Mutagenetix > Incidental Mutation

Incidental Mutation 'R8214:Vmn2r105'

636333

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r105

Ensembl Gene

ENSMUSG00000091670

Gene Name

vomeronasal 2, receptor 105

Synonyms

EG627743

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8214 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20208230-20234872 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 20228513 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Alanine at position 134 (E134A)

Ref Sequence

ENSEMBL: ENSMUSP00000129762 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167382]

AlphaFold

E9Q3A5

Predicted Effect

probably benign
Transcript: ENSMUST00000167382
AA Change: E134A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: E134A

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	85	469	6.5e-42	PFAM
Pfam:NCD3G	512	565	3.2e-21	PFAM
Pfam:7tm_3	598	833	2.5e-51	PFAM

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (42/42)

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930438A08Rik	G	A	11: 58,286,621	R52Q		Het
Abcc3	C	T	11: 94,363,518	R718H	probably damaging	Het
Abcc4	T	C	14: 118,500,841	M1166V	probably benign	Het
Abhd16b	C	T	2: 181,494,190	T295I	probably damaging	Het
Amph	A	G	13: 19,104,298	N319S	possibly damaging	Het
Ankrd27	A	G	7: 35,614,519	D425G	probably damaging	Het
Atg4b	T	C	1: 93,784,887	S316P	probably damaging	Het
Brd4	A	G	17: 32,212,947	S649P	probably benign	Het
Bzw1	T	C	1: 58,405,037	S411P	probably damaging	Het
Dnah6	T	C	6: 73,044,728	D3537G	probably damaging	Het
Dnpep	A	T	1: 75,315,998	W126R	probably damaging	Het
Efcab2	T	C	1: 178,437,450	V27A	probably benign	Het
Kctd21	T	C	7: 97,347,341	L7P	probably damaging	Het
Kidins220	C	T	12: 24,994,855	T216I	probably damaging	Het
Lpl	T	A	8: 68,892,605	M87K	probably damaging	Het
Lrrc16a	T	C	13: 24,044,232	E987G	probably damaging	Het
Ltn1	A	G	16: 87,380,803	V1646A	probably benign	Het
Madcam1	A	G	10: 79,666,758	T359A	probably benign	Het
Muc5ac	A	G	7: 141,802,948	K1092E	possibly damaging	Het
Nrg2	T	C	18: 36,196,676	E162G	probably benign	Het
Olfr1333	A	T	4: 118,830,091	F117L	probably benign	Het
Olfr474	T	A	7: 107,954,967	S109T	probably benign	Het
Olfr589	A	C	7: 103,155,406	S114A	probably damaging	Het
Pcdhb5	G	T	18: 37,321,583	V339L	probably benign	Het
Plec	A	G	15: 76,192,284	W145R	unknown	Het
Polr3f	A	G	2: 144,536,310	N201D	probably benign	Het
Skint5	T	C	4: 113,804,942		probably null	Het
Slc12a2	A	G	18: 57,937,719	I1048V	probably benign	Het
Sult2a4	A	G	7: 13,989,476	I39T	probably benign	Het
Tenm4	T	C	7: 96,895,407	V2247A	probably damaging	Het
Tg	C	T	15: 66,773,398	R2385C	probably damaging	Het
Tomm70a	G	T	16: 57,121,967	A36S	unknown	Het
Top2b	G	A	14: 16,383,177	R55H	probably damaging	Het
Unc45b	A	G	11: 82,933,888	I629M	possibly damaging	Het
Vmn1r16	T	C	6: 57,323,439	E66G	noncoding transcript	Het
Vmn1r189	C	T	13: 22,102,131	V179I	probably benign	Het
Wdr70	G	A	15: 7,887,370	A522V	probably benign	Het
Zcchc11	A	G	4: 108,512,150	I636V	probably benign	Het
Zfp184	T	A	13: 21,958,825	C234S	probably damaging	Het
Zscan5b	C	T	7: 6,233,947	P232S	possibly damaging	Het

