|Institutional Source||Beutler Lab|
|Gene Name||BICD cargo adaptor 2|
|Is this an essential gene?||Possibly essential (E-score: 0.555)|
|Stock #||R0718 (G1)|
|Chromosomal Location||49341585-49387026 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to A at 49377875 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000105712 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000048544] [ENSMUST00000110084] [ENSMUST00000110085]|
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (96/96)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele show postnatal and premature death associated with progressive hydrocephalus, enlarged lateral ventricles, aqueductal stenosis, abnormal gait, disrupted laminar organization of the cerebral cortex and cerebellum, and impaired cerebellar granule cell migration. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Bicd2||
(F):5'- ACTTCTAGTGCTCTAGATGGCCCC -3'
(R):5'- TGCTCATGTAGTGCGACAACTCC -3'
(F):5'- TAGATGGCCCCTCCTAGC -3'
(R):5'- CGCAGGTTGTTCTTCTGCTC -3'