Incidental Mutation 'R8228:Dusp9'
ID 637085
Institutional Source Beutler Lab
Gene Symbol Dusp9
Ensembl Gene ENSMUSG00000031383
Gene Name dual specificity phosphatase 9
Synonyms Mpk4, Pyst3
MMRRC Submission 067661-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.203) question?
Stock # R8228 (G1)
Quality Score 170.459
Status Not validated
Chromosome X
Chromosomal Location 72683025-72687120 bp(+) (GRCm39)
Type of Mutation small deletion
DNA Base Change (assembly) TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG to TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG,TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG at 72684217 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000019701 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019701]
AlphaFold Q7TNL7
Predicted Effect probably benign
Transcript: ENSMUST00000019701
SMART Domains Protein: ENSMUSP00000019701
Gene: ENSMUSG00000031383

DomainStartEndE-ValueType
RHOD 8 204 2.51e-9 SMART
low complexity region 236 249 N/A INTRINSIC
DSPc 271 411 6.09e-67 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Hemizygous null male and heterozygous null female mice display embryonic lethality during organogenesis with abnormal placental labyrinth morphology when the allele is maternally inherited. Tetraploid rescue produces viable heterozygous and hemizygous mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610030E20Rik T C 6: 72,324,500 (GRCm39) probably null Het
1700008O03Rik A G 7: 44,009,729 (GRCm39) Y158H probably benign Het
4930438A08Rik T A 11: 58,182,381 (GRCm39) I252N Het
A930011G23Rik G A 5: 99,524,980 (GRCm39) P60S probably damaging Het
Abcf1 A G 17: 36,271,933 (GRCm39) probably null Het
AI987944 T C 7: 41,026,260 (GRCm39) T14A probably damaging Het
Alox12b T C 11: 69,054,755 (GRCm39) Y253H probably damaging Het
Anapc1 T A 2: 128,461,837 (GRCm39) K1756* probably null Het
Arid5b T A 10: 68,114,536 (GRCm39) E2V possibly damaging Het
Atp13a1 G A 8: 70,251,569 (GRCm39) V545M probably damaging Het
Atp2b4 TTCTTC TTCTTCCTCTTC 1: 133,629,459 (GRCm39) probably benign Het
Cert1 A G 13: 96,679,723 (GRCm39) T18A probably benign Het
Cfap119 G A 7: 127,184,179 (GRCm39) T239M probably benign Het
Col1a1 T G 11: 94,836,426 (GRCm39) probably null Het
Csdc2 C T 15: 81,833,411 (GRCm39) T136I possibly damaging Het
Dpp9 A T 17: 56,498,129 (GRCm39) I609N probably damaging Het
Gjb6 T C 14: 57,361,926 (GRCm39) R112G probably benign Het
Gm19410 A G 8: 36,252,992 (GRCm39) K646E possibly damaging Het
Grik5 T C 7: 24,709,933 (GRCm39) E934G probably damaging Het
Grik5 A T 7: 24,745,735 (GRCm39) F446Y possibly damaging Het
Iffo2 C G 4: 139,302,483 (GRCm39) N75K probably damaging Het
Kif15 A G 9: 122,821,041 (GRCm39) N649D possibly damaging Het
Lrit2 G A 14: 36,791,148 (GRCm39) A276T probably damaging Het
Mcm8 T C 2: 132,684,714 (GRCm39) probably null Het
Mmut A G 17: 41,248,219 (GRCm39) E82G possibly damaging Het
Or4n4 A G 14: 50,518,997 (GRCm39) S238P probably damaging Het
Or5w8 T A 2: 87,688,284 (GRCm39) M255K probably benign Het
Pcdhga8 A G 18: 37,861,236 (GRCm39) Q764R probably benign Het
Pcgf2 T C 11: 97,582,865 (GRCm39) Y138C probably benign Het
Phf20l1 G T 15: 66,511,789 (GRCm39) V922F possibly damaging Het
Pkd1l2 A T 8: 117,792,514 (GRCm39) I426N probably damaging Het
Psmd6 T C 14: 14,116,843 (GRCm38) N160S possibly damaging Het
Robo1 A G 16: 72,809,768 (GRCm39) D1172G probably benign Het
Sdr9c7 T C 10: 127,734,544 (GRCm39) Y11H possibly damaging Het
Sec24c G T 14: 20,739,975 (GRCm39) A635S probably benign Het
Tex2 T C 11: 106,457,997 (GRCm39) I478V probably benign Het
Traip T C 9: 107,838,265 (GRCm39) M166T probably benign Het
Trdn T C 10: 33,033,014 (GRCm39) S80P probably damaging Het
Trim46 G T 3: 89,142,255 (GRCm39) T744N probably benign Het
Tsc1 C A 2: 28,566,141 (GRCm39) A520D probably benign Het
Usp36 T C 11: 118,155,716 (GRCm39) E852G possibly damaging Het
Vmn2r101 C T 17: 19,811,284 (GRCm39) T456I probably benign Het
Zc3h7a A G 16: 10,956,954 (GRCm39) F885S probably damaging Het
Zfp335 G A 2: 164,746,818 (GRCm39) R354W probably damaging Het
Zfp456 C A 13: 67,514,533 (GRCm39) C391F probably damaging Het
Other mutations in Dusp9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02968:Dusp9 APN X 72,685,039 (GRCm39) missense probably benign 0.00
R4654:Dusp9 UTSW X 72,684,378 (GRCm39) missense probably benign 0.31
R7075:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R7389:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R7412:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R7930:Dusp9 UTSW X 72,684,128 (GRCm39) small deletion probably benign
R7958:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8258:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8334:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8970:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9010:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9140:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9173:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9241:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9359:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9373:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9474:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9548:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9780:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
RF030:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
RF039:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- AGAGTCTGAGTCGGTCATGC -3'
(R):5'- ACCCTCACTTACCCTGTAGG -3'

Sequencing Primer
(F):5'- AGCTGTATGAGTCGGCGC -3'
(R):5'- CCCTGTAGGTAGTATGCTGGG -3'
Posted On 2020-07-13