Incidental Mutation 'R8224:Or2d2'
ID 636891
Institutional Source Beutler Lab
Gene Symbol Or2d2
Ensembl Gene ENSMUSG00000060503
Gene Name olfactory receptor family 2 subfamily D member 2
Synonyms Olfr715, MOR260-1, GA_x6K02T2PBJ9-9479517-9478573
MMRRC Submission 067660-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.349) question?
Stock # R8224 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 106727559-106728689 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 106728079 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 174 (I174F)
Ref Sequence ENSEMBL: ENSMUSP00000076225 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076958]
AlphaFold Q8VG49
Predicted Effect probably damaging
Transcript: ENSMUST00000076958
AA Change: I174F

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000076225
Gene: ENSMUSG00000060503
AA Change: I174F

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.6e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 222 1.4e-8 PFAM
Pfam:7tm_1 41 288 1.7e-26 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 98.3%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A T 10: 29,094,249 (GRCm39) E45V probably damaging Het
Adamts9 A T 6: 92,773,351 (GRCm39) V1754D probably damaging Het
Ankrd26 G A 6: 118,502,716 (GRCm39) T818M probably damaging Het
Card11 T C 5: 140,888,632 (GRCm39) E242G possibly damaging Het
Cdh20 G T 1: 109,921,933 (GRCm39) L8F probably benign Het
Cenpa T C 5: 30,830,699 (GRCm39) probably benign Het
Cfap61 T C 2: 145,781,800 (GRCm39) V11A probably benign Het
Chfr T A 5: 110,308,109 (GRCm39) probably null Het
Col14a1 A T 15: 55,271,137 (GRCm39) Y630F unknown Het
Cst5 A G 2: 149,251,902 (GRCm39) N126D possibly damaging Het
Cubn T C 2: 13,354,688 (GRCm39) T1903A probably benign Het
Dnajb8 C T 6: 88,199,940 (GRCm39) R159C possibly damaging Het
Gon4l A G 3: 88,802,449 (GRCm39) E1020G probably damaging Het
Gp1ba A G 11: 70,530,683 (GRCm39) N150D unknown Het
Gstm2 T C 3: 107,891,314 (GRCm39) I169V probably benign Het
Ighv1-75 A T 12: 115,797,859 (GRCm39) V21D probably benign Het
Il7 T C 3: 7,642,308 (GRCm39) M51V possibly damaging Het
Insm2 A T 12: 55,646,763 (GRCm39) D169V probably damaging Het
Jmjd1c A G 10: 67,080,628 (GRCm39) D373G noncoding transcript Het
Kif16b T C 2: 142,676,008 (GRCm39) N431D probably benign Het
Kmt2a A C 9: 44,719,326 (GRCm39) I3925S unknown Het
Lgi4 G A 7: 30,763,017 (GRCm39) C164Y probably damaging Het
Lrfn5 A T 12: 61,890,192 (GRCm39) I494F possibly damaging Het
Map9 T C 3: 82,266,370 (GRCm39) I5T probably benign Het
Ncf2 T C 1: 152,706,144 (GRCm39) V252A possibly damaging Het
Nlrp4g A T 9: 124,353,374 (GRCm38) I573F noncoding transcript Het
Nrn1 G A 13: 36,918,258 (GRCm39) L3F probably damaging Het
Or1ab2 A G 8: 72,864,223 (GRCm39) D271G noncoding transcript Het
Or5h24 A T 16: 58,919,117 (GRCm39) D79E unknown Het
Or6c8 A G 10: 128,915,304 (GRCm39) F176S possibly damaging Het
