Incidental Mutation 'R8223:Or7e166'
ID 636830
Institutional Source Beutler Lab
Gene Symbol Or7e166
Ensembl Gene ENSMUSG00000094678
Gene Name olfactory receptor family 7 subfamily E member 166
Synonyms MOR146-8P, Olfr857, GA_x6K02T2PVTD-13452606-13453535
MMRRC Submission 067641-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R8223 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 19624125-19625054 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19624705 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 194 (I194T)
Ref Sequence ENSEMBL: ENSMUSP00000076281 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077023] [ENSMUST00000212013]
AlphaFold A0A1L1SUS1
Predicted Effect probably benign
Transcript: ENSMUST00000077023
AA Change: I194T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000076281
Gene: ENSMUSG00000094678
AA Change: I194T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.5e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 304 1.5e-5 PFAM
Pfam:7tm_1 41 290 9.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212013
AA Change: I194T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212753
AA Change: I159T
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre1 T A 17: 57,668,692 (GRCm39) W18R probably damaging Het
Alms1 T A 6: 85,620,222 (GRCm39) Y2417* probably null Het
Apold1 T A 6: 134,961,148 (GRCm39) S201T probably benign Het
Arhgap31 G A 16: 38,424,084 (GRCm39) P661S probably benign Het
Cacfd1 T C 2: 26,908,396 (GRCm39) V110A possibly damaging Het
Capn2 A G 1: 182,310,099 (GRCm39) probably null Het
Chadl T C 15: 81,579,335 (GRCm39) E98G possibly damaging Het
Crxos T C 7: 15,631,394 (GRCm39) Y31H probably benign Het
Cyp4f14 A C 17: 33,130,627 (GRCm39) probably null Het
Cyp4f39 T C 17: 32,689,839 (GRCm39) I95T probably benign Het
Dars1 T C 1: 128,299,961 (GRCm39) E341G probably benign Het
Dchs1 G T 7: 105,411,824 (GRCm39) R1431S possibly damaging Het
Dop1a T A 9: 86,400,345 (GRCm39) H1001Q probably damaging Het
Efemp1 T C 11: 28,804,528 (GRCm39) Y19H probably benign Het
Eml1 T G 12: 108,502,569 (GRCm39) F726V probably benign Het
Fdx1 A T 9: 51,859,921 (GRCm39) D136E probably benign Het
Ganab A T 19: 8,888,192 (GRCm39) D446V probably damaging Het
Gusb A G 5: 130,018,953 (GRCm39) V561A probably benign Het
Hcn1 A T 13: 118,010,406 (GRCm39) D328V unknown Het
Hdgfl1 A G 13: 26,954,047 (GRCm39) Y9H probably damaging Het
Hes3 T A 4: 152,371,572 (GRCm39) S101C probably damaging Het
Igkv2-112 T C 6: 68,197,579 (GRCm39) S84P probably benign Het
Ints9 C T 14: 65,257,809 (GRCm39) P330S possibly damaging Het
Kdm7a A T 6: 39,126,235 (GRCm39) N583K probably damaging Het
Klhl10 C T 11: 100,338,227 (GRCm39) T322M probably damaging Het
Kmt2c A T 5: 25,529,216 (GRCm39) V1545D possibly damaging Het
Laptm5 T C 4: 130,653,511 (GRCm39) probably null Het
Ldlr A G 9: 21,658,546 (GRCm39) T833A probably damaging Het
Llgl1 G T 11: 60,593,648 (GRCm39) L40F possibly damaging Het
Lrrc14 T C 15: 76,598,756 (GRCm39) L464S probably damaging Het
Lrrc38 G A 4: 143,077,303 (GRCm39) G189R probably damaging Het
Lysmd3 T A 13: 81,817,386 (GRCm39) L121H Het
Map2 T C 1: 66,464,649 (GRCm39) S1680P probably damaging Het
Med12l T C 3: 58,993,784 (GRCm39) V583A possibly damaging Het
Mfsd4b5 A G 10: 39,846,246 (GRCm39) Y445H probably damaging Het
Morf4l1 G A 9: 89,979,475 (GRCm39) P169S probably benign Het
Nab2 C A 10: 127,498,645 (GRCm39) V475L probably benign Het
Ola1 A G 2: 72,929,694 (GRCm39) L303P probably damaging Het
Or1j19 T A 2: 36,677,409 (GRCm39) Y291N Het
Or1o2 T C 17: 37,542,727 (GRCm39) D178G possibly damaging Het
Or9i2 G T 19: 13,816,225 (GRCm39) T104K probably damaging Het
Pdlim3 A T 8: 46,353,562 (GRCm39) H99L possibly damaging Het
Plagl2 G T 2: 153,073,461 (GRCm39) T480N probably benign Het
Pramel20 T G 4: 143,298,530 (GRCm39) Y158D probably benign Het
