Incidental Mutation 'R8237:Vmn2r69'
| ID |
637412 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r69
|
| Ensembl Gene |
ENSMUSG00000091006 |
| Gene Name |
vomeronasal 2, receptor 69 |
| Synonyms |
|
| MMRRC Submission |
067669-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R8237 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85055584-85064884 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 85060340 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 415
(S415P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132726
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171213]
|
| AlphaFold |
G3XA45 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171213
AA Change: S415P
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000132726
Gene: ENSMUSG00000091006
AA Change: S415P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.3e-28 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
1.8e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
3.2e-54 |
PFAM |
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.3%
- 20x: 98.2%
|
| Validation Efficiency |
100% (57/57) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
T |
C |
11: 58,771,373 (GRCm39) |
L285P |
probably damaging |
Het |
| Abca4 |
T |
C |
3: 121,955,952 (GRCm39) |
I1905T |
probably benign |
Het |
| Abca5 |
A |
T |
11: 110,200,981 (GRCm39) |
I473K |
probably benign |
Het |
| Adgrl3 |
CAA |
CA |
5: 81,935,408 (GRCm39) |
|
probably null |
Het |
| Ap2a1 |
C |
A |
7: 44,550,220 (GRCm39) |
R959L |
probably damaging |
Het |
| Birc6 |
G |
C |
17: 74,918,126 (GRCm39) |
L1845F |
probably damaging |
Het |
| Cbs |
T |
C |
17: 31,834,454 (GRCm39) |
I512V |
probably benign |
Het |
| Ccn4 |
C |
A |
15: 66,791,083 (GRCm39) |
T295N |
probably benign |
Het |
| Ceacam3 |
T |
C |
7: 16,897,082 (GRCm39) |
Y683H |
|
Het |
| Chd8 |
C |
T |
14: 52,450,809 (GRCm39) |
S1426N |
probably damaging |
Het |
| Cog8 |
T |
C |
8: 107,782,923 (GRCm39) |
D122G |
probably benign |
Het |
| Crybg1 |
G |
A |
10: 43,842,376 (GRCm39) |
Q1772* |
probably null |
Het |
| Cspg4 |
T |
C |
9: 56,799,964 (GRCm39) |
F1576S |
probably damaging |
Het |
| Ctse |
T |
A |
1: 131,590,467 (GRCm39) |
V63E |
probably benign |
Het |
| Dnah3 |
G |
T |
7: 119,525,636 (GRCm39) |
T3917N |
probably benign |
Het |
| Dst |
C |
T |
1: 34,208,874 (GRCm39) |
T1124M |
possibly damaging |
Het |
| Fkbp10 |
A |
G |
11: 100,306,785 (GRCm39) |
Q59R |
probably damaging |
Het |
| Fsip1 |
A |
G |
2: 118,063,483 (GRCm39) |
S329P |
probably damaging |
Het |
| Ginm1 |
G |
T |
10: 7,668,419 (GRCm39) |
S56R |
unknown |
Het |
| Gm10110 |
C |
T |
14: 90,135,677 (GRCm39) |
V76M |
noncoding transcript |
Het |
| Gm6401 |
T |
A |
14: 41,787,452 (GRCm39) |
I125F |
probably damaging |
Het |
| Helz2 |
T |
C |
2: 180,871,124 (GRCm39) |
D2815G |
possibly damaging |
Het |
| Hes1 |
T |
C |
16: 29,886,047 (GRCm39) |
V217A |
probably damaging |
Het |
| Hsd3b1 |
C |
T |
3: 98,760,426 (GRCm39) |
M188I |
possibly damaging |
Het |
| Ighv1-75 |
T |
C |
12: 115,797,876 (GRCm39) |
|
probably benign |
Het |
| Itprid2 |
T |
C |
2: 79,487,614 (GRCm39) |
S566P |
probably benign |
Het |
| Kif1b |
T |
A |
4: 149,275,642 (GRCm39) |
N1423I |
probably benign |
Het |
| Lmntd1 |
G |
A |
6: 145,373,146 (GRCm39) |
T129M |
probably damaging |
Het |
| Lonrf2 |
T |
A |
1: 38,839,854 (GRCm39) |
T414S |
probably benign |
Het |
| Lrp1b |
T |
C |
2: 40,741,786 (GRCm39) |
D3161G |
|
Het |
| Lyst |
T |
C |
13: 13,826,317 (GRCm39) |
I1608T |
probably benign |
Het |
| Map9 |
C |
T |
3: 82,284,467 (GRCm39) |
P347L |
probably damaging |
Het |
| Mixl1 |
G |
A |
1: 180,524,322 (GRCm39) |
Q86* |
probably null |
Het |
| Muc5b |
T |
C |
7: 141,411,697 (GRCm39) |
S1548P |
unknown |
Het |
| Myo15b |
A |
G |
11: 115,767,827 (GRCm39) |
K1376E |
|
Het |
| Nlrc5 |
A |
G |
8: 95,252,753 (GRCm39) |
T105A |
unknown |
Het |
| Npepps |
A |
G |
11: 97,139,026 (GRCm39) |
|
probably null |
Het |
| Nup205 |
T |
A |
6: 35,204,438 (GRCm39) |
F1441L |
possibly damaging |
Het |
| Or5p69 |
A |
C |
7: 107,967,234 (GRCm39) |
H179P |
probably damaging |
