Incidental Mutation 'R8215:Or5p51'
ID 636367
Institutional Source Beutler Lab
Gene Symbol Or5p51
Ensembl Gene ENSMUSG00000109542
Gene Name olfactory receptor family 5 subfamily P member 51
Synonyms MOR204-22, Olfr470, GA_x6K02T2PBJ9-10175273-10174329
MMRRC Submission 067657-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R8215 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 107443994-107444938 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 107444124 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 272 (D272A)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073059] [ENSMUST00000220193]
AlphaFold Q8VF65
Predicted Effect possibly damaging
Transcript: ENSMUST00000073059
AA Change: D272A

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000072810
Gene: ENSMUSG00000109542
AA Change: D272A

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2e-56 PFAM
Pfam:7tm_1 44 293 2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000084757
AA Change: D272A

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000081812
Gene: ENSMUSG00000094289
AA Change: D272A

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2.5e-51 PFAM
Pfam:7tm_1 44 293 1.8e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207145
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219309
Predicted Effect possibly damaging
Transcript: ENSMUST00000220193
AA Change: D272A

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.1116 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 93.8%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik G T 15: 81,949,301 (GRCm39) R1066L probably benign Het
Abca14 A C 7: 119,893,425 (GRCm39) I1292L probably benign Het
Adam34l T A 8: 44,079,538 (GRCm39) T229S probably benign Het
Adamtsl1 T G 4: 86,261,382 (GRCm39) F1206V probably benign Het
Agl T C 3: 116,582,293 (GRCm39) H243R probably damaging Het
Btn2a2 A C 13: 23,666,040 (GRCm39) L264R probably damaging Het
Ccdc33 A T 9: 57,939,995 (GRCm39) S749T probably benign Het
Cd55b CTTTT CTTTTT 1: 130,347,337 (GRCm39) probably null Het
Cdh8 A G 8: 99,757,498 (GRCm39) I700T possibly damaging Het
Cfap65 A G 1: 74,949,902 (GRCm39) L1201P probably damaging Het
Chsy3 C T 18: 59,308,941 (GRCm39) Q65* probably null Het
Clic5 T A 17: 44,586,228 (GRCm39) L239* probably null Het
Corin T C 5: 72,462,361 (GRCm39) D957G probably damaging Het
Cped1 A T 6: 22,132,277 (GRCm39) Y486F probably damaging Het
Csnk1g3 C T 18: 54,081,151 (GRCm39) T374M probably benign Het
D930020B18Rik T A 10: 121,503,429 (GRCm39) C201* probably null Het
Dnah2 A G 11: 69,326,193 (GRCm39) F3653L probably damaging Het
F11r GGTGTG GGTGTGTG 1: 171,290,656 (GRCm39) probably null Het
Foxj3 T G 4: 119,478,808 (GRCm39) S455R unknown Het
Gcnt3 T C 9: 69,941,455 (GRCm39) D371G probably damaging Het
Gm10837 A G 14: 122,728,193 (GRCm39) E23G unknown Het
Hivep3 T C 4: 119,980,098 (GRCm39) V1712A probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hoxa2 A G 6: 52,140,041 (GRCm39) V315A probably damaging Het
Irx5 A T 8: 93,086,241 (GRCm39) Y108F possibly damaging Het
Itsn1 T C 16: 91,608,996 (GRCm39) I248T probably damaging Het
Kcnb1 T C 2: 166,946,361 (GRCm39) K829R probably benign Het
Klhl17 A G 4: 156,314,510 (GRCm39) V635A unknown Het
Krr1 C T 10: 111,815,834 (GRCm39) R234* probably null Het
Lrrc7 A T 3: 157,915,387 (GRCm39) D209E probably benign Het
Mcm2 T C 6: 88,874,293 (GRCm39) E71G probably damaging Het
