Incidental Mutation 'R8211:Or8b54'
| ID |
636171 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or8b54
|
| Ensembl Gene |
ENSMUSG00000049926 |
| Gene Name |
olfactory receptor family 8 subfamily B member 54 |
| Synonyms |
MOR165-8, GA_x6K02T2PVTD-32478047-32478988, Olfr921 |
| MMRRC Submission |
067634-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
R8211 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
38684384-38687650 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 38686577 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 9
(V9M)
|
| Gene Model |
predicted gene model for transcript(s):
|
| AlphaFold |
Q7TRC0 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000062124
AA Change: V9M
|
| SMART Domains |
Protein: ENSMUSP00000051879
Gene: ENSMUSG00000049926
AA Change: V9M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
308 |
1.8e-48 |
PFAM |
|
Pfam:7tm_1
|
41 |
290 |
6.3e-23 |
PFAM |
|
| Meta Mutation Damage Score |
0.0852 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.4%
|
| Validation Efficiency |
100% (43/43) |
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 45 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A330017A19Rik |
A |
G |
17: 47,201,309 (GRCm39) |
|
probably benign |
Het |
| Adamtsl3 |
T |
C |
7: 82,172,371 (GRCm39) |
S445P |
probably damaging |
Het |
| Afp |
T |
C |
5: 90,649,345 (GRCm39) |
I304T |
possibly damaging |
Het |
| Alk |
G |
A |
17: 72,176,702 (GRCm39) |
A1534V |
probably benign |
Het |
| Ank3 |
C |
T |
10: 69,703,228 (GRCm39) |
P287L |
unknown |
Het |
| Appl1 |
T |
C |
14: 26,667,555 (GRCm39) |
I367V |
probably benign |
Het |
| Arpin |
T |
A |
7: 79,584,992 (GRCm39) |
M1L |
probably damaging |
Het |
| Aven |
C |
T |
2: 112,390,120 (GRCm39) |
R8W |
probably benign |
Het |
| B430203G13Rik |
A |
T |
12: 17,974,540 (GRCm39) |
H82L |
noncoding transcript |
Het |
| Bcl11a |
T |
A |
11: 24,028,394 (GRCm39) |
S2T |
probably damaging |
Het |
| Cfap299 |
A |
G |
5: 98,477,294 (GRCm39) |
I28V |
possibly damaging |
Het |
| Cfap46 |
T |
A |
7: 139,213,220 (GRCm39) |
M1605L |
unknown |
Het |
| Chga |
C |
A |
12: 102,527,678 (GRCm39) |
Q111K |
possibly damaging |
Het |
| Drc7 |
A |
G |
8: 95,782,707 (GRCm39) |
E24G |
unknown |
Het |
| Dst |
T |
C |
1: 34,251,532 (GRCm39) |
L2195P |
probably damaging |
Het |
| Enpp5 |
G |
A |
17: 44,392,402 (GRCm39) |
|
probably null |
Het |
| Fat2 |
A |
G |
11: 55,203,035 (GRCm39) |
L13P |
possibly damaging |
Het |
| Grhl1 |
T |
C |
12: 24,636,151 (GRCm39) |
|
probably null |
Het |
| Ikbke |
A |
G |
1: 131,199,515 (GRCm39) |
I326T |
probably damaging |
Het |
| Krt26 |
C |
T |
11: 99,226,110 (GRCm39) |
D195N |
probably damaging |
Het |
| Lamc2 |
A |
T |
1: 153,042,024 (GRCm39) |
C37S |
probably damaging |
Het |
| Lrriq1 |
A |
G |
10: 103,006,408 (GRCm39) |
L1239P |
probably damaging |
Het |
| Mrps5 |
T |
A |
2: 127,445,644 (GRCm39) |
H390Q |
probably benign |
Het |
| Nphp3 |
T |
A |
9: 103,909,096 (GRCm39) |
C769S |
possibly damaging |
Het |
| Obscn |
A |
G |
11: 59,006,620 (GRCm39) |
S1181P |
probably damaging |
Het |
| Pabpc6 |
G |
T |
17: 9,888,386 (GRCm39) |
A55E |
probably damaging |
Het |
| Pcdha9 |
A |
T |
18: 37,131,912 (GRCm39) |
E327V |
possibly damaging |
Het |
| Pds5b |
A |
G |
5: 150,652,407 (GRCm39) |
T225A |
possibly damaging |
Het |
| Pi4ka |
A |
C |
16: 17,100,769 (GRCm39) |
I1807S |
|
Het |
| Pick1 |
T |
A |
15: 79,132,930 (GRCm39) |
I330N |
probably damaging |
Het |
| Rbm46 |
C |
T |
3: 82,772,775 (GRCm39) |
R119Q |
probably benign |
Het |
| Rubcn |
A |
C |
16: 32,656,913 (GRCm39) |
C502W |
possibly damaging |
Het |
| Slc26a10 |
G |
A |
10: 127,009,834 (GRCm39) |
R571C |
probably benign |
Het |
| Slc44a2 |
A |
T |
9: 21,259,434 (GRCm39) |
N587Y |
probably damaging |
Het |
| Slfn2 |
T |
G |
11: 82,960,585 (GRCm39) |