Het |
| Pbx4 |
A |
G |
8: 70,317,093 (GRCm39) |
T117A |
probably benign |
Het |
| Phf2 |
T |
A |
13: 48,976,514 (GRCm39) |
T234S |
unknown |
Het |
| Pik3r2 |
G |
A |
8: 71,224,794 (GRCm39) |
A194V |
probably benign |
Het |
| Plaat1 |
C |
A |
16: 29,039,106 (GRCm39) |
T62K |
probably benign |
Het |
| Plbd2 |
T |
C |
5: 120,637,114 (GRCm39) |
D116G |
probably damaging |
Het |
| Plpp2 |
G |
A |
10: 79,363,294 (GRCm39) |
A235V |
possibly damaging |
Het |
| Prkce |
G |
T |
17: 86,866,646 (GRCm39) |
R502L |
probably damaging |
Het |
| Psrc1 |
C |
T |
3: 108,293,930 (GRCm39) |
A249V |
probably damaging |
Het |
| Ptdss1 |
T |
C |
13: 67,124,841 (GRCm39) |
C347R |
probably damaging |
Het |
| Serpina1b |
C |
A |
12: 103,785,063 (GRCm39) |
|
probably null |
Het |
| Spcs1 |
C |
G |
14: 30,722,658 (GRCm39) |
A113P |
noncoding transcript |
Het |
| Stxbp2 |
C |
T |
8: 3,685,695 (GRCm39) |
T247M |
|
Het |
| Tex15 |
A |
G |
8: 34,067,427 (GRCm39) |
T2286A |
possibly damaging |
Het |
| Usp45 |
T |
G |
4: 21,834,274 (GRCm39) |
V736G |
probably damaging |
Het |
| Zfp407 |
T |
C |
18: 84,578,269 (GRCm39) |
E948G |
possibly damaging |
Het |
| Zfp942 |
A |
T |
17: 22,147,226 (GRCm39) |
C468S |
possibly damaging |
Het |
| Zmym6 |
A |
G |
4: 127,016,544 (GRCm39) |
E775G |
probably damaging |
Het |
| Zranb2 |
A |
G |
3: 157,250,677 (GRCm39) |
R283G |
probably null |
Het |
|
| Other mutations in Vmn2r69 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01019:Vmn2r69
|
APN |
7 |
85,055,739 (GRCm39) |
missense |
probably benign |
|
|
IGL01457:Vmn2r69
|
APN |
7 |
85,055,836 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01760:Vmn2r69
|
APN |
7 |
85,056,072 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01834:Vmn2r69
|
APN |
7 |
85,061,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02001:Vmn2r69
|
APN |
7 |
85,056,434 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02057:Vmn2r69
|
APN |
7 |
85,060,990 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02289:Vmn2r69
|
APN |
7 |
85,056,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Vmn2r69
|
APN |
7 |
85,058,960 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02478:Vmn2r69
|
APN |
7 |
85,055,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02554:Vmn2r69
|
APN |
7 |
85,059,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02723:Vmn2r69
|
APN |
7 |
85,059,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0526:Vmn2r69
|
UTSW |
7 |
85,060,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0560:Vmn2r69
|
UTSW |
7 |
85,058,922 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0909:Vmn2r69
|
UTSW |
7 |
85,055,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0976:Vmn2r69
|
UTSW |
7 |
85,056,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1158:Vmn2r69
|
UTSW |
7 |
85,059,058 (GRCm39) |
splice site |
probably benign |
|
|
R1459:Vmn2r69
|
UTSW |
7 |
85,055,908 (GRCm39) |
nonsense |
probably null |
|
|
R1482:Vmn2r69
|
UTSW |
7 |
85,056,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1917:Vmn2r69
|
UTSW |
7 |
85,060,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2016:Vmn2r69
|
UTSW |
7 |
85,056,493 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2108:Vmn2r69
|
UTSW |
7 |
85,059,404 (GRCm39) |
missense |
probably benign |
|
|
R2571:Vmn2r69
|
UTSW |
7 |
85,064,764 (GRCm39) |
missense |
probably benign |
|
|
R2910:Vmn2r69
|
UTSW |
7 |
85,055,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2920:Vmn2r69
|
UTSW |
7 |
85,060,973 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3708:Vmn2r69
|
UTSW |
7 |
85,061,029 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3710:Vmn2r69
|
UTSW |
7 |
85,055,601 (GRCm39) |
missense |
probably benign |
|
|
R4757:Vmn2r69
|
UTSW |
7 |
85,061,575 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4823:Vmn2r69
|
UTSW |
7 |
85,060,508 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4870:Vmn2r69
|
UTSW |
7 |
85,060,793 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4918:Vmn2r69
|
UTSW |
7 |
85,055,967 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5022:Vmn2r69
