Incidental Mutation 'R8219:Olfr894'
ID636559
Institutional Source Beutler Lab
Gene Symbol Olfr894
Ensembl Gene ENSMUSG00000070311
Gene Nameolfactory receptor 894
SynonymsGA_x6K02T2PVTD-31898993-31899934, MOR170-5
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #R8219 (G1)
Quality Score225.009
Status Validated
Chromosome9
Chromosomal Location38218055-38221706 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 38219372 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Alanine at position 183 (D183A)
Ref Sequence ENSEMBL: ENSMUSP00000091389 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093866] [ENSMUST00000212992]
Predicted Effect probably damaging
Transcript: ENSMUST00000093866
AA Change: D183A

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000091389
Gene: ENSMUSG00000070311
AA Change: D183A

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 8.8e-47 PFAM
Pfam:7tm_1 44 293 1.1e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212992
AA Change: D180A

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.7%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933414I15Rik A T 11: 50,942,536 S80T unknown Het
Acnat1 T A 4: 49,447,748 I278F probably benign Het
Adgrf5 A T 17: 43,449,859 Q815L probably benign Het
Aff1 T A 5: 103,846,333 Y1022N probably damaging Het
Ahi1 A G 10: 21,074,436 K1034E probably benign Het
Ano8 A T 8: 71,480,713 L645Q unknown Het
Atg9b A G 5: 24,386,332 L756P probably damaging Het
Atp2b2 A T 6: 113,793,850 I411N probably damaging Het
BC080695 T G 4: 143,571,960 Y158D probably benign Het
Bmp6 T A 13: 38,345,987 C19S unknown Het
Borcs5 A G 6: 134,644,350 H27R probably benign Het
C77080 T A 4: 129,248,153 D65V possibly damaging Het
Cachd1 C A 4: 100,990,962 D1091E probably benign Het
Ccdc186 T A 19: 56,793,345 M801L probably benign Het
Clcn3 A T 8: 60,922,966 M658K probably damaging Het
Col1a1 C T 11: 94,943,358 R500C probably damaging Het
Cul4a T A 8: 13,146,540 D731E possibly damaging Het
Dnajb8 C T 6: 88,222,958 R159C possibly damaging Het
E2f7 T A 10: 110,759,843 V133E probably damaging Het
Fam161b T C 12: 84,346,874 E575G probably benign Het
Fubp1 T A 3: 152,220,466 V275D probably damaging Het
Gabrg1 T A 5: 70,774,300 R367* probably null Het
Gm6902 G A 7: 23,273,718 A128V probably benign Het
Gnptab A G 10: 88,433,792 T786A probably benign Het
Golga2 A G 2: 32,306,480 N981D probably damaging Het
Gsap A T 5: 21,251,115 I437L probably benign Het
Gulp1 A G 1: 44,754,341 probably null Het
Kcnn1 T C 8: 70,852,855 Y237C probably damaging Het
Klhl28 A T 12: 64,951,657 N354K probably benign Het
Lama3 T C 18: 12,439,360 Y541H probably benign Het
Lamc1 A G 1: 153,247,327 Y706H probably damaging Het
Lima1 G T 15: 99,780,790 T590K probably damaging Het
Lrrc38 G A 4: 143,350,733 G189R probably damaging Het
Mrgprb8 G A 7: 48,388,901 V107M possibly damaging Het
Mrpl3 T A 9: 105,057,072 N139K possibly damaging Het
Nudt16 T A 9: 105,130,437 N161I probably damaging Het
Obscn G A 11: 59,122,748 S1091L probably benign Het
Olfr1458 A C 19: 13,102,920 L122R probably damaging Het
Oog4 T C 4: 143,439,938 M99V probably benign Het
Osbpl6 A T 2: 76,555,903 D303V probably damaging Het
Pcdhb21 T C 18: 37,514,655 F279S probably damaging Het
Peg3 G A 7: 6,708,365 T1286I probably benign Het
Phax A G 18: 56,575,682 N106S probably damaging Het
Pkdrej A G 15: 85,821,292 Y148H probably damaging Het
Ptprn2 C A 12: 117,184,737 Q706K probably benign Het
Rdh11 T G 12: 79,189,106 K23Q probably benign Het
Rit2 T A 18: 30,975,494 E146V probably damaging Het
Rnf141 T C 7: 110,837,265 probably benign Het
Sars T A 3: 108,445,062 E24V probably benign Het
Sh3tc2 A G 18: 62,011,861 I1129V probably benign Het
Slc10a5 G T 3: 10,335,324 P92Q probably benign Het
Slc24a5 A T 2: 125,085,655 probably null Het
Slc5a8 A G 10: 88,921,699 Y517C probably damaging Het
Slc6a5 A G 7: 49,912,163 M148V probably benign Het
Sorl1 T C 9: 42,041,561 probably null Het
Tgm4 A T 9: 123,045,052 Y119F probably benign Het
Tgm6 A G 2: 130,151,280 K562R probably benign Het
Tlr3 T C 8: 45,397,979 E627G possibly damaging Het
Tmprss11f A G 5: 86,530,019 L297P probably damaging Het
Tpbgl T C 7: 99,625,771 H293R probably benign Het
Trank1 A C 9: 111,364,909 K667T probably damaging Het
Trpm1 A T 7: 64,201,951 Q139L probably benign Het
Ttf2 T G 3: 100,962,563 K398T possibly damaging Het
Xpa A T 4: 46,183,150 M213K probably benign Het
Zmym2 T A 14: 56,925,859 S623T probably benign Het
Other mutations in Olfr894
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Olfr894 APN 9 38219743 missense probably benign 0.18
IGL01772:Olfr894 APN 9 38219609 missense probably damaging 0.97
IGL02253:Olfr894 APN 9 38219735 missense probably benign 0.01
IGL02279:Olfr894 APN 9 38219093 missense probably benign 0.00
IGL03031:Olfr894 APN 9 38219065 missense probably damaging 0.99
IGL03163:Olfr894 APN 9 38219414 missense probably benign 0.00
R0417:Olfr894 UTSW 9 38219455 missense probably benign 0.01
R0458:Olfr894 UTSW 9 38219048 missense probably damaging 0.97
R1498:Olfr894 UTSW 9 38219380 missense probably damaging 1.00
R1765:Olfr894 UTSW 9 38219252 missense probably benign 0.01
R2020:Olfr894 UTSW 9 38219432 missense possibly damaging 0.47
R2282:Olfr894 UTSW 9 38218828 missense probably benign 0.01
R3928:Olfr894 UTSW 9 38218835 start codon destroyed probably null 0.63
R4716:Olfr894 UTSW 9 38219418 missense probably damaging 0.99
R4911:Olfr894 UTSW 9 38219096 missense probably damaging 0.99
R5148:Olfr894 UTSW 9 38219021 missense probably benign 0.01
R7677:Olfr894 UTSW 9 38219028 missense probably damaging 1.00
R7971:Olfr894 UTSW 9 38219547 missense probably benign 0.00
R8754:Olfr894 UTSW 9 38219569 missense possibly damaging 0.56
X0050:Olfr894 UTSW 9 38219150 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAGCAATGGCCTATGATCGC -3'
(R):5'- GACTAACAGTTATGATGTGAGACCC -3'

Sequencing Primer
(F):5'- ATGATCGCTATGTGGCCATC -3'
(R):5'- GTGAGACCCACAAGTGCC -3'
Posted On2020-07-13