Incidental Mutation 'R8239:Vmn2r92'
| ID |
637532 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r92
|
| Ensembl Gene |
ENSMUSG00000091350 |
| Gene Name |
vomeronasal 2, receptor 92 |
| Synonyms |
EG627111 |
| MMRRC Submission |
067646-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.082)
|
| Stock # |
R8239 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
18372192-18405440 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 18405278 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Isoleucine
at position 807
(M807I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128685
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169686]
|
| AlphaFold |
L7N2A4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169686
AA Change: M807I
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000128685
Gene: ENSMUSG00000091350
AA Change: M807I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
463 |
4.7e-38 |
PFAM |
|
Pfam:NCD3G
|
510 |
564 |
2.5e-19 |
PFAM |
|
Pfam:7tm_3
|
597 |
832 |
1.1e-52 |
PFAM |
|
low complexity region
|
843 |
855 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.5%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam39 |
T |
C |
8: 41,278,106 (GRCm39) |
S166P |
probably damaging |
Het |
| Appl1 |
T |
A |
14: 26,686,914 (GRCm39) |
T19S |
probably damaging |
Het |
| Arid4b |
T |
A |
13: 14,344,594 (GRCm39) |
D557E |
probably benign |
Het |
| Aven |
C |
T |
2: 112,390,120 (GRCm39) |
R8W |
probably benign |
Het |
| C2cd2l |
T |
C |
9: 44,227,502 (GRCm39) |
E307G |
possibly damaging |
Het |
| Cdh20 |
A |
C |
1: 110,027,832 (GRCm39) |
T526P |
probably benign |
Het |
| Dchs1 |
C |
T |
7: 105,414,718 (GRCm39) |
V775M |
probably benign |
Het |
| Dennd1b |
A |
G |
1: 138,969,673 (GRCm39) |
N63S |
probably benign |
Het |
| Dtnb |
A |
T |
12: 3,694,056 (GRCm39) |
Y248F |
unknown |
Het |
| Ehbp1l1 |
T |
A |
19: 5,770,089 (GRCm39) |
T405S |
possibly damaging |
Het |
| Fam149a |
A |
G |
8: 45,803,490 (GRCm39) |
Y415H |
possibly damaging |
Het |
| Fam186a |
A |
G |
15: 99,839,191 (GRCm39) |
L2351P |
unknown |
Het |
| Fsip2 |
T |
G |
2: 82,819,687 (GRCm39) |
I5140S |
possibly damaging |
Het |
| Gm8674 |
T |
C |
13: 50,054,262 (GRCm39) |
T749A |
noncoding transcript |
Het |
| Kalrn |
A |
G |
16: 33,870,153 (GRCm39) |
V1894A |
noncoding transcript |
Het |
| Kpna3 |
A |
T |
14: 61,624,919 (GRCm39) |
N141K |
probably damaging |
Het |
| Lrba |
G |
A |
3: 86,449,882 (GRCm39) |
G2067D |
probably damaging |
Het |
| Lrp2 |
G |
T |
2: 69,311,611 (GRCm39) |
Y2622* |
probably null |
Het |
| Lrtm2 |
A |
C |
6: 119,297,778 (GRCm39) |
F88V |
probably damaging |
Het |
| Mboat1 |
T |
C |
13: 30,429,333 (GRCm39) |
S454P |
probably damaging |
Het |
| Nkpd1 |
C |
T |
7: 19,253,753 (GRCm39) |
P40S |
probably benign |
Het |
| Or2b7 |
T |
C |
13: 21,739,788 (GRCm39) |
I135V |
probably benign |
Het |
| Or4a76 |
T |
A |
2: 89,460,907 (GRCm39) |
I112F |
probably damaging |
Het |
| Or8b54 |
G |
A |
9: 38,686,577 (GRCm39) |
V9M |
noncoding transcript |
Het |
| Or8k27 |
C |
A |
2: 86,275,473 (GRCm39) |
M284I |
noncoding transcript |
Het |
| Patj |
A |
G |
4: 98,570,308 (GRCm39) |
E1711G |
possibly damaging |
Het |
| Pcdha4 |
A |
T |
18: 37,086,128 (GRCm39) |
I104F |
probably damaging |
Het |
| Peg10 |
GC |
GCTCC |
6: 4,756,452 (GRCm39) |
|
probably benign |
Het |
| Plekhg4 |
C |
T |
8: 106,107,546 (GRCm39) |
R990* |
probably null |
Het |
| Pphln1 |
T |
C |
15: 93,386,930 (GRCm39) |
S343P |
probably benign |
Het |
| Pram1 |
A |
T |
17: 33,860,241 (GRCm39) |
K269N |
probably damaging |
Het |
| Psmd13 |
T |
A |
7: 140,466,450 (GRCm39) |
I79K |
probably damaging |
Het |
| Ptprf |
T |
C |
4: 118,069,309 (GRCm39) |
D1586G |
possibly damaging |
Het |
| Ptprh |
T |
A |
7: 4,584,090 (GRCm39) |
Q167H |
probably damaging |
Het |
| Rbm46 |
C |
T |
3: 82,772,775 (GRCm39) |
R119Q |
probably benign |
Het |
| Rreb1 |
T |
C |
13: 38,077,848 (GRCm39) |
M20T |
probably damaging |
Het |
| Scrn2 |
T |
G |
11: 96,923,046 (GRCm39) |
L163R |
probably damaging |
Het |
| Slc36a3 |
C |
T |
11: 55,022,433 (GRCm39) |
V254I |
probably benign |
Het |
| Slc6a6 |
T |
C |
6: 91,701,951 (GRCm39) |
F120L |
probably benign |
Het |
| Slc8a2 |
A |
T |
7: 15,879,230 (GRCm39) |
H572L |
probably benign |
Het |
| Spats2 |
T |
A |
15: 99,106,776 (GRCm39) |
D357E |
probably damaging |
Het |
| Speg |
A |
T |
1: 75,395,677 (GRCm39) |
N1816I |
probably damaging |
Het |
| Sult2b1 |
A |
G |
7: 45,433,361 (GRCm39) |
V2A |
unknown |
Het |
| Susd3 |
T |
C |
13: 49,384,731 (GRCm39) |
T231A |
probably benign |
Het |
| Tamalin |
C |
T |
15: 101,128,902 (GRCm39) |
L217F |
probably damaging |
Het |
| Tcp1 |
A |
G |
17: 13,139,738 (GRCm39) |
D261G |
probably benign |
Het |
| Trpm2 |
C |
G |
10: 77,771,836 (GRCm39) |
S601T |
probably benign |
Het |
| Ugt2b38 |
A |
T |
5: 87,571,659 (GRCm39) |
F124L |
probably benign |
Het |
| Unc80 |
G |
T |
1: 66,693,178 (GRCm39) |
E2522D |
probably benign |
