Incidental Mutation 'R8272:Vmn2r65'
| ID |
637782 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r65
|
| Ensembl Gene |
ENSMUSG00000066372 |
| Gene Name |
vomeronasal 2, receptor 65 |
| Synonyms |
ENSMUSG00000070600 |
| MMRRC Submission |
067695-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R8272 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
84589377-84613217 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 84596817 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 79
(F79L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000036551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044583]
|
| AlphaFold |
G3X931 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044583
AA Change: F79L
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000036551
Gene: ENSMUSG00000066372
AA Change: F79L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
435 |
5.6e-41 |
PFAM |
|
Pfam:NCD3G
|
501 |
553 |
1.3e-21 |
PFAM |
|
Pfam:7tm_3
|
584 |
821 |
2.3e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931422A03Rik |
G |
A |
2: 103,856,499 (GRCm39) |
R21C |
unknown |
Het |
| 4933407L21Rik |
G |
T |
1: 85,859,118 (GRCm39) |
E90* |
probably null |
Het |
| Abca15 |
A |
G |
7: 120,006,665 (GRCm39) |
Y1643C |
probably damaging |
Het |
| Adtrp |
G |
T |
13: 41,969,630 (GRCm39) |
A123D |
probably damaging |
Het |
| Asmt |
A |
T |
X: 169,106,460 (GRCm39) |
D20V |
possibly damaging |
Het |
| Bid |
T |
C |
6: 120,877,176 (GRCm39) |
E55G |
probably damaging |
Het |
| Brd3 |
A |
G |
2: 27,351,725 (GRCm39) |
V176A |
probably benign |
Het |
| Btnl2 |
G |
T |
17: 34,575,275 (GRCm39) |
|
probably null |
Het |
| Card11 |
A |
G |
5: 140,875,794 (GRCm39) |
S562P |
probably damaging |
Het |
| Carmil1 |
T |
G |
13: 24,220,562 (GRCm39) |
H1054P |
probably benign |
Het |
| Casp8 |
T |
G |
1: 58,872,901 (GRCm39) |
M259R |
probably damaging |
Het |
| Ccin |
G |
A |
4: 43,984,064 (GRCm39) |
R157H |
probably damaging |
Het |
| Cfap45 |
G |
A |
1: 172,355,406 (GRCm39) |
R18Q |
possibly damaging |
Het |
| Chuk |
A |
G |
19: 44,092,175 (GRCm39) |
I41T |
possibly damaging |
Het |
| Col28a1 |
G |
A |
6: 8,154,175 (GRCm39) |
P333L |
possibly damaging |
Het |
| Cspg4b |
A |
T |
13: 113,504,889 (GRCm39) |
D1979V |
|
Het |
| Ctnna3 |
T |
G |
10: 64,838,377 (GRCm39) |
V818G |
probably damaging |
Het |
| Cyp4f18 |
G |
T |
8: 72,742,935 (GRCm39) |
L456M |
probably benign |
Het |
| Ddx50 |
A |
G |
10: 62,457,256 (GRCm39) |
V598A |
probably benign |
Het |
| Dhrs7b |
C |
A |
11: 60,742,580 (GRCm39) |
Q91K |
probably benign |
Het |
| Dnah11 |
T |
A |
12: 118,074,752 (GRCm39) |
T1367S |
probably benign |
Het |
| Fam98b |
T |
A |
2: 117,093,335 (GRCm39) |
C183S |
probably benign |
Het |
| Fbxl12 |
C |
A |
9: 20,550,160 (GRCm39) |
R165L |
possibly damaging |
Het |
| Fbxw15 |
A |
C |
9: 109,388,828 (GRCm39) |
S194A |
probably benign |
Het |
| Flrt3 |
G |
T |
2: 140,502,617 (GRCm39) |
P337Q |
probably damaging |
Het |
| Gm12695 |
A |
G |
4: 96,612,183 (GRCm39) |
Y527H |
possibly damaging |
Het |
| Gramd1b |
T |
C |
9: 40,215,820 (GRCm39) |
T677A |
probably benign |
Het |
| Grm8 |
A |
T |
6: 27,363,281 (GRCm39) |
S745T |
probably damaging |
Het |
| Kctd8 |
T |
C |
5: 69,267,803 (GRCm39) |
K436E |
probably benign |
Het |
| Klf5 |
G |
T |
14: 99,539,540 (GRCm39) |
A318S |
possibly damaging |
Het |
| L3mbtl3 |
C |
T |
10: 26,179,566 (GRCm39) |
V505M |
unknown |
Het |
| Letm2 |
A |
G |
8: 26,076,672 (GRCm39) |
L310P |
probably damaging |
Het |
| Lrrc4 |
T |
C |
6: 28,662,192 (GRCm39) |
H174R |
unknown |
Het |
| Myh11 |
T |
C |
16: 14,036,718 (GRCm39) |
S995G |
|
Het |
| Myh7b |
A |
T |
2: 155,474,824 (GRCm39) |
E1787D |
probably damaging |
Het |
| Myoc |
T |
C |
1: 162,466,995 (GRCm39) |
S55P |
probably benign |
Het |
| Naaladl2 |
T |
C |
3: 24,112,366 (GRCm39) |
Q572R |
probably damaging |
Het |
| Nanog |
T |
A |
6: 122,688,736 (GRCm39) |
S131T |
probably benign |
Het |
| Nifk |
A |
G |
1: 118,260,134 (GRCm39) |
K230E |
probably benign |
Het |
| Nlrp10 |
A |
G |
7: 108,525,103 (GRCm39) |
S126P |
probably benign |
Het |
| Npc1l1 |
T |
A |
11: 6,179,327 (GRCm39) |
K28* |
probably null |
Het |
| Or13m2-ps1 |
A |
G |
