Incidental Mutation 'R8234:Rasd1'
ID 637275
Institutional Source Beutler Lab
Gene Symbol Rasd1
Ensembl Gene ENSMUSG00000049892
Gene Name RAS, dexamethasone-induced 1
Synonyms Dexras1
MMRRC Submission 067666-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8234 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 59854007-59855770 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 59855118 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 121 (I121V)
Ref Sequence ENSEMBL: ENSMUSP00000051959 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062405] [ENSMUST00000081980]
AlphaFold O35626
Predicted Effect probably damaging
Transcript: ENSMUST00000062405
AA Change: I121V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051959
Gene: ENSMUSG00000049892
AA Change: I121V

DomainStartEndE-ValueType
RAS 22 198 4.81e-81 SMART
low complexity region 217 243 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000081980
SMART Domains Protein: ENSMUSP00000080641
Gene: ENSMUSG00000061650

DomainStartEndE-ValueType
low complexity region 16 52 N/A INTRINSIC
Pfam:Med9 59 135 3.2e-27 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.8%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for disruptions in this gene have a reduced ability to entrain to low intensity light with resulting abnormalities in circadian rhythm. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd4 T A 14: 54,499,133 (GRCm39) M38K probably benign Het
Ackr1 T A 1: 173,159,582 (GRCm39) R312S probably benign Het
Akap9 T C 5: 4,094,845 (GRCm39) V2213A probably benign Het
Alox5 T A 6: 116,390,835 (GRCm39) R439W probably damaging Het
Atrn A T 2: 130,864,920 (GRCm39) probably null Het
Casd1 A G 6: 4,601,209 (GRCm39) N14S probably damaging Het
Cry2 T C 2: 92,242,974 (GRCm39) S542G probably benign Het
Cyb5rl A G 4: 106,925,935 (GRCm39) Y39C probably damaging Het
Dmpk A T 7: 18,822,048 (GRCm39) K335N probably benign Het
Dnai1 A G 4: 41,625,221 (GRCm39) D395G probably benign Het
Dock4 C T 12: 40,884,837 (GRCm39) probably null Het
Eif1ad5 A T 12: 87,940,508 (GRCm39) I71L noncoding transcript Het
Fmo4 T C 1: 162,632,757 (GRCm39) D198G probably damaging Het
Foxc2 G A 8: 121,844,777 (GRCm39) R475Q probably damaging Het
Gipr C A 7: 18,898,533 (GRCm39) G37V unknown Het
Gpat3 T C 5: 101,005,076 (GRCm39) probably null Het
Hcn4 A G 9: 58,751,433 (GRCm39) D353G unknown Het
Hectd4 T A 5: 121,477,607 (GRCm39) N2843K possibly damaging Het
Hmcn1 C T 1: 150,469,761 (GRCm39) V4973M possibly damaging Het
Il20rb C T 9: 100,341,263 (GRCm39) S281N probably benign Het
Kcnh4 A T 11: 100,643,093 (GRCm39) N391K possibly damaging Het
Kitl A G 10: 99,887,708 (GRCm39) T6A probably damaging Het
Krt36 A G 11: 99,995,027 (GRCm39) Y182H probably damaging Het
Lrp1b T G 2: 41,202,668 (GRCm39) I1262L Het
Mtf1 A G 4: 124,738,039 (GRCm39) E644G probably benign Het
Mtx2 A G 2: 74,699,706 (GRCm39) Y159C probably damaging Het
Nags C T 11: 102,039,824 (GRCm39) S504F probably damaging Het
Ncam1 A T 9: 49,456,523 (GRCm39) F475L probably damaging Het
Nipal2 G T 15: 34,600,178 (GRCm39) T213N possibly damaging Het
Or52m1 T A 7: 102,289,678 (GRCm39) L75Q probably damaging Het
Or8h8 A G 2: 86,753,313 (GRCm39) S188P probably damaging Het
Pkm T C 9: 59,577,882 (GRCm39) V233A possibly damaging Het
Pros1 T A 16: 62,748,540 (GRCm39) I671N possibly damaging Het
Relch T C 1: 105,681,235 (GRCm39) S1180P possibly damaging Het
Samhd1 A G 2: 156,958,270 (GRCm39) probably null Het
Serpinb9f A T 13: 33,509,898 (GRCm39) Y30F probably benign Het
Slc5a10 T C 11: 61,564,107 (GRCm39) I543V probably benign Het
Stat5a A G 11: 100,770,129 (GRCm39) I469V possibly damaging Het
Sugct T C 13: 17,032,459 (GRCm39) E431G probably benign Het
Tecr C A 8: 84,299,880 (GRCm39) R133L possibly damaging Het
Tiparp A G 3: 65,439,002 (GRCm39) N106S probably benign Het
Triml1 T C 8: 43,594,285 (GRCm39) S49G probably benign Het
Trpm3 T A 19: 22,692,640 (GRCm39) S244T possibly damaging Het
Ttn T C 2: 76,553,324 (GRCm39) D31055G probably damaging Het
Vcp A T 4: 42,985,242 (GRCm39) I369N probably damaging Het
Vmn2r110 A C 17: 20,804,691 (GRCm39) N76K probably benign Het
Vmn2r12 T C 5: 109,234,074 (GRCm39) T713A probably benign Het
Vmn2r17 A T 5: 109,601,235 (GRCm39) K844N probably benign Het
Other mutations in Rasd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01095:Rasd1 APN 11 59,855,117 (GRCm39) missense probably damaging 1.00
IGL02206:Rasd1 APN 11 59,854,778 (GRCm39) missense possibly damaging 0.69
IGL02534:Rasd1 APN 11 59,855,615 (GRCm39) missense possibly damaging 0.86
IGL03306:Rasd1 APN 11 59,855,181 (GRCm39) missense possibly damaging 0.64
R0833:Rasd1 UTSW 11 59,855,379 (GRCm39) missense probably damaging 1.00
R0836:Rasd1 UTSW 11 59,855,379 (GRCm39) missense probably damaging 1.00
R1160:Rasd1 UTSW 11 59,855,547 (GRCm39) missense possibly damaging 0.78
R1647:Rasd1 UTSW 11 59,854,920 (GRCm39) missense probably benign 0.26
R5114:Rasd1 UTSW 11 59,854,933 (GRCm39) missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- GAGATCTCGAAGTAGGCACAAC -3'
(R):5'- ATCCGGCAATCATCCGTTTC -3'

Sequencing Primer
(F):5'- TAGGCACAACGCTGAGGGTC -3'
(R):5'- ACCGGAGTCTTGAGGGG -3'
Posted On 2020-07-13