Incidental Mutation 'R8231:Btg4'
ID 637148
Institutional Source Beutler Lab
Gene Symbol Btg4
Ensembl Gene ENSMUSG00000032056
Gene Name BTG anti-proliferation factor 4
Synonyms PC3B
MMRRC Submission 067663-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.242) question?
Stock # R8231 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 51013486-51031224 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 51027868 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 13 (T13A)
Ref Sequence ENSEMBL: ENSMUSP00000110074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114431]
AlphaFold O70552
Predicted Effect possibly damaging
Transcript: ENSMUST00000114431
AA Change: T13A

PolyPhen 2 Score 0.796 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000110074
Gene: ENSMUSG00000032056
AA Change: T13A

DomainStartEndE-ValueType
btg1 1 108 7.37e-64 SMART
low complexity region 138 153 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg8 C T 17: 85,000,213 (GRCm39) R258C probably damaging Het
Acsf2 C G 11: 94,452,188 (GRCm39) E451D probably benign Het
Adam34 A T 8: 44,104,659 (GRCm39) S329T probably benign Het
Adamts16 A G 13: 70,925,599 (GRCm39) I535T probably damaging Het
Atp6v0d2 A G 4: 19,881,451 (GRCm39) F214S probably damaging Het
Ccdc121 T A 5: 31,643,551 (GRCm39) C94S probably benign Het
Cplane1 T C 15: 8,248,511 (GRCm39) Y1687H probably benign Het
Csmd1 A T 8: 16,747,939 (GRCm39) S271T possibly damaging Het
Cul9 T C 17: 46,831,427 (GRCm39) T1596A probably damaging Het
Cyp2a4 G A 7: 26,012,362 (GRCm39) D382N probably benign Het
Dbh C T 2: 27,060,555 (GRCm39) R244C probably benign Het
Dennd11 A T 6: 40,395,546 (GRCm39) H187Q probably benign Het
Dnajc2 T C 5: 21,966,689 (GRCm39) K426R probably benign Het
Dock4 T A 12: 40,752,950 (GRCm39) M428K possibly damaging Het
Duox2 A T 2: 122,120,044 (GRCm39) M822K possibly damaging Het
Golga5 T C 12: 102,438,558 (GRCm39) V91A probably benign Het
Gpatch2l T C 12: 86,290,963 (GRCm39) S49P probably damaging Het
Ints7 T A 1: 191,328,465 (GRCm39) L246* probably null Het
Kntc1 A G 5: 123,920,959 (GRCm39) T926A possibly damaging Het
Kyat1 T C 2: 30,081,978 (GRCm39) T54A probably benign Het
Megf6 C G 4: 154,336,975 (GRCm39) C359W probably damaging Het
Mlh3 A G 12: 85,307,572 (GRCm39) probably null Het
Neb C A 2: 52,125,491 (GRCm39) probably null Het
Nyap2 A T 1: 81,169,846 (GRCm39) Q201L probably benign Het
Pibf1 T G 14: 99,423,997 (GRCm39) H523Q probably benign Het
Piezo1 A G 8: 123,232,836 (GRCm39) S133P Het
Pnma8b T C 7: 16,680,515 (GRCm39) C500R probably benign Het
Ptpra A G 2: 130,379,523 (GRCm39) N359S probably damaging Het
Rce1 A T 19: 4,675,078 (GRCm39) I112N probably damaging Het
Rmdn1 T C 4: 19,586,853 (GRCm39) Y104H probably benign Het
Snx22 A T 9: 65,975,480 (GRCm39) D96E probably benign Het
Sox5 G T 6: 143,974,014 (GRCm39) Q245K probably damaging Het
Stat6 A G 10: 127,482,842 (GRCm39) D21G possibly damaging Het
Tbc1d15 T C 10: 115,065,045 (GRCm39) Y180C probably damaging Het
Tdrd6 T C 17: 43,933,026 (GRCm39) T2058A probably damaging Het
Thbs4 A T 13: 92,911,352 (GRCm39) V277E probably benign Het
Tmem255b A G 8: 13,504,225 (GRCm39) D139G probably damaging Het
Ttc27 C A 17: 75,024,959 (GRCm39) T18K probably benign Het
Zfp131 A G 13: 120,237,348 (GRCm39) F337L probably damaging Het
Other mutations in Btg4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02875:Btg4 APN 9 51,030,446 (GRCm39) missense probably benign 0.17
R1741:Btg4 UTSW 9 51,027,910 (GRCm39) missense probably benign 0.24
R1876:Btg4 UTSW 9 51,028,489 (GRCm39) missense probably damaging 1.00
R6794:Btg4 UTSW 9 51,030,651 (GRCm39) missense possibly damaging 0.72
R7384:Btg4 UTSW 9 51,030,413 (GRCm39) missense probably benign 0.13
R7606:Btg4 UTSW 9 51,029,307 (GRCm39) missense probably damaging 1.00
R7877:Btg4 UTSW 9 51,029,240 (GRCm39) missense probably benign 0.00
R8094:Btg4 UTSW 9 51,030,445 (GRCm39) missense probably benign 0.04
R9576:Btg4 UTSW 9 51,030,436 (GRCm39) missense probably damaging 0.96
R9594:Btg4 UTSW 9 51,030,560 (GRCm39) missense probably damaging 1.00
Z1176:Btg4 UTSW 9 51,030,475 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACTCTCCAGGTTGGTAGCTTG -3'
(R):5'- ATGCTACTGGTGACCCGATTC -3'

Sequencing Primer
(F):5'- GTATTGATATTCTCAGTTCACATGGG -3'
(R):5'- GGTGACCCGATTCCCCTC -3'
Posted On 2020-07-13