6: 42,778,038 (GRCm39) |
D121G |
probably damaging |
Het |
| Or5b102 |
G |
A |
19: 13,040,795 (GRCm39) |
V7M |
possibly damaging |
Het |
| Pcdhac2 |
T |
A |
18: 37,279,242 (GRCm39) |
C741S |
probably benign |
Het |
| Pcx |
A |
T |
19: 4,651,758 (GRCm39) |
N45I |
probably damaging |
Het |
| Peak1 |
A |
G |
9: 56,166,182 (GRCm39) |
V582A |
probably damaging |
Het |
| Plcxd3 |
G |
T |
15: 4,546,218 (GRCm39) |
R74L |
probably damaging |
Het |
| Ptpn21 |
G |
A |
12: 98,654,789 (GRCm39) |
A726V |
probably benign |
Het |
| Rftn1 |
G |
T |
17: 50,354,408 (GRCm39) |
A318D |
probably damaging |
Het |
| Rimbp3 |
T |
C |
16: 17,026,969 (GRCm39) |
V131A |
possibly damaging |
Het |
| Rrp1b |
A |
G |
17: 32,276,163 (GRCm39) |
K570R |
probably benign |
Het |
| Serpinb1a |
A |
T |
13: 33,029,720 (GRCm39) |
F167L |
probably damaging |
Het |
| Slc12a1 |
T |
C |
2: 125,070,736 (GRCm39) |
L1076S |
probably damaging |
Het |
| Sspo |
A |
T |
6: 48,425,453 (GRCm39) |
T25S |
probably benign |
Het |
| Syvn1 |
G |
A |
19: 6,097,971 (GRCm39) |
R3H |
probably damaging |
Het |
| Tead2 |
A |
G |
7: 44,878,166 (GRCm39) |
E280G |
probably benign |
Het |
| Tmem263 |
T |
A |
10: 84,950,431 (GRCm39) |
V74E |
possibly damaging |
Het |
| Tmem38b |
T |
A |
4: 53,854,332 (GRCm39) |
L188Q |
probably damaging |
Het |
| Tmod4 |
C |
T |
3: 95,033,171 (GRCm39) |
T55I |
probably damaging |
Het |
| Tmprss12 |
A |
T |
15: 100,180,146 (GRCm39) |
E62V |
probably benign |
Het |
| Trim27 |
G |
A |
13: 21,364,780 (GRCm39) |
C39Y |
probably benign |
Het |
| Vmn2r110 |
A |
G |
17: 20,816,490 (GRCm39) |
L11S |
probably damaging |
Het |
| Vmn2r125 |
A |
G |
4: 156,702,373 (GRCm39) |
Y53C |
probably damaging |
Het |
| Vps13a |
A |
G |
19: 16,727,209 (GRCm39) |
|
probably null |
Het |
| Zdbf2 |
A |
G |
1: 63,345,142 (GRCm39) |
T1174A |
probably benign |
Het |
| Zfhx4 |
T |
G |
3: 5,308,927 (GRCm39) |
S718A |
probably damaging |
Het |
| Zfp78 |
A |
G |
7: 6,376,213 (GRCm39) |
T41A |
probably benign |
Het |
|
| Other mutations in Vmn2r65 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00942:Vmn2r65
|
APN |
7 |
84,592,761 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01104:Vmn2r65
|
APN |
7 |
84,589,996 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01154:Vmn2r65
|
APN |
7 |
84,592,729 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01453:Vmn2r65
|
APN |
7 |
84,589,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Vmn2r65
|
APN |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01748:Vmn2r65
|
APN |
7 |
84,589,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01997:Vmn2r65
|
APN |
7 |
84,589,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02527:Vmn2r65
|
APN |
7 |
84,595,724 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02617:Vmn2r65
|
APN |
7 |
84,589,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02676:Vmn2r65
|
APN |
7 |
84,589,381 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL03084:Vmn2r65
|
APN |
7 |
84,592,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
A4554:Vmn2r65
|
UTSW |
7 |
84,595,791 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4651001:Vmn2r65
|
UTSW |
7 |
84,595,461 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0322:Vmn2r65
|
UTSW |
7 |
84,595,756 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0453:Vmn2r65
|
UTSW |
7 |
84,595,442 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0862:Vmn2r65
|
UTSW |
7 |
84,592,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1508:Vmn2r65
|
UTSW |
7 |
84,589,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1687:Vmn2r65
|
UTSW |
7 |
84,590,026 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1876:Vmn2r65
|
UTSW |
7 |
84,595,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Vmn2r65
|
UTSW |
7 |
84,592,781 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2259:Vmn2r65
|
UTSW |
7 |
84,590,119 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2338:Vmn2r65
|
UTSW |
7 |
84,590,051 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2880:Vmn2r65
|
UTSW |
7 |
84,613,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3410:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3411:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3770:Vmn2r65
