Incidental Mutation 'IGL00586:Prss1l'
ID 6363
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss1l
Ensembl Gene ENSMUSG00000058119
Gene Name serine protease 1 (trypsin 1) like
Synonyms Gm5771
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # IGL00586
Quality Score
Status
Chromosome 6
Chromosomal Location 41369290-41374164 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41373049 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 107 (I107T)
Ref Sequence ENSEMBL: ENSMUSP00000039684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049079]
AlphaFold Q792Y9
Predicted Effect probably damaging
Transcript: ENSMUST00000049079
AA Change: I107T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000039684
Gene: ENSMUSG00000058119
AA Change: I107T

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
Tryp_SPc 22 238 9.72e-105 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl5b T C 2: 15,074,746 (GRCm39) S76P probably benign Het
Asap3 A C 4: 135,933,879 (GRCm39) D17A probably damaging Het
Ccdc24 C T 4: 117,729,243 (GRCm39) R78H probably damaging Het
Crp T C 1: 172,526,568 (GRCm39) F218L probably benign Het
Dab2 T C 15: 6,459,306 (GRCm39) L385P probably benign Het
Dip2c C A 13: 9,660,791 (GRCm39) T855N probably damaging Het
Dnai7 A T 6: 145,137,302 (GRCm39) F269I possibly damaging Het
Dync2i1 A T 12: 116,205,400 (GRCm39) D396E probably benign Het
Ep400 A G 5: 110,887,460 (GRCm39) V541A probably damaging Het
Gbgt1 A T 2: 28,392,207 (GRCm39) probably null Het
Gm6871 A T 7: 41,195,845 (GRCm39) D297E possibly damaging Het
Gpr107 T A 2: 31,062,006 (GRCm39) F145I probably benign Het
Itgb6 T G 2: 60,450,696 (GRCm39) D581A probably benign Het
Lce1a1 C T 3: 92,554,470 (GRCm39) M1I probably null Het
Lmbrd2 G A 15: 9,157,382 (GRCm39) V207M probably damaging Het
Muc5b T A 7: 141,395,129 (GRCm39) V45E unknown Het
Mybpc2 A G 7: 44,154,806 (GRCm39) V977A probably damaging Het
Oas1c T C 5: 120,946,744 (GRCm39) T29A probably benign Het
Pdzd2 G T 15: 12,365,853 (GRCm39) probably null Het
Plk2 T C 13: 110,532,912 (GRCm39) Y158H possibly damaging Het
Ptprq A G 10: 107,443,983 (GRCm39) probably benign Het
Rnf17 C T 14: 56,658,539 (GRCm39) T76I probably damaging Het
Serpinb1c T C 13: 33,067,958 (GRCm39) K213E probably damaging Het
Sidt2 A G 9: 45,854,350 (GRCm39) V624A possibly damaging Het
Sin3b T C 8: 73,483,628 (GRCm39) V1005A probably benign Het
Ubr4 T C 4: 139,182,495 (GRCm39) V358A possibly damaging Het
Zfp120 T C 2: 149,961,748 (GRCm39) I67V possibly damaging Het
Zfp942 A T 17: 22,147,605 (GRCm39) H341Q probably damaging Het
Other mutations in Prss1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Prss1l APN 6 41,371,707 (GRCm39) missense probably damaging 1.00
IGL01103:Prss1l APN 6 41,374,091 (GRCm39) missense probably damaging 1.00
IGL01368:Prss1l APN 6 41,373,620 (GRCm39) missense possibly damaging 0.94
IGL01458:Prss1l APN 6 41,373,621 (GRCm39) missense probably benign 0.01
IGL03114:Prss1l APN 6 41,374,012 (GRCm39) missense probably damaging 1.00
R0167:Prss1l UTSW 6 41,373,195 (GRCm39) splice site probably benign
R1548:Prss1l UTSW 6 41,372,945 (GRCm39) missense probably damaging 1.00
R4584:Prss1l UTSW 6 41,373,701 (GRCm39) missense probably benign 0.35
R5622:Prss1l UTSW 6 41,373,084 (GRCm39) missense probably damaging 1.00
R5664:Prss1l UTSW 6 41,371,605 (GRCm39) missense probably benign 0.04
R6222:Prss1l UTSW 6 41,374,100 (GRCm39) missense probably damaging 0.98
R6325:Prss1l UTSW 6 41,373,590 (GRCm39) missense probably benign 0.00
R7816:Prss1l UTSW 6 41,371,707 (GRCm39) missense probably damaging 1.00
R7986:Prss1l UTSW 6 41,373,058 (GRCm39) missense probably damaging 1.00
R8016:Prss1l UTSW 6 41,374,100 (GRCm39) missense probably damaging 0.98
Posted On 2012-04-20