Incidental Mutation 'R8224:Olfr767'
ID 636899
Institutional Source Beutler Lab
Gene Symbol Olfr767
Ensembl Gene ENSMUSG00000059762
Gene Name olfactory receptor 767
Synonyms MOR115-1, GA_x6K02T2PULF-10765431-10764502
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R8224 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129074825-129082910 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129079435 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 176 (F176S)
Ref Sequence ENSEMBL: ENSMUSP00000080775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082131]
AlphaFold Q8VG33
Predicted Effect possibly damaging
Transcript: ENSMUST00000082131
AA Change: F176S

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000080775
Gene: ENSMUSG00000059762
AA Change: F176S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.9e-49 PFAM
Pfam:7tm_1 39 288 3.6e-22 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 98.3%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A T 10: 29,218,253 E45V probably damaging Het
Adamts9 A T 6: 92,796,370 V1754D probably damaging Het
Ankrd26 G A 6: 118,525,755 T818M probably damaging Het
Card11 T C 5: 140,902,877 E242G possibly damaging Het
Cdh7 G T 1: 109,994,203 L8F probably benign Het
Cenpa T C 5: 30,673,355 probably benign Het
Cfap61 T C 2: 145,939,880 V11A probably benign Het
Chfr T A 5: 110,160,243 probably null Het
Col14a1 A T 15: 55,407,741 Y630F unknown Het
Cst10 A G 2: 149,409,982 N126D possibly damaging Het
Cubn T C 2: 13,349,877 T1903A probably benign Het
Dnajb8 C T 6: 88,222,958 R159C possibly damaging Het
Fam21 A C 6: 116,241,496 K634T probably damaging Het
Gon4l A G 3: 88,895,142 E1020G probably damaging Het
Gp1ba A G 11: 70,639,857 N150D unknown Het
Gstm2 T C 3: 107,983,998 I169V probably benign Het
Ighv1-75 A T 12: 115,834,239 V21D probably benign Het
Il7 T C 3: 7,577,248 M51V possibly damaging Het
Insm2 A T 12: 55,599,978 D169V probably damaging Het
Jmjd1c A G 10: 67,244,849 D373G noncoding transcript Het
Kif16b T C 2: 142,834,088 N431D probably benign Het
Kmt2a A C 9: 44,808,029 I3925S unknown Het
Lgi4 G A 7: 31,063,592 C164Y probably damaging Het
Lrfn5 A T 12: 61,843,406 I494F possibly damaging Het
Map9 T C 3: 82,359,063 I5T probably benign Het
Ncf2 T C 1: 152,830,393 V252A possibly damaging Het
Nlrp4g A T 9: 124,353,374 I573F noncoding transcript Het
Nrn1 G A 13: 36,734,284 L3F probably damaging Het
Olfr192 A T 16: 59,098,754 D79E unknown Het
Olfr374 A G 8: 72,110,379 D271G noncoding transcript Het
Olfr715 T A 7: 107,128,872 I174F probably damaging Het
Otop1 C A 5: 38,300,503 T535K possibly damaging Het
Pacs2 A G 12: 113,059,760 T333A probably damaging Het
Pax3 T C 1: 78,121,690 Y354C probably damaging Het
Phlpp1 T C 1: 106,392,618 S1448P probably damaging Het
Pias4 C A 10: 81,167,731 probably benign Het
Ppp1r12b T C 1: 134,902,462 N113S probably benign Het
Ptpn12 G T 5: 20,998,658 P374Q probably damaging Het
Reg4 A T 3: 98,224,695 probably benign Het
Sh3bp5 T C 14: 31,377,516 D256G probably damaging Het
Slc25a32 C G 15: 39,112,620 probably benign Het
Tnip2 C T 5: 34,513,659 R80Q possibly damaging Het
Uroc1 A G 6: 90,344,067 probably null Het
Xpot A T 10: 121,607,608 Y405N probably damaging Het
Yes1 T C 5: 32,659,073 Y365H probably benign Het
Zfp607a A T 7: 27,878,111 E202V probably damaging Het
Zfp932 T C 5: 109,996,614 probably benign Het
Zfp947 A C 17: 22,145,382 M437R probably benign Het
Zscan10 A G 17: 23,609,392 T303A probably benign Het
Other mutations in Olfr767
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01784:Olfr767 APN 10 129079355 missense probably benign 0.13
IGL01945:Olfr767 APN 10 129079303 missense probably damaging 1.00
IGL02341:Olfr767 APN 10 129079461 nonsense probably null
IGL02389:Olfr767 APN 10 129079230 missense probably damaging 0.97
IGL02516:Olfr767 APN 10 129079793 missense possibly damaging 0.95
IGL02755:Olfr767 APN 10 129079196 missense probably benign 0.00
R0145:Olfr767 UTSW 10 129079363 missense probably damaging 0.97
R0453:Olfr767 UTSW 10 129079771 missense probably damaging 0.97
R0578:Olfr767 UTSW 10 129079193 missense probably damaging 1.00
R1034:Olfr767 UTSW 10 129079961 start codon destroyed probably benign 0.43
R1494:Olfr767 UTSW 10 129079615 missense probably damaging 1.00
R1941:Olfr767 UTSW 10 129079954 missense probably damaging 0.99
R3707:Olfr767 UTSW 10 129079385 missense probably benign 0.31
R5405:Olfr767 UTSW 10 129079396 missense probably damaging 0.99
R5716:Olfr767 UTSW 10 129079555 missense probably benign 0.00
R9680:Olfr767 UTSW 10 129079489 missense probably benign 0.02
Z1177:Olfr767 UTSW 10 129080052 critical splice acceptor site probably benign
Predicted Primers PCR Primer
(F):5'- AAAGCCTTTGTCCTTTGCTGG -3'
(R):5'- CCATCTTTCTTGGAGCAACAGAG -3'

Sequencing Primer
(F):5'- CTGGGCTGAAGGGAGCTTGAG -3'
(R):5'- GAGCAACAGAGTTTTATCTCCTGGC -3'
Posted On 2020-07-13