|
UTSW |
7 |
84,589,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3800:Vmn2r65
|
UTSW |
7 |
84,589,738 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3850:Vmn2r65
|
UTSW |
7 |
84,595,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4105:Vmn2r65
|
UTSW |
7 |
84,595,691 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4568:Vmn2r65
|
UTSW |
7 |
84,596,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4677:Vmn2r65
|
UTSW |
7 |
84,613,082 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4768:Vmn2r65
|
UTSW |
7 |
84,596,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4778:Vmn2r65
|
UTSW |
7 |
84,592,801 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5057:Vmn2r65
|
UTSW |
7 |
84,589,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5279:Vmn2r65
|
UTSW |
7 |
84,589,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r65
|
UTSW |
7 |
84,595,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5394:Vmn2r65
|
UTSW |
7 |
84,595,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5487:Vmn2r65
|
UTSW |
7 |
84,595,529 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5580:Vmn2r65
|
UTSW |
7 |
84,596,802 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Vmn2r65
|
UTSW |
7 |
84,590,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5673:Vmn2r65
|
UTSW |
7 |
84,596,615 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5688:Vmn2r65
|
UTSW |
7 |
84,589,900 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5935:Vmn2r65
|
UTSW |
7 |
84,592,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6354:Vmn2r65
|
UTSW |
7 |
84,589,574 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6372:Vmn2r65
|
UTSW |
7 |
84,589,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6924:Vmn2r65
|
UTSW |
7 |
84,613,198 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7021:Vmn2r65
|
UTSW |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7195:Vmn2r65
|
UTSW |
7 |
84,592,347 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7422:Vmn2r65
|
UTSW |
7 |
84,595,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7654:Vmn2r65
|
UTSW |
7 |
84,590,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Vmn2r65
|
UTSW |
7 |
84,589,744 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7691:Vmn2r65
|
UTSW |
7 |
84,592,851 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,596,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,595,530 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8103:Vmn2r65
|
UTSW |
7 |
84,595,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8303:Vmn2r65
|
UTSW |
7 |
84,589,391 (GRCm39) |
nonsense |
probably null |
|
|
R8354:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8454:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8489:Vmn2r65
|
UTSW |
7 |
84,589,964 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8554:Vmn2r65
|
UTSW |
7 |
84,595,960 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8680:Vmn2r65
|
UTSW |
7 |
84,589,388 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8731:Vmn2r65
|
UTSW |
7 |
84,589,447 (GRCm39) |
nonsense |
probably null |
|
|
R8839:Vmn2r65
|
UTSW |
7 |
84,595,489 (GRCm39) |
nonsense |
probably null |
|
|
R8847:Vmn2r65
|
UTSW |
7 |
84,590,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Vmn2r65
|
UTSW |
7 |
84,595,665 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9254:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9392:Vmn2r65
|
UTSW |
7 |
84,589,718 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9563:Vmn2r65
|
UTSW |
7 |
84,589,880 (GRCm39) |
nonsense |
probably null |
|
|
R9686:Vmn2r65
|
UTSW |
7 |
84,590,084 (GRCm39) |
missense |
probably benign |
0.45 |
|
X0067:Vmn2r65
|
UTSW |
7 |
84,590,113 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1088:Vmn2r65
|
UTSW |
7 |
84,592,473 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Vmn2r65
|
UTSW |
7 |
84,590,234 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAAGATGTGTAGGAATGGCCC -3'
(R):5'- CTCCAACAGACCTGTGTCAC -3'
Sequencing Primer
(F):5'- TATGGCAGATGAAAACCACCTTG -3'
(R):5'- CAGACCTGTGTCACCATTGAAATG -3'
|
| Posted On |
2020-07-28 |
Incidental Mutation