Incidental Mutation 'R8213:Vmn2r108'
ID |
636288 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r108
|
Ensembl Gene |
ENSMUSG00000091805 |
Gene Name |
vomeronasal 2, receptor 108 |
Synonyms |
EG627805 |
MMRRC Submission |
067655-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.073)
|
Stock # |
R8213 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
20682635-20701498 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 20690350 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Phenylalanine
at position 494
(S494F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000130373
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167314]
|
AlphaFold |
E9PYS0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000167314
AA Change: S494F
PolyPhen 2
Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
|
SMART Domains |
Protein: ENSMUSP00000130373 Gene: ENSMUSG00000091805 AA Change: S494F
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
83 |
467 |
6e-33 |
PFAM |
Pfam:NCD3G
|
510 |
563 |
9.2e-22 |
PFAM |
Pfam:7tm_3
|
593 |
831 |
2.2e-51 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.4%
- 20x: 98.1%
|
Validation Efficiency |
98% (65/66) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 64 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A1bg |
T |
C |
15: 60,791,605 (GRCm39) |
Y277C |
probably damaging |
Het |
Acss1 |
T |
A |
2: 150,461,630 (GRCm39) |
D651V |
possibly damaging |
Het |
Aktip |
G |
T |
8: 91,851,494 (GRCm39) |
P243H |
possibly damaging |
Het |
Arl11 |
T |
G |
14: 61,548,714 (GRCm39) |
S175A |
probably benign |
Het |
Aup1 |
A |
G |
6: 83,031,588 (GRCm39) |
|
probably benign |
Het |
Avil |
A |
T |
10: 126,844,190 (GRCm39) |
I250F |
probably damaging |
Het |
Btnl6 |
A |
T |
17: 34,727,857 (GRCm39) |
|
probably null |
Het |
Ccdc7b |
C |
A |
8: 129,904,772 (GRCm39) |
Q137K |
probably benign |
Het |
Cdk11b |
G |
A |
4: 155,724,338 (GRCm39) |
E319K |
unknown |
Het |
Chka |
A |
C |
19: 3,935,882 (GRCm39) |
E196A |
probably damaging |
Het |
Depdc5 |
C |
T |
5: 33,094,981 (GRCm39) |
R753C |
probably damaging |
Het |
Dhx57 |
T |
A |
17: 80,582,585 (GRCm39) |
D340V |
possibly damaging |
Het |
Dicer1 |
A |
T |
12: 104,668,952 (GRCm39) |
D1243E |
probably benign |
Het |
Dnajb9 |
A |
T |
12: 44,253,916 (GRCm39) |
L164M |
probably benign |
Het |
Dock6 |
A |
G |
9: 21,742,740 (GRCm39) |
V785A |
possibly damaging |
Het |
Efcab5 |
T |
C |
11: 77,006,897 (GRCm39) |
Y909C |
probably damaging |
Het |
Erp44 |
A |
T |
4: 48,208,783 (GRCm39) |
S226T |
probably benign |
Het |
Fgd6 |
A |
T |
10: 93,879,914 (GRCm39) |
D256V |
probably benign |
Het |
Fhl5 |
A |
T |
4: 25,207,113 (GRCm39) |
Y218* |
probably null |
Het |
Filip1 |
C |
A |
9: 79,725,374 (GRCm39) |
A1082S |
probably benign |
Het |
Heatr5a |
G |
A |
12: 51,938,226 (GRCm39) |
T1484M |
probably damaging |
Het |
Herc1 |
G |
T |
9: 66,358,170 (GRCm39) |
R2417L |
probably damaging |
Het |
Hnrnpr |
A |
G |
4: 136,044,486 (GRCm39) |
|
probably benign |
Het |
Igsf5 |
A |
T |
16: 96,174,188 (GRCm39) |
I73F |
probably damaging |
Het |
Il17ra |
T |
C |
6: 120,449,995 (GRCm39) |
V91A |
probably benign |
Het |
Inpp5f |
A |
G |
7: 128,281,529 (GRCm39) |
D510G |
probably damaging |
