Incidental Mutation 'R8231:Ints7'
ID 637128
Institutional Source Beutler Lab
Gene Symbol Ints7
Ensembl Gene ENSMUSG00000037461
Gene Name integrator complex subunit 7
Synonyms 5930412E23Rik
MMRRC Submission 067663-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.952) question?
Stock # R8231 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 191307748-191355800 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 191328465 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 246 (L246*)
Ref Sequence ENSEMBL: ENSMUSP00000036277 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045450] [ENSMUST00000193569] [ENSMUST00000194785] [ENSMUST00000194877]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000045450
AA Change: L246*
SMART Domains Protein: ENSMUSP00000036277
Gene: ENSMUSG00000037461
AA Change: L246*

DomainStartEndE-ValueType
SCOP:d1gw5a_ 76 530 1e-10 SMART
low complexity region 937 960 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193569
Predicted Effect probably benign
Transcript: ENSMUST00000194785
Predicted Effect probably benign
Transcript: ENSMUST00000194877
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg8 C T 17: 85,000,213 (GRCm39) R258C probably damaging Het
Acsf2 C G 11: 94,452,188 (GRCm39) E451D probably benign Het
Adam34 A T 8: 44,104,659 (GRCm39) S329T probably benign Het
Adamts16 A G 13: 70,925,599 (GRCm39) I535T probably damaging Het
Atp6v0d2 A G 4: 19,881,451 (GRCm39) F214S probably damaging Het
Btg4 A G 9: 51,027,868 (GRCm39) T13A possibly damaging Het
Ccdc121 T A 5: 31,643,551 (GRCm39) C94S probably benign Het
Cplane1 T C 15: 8,248,511 (GRCm39) Y1687H probably benign Het
Csmd1 A T 8: 16,747,939 (GRCm39) S271T possibly damaging Het
Cul9 T C 17: 46,831,427 (GRCm39) T1596A probably damaging Het
Cyp2a4 G A 7: 26,012,362 (GRCm39) D382N probably benign Het
Dbh C T 2: 27,060,555 (GRCm39) R244C probably benign Het
Dennd11 A T 6: 40,395,546 (GRCm39) H187Q probably benign Het
Dnajc2 T C 5: 21,966,689 (GRCm39) K426R probably benign Het
Dock4 T A 12: 40,752,950 (GRCm39) M428K possibly damaging Het
Duox2 A T 2: 122,120,044 (GRCm39) M822K possibly damaging Het
Golga5 T C 12: 102,438,558 (GRCm39) V91A probably benign Het
Gpatch2l T C 12: 86,290,963 (GRCm39) S49P probably damaging Het
Kntc1 A G 5: 123,920,959 (GRCm39) T926A possibly damaging Het
Kyat1 T C 2: 30,081,978 (GRCm39) T54A probably benign Het
Megf6 C G 4: 154,336,975 (GRCm39) C359W probably damaging Het
Mlh3 A G 12: 85,307,572 (GRCm39) probably null Het
Neb C A 2: 52,125,491 (GRCm39) probably null Het
Nyap2 A T 1: 81,169,846 (GRCm39) Q201L probably benign Het
Pibf1 T G 14: 99,423,997 (GRCm39) H523Q probably benign Het
Piezo1 A G 8: 123,232,836 (GRCm39) S133P Het
Pnma8b T C 7: 16,680,515 (GRCm39) C500R probably benign Het
Ptpra A G 2: 130,379,523 (GRCm39) N359S probably damaging Het
Rce1 A T 19: 4,675,078 (GRCm39) I112N probably damaging Het
Rmdn1 T C 4: 19,586,853 (GRCm39) Y104H probably benign Het
Snx22 A T 9: 65,975,480 (GRCm39) D96E probably benign Het
Sox5 G T 6: 143,974,014 (GRCm39) Q245K probably damaging Het
Stat6 A G 10: 127,482,842 (GRCm39) D21G possibly damaging Het
Tbc1d15 T C 10: 115,065,045 (GRCm39) Y180C probably damaging Het
Tdrd6 T C 17: 43,933,026 (GRCm39) T2058A probably damaging Het
Thbs4 A T 13: 92,911,352 (GRCm39) V277E probably benign Het
Tmem255b A G 8: 13,504,225 (GRCm39) D139G probably damaging Het
Ttc27 C A 17: 75,024,959 (GRCm39) T18K probably benign Het
Zfp131 A G 13: 120,237,348 (GRCm39) F337L probably damaging Het