Ptprq C T 10: 107,535,499 (GRCm39) R422Q probably benign Het
Rad18 T A 6: 112,664,982 (GRCm39) R51* probably null Het
Rpap3 T A 15: 97,589,185 (GRCm39) T250S probably benign Het
Serpinb11 T C 1: 107,305,262 (GRCm39) Y213H probably benign Het
Slc15a4 A G 5: 127,686,080 (GRCm39) F201L possibly damaging Het
Slc25a4 A G 8: 46,663,896 (GRCm39) S22P probably damaging Het
Slfn1 T A 11: 83,012,245 (GRCm39) N120K probably damaging Het
Smok3c T C 5: 138,063,655 (GRCm39) S381P probably benign Het
Sry T A Y: 2,663,204 (GRCm39) Q152L unknown Het
Taar2 T A 10: 23,817,248 (GRCm39) W263R probably damaging Het
Thnsl1 T A 2: 21,216,924 (GRCm39) V226E probably benign Het
Tmeff2 T C 1: 51,172,279 (GRCm39) probably null Het
Tox A G 4: 6,842,408 (GRCm39) Y41H probably damaging Het
Trank1 T A 9: 111,194,957 (GRCm39) Y994N probably damaging Het
Trim9 C T 12: 70,297,789 (GRCm39) A713T probably damaging Het
Tub T A 7: 108,628,533 (GRCm39) M393K probably benign Het
Ube4a A G 9: 44,871,333 (GRCm39) L22P possibly damaging Het
Usp47 A G 7: 111,703,583 (GRCm39) K1165R probably damaging Het
Usp6nl T A 2: 6,435,327 (GRCm39) I362K probably damaging Het
Vmn1r217 T C 13: 23,298,369 (GRCm39) I178V probably benign Het
Vmn1r45 T A 6: 89,910,074 (GRCm39) T299S probably damaging Het
Vmn2r5 A T 3: 64,398,726 (GRCm39) L751* probably null Het
Xkr8 G A 4: 132,458,246 (GRCm39) P144L probably damaging Het
Zfpm2 T C 15: 40,616,355 (GRCm39) I35T probably benign Het
Other mutations in Or7e166
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01510:Or7e166 APN 9 19,624,575 (GRCm39) missense probably benign 0.00
IGL01919:Or7e166 APN 9 19,624,638 (GRCm39) missense probably benign 0.00
IGL02157:Or7e166 APN 9 19,624,585 (GRCm39) missense probably benign 0.07
IGL02550:Or7e166 APN 9 19,624,343 (GRCm39) missense possibly damaging 0.92
IGL03329:Or7e166 APN 9 19,624,597 (GRCm39) missense probably benign 0.16
IGL02799:Or7e166 UTSW 9 19,624,314 (GRCm39) missense probably damaging 0.99
R0356:Or7e166 UTSW 9 19,624,743 (GRCm39) missense probably damaging 1.00
R0927:Or7e166 UTSW 9 19,624,945 (GRCm39) missense probably benign 0.39
R1161:Or7e166 UTSW 9 19,624,476 (GRCm39) missense probably damaging 1.00
R1848:Or7e166 UTSW 9 19,624,386 (GRCm39) missense probably benign 0.01
R5191:Or7e166 UTSW 9 19,624,630 (GRCm39) missense probably damaging 0.98
R5216:Or7e166 UTSW 9 19,624,585 (GRCm39) missense probably benign 0.07
R5259:Or7e166 UTSW 9 19,624,109 (GRCm39) splice site probably null
R5342:Or7e166 UTSW 9 19,624,333 (GRCm39) missense probably damaging 1.00
R5506:Or7e166 UTSW 9 19,624,570 (GRCm39) missense possibly damaging 0.61
R5526:Or7e166 UTSW 9 19,624,994 (GRCm39) nonsense probably null
R5594:Or7e166 UTSW 9 19,624,302 (GRCm39) missense probably damaging 0.99
R5928:Or7e166 UTSW 9 19,625,049 (GRCm39) missense probably benign 0.02
R6569:Or7e166 UTSW 9 19,624,638 (GRCm39) missense probably benign 0.00
R6858:Or7e166 UTSW 9 19,624,765 (GRCm39) missense probably damaging 0.98
R7077:Or7e166 UTSW 9 19,624,428 (GRCm39) missense probably benign
R7378:Or7e166 UTSW 9 19,624,183 (GRCm39) missense probably damaging 1.00
R7771:Or7e166 UTSW 9 19,624,767 (GRCm39) missense probably benign
R8038:Or7e166 UTSW 9 19,624,976 (GRCm39) missense possibly damaging 0.52
R8160:Or7e166 UTSW 9 19,624,085 (GRCm39) intron probably benign
R8400:Or7e166 UTSW 9 19,624,389 (GRCm39) missense probably benign 0.45
R8780:Or7e166 UTSW 9 19,624,653 (GRCm39) missense possibly damaging 0.92
R8946:Or7e166 UTSW 9 19,624,885 (GRCm39) missense probably damaging 0.99
R9164:Or7e166 UTSW 9 19,624,954 (GRCm39) missense probably benign 0.25
R9475:Or7e166 UTSW 9 19,624,939 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AAGCCCTTGCCTCTGTAGATG -3'
(R):5'- CCCTGGAAGAACTAGAAACTGTGG -3'

Sequencing Primer
(F):5'- CCCTTGCCTCTGTAGATGTTTGG -3'
(R):5'- GGAACTGAGGTAAACTCCTATACCTG -3'
Posted On 2020-07-13