Otop1 C A 5: 38,457,846 (GRCm39) T535K possibly damaging Het
Pacs2 A G 12: 113,023,380 (GRCm39) T333A probably damaging Het
Pax3 T C 1: 78,098,327 (GRCm39) Y354C probably damaging Het
Phlpp1 T C 1: 106,320,348 (GRCm39) S1448P probably damaging Het
Pias4 C A 10: 81,003,565 (GRCm39) probably benign Het
Ppp1r12b T C 1: 134,830,200 (GRCm39) N113S probably benign Het
Ptpn12 G T 5: 21,203,656 (GRCm39) P374Q probably damaging Het
Reg4 A T 3: 98,132,011 (GRCm39) probably benign Het
Sh3bp5 T C 14: 31,099,473 (GRCm39) D256G probably damaging Het
Slc25a32 C G 15: 38,976,015 (GRCm39) probably benign Het
Tnip2 C T 5: 34,671,003 (GRCm39) R80Q possibly damaging Het
Uroc1 A G 6: 90,321,049 (GRCm39) probably null Het
Washc2 A C 6: 116,218,457 (GRCm39) K634T probably damaging Het
Xpot A T 10: 121,443,513 (GRCm39) Y405N probably damaging Het
Yes1 T C 5: 32,816,417 (GRCm39) Y365H probably benign Het
Zfp607a A T 7: 27,577,536 (GRCm39) E202V probably damaging Het
Zfp932 T C 5: 110,144,480 (GRCm39) probably benign Het
Zfp947 A C 17: 22,364,363 (GRCm39) M437R probably benign Het
Zscan10 A G 17: 23,828,366 (GRCm39) T303A probably benign Het
Other mutations in Or2d2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00963:Or2d2 APN 7 106,728,272 (GRCm39) nonsense probably null
IGL02238:Or2d2 APN 7 106,728,244 (GRCm39) missense probably damaging 1.00
H8562:Or2d2 UTSW 7 106,728,448 (GRCm39) missense probably benign 0.00
PIT4810001:Or2d2 UTSW 7 106,727,766 (GRCm39) missense probably benign 0.11
R0440:Or2d2 UTSW 7 106,727,939 (GRCm39) missense probably benign 0.03
R0592:Or2d2 UTSW 7 106,728,550 (GRCm39) missense probably benign 0.02
R1051:Or2d2 UTSW 7 106,728,123 (GRCm39) missense possibly damaging 0.94
R1959:Or2d2 UTSW 7 106,727,717 (GRCm39) missense possibly damaging 0.76
R4237:Or2d2 UTSW 7 106,728,244 (GRCm39) missense probably damaging 1.00
R4985:Or2d2 UTSW 7 106,728,234 (GRCm39) missense probably damaging 1.00
R4994:Or2d2 UTSW 7 106,728,271 (GRCm39) missense probably benign 0.03
R6376:Or2d2 UTSW 7 106,727,848 (GRCm39) missense probably benign 0.39
R6931:Or2d2 UTSW 7 106,728,108 (GRCm39) missense probably damaging 1.00
R7593:Or2d2 UTSW 7 106,727,782 (GRCm39) missense probably damaging 1.00
R7718:Or2d2 UTSW 7 106,727,925 (GRCm39) missense probably damaging 1.00
R8390:Or2d2 UTSW 7 106,728,522 (GRCm39) missense probably benign 0.02
R8756:Or2d2 UTSW 7 106,728,019 (GRCm39) missense probably benign
R9269:Or2d2 UTSW 7 106,727,833 (GRCm39) missense probably benign 0.16
R9741:Or2d2 UTSW 7 106,728,366 (GRCm39) missense possibly damaging 0.93
Z1177:Or2d2 UTSW 7 106,728,307 (GRCm39) missense probably benign 0.07
Z1177:Or2d2 UTSW 7 106,728,091 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTAGAAAATGCCTTGAACCTCCC -3'
(R):5'- TGGGTGTACACAATGTGCCC -3'

Sequencing Primer
(F):5'- CAGCAGCTGATTTCATCTTGACAAC -3'
(R):5'- GTACACAATGTGCCCTTTTGG -3'
Posted On 2020-07-13