Het |
Kbtbd3 |
A |
G |
9: 4,331,269 (GRCm39) |
K548E |
probably damaging |
Het |
Kdm5d |
T |
A |
Y: 941,515 (GRCm39) |
C1239S |
probably damaging |
Het |
Mamdc4 |
G |
A |
2: 25,456,368 (GRCm39) |
T709M |
probably benign |
Het |
Mybbp1a |
T |
A |
11: 72,335,547 (GRCm39) |
Y353N |
probably damaging |
Het |
Nepn |
A |
T |
10: 52,267,855 (GRCm39) |
E40D |
probably benign |
Het |
Nhsl3 |
A |
T |
4: 129,115,252 (GRCm39) |
V1070D |
possibly damaging |
Het |
Npat |
G |
T |
9: 53,481,870 (GRCm39) |
E1193* |
probably null |
Het |
Nrde2 |
G |
A |
12: 100,097,262 (GRCm39) |
S846L |
probably benign |
Het |
Nup205 |
T |
C |
6: 35,202,138 (GRCm39) |
V1290A |
probably benign |
Het |
Or10a49 |
C |
A |
7: 108,467,726 (GRCm39) |
V212L |
probably benign |
Het |
Or4d10b |
A |
G |
19: 12,036,456 (GRCm39) |
V220A |
probably benign |
Het |
Or5g9 |
T |
A |
2: 85,551,845 (GRCm39) |
L32Q |
probably null |
Het |
Pde6a |
A |
T |
18: 61,353,768 (GRCm39) |
K31M |
possibly damaging |
Het |
Pms2 |
C |
T |
5: 143,851,589 (GRCm39) |
R169C |
probably damaging |
Het |
Polr2g |
A |
T |
19: 8,775,621 (GRCm39) |
L30Q |
probably damaging |
Het |
Pramel22 |
T |
A |
4: 143,380,755 (GRCm39) |
M423L |
probably benign |
Het |
Pramel30 |
A |
T |
4: 144,057,030 (GRCm39) |
D71V |
probably benign |
Het |
Prdm15 |
T |
A |
16: 97,608,260 (GRCm39) |
H679L |
probably damaging |
Het |
Prl4a1 |
T |
G |
13: 28,207,369 (GRCm39) |
Y214* |
probably null |
Het |
Prlr |
C |
T |
15: 10,329,328 (GRCm39) |
T601M |
possibly damaging |
Het |
Psen2 |
A |
C |
1: 180,073,256 (GRCm39) |
S22A |
probably benign |
Het |
Ralgapa1 |
C |
A |
12: 55,769,699 (GRCm39) |
R764L |
probably damaging |
Het |
Scgb2b11 |
T |
C |
7: 31,908,833 (GRCm39) |
E89G |
probably damaging |
Het |
Serpina10 |
T |
C |
12: 103,594,536 (GRCm39) |
I228V |
probably benign |
Het |
Serpinb1a |
T |
A |
13: 33,026,982 (GRCm39) |
H320L |
probably damaging |
Het |
Sesn2 |
C |
A |
4: 132,225,364 (GRCm39) |
Q267H |
possibly damaging |
Het |
Sgsm1 |
A |
T |
5: 113,398,877 (GRCm39) |
W1019R |
probably damaging |
Het |
Sqle |
A |
G |
15: 59,193,151 (GRCm39) |
|
probably null |
Het |
Syt14 |
T |
C |
1: 192,669,137 (GRCm39) |
M39V |
probably benign |
Het |
Tgm7 |
A |
G |
2: 120,931,545 (GRCm39) |
V206A |
probably damaging |
Het |
Thbs4 |
T |
C |
13: 92,897,094 (GRCm39) |
|
probably null |
Het |
Trpv1 |
T |
C |
11: 73,145,077 (GRCm39) |
F721S |
probably damaging |
Het |
Ttll10 |
A |
T |
4: 156,120,691 (GRCm39) |
M433K |
probably benign |
Het |
Vmn1r216 |
T |
C |
13: 23,283,695 (GRCm39) |
I126T |
probably benign |
Het |
Vwa3b |
C |
T |
1: 37,168,020 (GRCm39) |
A603V |
probably benign |
Het |
Xirp2 |
T |
A |
2: 67,307,210 (GRCm39) |
N19K |
probably damaging |
Het |
Zfp397 |
T |
A |
18: 24,093,779 (GRCm39) |
N421K |
probably damaging |
Het |
Zscan5b |
C |
T |
7: 6,236,946 (GRCm39) |
P232S |
possibly damaging |
Het |
|
Other mutations in Vmn2r108 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00903:Vmn2r108
|
APN |
17 |
20,682,774 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01143:Vmn2r108
|
APN |
17 |
20,682,727 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL01311:Vmn2r108
|
APN |
17 |
20,682,939 (GRCm39) |
nonsense |
probably null |
|