Other mutations in Ints7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00904:Ints7 APN 1 191,328,276 (GRCm39) splice site probably null
IGL01285:Ints7 APN 1 191,347,890 (GRCm39) missense probably benign 0.00
IGL01289:Ints7 APN 1 191,347,890 (GRCm39) missense probably benign 0.00
IGL01572:Ints7 APN 1 191,347,905 (GRCm39) missense possibly damaging 0.71
IGL01665:Ints7 APN 1 191,345,331 (GRCm39) splice site probably benign
IGL02059:Ints7 APN 1 191,347,872 (GRCm39) missense probably benign 0.23
IGL02684:Ints7 APN 1 191,345,749 (GRCm39) critical splice acceptor site probably null
IGL02686:Ints7 APN 1 191,318,704 (GRCm39) missense probably damaging 1.00
IGL02812:Ints7 APN 1 191,351,853 (GRCm39) missense probably damaging 1.00
IGL03119:Ints7 APN 1 191,342,477 (GRCm39) missense probably damaging 1.00
IGL03162:Ints7 APN 1 191,353,524 (GRCm39) utr 3 prime probably benign
PIT4810001:Ints7 UTSW 1 191,328,348 (GRCm39) missense probably damaging 0.99
R0294:Ints7 UTSW 1 191,344,003 (GRCm39) missense possibly damaging 0.91
R0479:Ints7 UTSW 1 191,346,666 (GRCm39) splice site probably null
R0698:Ints7 UTSW 1 191,326,576 (GRCm39) missense probably damaging 0.97
R1420:Ints7 UTSW 1 191,345,169 (GRCm39) missense possibly damaging 0.73
R1680:Ints7 UTSW 1 191,353,274 (GRCm39) splice site probably null
R1781:Ints7 UTSW 1 191,328,396 (GRCm39) missense possibly damaging 0.95
R2141:Ints7 UTSW 1 191,336,972 (GRCm39) missense possibly damaging 0.73
R2291:Ints7 UTSW 1 191,338,315 (GRCm39) splice site probably null
R4718:Ints7 UTSW 1 191,315,389 (GRCm39) missense possibly damaging 0.60
R4741:Ints7 UTSW 1 191,351,747 (GRCm39) missense probably benign 0.29
R4797:Ints7 UTSW 1 191,329,045 (GRCm39) missense probably damaging 1.00
R4812:Ints7 UTSW 1 191,326,542 (GRCm39) missense possibly damaging 0.73
R4826:Ints7 UTSW 1 191,344,018 (GRCm39) missense probably damaging 0.97
R4870:Ints7 UTSW 1 191,328,443 (GRCm39) missense probably damaging 0.97
R5169:Ints7 UTSW 1 191,345,202 (GRCm39) missense probably benign 0.00
R5281:Ints7 UTSW 1 191,347,883 (GRCm39) missense possibly damaging 0.90
R5694:Ints7 UTSW 1 191,318,730 (GRCm39) missense probably damaging 1.00
R5752:Ints7 UTSW 1 191,308,005 (GRCm39) missense probably benign 0.00
R6048:Ints7 UTSW 1 191,353,524 (GRCm39) utr 3 prime probably benign
R6341:Ints7 UTSW 1 191,345,239 (GRCm39) missense probably damaging 1.00
R6419:Ints7 UTSW 1 191,334,414 (GRCm39) missense possibly damaging 0.69
R7037:Ints7 UTSW 1 191,351,717 (GRCm39) missense probably benign 0.16
R7163:Ints7 UTSW 1 191,349,949 (GRCm39) missense possibly damaging 0.67
R7603:Ints7 UTSW 1 191,328,336 (GRCm39) missense probably damaging 1.00
R7801:Ints7 UTSW 1 191,347,859 (GRCm39) missense possibly damaging 0.84
R7899:Ints7 UTSW 1 191,353,427 (GRCm39) missense probably damaging 1.00
R8034:Ints7 UTSW 1 191,345,183 (GRCm39) frame shift probably null
R8034:Ints7 UTSW 1 191,345,180 (GRCm39) frame shift probably null
R8251:Ints7 UTSW 1 191,353,545 (GRCm39) missense unknown
R8520:Ints7 UTSW 1 191,314,603 (GRCm39) missense probably damaging 1.00
R8966:Ints7 UTSW 1 191,351,717 (GRCm39) missense probably benign 0.16
R9198:Ints7 UTSW 1 191,351,872 (GRCm39) missense probably benign 0.42
R9382:Ints7 UTSW 1 191,351,793 (GRCm39) missense probably damaging 1.00
Z1177:Ints7 UTSW 1 191,342,570 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- ACTCAGGCTTAGCTACACCG -3'
(R):5'- TGTCCTCCAGAGCTCACAAG -3'

Sequencing Primer
(F):5'- TTAGCTACACCGGTGGACCTG -3'
(R):5'- TCACAAGTATGAGAGAGAGAGAGAC -3'
Posted On 2020-07-13