Other mutations in Vmn2r105

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01433:Vmn2r105	APN	17	20228555	missense	probably benign	0.01
IGL01909:Vmn2r105	APN	17	20224656	missense	probably damaging	1.00
IGL01925:Vmn2r105	APN	17	20208711	missense	possibly damaging	0.94
IGL02021:Vmn2r105	APN	17	20227895	missense	possibly damaging	0.49
IGL02828:Vmn2r105	APN	17	20209083	missense	possibly damaging	0.80
IGL02838:Vmn2r105	APN	17	20227585	missense	probably damaging	1.00
IGL03343:Vmn2r105	APN	17	20226369	nonsense	probably null
R0096:Vmn2r105	UTSW	17	20227479	missense	possibly damaging	0.49
R0096:Vmn2r105	UTSW	17	20227479	missense	possibly damaging	0.49
R0212:Vmn2r105	UTSW	17	20208565	missense	possibly damaging	0.90
R0268:Vmn2r105	UTSW	17	20208676	missense	probably benign	0.18
R0271:Vmn2r105	UTSW	17	20234703	missense	probably damaging	0.96
R0613:Vmn2r105	UTSW	17	20208316	missense	probably damaging	1.00
R0765:Vmn2r105	UTSW	17	20227711	missense	probably benign	0.20
R0765:Vmn2r105	UTSW	17	20227857	missense	probably damaging	0.98
R1162:Vmn2r105	UTSW	17	20227711	missense	probably benign	0.20
R1263:Vmn2r105	UTSW	17	20208322	missense	probably damaging	1.00
R1363:Vmn2r105	UTSW	17	20208670	missense	probably benign	0.00
R1464:Vmn2r105	UTSW	17	20228742	splice site	probably benign
R2029:Vmn2r105	UTSW	17	20224578	missense	probably damaging	0.99
R2420:Vmn2r105	UTSW	17	20227835	missense	probably benign	0.15
R2421:Vmn2r105	UTSW	17	20227835	missense	probably benign	0.15
R2422:Vmn2r105	UTSW	17	20227835	missense	probably benign	0.15
R2570:Vmn2r105	UTSW	17	20227323	missense	probably damaging	1.00
R3847:Vmn2r105	UTSW	17	20208690	missense	possibly damaging	0.85
R3848:Vmn2r105	UTSW	17	20208690	missense	possibly damaging	0.85
R4030:Vmn2r105	UTSW	17	20208754	missense	probably damaging	0.99
R4275:Vmn2r105	UTSW	17	20228640	missense	probably damaging	1.00
R4551:Vmn2r105	UTSW	17	20226351	missense	probably benign
R4801:Vmn2r105	UTSW	17	20227294	missense	probably benign	0.00
R4802:Vmn2r105	UTSW	17	20227294	missense	probably benign	0.00
R4816:Vmn2r105	UTSW	17	20208691	missense	probably benign	0.27
R4929:Vmn2r105	UTSW	17	20228018	missense	probably benign	0.44
R5022:Vmn2r105	UTSW	17	20208414	missense	probably damaging	0.99
R5475:Vmn2r105	UTSW	17	20234782	missense	probably benign
R5576:Vmn2r105	UTSW	17	20224574	critical splice donor site	probably null
R5795:Vmn2r105	UTSW	17	20228736	missense	probably benign	0.00
R5895:Vmn2r105	UTSW	17	20228667	missense	probably benign	0.10
R6017:Vmn2r105	UTSW	17	20208627	missense	probably damaging	0.97
R6210:Vmn2r105	UTSW	17	20228496	missense	probably damaging	1.00
R6491:Vmn2r105	UTSW	17	20227730	nonsense	probably null
R6542:Vmn2r105	UTSW	17	20228541	missense	probably benign	0.03
R6729:Vmn2r105	UTSW	17	20208343	missense	probably damaging	0.99
R7020:Vmn2r105	UTSW	17	20209074	missense	probably damaging	1.00
R7033:Vmn2r105	UTSW	17	20208612	missense	probably damaging	0.97
R7488:Vmn2r105	UTSW	17	20208783	missense	probably damaging	1.00
R7491:Vmn2r105	UTSW	17	20228565	missense	probably benign	0.02
R7555:Vmn2r105	UTSW	17	20227675	missense	probably damaging	0.98
R7863:Vmn2r105	UTSW	17	20208675	missense	probably benign	0.18
R8137:Vmn2r105	UTSW	17	20234704	missense	probably benign	0.02
R8166:Vmn2r105	UTSW	17	20208642	missense	probably benign	0.07
R8186:Vmn2r105	UTSW	17	20224618	nonsense	probably null
R8497:Vmn2r105	UTSW	17	20234872	start codon destroyed	probably null	0.75
R8850:Vmn2r105	UTSW	17	20208610	missense	probably damaging	1.00
R8880:Vmn2r105	UTSW	17	20208967	missense	probably damaging	0.99
R9272:Vmn2r105	UTSW	17	20227423	missense	probably damaging	1.00
R9506:Vmn2r105	UTSW	17	20209142	missense	probably benign	0.00
R9549:Vmn2r105	UTSW	17	20227761	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- AATGTGGATTGATCTCCTCGTG -3'
(R):5'- CCAATAACTTGTAGCAGCAGATCTG -3'

Sequencing Primer
(F):5'- ATTGATCTCCTCGTGTTTGAGTC -3'
(R):5'- GTCATGTGACATAAAGGCAATATTCC -3'

Posted On

2020-07-13