Incidental Mutation 'R8231:Tmem255b'
ID 637144
Institutional Source Beutler Lab
Gene Symbol Tmem255b
Ensembl Gene ENSMUSG00000038457
Gene Name transmembrane protein 255B
Synonyms Fam70b, LOC272465
MMRRC Submission 067663-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R8231 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 13485189-13518473 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13504225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 139 (D139G)
Ref Sequence ENSEMBL: ENSMUSP00000130504 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167071] [ENSMUST00000167505] [ENSMUST00000210804]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000167071
AA Change: D118G

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000127421
Gene: ENSMUSG00000038457
AA Change: D118G

DomainStartEndE-ValueType
Pfam:FAM70 1 68 8.2e-28 PFAM
Pfam:FAM70 66 307 1.8e-119 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000167505
AA Change: D139G

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000130504
Gene: ENSMUSG00000038457
AA Change: D139G

DomainStartEndE-ValueType
Pfam:FAM70 6 328 6e-166 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210804
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg8 C T 17: 85,000,213 (GRCm39) R258C probably damaging Het
Acsf2 C G 11: 94,452,188 (GRCm39) E451D probably benign Het
Adam34 A T 8: 44,104,659 (GRCm39) S329T probably benign Het
Adamts16 A G 13: 70,925,599 (GRCm39) I535T probably damaging Het
Atp6v0d2 A G 4: 19,881,451 (GRCm39) F214S probably damaging Het
Btg4 A G 9: 51,027,868 (GRCm39) T13A possibly damaging Het
Ccdc121 T A 5: 31,643,551 (GRCm39) C94S probably benign Het
Cplane1 T C 15: 8,248,511 (GRCm39) Y1687H probably benign Het
Csmd1 A T 8: 16,747,939 (GRCm39) S271T possibly damaging Het
Cul9 T C 17: 46,831,427 (GRCm39) T1596A probably damaging Het
Cyp2a4 G A 7: 26,012,362 (GRCm39) D382N probably benign Het
Dbh C T 2: 27,060,555 (GRCm39) R244C probably benign Het
Dennd11 A T 6: 40,395,546 (GRCm39) H187Q probably benign Het
Dnajc2 T C 5: 21,966,689 (GRCm39) K426R probably benign Het
Dock4 T A 12: 40,752,950 (GRCm39) M428K possibly damaging Het
Duox2 A T 2: 122,120,044 (GRCm39) M822K possibly damaging Het
Golga5 T C 12: 102,438,558 (GRCm39) V91A probably benign Het
Gpatch2l T C 12: 86,290,963 (GRCm39) S49P probably damaging Het
Ints7 T A 1: 191,328,465 (GRCm39) L246* probably null Het
Kntc1 A G 5: 123,920,959 (GRCm39) T926A possibly damaging Het
Kyat1 T C 2: 30,081,978 (GRCm39) T54A probably benign Het
Megf6 C G 4: 154,336,975 (GRCm39) C359W probably damaging Het
Mlh3 A G 12: 85,307,572 (GRCm39) probably null Het
Neb C A 2: 52,125,491 (GRCm39) probably null Het
Nyap2 A T 1: 81,169,846 (GRCm39) Q201L probably benign Het
Pibf1 T G 14: 99,423,997 (GRCm39) H523Q probably benign Het
Piezo1 A G 8: 123,232,836 (GRCm39) S133P Het
Pnma8b T C 7: 16,680,515 (GRCm39) C500R probably benign Het
Ptpra A G 2: 130,379,523 (GRCm39) N359S probably damaging Het
Rce1 A T 19: 4,675,078 (GRCm39) I112N probably damaging Het
Rmdn1 T C 4: 19,586,853 (GRCm39) Y104H probably benign Het
Snx22 A T 9: 65,975,480 (GRCm39) D96E probably benign Het
Sox5 G T 6: 143,974,014 (GRCm39) Q245K probably damaging Het
Stat6 A G 10: 127,482,842 (GRCm39) D21G possibly damaging Het
Tbc1d15 T C 10: 115,065,045 (GRCm39) Y180C probably damaging Het
Tdrd6 T C 17: 43,933,026 (GRCm39) T2058A probably damaging Het
Thbs4 A T 13: 92,911,352 (GRCm39) V277E probably benign Het
Ttc27 C A 17: 75,024,959 (GRCm39) T18K probably benign Het
Zfp131 A G 13: 120,237,348 (GRCm39) F337L probably damaging Het
Other mutations in Tmem255b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00823:Tmem255b APN 8 13,507,054 (GRCm39) missense probably benign
IGL02635:Tmem255b APN 8 13,505,195 (GRCm39) missense probably damaging 1.00
IGL02679:Tmem255b APN 8 13,507,055 (GRCm39) missense probably benign 0.04
IGL02945:Tmem255b APN 8 13,505,141 (GRCm39) missense probably damaging 0.98
IGL03007:Tmem255b APN 8 13,507,066 (GRCm39) missense possibly damaging 0.94
IGL03146:Tmem255b APN 8 13,504,174 (GRCm39) missense probably damaging 1.00
R2278:Tmem255b UTSW 8 13,501,081 (GRCm39) missense probably damaging 1.00
R2410:Tmem255b UTSW 8 13,491,278 (GRCm39) missense probably benign 0.22
R3081:Tmem255b UTSW 8 13,501,048 (GRCm39) missense probably damaging 0.99
R4498:Tmem255b UTSW 8 13,505,998 (GRCm39) missense probably damaging 1.00
R4612:Tmem255b UTSW 8 13,504,228 (GRCm39) missense probably benign 0.00
R6018:Tmem255b UTSW 8 13,505,138 (GRCm39) missense probably benign 0.00
R6073:Tmem255b UTSW 8 13,506,958 (GRCm39) missense probably damaging 0.98
R6240:Tmem255b UTSW 8 13,504,216 (GRCm39) missense probably damaging 1.00
R6737:Tmem255b UTSW 8 13,507,096 (GRCm39) critical splice donor site probably null
R9653:Tmem255b UTSW 8 13,506,005 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAGGGTGTCTGTAATCCTTTCCC -3'
(R):5'- ATGCAGCTGTGATCCCAGAG -3'

Sequencing Primer
(F):5'- CTATGGCAAGCAGTAACTCGTGTG -3'
(R):5'- GCTGTGATCCCAGAGAGAACC -3'
Posted On 2020-07-13