GRCm39) |
E735G |
probably benign |
Het |
Vmn2r-ps158 |
T |
A |
7: 42,673,462 (GRCm39) |
N180K |
probably benign |
Het |
Zfyve26 |
A |
T |
12: 79,302,037 (GRCm39) |
V1853D |
probably damaging |
Het |
Zkscan17 |
A |
G |
11: 59,394,574 (GRCm39) |
V9A |
probably damaging |
Het |
|
Other mutations in Slc1a6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00335:Slc1a6
|
APN |
10 |
78,637,647 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00496:Slc1a6
|
APN |
10 |
78,629,142 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01099:Slc1a6
|
APN |
10 |
78,624,831 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL02299:Slc1a6
|
APN |
10 |
78,629,137 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02677:Slc1a6
|
APN |
10 |
78,624,898 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02705:Slc1a6
|
APN |
10 |
78,637,788 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03024:Slc1a6
|
APN |
10 |
78,650,442 (GRCm39) |
missense |
probably benign |
|
IGL03185:Slc1a6
|
APN |
10 |
78,637,741 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03046:Slc1a6
|
UTSW |
10 |
78,636,008 (GRCm39) |
missense |
probably benign |
0.19 |
R0183:Slc1a6
|
UTSW |
10 |
78,627,067 (GRCm39) |
missense |
probably damaging |
1.00 |
R0373:Slc1a6
|
UTSW |
10 |
78,637,756 (GRCm39) |
nonsense |
probably null |
|
R0730:Slc1a6
|
UTSW |
10 |
78,631,842 (GRCm39) |
missense |
probably benign |
0.13 |
R0774:Slc1a6
|
UTSW |
10 |
78,648,658 (GRCm39) |
missense |
probably benign |
0.03 |
R0838:Slc1a6
|
UTSW |
10 |
78,632,056 (GRCm39) |
missense |
probably damaging |
1.00 |
R1449:Slc1a6
|
UTSW |
10 |
78,635,951 (GRCm39) |
missense |
probably damaging |
0.99 |
R1822:Slc1a6
|
UTSW |
10 |
78,648,765 (GRCm39) |
nonsense |
probably null |
|
R1853:Slc1a6
|
UTSW |
10 |
78,648,758 (GRCm39) |
missense |
probably damaging |
0.97 |
R1854:Slc1a6
|
UTSW |
10 |
78,648,758 (GRCm39) |
missense |
probably damaging |
0.97 |
R1855:Slc1a6
|
UTSW |
10 |
78,648,758 (GRCm39) |
missense |
probably damaging |
0.97 |
R1866:Slc1a6
|
UTSW |
10 |
78,627,183 (GRCm39) |
missense |
probably damaging |
0.99 |
R2073:Slc1a6
|
UTSW |
10 |
78,635,964 (GRCm39) |
missense |
possibly damaging |
0.93 |
R2279:Slc1a6
|
UTSW |
10 |
78,624,882 (GRCm39) |
missense |
probably benign |
0.12 |
R2360:Slc1a6
|
UTSW |
10 |
78,648,718 (GRCm39) |
missense |
possibly damaging |
0.91 |
R2939:Slc1a6
|
UTSW |
10 |
78,650,448 (GRCm39) |
makesense |
probably null |
|
R3111:Slc1a6
|
UTSW |
10 |
78,624,915 (GRCm39) |
missense |
probably damaging |
0.99 |
R3926:Slc1a6
|
UTSW |
10 |
78,648,715 (GRCm39) |
missense |
possibly damaging |
0.91 |
R4116:Slc1a6
|
UTSW |
10 |
78,623,723 (GRCm39) |
missense |
probably benign |
0.00 |
R4798:Slc1a6
|
UTSW |
10 |
78,635,952 (GRCm39) |
missense |
probably damaging |