Het |
| Usp34 |
A |
G |
11: 23,396,750 (GRCm39) |
T2365A |
|
Het |
| Vps13b |
C |
A |
15: 35,597,550 (GRCm39) |
P1030Q |
probably damaging |
Het |
| Wrn |
T |
G |
8: 33,819,213 (GRCm39) |
K246N |
probably damaging |
Het |
| Zer1 |
T |
A |
2: 29,991,147 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r92 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01591:Vmn2r92
|
APN |
17 |
18,405,423 (GRCm39) |
missense |
unknown |
|
|
IGL01758:Vmn2r92
|
APN |
17 |
18,372,275 (GRCm39) |
nonsense |
probably null |
|
|
IGL02614:Vmn2r92
|
APN |
17 |
18,387,503 (GRCm39) |
splice site |
probably benign |
|
|
IGL03095:Vmn2r92
|
APN |
17 |
18,386,972 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL03403:Vmn2r92
|
APN |
17 |
18,387,114 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0133:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0225:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0227:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0266:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0267:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0420:Vmn2r92
|
UTSW |
17 |
18,389,183 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0426:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0494:Vmn2r92
|
UTSW |
17 |
18,388,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1253:Vmn2r92
|
UTSW |
17 |
18,387,028 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1497:Vmn2r92
|
UTSW |
17 |
18,387,625 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1571:Vmn2r92
|
UTSW |
17 |
18,372,352 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1656:Vmn2r92
|
UTSW |
17 |
18,372,198 (GRCm39) |
missense |
probably benign |
|
|
R1816:Vmn2r92
|
UTSW |
17 |
18,386,939 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2229:Vmn2r92
|
UTSW |
17 |
18,387,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2909:Vmn2r92
|
UTSW |
17 |
18,405,377 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3694:Vmn2r92
|
UTSW |
17 |
18,372,205 (GRCm39) |
nonsense |
probably null |
|
|
R4207:Vmn2r92
|
UTSW |
17 |
18,404,523 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4548:Vmn2r92
|
UTSW |
17 |
18,391,578 (GRCm39) |
missense |
probably benign |
|
|
R4612:Vmn2r92
|
UTSW |
17 |
18,387,132 (GRCm39) |
missense |
probably benign |
0.25 |
|
R4742:Vmn2r92
|
UTSW |
17 |
18,387,119 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4824:Vmn2r92
|
UTSW |
17 |
18,372,183 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4865:Vmn2r92
|
UTSW |
17 |
18,387,634 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4900:Vmn2r92
|
UTSW |
17 |
18,404,605 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5084:Vmn2r92
|
UTSW |
17 |
18,405,439 (GRCm39) |
makesense |
probably null |
|
|
R5140:Vmn2r92
|
UTSW |
17 |
18,372,312 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5995:Vmn2r92
|
UTSW |
17 |
18,389,213 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6045:Vmn2r92
|
UTSW |
17 |
18,388,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6269:Vmn2r92
|
UTSW |
17 |
18,387,036 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6877:Vmn2r92
|
UTSW |
17 |
18,389,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Vmn2r92
|
UTSW |
17 |
18,387,005 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7260:Vmn2r92
|
UTSW |
17 |
18,387,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7344:Vmn2r92
|
UTSW |
17 |
18,387,513 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7514:Vmn2r92
|
UTSW |
17 |
18,391,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7576:Vmn2r92
|
UTSW |
17 |
18,387,621 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7584:Vmn2r92
|
UTSW |
17 |
18,387,028 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7912:Vmn2r92
|
UTSW |
17 |
18,404,970 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7941:Vmn2r92
|
UTSW |
17 |
18,405,099 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8178:Vmn2r92
|
UTSW |
17 |
18,386,988 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8238:Vmn2r92
|
UTSW |
17 |
18,405,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8252:Vmn2r92
|
UTSW |
17 |
18,387,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Vmn2r92
|
UTSW |
17 |
18,386,886 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8355:Vmn2r92
|
UTSW |
17 |
18,405,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9399:Vmn2r92
|
UTSW |
17 |
18,389,137 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9639:Vmn2r92
|
UTSW |
17 |
18,372,352 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9747:Vmn2r92
|
UTSW |
17 |
18,405,201 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9773:Vmn2r92
|
UTSW |
17 |
18,386,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0066:Vmn2r92
|
UTSW |
17 |
18,405,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r92
|
UTSW |
17 |
18,404,795 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
|
| Posted On |
2020-07-13 |
Incidental Mutation