IGL01411:Vmn2r108
|
APN |
17 |
20,691,282 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01414:Vmn2r108
|
APN |
17 |
20,691,942 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01536:Vmn2r108
|
APN |
17 |
20,683,543 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01748:Vmn2r108
|
APN |
17 |
20,683,476 (GRCm39) |
missense |
probably benign |
0.03 |
IGL01769:Vmn2r108
|
APN |
17 |
20,691,280 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02022:Vmn2r108
|
APN |
17 |
20,691,987 (GRCm39) |
missense |
possibly damaging |
0.77 |
IGL02041:Vmn2r108
|
APN |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02049:Vmn2r108
|
APN |
17 |
20,691,608 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02344:Vmn2r108
|
APN |
17 |
20,689,405 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02939:Vmn2r108
|
APN |
17 |
20,691,545 (GRCm39) |
missense |
probably benign |
0.05 |
IGL03202:Vmn2r108
|
APN |
17 |
20,691,319 (GRCm39) |
nonsense |
probably null |
|
PIT4498001:Vmn2r108
|
UTSW |
17 |
20,683,279 (GRCm39) |
missense |
probably damaging |
1.00 |
R0112:Vmn2r108
|
UTSW |
17 |
20,691,897 (GRCm39) |
missense |
probably benign |
0.07 |
R0505:Vmn2r108
|
UTSW |
17 |
20,683,096 (GRCm39) |
missense |
possibly damaging |
0.77 |
R0833:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
R0836:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
R0943:Vmn2r108
|
UTSW |
17 |
20,691,397 (GRCm39) |
nonsense |
probably null |
|
R1411:Vmn2r108
|
UTSW |
17 |
20,683,107 (GRCm39) |
missense |
probably damaging |
0.98 |
R1442:Vmn2r108
|
UTSW |
17 |
20,692,623 (GRCm39) |
nonsense |
probably null |
|
R1587:Vmn2r108
|
UTSW |
17 |
20,692,383 (GRCm39) |
missense |
probably damaging |
1.00 |
R1751:Vmn2r108
|
UTSW |
17 |
20,682,786 (GRCm39) |
missense |
probably damaging |
1.00 |
R1773:Vmn2r108
|
UTSW |
17 |
20,689,335 (GRCm39) |
missense |
probably damaging |
1.00 |
R2021:Vmn2r108
|
UTSW |
17 |
20,691,252 (GRCm39) |
missense |
probably benign |
0.00 |
R2159:Vmn2r108
|
UTSW |
17 |
20,689,363 (GRCm39) |
missense |
probably benign |
0.41 |
R2224:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
R2226:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
R2517:Vmn2r108
|
UTSW |
17 |
20,692,577 (GRCm39) |
missense |
probably damaging |
1.00 |
R3710:Vmn2r108
|
UTSW |
17 |
20,682,932 (GRCm39) |
missense |
probably benign |
|
R4470:Vmn2r108
|
UTSW |
17 |
20,682,990 (GRCm39) |
missense |
probably damaging |
1.00 |
R4686:Vmn2r108
|
UTSW |
17 |
20,691,636 (GRCm39) |
missense |
probably damaging |
0.99 |
R4729:Vmn2r108
|
UTSW |
17 |
20,692,632 (GRCm39) |
missense |
probably damaging |
0.99 |
R4799:Vmn2r108
|
UTSW |
17 |
20,682,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R4993:Vmn2r108
|
UTSW |
17 |
20,701,449 (GRCm39) |
missense |
probably benign |
0.04 |
R5088:Vmn2r108
|
UTSW |
17 |
20,690,454 (GRCm39) |
missense |
possibly damaging |
0.46 |
R5213:Vmn2r108
|
UTSW |
17 |
20,691,755 (GRCm39) |
missense |
probably benign |
0.00 |
R5289:Vmn2r108
|
UTSW |
17 |
20,691,866 (GRCm39) |
missense |
probably damaging |
1.00 |
R5290:Vmn2r108
|
UTSW |
17 |
20,691,665 (GRCm39) |
missense |
probably benign |
0.00 |
R5713:Vmn2r108
|
UTSW |
17 |
20,691,290 (GRCm39) |
missense |