|
UTSW |
7 |
85,060,367 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5174:Vmn2r69
|
UTSW |
7 |
85,064,739 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5200:Vmn2r69
|
UTSW |
7 |
85,055,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Vmn2r69
|
UTSW |
7 |
85,060,991 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5643:Vmn2r69
|
UTSW |
7 |
85,056,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5996:Vmn2r69
|
UTSW |
7 |
85,061,117 (GRCm39) |
splice site |
probably null |
|
|
R6083:Vmn2r69
|
UTSW |
7 |
85,055,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6140:Vmn2r69
|
UTSW |
7 |
85,060,657 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6306:Vmn2r69
|
UTSW |
7 |
85,064,799 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6330:Vmn2r69
|
UTSW |
7 |
85,060,835 (GRCm39) |
missense |
probably benign |
|
|
R6380:Vmn2r69
|
UTSW |
7 |
85,061,067 (GRCm39) |
missense |
probably benign |
|
|
R6466:Vmn2r69
|
UTSW |
7 |
85,056,378 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6542:Vmn2r69
|
UTSW |
7 |
85,060,413 (GRCm39) |
nonsense |
probably null |
|
|
R6583:Vmn2r69
|
UTSW |
7 |
85,059,017 (GRCm39) |
missense |
probably benign |
|
|
R6623:Vmn2r69
|
UTSW |
7 |
85,056,309 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6709:Vmn2r69
|
UTSW |
7 |
85,061,069 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6732:Vmn2r69
|
UTSW |
7 |
85,060,351 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6741:Vmn2r69
|
UTSW |
7 |
85,061,724 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7070:Vmn2r69
|
UTSW |
7 |
85,060,688 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7234:Vmn2r69
|
UTSW |
7 |
85,056,315 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7323:Vmn2r69
|
UTSW |
7 |
85,060,972 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7427:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7428:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7453:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7532:Vmn2r69
|
UTSW |
7 |
85,059,622 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7556:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7562:Vmn2r69
|
UTSW |
7 |
85,056,420 (GRCm39) |
missense |
probably benign |
|
|
R7592:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7708:Vmn2r69
|
UTSW |
7 |
85,061,755 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7803:Vmn2r69
|
UTSW |
7 |
85,056,324 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7960:Vmn2r69
|
UTSW |
7 |
85,055,973 (GRCm39) |
missense |
probably benign |
|
|
R7966:Vmn2r69
|
UTSW |
7 |
85,060,762 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8071:Vmn2r69
|
UTSW |
7 |
85,055,713 (GRCm39) |
nonsense |
probably null |
|
|
R8347:Vmn2r69
|
UTSW |
7 |
85,064,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8737:Vmn2r69
|
UTSW |
7 |
85,055,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8795:Vmn2r69
|
UTSW |
7 |
85,064,883 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R8831:Vmn2r69
|
UTSW |
7 |
85,059,018 (GRCm39) |
nonsense |
probably null |
|
|
R8856:Vmn2r69
|
UTSW |
7 |
85,061,663 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8998:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8999:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9161:Vmn2r69
|
UTSW |
7 |
85,056,177 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9228:Vmn2r69
|
UTSW |
7 |
85,064,697 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9494:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9494:Vmn2r69
|
UTSW |
7 |
85,056,084 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9541:Vmn2r69
|
UTSW |
7 |
85,056,209 (GRCm39) |
missense |
probably benign |
|
|
R9620:Vmn2r69
|
UTSW |
7 |
85,061,504 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1176:Vmn2r69
|
UTSW |
7 |
85,055,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACATGCATACCAGTGTTCAC -3'
(R):5'- ATGTTCATTGCCACCATCGAATTG -3'
Sequencing Primer
(F):5'- ATGCATACCAGTGTTCACTGTGTC -3'
(R):5'- TTGCCACCATCGAATTGTAAGAAGC -3'
|
| Posted On |
2020-07-13 |
Incidental Mutation