Incidental Mutation 'R8242:Or4p7'
ID 637589
Institutional Source Beutler Lab
Gene Symbol Or4p7
Ensembl Gene ENSMUSG00000056995
Gene Name olfactory receptor family 4 subfamily P member 7
Synonyms Olfr1178, GA_x6K02T2Q125-49870417-49871388, MOR225-6P
MMRRC Submission 067647-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R8242 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88221593-88222564 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88222418 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 276 (I276V)
Ref Sequence ENSEMBL: ENSMUSP00000075066 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075640]
AlphaFold Q7TR20
Predicted Effect possibly damaging
Transcript: ENSMUST00000075640
AA Change: I276V

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000075066
Gene: ENSMUSG00000056995
AA Change: I276V

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.5e-49 PFAM
Pfam:7tm_1 39 285 7.2e-20 PFAM
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.2%
  • 20x: 98.2%
Validation Efficiency 98% (42/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy10 T C 1: 165,374,118 (GRCm39) Y736H possibly damaging Het
Akr1c12 G A 13: 4,322,269 (GRCm39) R258* probably null Het
Ankfn1 C G 11: 89,417,271 (GRCm39) probably null Het
Arfgef3 T C 10: 18,505,824 (GRCm39) K947E probably benign Het
Barx2 C A 9: 31,824,227 (GRCm39) R54L probably damaging Het
BC030500 T C 8: 59,365,388 (GRCm39) I13T unknown Het
Bcl11a T A 11: 24,113,208 (GRCm39) F184I probably benign Het
Cfap251 T A 5: 123,411,914 (GRCm39) D515E possibly damaging Het
Cfap43 A G 19: 47,885,808 (GRCm39) L269P probably damaging Het
Col8a1 G T 16: 57,452,721 (GRCm39) P94Q possibly damaging Het
Coq5 T C 5: 115,417,806 (GRCm39) V12A probably benign Het
Csmd1 A G 8: 16,760,670 (GRCm39) V155A probably benign Het
Defb22 A C 2: 152,328,007 (GRCm39) C59W probably damaging Het
Dsg3 A G 18: 20,669,980 (GRCm39) T665A possibly damaging Het
Gm10542 A G 18: 44,337,708 (GRCm39) D62G possibly damaging Het
Gm45861 G A 8: 28,038,821 (GRCm39) S987N unknown Het
Gm5591 T A 7: 38,219,746 (GRCm39) T376S probably benign Het
Hps3 C T 3: 20,068,290 (GRCm39) R588H possibly damaging Het
Itpr1 A T 6: 108,363,658 (GRCm39) D760V probably benign Het
Mfsd8 G A 3: 40,789,628 (GRCm39) R140C probably damaging Het
Mroh2b A T 15: 4,938,522 (GRCm39) R270S probably benign Het
Mroh4 G T 15: 74,488,157 (GRCm39) H350N possibly damaging Het
Nsd3 G T 8: 26,196,567 (GRCm39) E1183* probably null Het
Or13a19 T A 7: 139,902,696 (GRCm39) L28* probably null Het
Or51f23b T C 7: 102,402,306 (GRCm39) M277V probably benign Het
Or8k53 A T 2: 86,177,426 (GRCm39) M228K probably damaging Het
Pex5l T A 3: 33,060,184 (GRCm39) T196S probably benign Het
Phlpp2 T C 8: 110,666,834 (GRCm39) V1121A probably benign Het
Rab3gap2 T A 1: 184,954,050 (GRCm39) S41T probably benign Het
Rad51c A T 11: 87,280,712 (GRCm39) N293K probably damaging Het
Rgs3 C A 4: 62,538,022 (GRCm39) Q18K probably benign Het
Ripk2 C T 4: 16,124,430 (GRCm39) G426D probably benign Het
Rpl22l1 T C 3: 28,860,914 (GRCm39) V44A possibly damaging Het
Sntb1 C T 15: 55,655,629 (GRCm39) A196T possibly damaging Het
Sorcs3 C T 19: 48,194,913 (GRCm39) R99W possibly damaging Het
Tdrd6 T C 17: 43,939,821 (GRCm39) E409G probably damaging Het
Timm50 A T 7: 28,007,836 (GRCm39) D105E probably benign Het
Tsga10 A T 1: 37,846,182 (GRCm39) S315T probably benign Het
Ttpa G A 4: 20,028,511 (GRCm39) C256Y probably damaging Het
Vinac1 G T 2: 128,881,313 (GRCm39) C204* probably null Het
Vmn2r13 T C 5: 109,322,872 (GRCm39) Y139C possibly damaging Het
Washc5 A G 15: 59,215,971 (GRCm39) S803P probably damaging Het
Zfp985 A C 4: 147,668,639 (GRCm39) K502N possibly damaging Het
Other mutations in Or4p7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01017:Or4p7 APN 2 88,222,245 (GRCm39) missense possibly damaging 0.79
IGL02261:Or4p7 APN 2 88,221,725 (GRCm39) missense probably benign 0.05
IGL03023:Or4p7 APN 2 88,221,687 (GRCm39) missense probably damaging 1.00
IGL03053:Or4p7 APN 2 88,221,938 (GRCm39) missense probably damaging 1.00
IGL03168:Or4p7 APN 2 88,221,938 (GRCm39) missense probably damaging 1.00
R0432:Or4p7 UTSW 2 88,222,377 (GRCm39) missense probably damaging 0.98
R1738:Or4p7 UTSW 2 88,221,671 (GRCm39) missense probably benign 0.01
R2051:Or4p7 UTSW 2 88,221,882 (GRCm39) missense possibly damaging 0.49
R2136:Or4p7 UTSW 2 88,221,663 (GRCm39) missense probably benign 0.24
R3236:Or4p7 UTSW 2 88,221,750 (GRCm39) missense probably benign 0.01
R4407:Or4p7 UTSW 2 88,222,427 (GRCm39) missense probably benign 0.37
R4930:Or4p7 UTSW 2 88,222,284 (GRCm39) missense probably benign 0.12
R4959:Or4p7 UTSW 2 88,221,674 (GRCm39) missense probably benign 0.37
R4973:Or4p7 UTSW 2 88,221,674 (GRCm39) missense probably benign 0.37
R5178:Or4p7 UTSW 2 88,221,819 (GRCm39) missense possibly damaging 0.50
R5411:Or4p7 UTSW 2 88,221,605 (GRCm39) missense probably benign 0.01
R6282:Or4p7 UTSW 2 88,221,877 (GRCm39) nonsense probably null
R7289:Or4p7 UTSW 2 88,222,050 (GRCm39) missense probably damaging 0.99
R7493:Or4p7 UTSW 2 88,222,224 (GRCm39) missense possibly damaging 0.94
R7591:Or4p7 UTSW 2 88,222,220 (GRCm39) missense probably benign 0.17
R8060:Or4p7 UTSW 2 88,221,848 (GRCm39) missense probably benign 0.00
Z1176:Or4p7 UTSW 2 88,222,377 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCATTGCTAACTCTGGCCTAATGG -3'
(R):5'- ACAGGACATTTGTCTTTTGCTG -3'

Sequencing Primer
(F):5'- CATATGGTGTGATCTTATACACTGTC -3'
(R):5'- GGACATTTGTCTTTTGCTGATTAAAG -3'
Posted On 2020-07-13