Incidental Mutation 'R8214:Olfr589'
ID 636313
Institutional Source Beutler Lab
Gene Symbol Olfr589
Ensembl Gene ENSMUSG00000051362
Gene Name olfactory receptor 589
Synonyms MOR32-3, GA_x6K02T2PBJ9-5871256-5870303
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # R8214 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 103154792-103156356 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to C at 103155406 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 114 (S114A)
Ref Sequence ENSEMBL: ENSMUSP00000060166 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061055]
AlphaFold Q8VGV8
Predicted Effect probably damaging
Transcript: ENSMUST00000061055
AA Change: S114A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000060166
Gene: ENSMUSG00000051362
AA Change: S114A

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 3.1e-132 PFAM
Pfam:7TM_GPCR_Srsx 37 171 1.5e-7 PFAM
Pfam:7tm_1 43 293 1.1e-12 PFAM
Meta Mutation Damage Score 0.3897 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930438A08Rik G A 11: 58,286,621 R52Q Het
Abcc3 C T 11: 94,363,518 R718H probably damaging Het
Abcc4 T C 14: 118,500,841 M1166V probably benign Het
Abhd16b C T 2: 181,494,190 T295I probably damaging Het
Amph A G 13: 19,104,298 N319S possibly damaging Het
Ankrd27 A G 7: 35,614,519 D425G probably damaging Het
Atg4b T C 1: 93,784,887 S316P probably damaging Het
Brd4 A G 17: 32,212,947 S649P probably benign Het
Bzw1 T C 1: 58,405,037 S411P probably damaging Het
Carmil1 T C 13: 24,044,232 E987G probably damaging Het
Dnah6 T C 6: 73,044,728 D3537G probably damaging Het
Dnpep A T 1: 75,315,998 W126R probably damaging Het
Efcab2 T C 1: 178,437,450 V27A probably benign Het
Kctd21 T C 7: 97,347,341 L7P probably damaging Het
Kidins220 C T 12: 24,994,855 T216I probably damaging Het
Lpl T A 8: 68,892,605 M87K probably damaging Het
Ltn1 A G 16: 87,380,803 V1646A probably benign Het
Madcam1 A G 10: 79,666,758 T359A probably benign Het
Muc5ac A G 7: 141,802,948 K1092E possibly damaging Het
Nrg2 T C 18: 36,196,676 E162G probably benign Het
Olfr1333 A T 4: 118,830,091 F117L probably benign Het
Olfr474 T A 7: 107,954,967 S109T probably benign Het
Pcdhb5 G T 18: 37,321,583 V339L probably benign Het
Plec A G 15: 76,192,284 W145R unknown Het
Polr3f A G 2: 144,536,310 N201D probably benign Het
Skint5 T C 4: 113,804,942 probably null Het
Slc12a2 A G 18: 57,937,719 I1048V probably benign Het
Sult2a4 A G 7: 13,989,476 I39T probably benign Het
Tenm4 T C 7: 96,895,407 V2247A probably damaging Het
Tg C T 15: 66,773,398 R2385C probably damaging Het
Tomm70a G T 16: 57,121,967 A36S unknown Het
Top2b G A 14: 16,383,177 R55H probably damaging Het
Unc45b A G 11: 82,933,888 I629M possibly damaging Het
Vmn1r16 T C 6: 57,323,439 E66G noncoding transcript Het
Vmn1r189 C T 13: 22,102,131 V179I probably benign Het
Vmn2r105 T G 17: 20,228,513 E134A probably benign Het
Wdr70 G A 15: 7,887,370 A522V probably benign Het
Zcchc11 A G 4: 108,512,150 I636V probably benign Het
Zfp184 T A 13: 21,958,825 C234S probably damaging Het
Zscan5b C T 7: 6,233,947 P232S possibly damaging Het
Other mutations in Olfr589
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01955:Olfr589 APN 7 103154854 nonsense probably null
IGL02059:Olfr589 APN 7 103155103 missense probably benign 0.14
IGL02336:Olfr589 APN 7 103155565 missense probably benign 0.09
IGL03355:Olfr589 APN 7 103155201 missense probably damaging 1.00
PIT4508001:Olfr589 UTSW 7 103155313 missense probably benign
R0900:Olfr589 UTSW 7 103155313 missense probably benign
R2250:Olfr589 UTSW 7 103154950 missense probably damaging 1.00
R3500:Olfr589 UTSW 7 103155090 missense probably damaging 1.00
R4756:Olfr589 UTSW 7 103155125 missense probably benign 0.24
R4776:Olfr589 UTSW 7 103155414 missense probably benign 0.40
R5022:Olfr589 UTSW 7 103155735 missense probably benign
R5151:Olfr589 UTSW 7 103155386 missense probably damaging 0.99
R5231:Olfr589 UTSW 7 103154968 missense probably damaging 1.00
R5870:Olfr589 UTSW 7 103155741 missense probably benign 0.00
R5973:Olfr589 UTSW 7 103154874 missense possibly damaging 0.93
R6567:Olfr589 UTSW 7 103154928 missense possibly damaging 0.94
R7095:Olfr589 UTSW 7 103155330 missense probably damaging 1.00
R8915:Olfr589 UTSW 7 103155204 missense probably damaging 1.00
R8921:Olfr589 UTSW 7 103155453 missense probably benign
R9258:Olfr589 UTSW 7 103155202 nonsense probably null
R9679:Olfr589 UTSW 7 103155445 missense probably benign
Predicted Primers PCR Primer
(F):5'- CATGTGCTCACAGTAGGTATGG -3'
(R):5'- TCAAAACTGAGAGCAGCCTC -3'

Sequencing Primer
(F):5'- GGGAATGATGTGATGCCCAC -3'
(R):5'- CCACCAACCCATGTTCTATTTTCTGG -3'
Posted On 2020-07-13