Mutagenetix > Incidental Mutation

Incidental Mutation 'R8271:Or5m11b'

637695

Institutional Source

Beutler Lab

Gene Symbol

Or5m11b

Ensembl Gene

ENSMUSG00000059873

Gene Name

olfactory receptor family 5 subfamily M member 11B

Synonyms

GA_x6K02T2Q125-47454152-47455126, Olfr1029, MOR198-1P

MMRRC Submission

067652-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R8271 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

85805557-85806617 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 85806085 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Arginine at position 166 (M166R)

Ref Sequence

ENSEMBL: ENSMUSP00000080828 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082191]

AlphaFold

A2ATE0

Predicted Effect

probably benign
Transcript: ENSMUST00000082191
AA Change: M166R

PolyPhen 2 Score 0.395 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000080828
Gene: ENSMUSG00000059873
AA Change: M166R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	4.2e-56	PFAM
Pfam:7tm_1	41	290	2.1e-25	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (65/65)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1a	A	T	5: 8,736,212 (GRCm39)	I202L	probably benign	Het
Acadsb	A	T	7: 131,045,423 (GRCm39)	T452S	unknown	Het
Ago2	A	T	15: 72,991,315 (GRCm39)	L541Q	probably damaging	Het
Ap2a2	A	T	7: 141,200,812 (GRCm39)	E553V	probably damaging	Het
Astn2	T	C	4: 65,910,663 (GRCm39)	K442E	unknown	Het
Bicd1	A	G	6: 149,414,633 (GRCm39)	T449A	probably benign	Het
Btn1a1	T	A	13: 23,645,919 (GRCm39)	Q150L	probably benign	Het
C1ra	G	A	6: 124,499,610 (GRCm39)	G599R	probably damaging	Het
Camta2	T	A	11: 70,561,886 (GRCm39)	Q1076L	probably benign	Het
Capza2	T	A	6: 17,657,214 (GRCm39)	C157S	probably damaging	Het
Ccnk	A	G	12: 108,162,114 (GRCm39)		probably benign	Het
Chd3	T	A	11: 69,251,483 (GRCm39)	D516V	probably damaging	Het
Cntnap5b	A	G	1: 99,999,832 (GRCm39)	T197A	probably benign	Het
Comp	A	G	8: 70,829,110 (GRCm39)	N260S	probably damaging	Het
Dcp1a	A	G	14: 30,244,883 (GRCm39)	T570A	possibly damaging	Het
Ddx60	T	A	8: 62,393,142 (GRCm39)		probably null	Het
Defb22	C	T	2: 152,327,712 (GRCm39)	V158I	unknown	Het
Diaph3	T	C	14: 87,103,949 (GRCm39)	S812G	probably damaging	Het
Dohh	G	T	10: 81,221,844 (GRCm39)	Q79H	probably benign	Het
Dyrk1b	T	G	7: 27,882,080 (GRCm39)	V147G	probably benign	Het
Fastkd2	C	T	1: 63,787,183 (GRCm39)	T539I	probably benign	Het
Itpr3	G	A	17: 27,306,622 (GRCm39)	D229N	probably damaging	Het
Kcnv1	A	T	15: 44,972,754 (GRCm39)	D376E	probably benign	Het
Kif13a	C	A	13: 46,906,057 (GRCm39)	V1577F	probably benign	Het
L3mbtl4	G	A	17: 68,793,938 (GRCm39)	R314H	probably damaging	Het
Mcoln2	A	C	3: 145,898,179 (GRCm39)	N100T	unknown	Het
Mdh1b	C	T	1: 63,759,164 (GRCm39)	V143M	possibly damaging	Het
Mfsd4b4	G	T	10: 39,768,101 (GRCm39)	Q377K	probably benign	Het
Mpv17l	T	C	16: 13,762,584 (GRCm39)	F122S	probably damaging	Het
Mylk	T	C	16: 34,742,949 (GRCm39)	S1154P	probably damaging	Het
Myo5b	A	G	18: 74,760,261 (GRCm39)	Y259C	probably damaging	Het
Nek1	G	A	8: 61,558,646 (GRCm39)	V931M	probably benign	Het
Nkd2	C	A	13: 73,969,437 (GRCm39)	G343V	probably damaging	Het
Obox8	T	A	7: 14,065,928 (GRCm39)	T197S	probably benign	Het
Or10j5	T	A	1: 172,784,744 (GRCm39)	C127*	probably null	Het
Or13g1	G	A	7: 85,955,962 (GRCm39)	R120C	probably benign	Het
Or4b1b	A	G	2: 90,112,616 (GRCm39)	F101S	possibly damaging	Het
Or5p57	A	G	7: 107,664,980 (GRCm39)	S342P	probably damaging	Het
Or5t7	T	A	2: 86,507,218 (GRCm39)	H153L	probably benign	Het
Palb2	A	T	7: 121,724,097 (GRCm39)	S551T	probably damaging	Het
Pcdha12	T	A	18: 37,154,953 (GRCm39)	D557E	probably damaging	Het
Pcdhb21	T	A	18: 37,648,921 (GRCm39)	D683E	probably benign	Het
Plekhb1	A	G	7: 100,305,936 (GRCm39)		probably benign	Het
Plekhg5	A	G	4: 152,187,464 (GRCm39)	N90D	probably damaging	Het
Pnpla1	A	G	17: 29,100,579 (GRCm39)	D482G	probably benign	Het
Rc3h1	A	T	1: 160,768,329 (GRCm39)		probably benign	Het
Rfpl4	C	T	7: 5,113,539 (GRCm39)	R214H	probably benign	Het
Rftn1	G	T	17: 50,354,408 (GRCm39)	A318D	probably damaging	Het
Setd5	T	C	6: 113,092,031 (GRCm39)	I284T	possibly damaging	Het
Smurf1	C	T	5: 144,830,897 (GRCm39)	E293K	possibly damaging	Het
Tas2r106	A	T	6: 131,655,023 (GRCm39)	I276N	probably damaging	Het
Tbc1d2	C	A	4: 46,649,791 (GRCm39)	A82S	possibly damaging	Het
Tex19.2	A	G	11: 121,008,010 (GRCm39)	I146T	possibly damaging	Het
Tmem107	T	G	11: 68,962,281 (GRCm39)	N79K	probably damaging	Het
Tpsab1	A	T	17: 25,564,305 (GRCm39)	S50T	probably benign	Het
Ttn	T	A	2: 76,553,594 (GRCm39)	K31008*	probably null	Het
Ubox5	T	C	2: 130,441,629 (GRCm39)	T353A	probably benign	Het
Usp24	T	A	4: 106,285,711 (GRCm39)	H2445Q	probably damaging	Het
Uvrag	T	C	7: 98,537,698 (GRCm39)	D499G	probably benign	Het
Xndc1	A	T	7: 101,728,343 (GRCm39)	N247I	possibly damaging	Het
Yipf2	A	T	9: 21,501,291 (GRCm39)	W226R	probably damaging	Het
Zfp335	T	A	2: 164,739,973 (GRCm39)	Q793L	probably damaging	Het
Zfp385c	A	G	11: 100,548,291 (GRCm39)	S54P	probably damaging	Het
Zpld2	G	T	4: 133,930,278 (GRCm39)	T9K	unknown	Het

