Incidental Mutation 'R8243:Prss21'
ID 637673
Institutional Source Beutler Lab
Gene Symbol Prss21
Ensembl Gene ENSMUSG00000024116
Gene Name serine protease 21
Synonyms TESP5, mT4, 1700023E12Rik, testisin
MMRRC Submission 067648-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R8243 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 24087046-24092087 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 24088376 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 114 (T114A)
Ref Sequence ENSEMBL: ENSMUSP00000024928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024928]
AlphaFold Q9JHJ7
Predicted Effect probably damaging
Transcript: ENSMUST00000024928
AA Change: T114A

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000024928
Gene: ENSMUSG00000024116
AA Change: T114A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Tryp_SPc 54 291 1.18e-94 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.5%
  • 10x: 98.7%
  • 20x: 96.0%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for one knock-out allele impaires fertilization of epididymal sperm only in an in vitro experiment. Mice homozygous for another knock-out allele exhibit defective sperm maturation during passage through the epididymis and decreased spermfertilization capability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam19 T A 11: 46,015,909 (GRCm39) H356Q probably damaging Het
BC030500 T C 8: 59,365,388 (GRCm39) I13T unknown Het
Bcl6 C T 16: 23,786,883 (GRCm39) C636Y probably damaging Het
Cabyr G T 18: 12,883,759 (GRCm39) C82F probably benign Het
Clec4a1 T C 6: 122,901,778 (GRCm39) V70A possibly damaging Het
Col11a1 C T 3: 113,855,141 (GRCm39) P134S unknown Het
Col27a1 A G 4: 63,144,120 (GRCm39) T603A probably damaging Het
Col6a6 T C 9: 105,576,468 (GRCm39) D1964G probably damaging Het
Dnajc8 A G 4: 132,278,775 (GRCm39) probably null Het
E330034G19Rik T C 14: 24,358,360 (GRCm39) Y318H Het
Efemp1 T A 11: 28,871,690 (GRCm39) S402T probably damaging Het
Emcn T C 3: 137,097,411 (GRCm39) V110A possibly damaging Het
Fgd5 C T 6: 91,966,004 (GRCm39) L746F possibly damaging Het
Gna13 A G 11: 109,287,239 (GRCm39) N354S probably damaging Het
Helq G T 5: 100,918,348 (GRCm39) S855R possibly damaging Het
Hps5 G T 7: 46,436,066 (GRCm39) A160E probably damaging Het
Igfbp7 T A 5: 77,549,339 (GRCm39) E188V probably benign Het
Ivd A G 2: 118,702,018 (GRCm39) Y150C probably damaging Het
Jade2 T C 11: 51,708,045 (GRCm39) T723A probably benign Het
Kif1b T C 4: 149,288,724 (GRCm39) N1239S probably benign Het
Klb A G 5: 65,536,338 (GRCm39) N556S possibly damaging Het
Klhdc8a C T 1: 132,230,304 (GRCm39) R140C possibly damaging Het
Klhl2 T A 8: 65,202,084 (GRCm39) M531L probably benign Het
Mark3 T A 12: 111,613,956 (GRCm39) S546R possibly damaging Het
Mfsd8 G A 3: 40,789,628 (GRCm39) R140C probably damaging Het
Musk G A 4: 58,293,600 (GRCm39) R63K probably benign Het
Nacad C T 11: 6,552,643 (GRCm39) E183K probably damaging Het
Oasl1 T C 5: 115,066,220 (GRCm39) Y113H probably benign Het
Or10g9b A T 9: 39,917,484 (GRCm39) C254S probably benign Het
Or1x2 C T 11: 50,918,138 (GRCm39) T103M probably benign Het
Or4c111 T A 2: 88,844,051 (GRCm39) Y119F probably benign Het
Or51ab3 A T 7: 103,201,205 (GRCm39) D71V probably damaging Het
Or8b56 A G 9: 38,739,803 (GRCm39) E272G Het
P4hb T C 11: 120,454,206 (GRCm39) D296G probably benign Het
Plat G T 8: 23,262,248 (GRCm39) G91W probably damaging Het
Plekhh1 G A 12: 79,125,843 (GRCm39) R1293H probably benign Het
Ptprn T C 1: 75,229,179 (GRCm39) D776G probably damaging Het
Rffl A G 11: 82,703,621 (GRCm39) C101R probably damaging Het
Rundc1 A G 11: 101,316,384 (GRCm39) D152G probably benign Het
Sema6c A G 3: 95,079,916 (GRCm39) T737A probably damaging Het
Sppl2c A G 11: 104,078,687 (GRCm39) T496A probably damaging Het
Supt7l T C 5: 31,673,013 (GRCm39) I412V probably benign Het
Trim38 T A 13: 23,975,378 (GRCm39) I439N probably damaging Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Usp18 G A 6: 121,246,103 (GRCm39) R353H probably benign Het
Usp42 T C 5: 143,700,849 (GRCm39) K1058R probably benign Het
Utp25 T C 1: 192,796,937 (GRCm39) D598G probably benign Het
Other mutations in Prss21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01921:Prss21 APN 17 24,091,414 (GRCm39) missense possibly damaging 0.48
IGL03151:Prss21 APN 17 24,088,376 (GRCm39) missense probably damaging 0.98
R1136:Prss21 UTSW 17 24,091,968 (GRCm39) missense probably damaging 1.00
R2299:Prss21 UTSW 17 24,088,563 (GRCm39) missense probably benign 0.18
R3615:Prss21 UTSW 17 24,091,805 (GRCm39) missense probably benign 0.20
R3616:Prss21 UTSW 17 24,091,805 (GRCm39) missense probably benign 0.20
R4589:Prss21 UTSW 17 24,091,796 (GRCm39) missense possibly damaging 0.96
R5691:Prss21 UTSW 17 24,087,759 (GRCm39) splice site probably null
R6946:Prss21 UTSW 17 24,087,138 (GRCm39) missense possibly damaging 0.92
R7835:Prss21 UTSW 17 24,088,425 (GRCm39) missense possibly damaging 0.57
R8421:Prss21 UTSW 17 24,088,342 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- AGGCTGACTCACCTTCTGTC -3'
(R):5'- ACTTGTACGTGGAGTTCAGG -3'

Sequencing Primer
(F):5'- TGTCTTTAGGACTACTCCAACAGAC -3'
(R):5'- TACGTGGAGTTCAGGAGGCAG -3'
Posted On 2020-07-13