V188G |
possibly damaging |
Het |
| Smok2b |
T |
C |
17: 13,454,680 (GRCm39) |
V280A |
probably benign |
Het |
| Snx19 |
A |
G |
9: 30,348,761 (GRCm39) |
E798G |
probably benign |
Het |
| Sspo |
T |
C |
6: 48,469,543 (GRCm39) |
|
probably null |
Het |
| Ugt2b37 |
T |
C |
5: 87,390,235 (GRCm39) |
I404V |
probably benign |
Het |
| Vmn1r160 |
T |
C |
7: 22,570,751 (GRCm39) |
F35L |
possibly damaging |
Het |
| Vmn1r193 |
A |
T |
13: 22,403,286 (GRCm39) |
Y235* |
probably null |
Het |
| Vmn2r53 |
T |
C |
7: 12,315,843 (GRCm39) |
I659V |
probably benign |
Het |
| Vmn2r91 |
A |
G |
17: 18,326,762 (GRCm39) |
D349G |
probably damaging |
Het |
| Zfp292 |
A |
T |
4: 34,806,163 (GRCm39) |
S2299T |
probably benign |
Het |
| Zfp938 |
T |
C |
10: 82,062,419 (GRCm39) |
N67S |
possibly damaging |
Het |
|
| Other mutations in Or8b54 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00948:Or8b54
|
APN |
9 |
38,687,108 (GRCm39) |
nonsense |
probably null |
|
|
IGL01016:Or8b54
|
APN |
9 |
38,686,737 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01391:Or8b54
|
APN |
9 |
38,686,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01451:Or8b54
|
APN |
9 |
38,687,225 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02250:Or8b54
|
APN |
9 |
38,686,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0026:Or8b54
|
UTSW |
9 |
38,686,892 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0334:Or8b54
|
UTSW |
9 |
38,686,535 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0655:Or8b54
|
UTSW |
9 |
38,686,850 (GRCm39) |
nonsense |
probably null |
|
|
R1024:Or8b54
|
UTSW |
9 |
38,686,631 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3522:Or8b54
|
UTSW |
9 |
38,687,016 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R3967:Or8b54
|
UTSW |
9 |
38,686,664 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3968:Or8b54
|
UTSW |
9 |
38,686,664 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3969:Or8b54
|
UTSW |
9 |
38,686,664 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4761:Or8b54
|
UTSW |
9 |
38,687,133 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4796:Or8b54
|
UTSW |
9 |
38,686,670 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4880:Or8b54
|
UTSW |
9 |
38,686,843 (GRCm39) |
nonsense |
probably null |
|
|
R5237:Or8b54
|
UTSW |
9 |
38,687,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5756:Or8b54
|
UTSW |
9 |
38,686,554 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R6230:Or8b54
|
UTSW |
9 |
38,687,073 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6487:Or8b54
|
UTSW |
9 |
38,686,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7514:Or8b54
|
UTSW |
9 |
38,686,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7573:Or8b54
|
UTSW |
9 |
38,686,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7755:Or8b54
|
UTSW |
9 |
38,687,073 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8195:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8196:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8197:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8199:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8212:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8236:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8239:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8279:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8282:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R8283:Or8b54
|
UTSW |
9 |
38,686,577 (GRCm39) |
missense |
noncoding transcript |
|
|
R9207:Or8b54
|
UTSW |
9 |
38,686,960 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAAGCTATTCGGAAATTTCATCC -3'
(R):5'- CATAGGCCATTGACACCAGTAC -3'
Sequencing Primer
(F):5'- GCTATTCGGAAATTTCATCCTGAGC -3'
(R):5'- AAGTAGAGTTGGGACATACATCC -3'
|
| Posted On |
2020-07-13 |
Incidental Mutation