Other mutations in Or5m11b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02020:Or5m11b	APN	2	85,805,579 (GRCm39)	utr 5 prime	probably benign
IGL02126:Or5m11b	APN	2	85,806,517 (GRCm39)	missense	probably benign	0.00
IGL02584:Or5m11b	APN	2	85,806,219 (GRCm39)	missense	probably damaging	0.96
IGL03410:Or5m11b	APN	2	85,805,764 (GRCm39)	missense	probably damaging	0.99
R1466:Or5m11b	UTSW	2	85,806,339 (GRCm39)	missense	probably damaging	1.00
R1466:Or5m11b	UTSW	2	85,806,339 (GRCm39)	missense	probably damaging	1.00
R1499:Or5m11b	UTSW	2	85,806,372 (GRCm39)	missense	possibly damaging	0.62
R1584:Or5m11b	UTSW	2	85,806,339 (GRCm39)	missense	probably damaging	1.00
R2925:Or5m11b	UTSW	2	85,806,125 (GRCm39)	nonsense	probably null
R2970:Or5m11b	UTSW	2	85,806,454 (GRCm39)	missense	possibly damaging	0.75
R4571:Or5m11b	UTSW	2	85,806,175 (GRCm39)	missense	probably damaging	0.97
R5533:Or5m11b	UTSW	2	85,805,797 (GRCm39)	missense	possibly damaging	0.78
R5654:Or5m11b	UTSW	2	85,806,500 (GRCm39)	missense	probably benign	0.00
R5827:Or5m11b	UTSW	2	85,805,650 (GRCm39)	missense	probably benign	0.00
R5967:Or5m11b	UTSW	2	85,806,535 (GRCm39)	missense	probably benign	0.01
R6291:Or5m11b	UTSW	2	85,805,926 (GRCm39)	missense	probably damaging	1.00
R6735:Or5m11b	UTSW	2	85,805,778 (GRCm39)	missense	possibly damaging	0.81
R6897:Or5m11b	UTSW	2	85,805,700 (GRCm39)	missense	possibly damaging	0.45
R7053:Or5m11b	UTSW	2	85,806,358 (GRCm39)	missense	possibly damaging	0.64
R7163:Or5m11b	UTSW	2	85,805,932 (GRCm39)	missense	probably damaging	1.00
R7358:Or5m11b	UTSW	2	85,805,780 (GRCm39)	missense	possibly damaging	0.81
R8047:Or5m11b	UTSW	2	85,806,271 (GRCm39)	missense	possibly damaging	0.52
R8271:Or5m11b	UTSW	2	85,805,766 (GRCm39)	missense	probably damaging	1.00
R8364:Or5m11b	UTSW	2	85,806,358 (GRCm39)	missense	possibly damaging	0.64
R9100:Or5m11b	UTSW	2	85,806,096 (GRCm39)	missense	probably benign	0.00
R9190:Or5m11b	UTSW	2	85,805,884 (GRCm39)	missense	possibly damaging	0.66
R9646:Or5m11b	UTSW	2	85,806,446 (GRCm39)	missense	probably benign	0.18

Predicted Primers

PCR Primer
(F):5'- TTGGCTGCTTTATCCAGTGC -3'
(R):5'- CAGCTGATTTGATCCTTAAGATGGC -3'

Sequencing Primer
(F):5'- TCATTGCACTTCTCCTTACAGAG -3'
(R):5'- GATCCTTAAGATGGCAGCAATAATG -3'

Posted On

2020-07-28