probably damaging |
1.00 |
R5753:Vmn2r108
|
UTSW |
17 |
20,683,179 (GRCm39) |
missense |
probably damaging |
0.99 |
R5792:Vmn2r108
|
UTSW |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
0.99 |
R5798:Vmn2r108
|
UTSW |
17 |
20,692,545 (GRCm39) |
missense |
probably benign |
0.39 |
R5897:Vmn2r108
|
UTSW |
17 |
20,691,580 (GRCm39) |
missense |
probably benign |
0.01 |
R6018:Vmn2r108
|
UTSW |
17 |
20,683,268 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6093:Vmn2r108
|
UTSW |
17 |
20,701,402 (GRCm39) |
missense |
probably benign |
0.00 |
R6156:Vmn2r108
|
UTSW |
17 |
20,692,447 (GRCm39) |
missense |
probably benign |
0.03 |
R6199:Vmn2r108
|
UTSW |
17 |
20,682,644 (GRCm39) |
missense |
probably benign |
0.01 |
R6259:Vmn2r108
|
UTSW |
17 |
20,683,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6309:Vmn2r108
|
UTSW |
17 |
20,691,660 (GRCm39) |
missense |
probably damaging |
0.98 |
R6324:Vmn2r108
|
UTSW |
17 |
20,691,977 (GRCm39) |
nonsense |
probably null |
|
R6364:Vmn2r108
|
UTSW |
17 |
20,691,260 (GRCm39) |
missense |
probably benign |
0.00 |
R6446:Vmn2r108
|
UTSW |
17 |
20,692,609 (GRCm39) |
nonsense |
probably null |
|
R6541:Vmn2r108
|
UTSW |
17 |
20,701,480 (GRCm39) |
missense |
probably benign |
0.02 |
R7025:Vmn2r108
|
UTSW |
17 |
20,691,345 (GRCm39) |
missense |
possibly damaging |
0.67 |
R7063:Vmn2r108
|
UTSW |
17 |
20,701,410 (GRCm39) |
missense |
probably damaging |
1.00 |
R7092:Vmn2r108
|
UTSW |
17 |
20,701,338 (GRCm39) |
missense |
probably benign |
0.10 |
R7096:Vmn2r108
|
UTSW |
17 |
20,682,762 (GRCm39) |
missense |
probably damaging |
1.00 |
R7203:Vmn2r108
|
UTSW |
17 |
20,683,038 (GRCm39) |
missense |
probably benign |
0.12 |
R7458:Vmn2r108
|
UTSW |
17 |
20,692,532 (GRCm39) |
missense |
probably benign |
0.17 |
R7619:Vmn2r108
|
UTSW |
17 |
20,692,457 (GRCm39) |
missense |
probably benign |
0.02 |
R7841:Vmn2r108
|
UTSW |
17 |
20,690,305 (GRCm39) |
critical splice donor site |
probably null |
|
R7944:Vmn2r108
|
UTSW |
17 |
20,691,890 (GRCm39) |
missense |
probably damaging |
0.99 |
R8048:Vmn2r108
|
UTSW |
17 |
20,691,762 (GRCm39) |
missense |
probably benign |
0.29 |
R8218:Vmn2r108
|
UTSW |
17 |
20,683,465 (GRCm39) |
missense |
probably damaging |
1.00 |
R8507:Vmn2r108
|
UTSW |
17 |
20,683,195 (GRCm39) |
nonsense |
probably null |
|
R8708:Vmn2r108
|
UTSW |
17 |
20,682,687 (GRCm39) |
missense |
probably damaging |
0.98 |
R8845:Vmn2r108
|
UTSW |
17 |
20,691,361 (GRCm39) |
missense |
probably benign |
0.03 |
R9030:Vmn2r108
|
UTSW |
17 |
20,690,312 (GRCm39) |
missense |
probably benign |
0.01 |
R9226:Vmn2r108
|
UTSW |
17 |
20,691,330 (GRCm39) |
missense |
probably benign |
|
R9278:Vmn2r108
|
UTSW |
17 |
20,692,561 (GRCm39) |
missense |
probably benign |
0.11 |
X0022:Vmn2r108
|
UTSW |
17 |
20,691,371 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Vmn2r108
|
UTSW |
17 |
20,691,375 (GRCm39) |
missense |
probably benign |
0.01 |
Z1177:Vmn2r108
|
UTSW |
17 |
20,691,219 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
PCR Primer
(F):5'- CAGTACCCTATTACTACCATTGTGG -3'
(R):5'- CAATTCTGTCTCTTGGGCCTGG -3'
Sequencing Primer
(F):5'- CAGAGTGATGGGCCTTAAAT -3'
(R):5'- GCCTGGTGTGAAATTCATGAATCTC -3'
|
Posted On |
2020-07-13 |