1.00 |
R4916:Slc1a6
|
UTSW |
10 |
78,632,085 (GRCm39) |
missense |
probably damaging |
1.00 |
R5054:Slc1a6
|
UTSW |
10 |
78,650,436 (GRCm39) |
missense |
probably damaging |
1.00 |
R5166:Slc1a6
|
UTSW |
10 |
78,632,103 (GRCm39) |
critical splice donor site |
probably null |
|
R5304:Slc1a6
|
UTSW |
10 |
78,629,141 (GRCm39) |
missense |
probably damaging |
1.00 |
R5367:Slc1a6
|
UTSW |
10 |
78,623,637 (GRCm39) |
missense |
probably damaging |
1.00 |
R5554:Slc1a6
|
UTSW |
10 |
78,631,816 (GRCm39) |
missense |
probably benign |
0.00 |
R5635:Slc1a6
|
UTSW |
10 |
78,624,925 (GRCm39) |
missense |
possibly damaging |
0.67 |
R5773:Slc1a6
|
UTSW |
10 |
78,629,111 (GRCm39) |
splice site |
probably null |
|
R6117:Slc1a6
|
UTSW |
10 |
78,624,822 (GRCm39) |
missense |
possibly damaging |
0.72 |
R6167:Slc1a6
|
UTSW |
10 |
78,637,671 (GRCm39) |
missense |
probably benign |
0.40 |
R6174:Slc1a6
|
UTSW |
10 |
78,637,741 (GRCm39) |
missense |
probably damaging |
1.00 |
R6221:Slc1a6
|
UTSW |
10 |
78,635,910 (GRCm39) |
missense |
probably damaging |
0.98 |
R6323:Slc1a6
|
UTSW |
10 |
78,648,721 (GRCm39) |
missense |
probably damaging |
1.00 |
R6339:Slc1a6
|
UTSW |
10 |
78,635,919 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6670:Slc1a6
|
UTSW |
10 |
78,623,646 (GRCm39) |
missense |
probably benign |
0.00 |
R7166:Slc1a6
|
UTSW |
10 |
78,648,646 (GRCm39) |
missense |
possibly damaging |
0.96 |
R7292:Slc1a6
|
UTSW |
10 |
78,650,438 (GRCm39) |
missense |
possibly damaging |
0.84 |
R7548:Slc1a6
|
UTSW |
10 |
78,650,265 (GRCm39) |
missense |
probably damaging |
1.00 |
R7779:Slc1a6
|
UTSW |
10 |
78,631,789 (GRCm39) |
missense |
probably damaging |
0.96 |
R7843:Slc1a6
|
UTSW |
10 |
78,632,094 (GRCm39) |
missense |
probably damaging |
1.00 |
R8068:Slc1a6
|
UTSW |
10 |
78,648,706 (GRCm39) |
missense |
possibly damaging |
0.96 |
R8190:Slc1a6
|
UTSW |
10 |
78,627,067 (GRCm39) |
missense |
probably damaging |
1.00 |
R8846:Slc1a6
|
UTSW |
10 |
78,637,781 (GRCm39) |
missense |
probably damaging |
1.00 |
R9216:Slc1a6
|
UTSW |
10 |
78,637,692 (GRCm39) |
missense |
probably damaging |
1.00 |
R9660:Slc1a6
|
UTSW |
10 |
78,648,698 (GRCm39) |
missense |
probably benign |
0.06 |
R9798:Slc1a6
|
UTSW |
10 |
78,629,167 (GRCm39) |
critical splice donor site |
probably null |
|
Z1176:Slc1a6
|
UTSW |
10 |
78,631,909 (GRCm39) |
missense |
possibly damaging |
0.65 |
Z1177:Slc1a6
|
UTSW |
10 |
78,648,728 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Slc1a6
|
UTSW |
10 |
78,627,101 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
Predicted Primers |
PCR Primer
(F):5'- TTTGAGGAGACTGTGCCTGTAC -3'
(R):5'- TCTCTGAGACAATGCACAAATGAG -3'
Sequencing Primer
(F):5'- TGTGCCTGTACCTGGCTCAG -3'
(R):5'- GGTCATGAACAGATGAATAAATCACC -3'
|
Posted On |
2020-07-13 |