Mroh5 C A 15: 73,691,139 (GRCm39) K10N probably damaging Het
Myh3 A G 11: 66,992,005 (GRCm39) E1850G probably damaging Het
Nedd9 T C 13: 41,492,319 (GRCm39) I64V probably benign Het
Nisch A G 14: 30,908,658 (GRCm39) S456P possibly damaging Het
Nrcam T C 12: 44,610,896 (GRCm39) V532A probably benign Het
Or51k1 T C 7: 103,661,330 (GRCm39) D193G possibly damaging Het
Or7g32 T C 9: 19,408,796 (GRCm39) F251L probably damaging Het
Or8k17 C T 2: 86,066,862 (GRCm39) V106M probably benign Het
Plekhg1 C T 10: 3,907,521 (GRCm39) P868S Het
Ptf1a A G 2: 19,450,760 (GRCm39) Q30R possibly damaging Het
Ptgs1 G T 2: 36,141,179 (GRCm39) C542F probably damaging Het
Rere T A 4: 150,701,424 (GRCm39) M1268K possibly damaging Het
Rp1 A G 1: 4,315,318 (GRCm39) F485L unknown Het
Samd14 A T 11: 94,905,213 (GRCm39) E8D probably benign Het
Serpinh1 A G 7: 98,995,545 (GRCm39) Y346H possibly damaging Het
Shq1 A T 6: 100,648,021 (GRCm39) M1K probably null Het
Tfrc T C 16: 32,443,848 (GRCm39) S551P probably damaging Het
Tnr A C 1: 159,715,860 (GRCm39) N874T possibly damaging Het
Trak1 C A 9: 121,298,096 (GRCm39) T667N probably damaging Het
Trpv2 A C 11: 62,481,757 (GRCm39) T423P probably damaging Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Vmn2r24 A G 6: 123,756,077 (GRCm39) T50A probably benign Het
Xirp2 T A 2: 67,346,853 (GRCm39) D3031E probably benign Het
Zbed6 G T 1: 133,586,530 (GRCm39) A269E probably damaging Het
Zbtb4 A C 11: 69,669,598 (GRCm39) I774L probably benign Het
Zbtb47 T C 9: 121,596,344 (GRCm39) S604P probably benign Het
Zfhx3 A G 8: 109,677,349 (GRCm39) T2800A probably benign Het
Other mutations in Or5p51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02034:Or5p51 APN 7 107,444,385 (GRCm39) missense probably benign 0.00
IGL02349:Or5p51 APN 7 107,444,812 (GRCm39) missense probably benign 0.03
IGL02365:Or5p51 APN 7 107,444,119 (GRCm39) missense probably damaging 1.00
R0070:Or5p51 UTSW 7 107,444,124 (GRCm39) missense probably damaging 0.99
R0540:Or5p51 UTSW 7 107,444,776 (GRCm39) missense probably damaging 0.98
R0607:Or5p51 UTSW 7 107,444,776 (GRCm39) missense probably damaging 0.98
R0624:Or5p51 UTSW 7 107,444,323 (GRCm39) missense possibly damaging 0.87
R1983:Or5p51 UTSW 7 107,444,619 (GRCm39) missense probably benign 0.36
R2420:Or5p51 UTSW 7 107,444,025 (GRCm39) missense probably benign 0.03
R2441:Or5p51 UTSW 7 107,444,185 (GRCm39) missense probably benign 0.10
R4395:Or5p51 UTSW 7 107,444,469 (GRCm39) missense probably damaging 1.00
R4734:Or5p51 UTSW 7 107,444,635 (GRCm39) missense probably benign 0.00
R4779:Or5p51 UTSW 7 107,444,755 (GRCm39) missense possibly damaging 0.96
R5874:Or5p51 UTSW 7 107,444,377 (GRCm39) missense probably benign
R6598:Or5p51 UTSW 7 107,444,470 (GRCm39) missense probably benign 0.06
R6807:Or5p51 UTSW 7 107,444,797 (GRCm39) missense possibly damaging 0.67
R6820:Or5p51 UTSW 7 107,444,298 (GRCm39) missense probably benign 0.01
R7305:Or5p51 UTSW 7 107,444,572 (GRCm39) missense probably damaging 1.00
R7413:Or5p51 UTSW 7 107,444,721 (GRCm39) missense probably damaging 1.00
R7954:Or5p51 UTSW 7 107,444,119 (GRCm39) missense probably benign 0.01
R8255:Or5p51 UTSW 7 107,444,368 (GRCm39) missense probably damaging 1.00
R8384:Or5p51 UTSW 7 107,444,465 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- TCAGAACATATATTTCAGCCACAGG -3'
(R):5'- ACAGTGTCTGTCATAGCCATCTC -3'

Sequencing Primer
(F):5'- GTGTCTGTCTGTAGGATGTTATTAC -3'
(R):5'- GTGTCTGTCATAGCCATCTCCTACAC -3'
Posted On 2020-07-13