Incidental Mutation 'R8232:Or5b107'
ID 637199
Institutional Source Beutler Lab
Gene Symbol Or5b107
Ensembl Gene ENSMUSG00000045883
Gene Name olfactory receptor family 5 subfamily B member 107
Synonyms GA_x6K02T2RE5P-3491834-3492772, Olfr1461, MOR202-35
MMRRC Submission 067664-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R8232 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13142380-13143318 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13142683 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 102 (M102V)
Ref Sequence ENSEMBL: ENSMUSP00000053269 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053772] [ENSMUST00000207113] [ENSMUST00000208489]
AlphaFold Q8VEV7
Predicted Effect probably benign
Transcript: ENSMUST00000053772
AA Change: M102V

PolyPhen 2 Score 0.280 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000053269
Gene: ENSMUSG00000045883
AA Change: M102V

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 6e-55 PFAM
Pfam:7TM_GPCR_Srsx 36 306 8e-6 PFAM
Pfam:7tm_1 42 291 2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207113
AA Change: M102V

PolyPhen 2 Score 0.280 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000208489
AA Change: M102V

PolyPhen 2 Score 0.280 (Sensitivity: 0.91; Specificity: 0.88)
Meta Mutation Damage Score 0.2322 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.5%
Validation Efficiency 100% (34/34)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acnat1 A T 4: 49,450,817 (GRCm39) M98K probably damaging Het
Actn3 A T 19: 4,921,683 (GRCm39) W166R probably damaging Het
Adamts16 C A 13: 70,941,217 (GRCm39) C390F probably damaging Het
Arhgap32 A T 9: 32,168,198 (GRCm39) D727V probably damaging Het
Bcr A G 10: 75,001,883 (GRCm39) Y929C probably damaging Het
Bmp1 T A 14: 70,757,329 (GRCm39) Y50F probably damaging Het
Camta2 G A 11: 70,573,841 (GRCm39) R171C unknown Het
Ccnd2 A G 6: 127,127,549 (GRCm39) L63P probably damaging Het
Clip1 G C 5: 123,785,981 (GRCm39) D234E probably benign Het
Dnah9 A T 11: 65,746,149 (GRCm39) I3988N possibly damaging Het
Frmpd2 T G 14: 33,261,724 (GRCm39) I843S probably damaging Het
Gcgr A G 11: 120,427,328 (GRCm39) Y146C probably damaging Het
Gm5930 T G 14: 44,573,181 (GRCm39) K158T probably damaging Het
Gnl1 T A 17: 36,298,487 (GRCm39) C410* probably null Het
Gtf2h1 T A 7: 46,451,103 (GRCm39) I4K probably benign Het
Il12b A G 11: 44,299,401 (GRCm39) S157G possibly damaging Het
Jcad G T 18: 4,674,862 (GRCm39) A875S probably benign Het
Kcnrg T A 14: 61,845,386 (GRCm39) M142K probably benign Het
Krtap4-6 A C 11: 99,556,568 (GRCm39) L53R unknown Het
Myo10 G A 15: 25,804,400 (GRCm39) G1565D possibly damaging Het
Nf1 A G 11: 79,469,157 (GRCm39) S806G probably damaging Het
Nlrp5 G T 7: 23,116,770 (GRCm39) V165L probably benign Het
Nppa T C 4: 148,085,795 (GRCm39) I134T possibly damaging Het
Or4a72 A T 2: 89,405,938 (GRCm39) V44E noncoding transcript Het
Or51ai2 G A 7: 103,586,980 (GRCm39) R131Q possibly damaging Het
Or5p68 A T 7: 107,945,495 (GRCm39) M231K probably damaging Het
Or6c202 C A 10: 128,996,097 (GRCm39) C252F probably damaging Het
Scyl2 A T 10: 89,498,309 (GRCm39) F167I probably damaging Het
Smarcal1 T C 1: 72,665,722 (GRCm39) L740S probably damaging Het
Tmem183a T A 1: 134,277,918 (GRCm39) D282V probably damaging Het
Trhde A T 10: 114,636,442 (GRCm39) V255E possibly damaging Het
Vmn1r229 T A 17: 21,035,309 (GRCm39) C185S probably damaging Het
Vmn2r58 A T 7: 41,514,076 (GRCm39) M189K probably damaging Het
Vps50 T G 6: 3,600,139 (GRCm39) V866G probably damaging Het
Other mutations in Or5b107
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Or5b107 APN 19 13,142,735 (GRCm39) missense probably damaging 1.00
IGL01370:Or5b107 APN 19 13,142,663 (GRCm39) missense possibly damaging 0.95
IGL01936:Or5b107 APN 19 13,142,767 (GRCm39) missense probably damaging 1.00
R0098:Or5b107 UTSW 19 13,143,026 (GRCm39) missense probably benign 0.12
R0270:Or5b107 UTSW 19 13,143,251 (GRCm39) missense probably damaging 1.00
R0575:Or5b107 UTSW 19 13,142,751 (GRCm39) nonsense probably null
R0627:Or5b107 UTSW 19 13,142,614 (GRCm39) missense probably benign 0.43
R1779:Or5b107 UTSW 19 13,142,404 (GRCm39) missense probably benign 0.00
R1956:Or5b107 UTSW 19 13,142,560 (GRCm39) missense probably damaging 1.00
R2446:Or5b107 UTSW 19 13,142,811 (GRCm39) missense probably benign 0.00
R3622:Or5b107 UTSW 19 13,143,020 (GRCm39) missense probably benign 0.06
R4485:Or5b107 UTSW 19 13,142,855 (GRCm39) missense possibly damaging 0.54
R4605:Or5b107 UTSW 19 13,142,612 (GRCm39) missense probably damaging 1.00
R4757:Or5b107 UTSW 19 13,143,277 (GRCm39) missense probably benign 0.01
R4816:Or5b107 UTSW 19 13,142,488 (GRCm39) missense probably benign 0.10
R5038:Or5b107 UTSW 19 13,142,955 (GRCm39) missense probably benign 0.39
R7026:Or5b107 UTSW 19 13,142,779 (GRCm39) missense probably benign 0.08
R8225:Or5b107 UTSW 19 13,142,507 (GRCm39) missense probably damaging 1.00
R9095:Or5b107 UTSW 19 13,143,310 (GRCm39) missense probably benign 0.01
R9127:Or5b107 UTSW 19 13,142,396 (GRCm39) missense probably damaging 1.00
R9697:Or5b107 UTSW 19 13,142,888 (GRCm39) missense possibly damaging 0.91
R9784:Or5b107 UTSW 19 13,142,813 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACTGATGATCCAGGCCTG -3'
(R):5'- TCTCCTAGATAAACTGAGACATTGAGG -3'

Sequencing Primer
(F):5'- ATCTACATCATCACCCTGGTAGG -3'
(R):5'- CTGAGACATTGAGGAAACTAAAACC -3'
Posted On 2020-07-13