Incidental Mutation 'R8275:Usp35'
ID |
637942 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Usp35
|
Ensembl Gene |
ENSMUSG00000035713 |
Gene Name |
ubiquitin specific peptidase 35 |
Synonyms |
LOC244144, LOC381901 |
MMRRC Submission |
067698-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.088)
|
Stock # |
R8275 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
96958587-96981227 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 96964026 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 436
(S436P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000137726
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000139582]
[ENSMUST00000168435]
|
AlphaFold |
M0QWN7 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000139582
AA Change: S436P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000137726 Gene: ENSMUSG00000035713 AA Change: S436P
Domain | Start | End | E-Value | Type |
low complexity region
|
86 |
102 |
N/A |
INTRINSIC |
Pfam:UCH
|
440 |
915 |
5.2e-50 |
PFAM |
Pfam:UCH_1
|
441 |
890 |
1.5e-29 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000168435
AA Change: S436P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000137927 Gene: ENSMUSG00000035713 AA Change: S436P
Domain | Start | End | E-Value | Type |
low complexity region
|
86 |
102 |
N/A |
INTRINSIC |
Pfam:UCH
|
440 |
915 |
7.1e-48 |
PFAM |
Pfam:UCH_1
|
441 |
890 |
7.4e-26 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
Validation Efficiency |
100% (39/39) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 38 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Alx1 |
T |
C |
10: 102,864,250 (GRCm39) |
D73G |
probably benign |
Het |
Asah1 |
G |
A |
8: 41,801,159 (GRCm39) |
H156Y |
probably damaging |
Het |
Cgn |
G |
A |
3: 94,682,263 (GRCm39) |
L439F |
possibly damaging |
Het |
Creb1 |
C |
A |
1: 64,597,687 (GRCm39) |
T7K |
probably benign |
Het |
Cyp2c54 |
T |
A |
19: 40,026,749 (GRCm39) |
I469L |
probably benign |
Het |
Cyp2s1 |
T |
A |
7: 25,508,735 (GRCm39) |
T236S |
probably benign |
Het |
Duox1 |
T |
C |
2: 122,175,249 (GRCm39) |
I1349T |
probably benign |
Het |
Efhd2 |
C |
T |
4: 141,602,073 (GRCm39) |
A36T |
probably benign |
Het |
Espl1 |
G |
A |
15: 102,211,188 (GRCm39) |
|
probably benign |
Het |
Fan1 |
T |
A |
7: 64,022,234 (GRCm39) |
N340Y |
probably damaging |
Het |
Fat3 |
T |
A |
9: 16,158,046 (GRCm39) |
Q1188L |
probably damaging |
Het |
Flt1 |
A |
T |
5: 147,614,957 (GRCm39) |
Y330N |
probably damaging |
Het |
Golga4 |
A |
T |
9: 118,361,627 (GRCm39) |
S202C |
probably damaging |
Het |
Htr2b |
C |
T |
1: 86,030,294 (GRCm39) |
D134N |
probably damaging |
Het |
Katna1 |
T |
A |
10: 7,628,574 (GRCm39) |
C268S |
probably damaging |
Het |
Lama4 |
T |
C |
10: 38,948,807 (GRCm39) |
Y857H |
probably damaging |
Het |
Lyst |
T |
C |
13: 13,950,667 (GRCm39) |
I3741T |
probably benign |
Het |
Mcm4 |
T |
C |
16: 15,452,435 (GRCm39) |
I233V |
probably damaging |
Het |
Mettl22 |
T |
C |
16: 8,303,792 (GRCm39) |
V286A |
possibly damaging |
Het |
Nav3 |
C |
A |
10: 109,527,984 (GRCm39) |
G1503V |
noncoding transcript |
Het |
Obox1 |
T |
A |
7: 15,290,153 (GRCm39) |
N165K |
probably damaging |
Het |
Or11g2 |
T |
A |
14: 50,855,868 (GRCm39) |
M63K |
probably damaging |
Het |
Oxa1l |
T |
A |
14: 54,600,758 (GRCm39) |
I77N |
possibly damaging |
Het |
Pakap |
T |
C |
4: 57,886,329 (GRCm39) |
|
probably null |
Het |
Papss2 |
T |
C |
19: 32,615,760 (GRCm39) |
L164P |
probably damaging |
Het |
Pikfyve |
T |
A |
1: 65,292,501 (GRCm39) |
|
probably benign |
Het |
Polr2a |
G |
A |
11: 69,638,882 (GRCm39) |
R51C |
probably damaging |
Het |
Rsph10b |
C |
G |
5: 143,903,323 (GRCm39) |
T606S |
possibly damaging |
Het |
Siglecg |
T |
C |
7: 43,061,892 (GRCm39) |
V546A |
probably benign |
Het |
Slc22a29 |
T |
C |
19: 8,146,681 (GRCm39) |
S374G |
probably benign |
Het |
Tia1 |
C |
T |
6: 86,404,718 (GRCm39) |
Q318* |
probably null |
Het |
Trpm2 |
T |
A |
10: 77,801,859 (GRCm39) |
K69* |
probably null |
Het |
Unc80 |
C |
T |
1: 66,679,773 (GRCm39) |
R2115* |
probably null |
Het |
Vmn1r220 |
A |
T |
13: 23,368,483 (GRCm39) |
L71* |
probably null |
Het |
Vmn2r15 |
A |
T |
5: 109,434,150 (GRCm39) |
D851E |
probably benign |
Het |
Vps33a |
A |
T |
5: 123,707,522 (GRCm39) |
D148E |
probably damaging |
Het |
Zfp729a |
G |
A |
13: 67,768,223 (GRCm39) |
H669Y |
probably benign |
Het |
Zfp804b |
C |
T |
5: 6,822,289 (GRCm39) |
R258Q |
probably benign |
Het |
|
Other mutations in Usp35 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL03239:Usp35
|
APN |
7 |
96,970,799 (GRCm39) |
missense |
possibly damaging |
0.62 |
R0046:Usp35
|
UTSW |
7 |
96,962,804 (GRCm39) |
splice site |
probably null |
|
R0046:Usp35
|
UTSW |
7 |
96,962,804 (GRCm39) |
splice site |
probably null |
|
R0739:Usp35
|
UTSW |
7 |
96,960,874 (GRCm39) |
nonsense |
probably null |
|
R2655:Usp35
|
UTSW |
7 |
96,961,354 (GRCm39) |
missense |
probably benign |
|
R3623:Usp35
|
UTSW |
7 |
96,961,827 (GRCm39) |
missense |
probably damaging |
1.00 |
R4750:Usp35
|
UTSW |
7 |
96,959,546 (GRCm39) |
missense |
possibly damaging |
0.85 |
R4967:Usp35
|
UTSW |
7 |
96,962,782 (GRCm39) |
missense |
probably damaging |
1.00 |
R5317:Usp35
|
UTSW |
7 |
96,960,846 (GRCm39) |
missense |
probably damaging |
0.99 |
R5341:Usp35
|
UTSW |
7 |
96,975,134 (GRCm39) |
missense |
probably damaging |
1.00 |
R5761:Usp35
|
UTSW |
7 |
96,961,558 (GRCm39) |
missense |
probably benign |
0.00 |
R5894:Usp35
|
UTSW |
7 |
96,962,284 (GRCm39) |
missense |
probably damaging |
1.00 |
R6113:Usp35
|
UTSW |
7 |
96,973,533 (GRCm39) |
missense |
probably damaging |
1.00 |
R6282:Usp35
|
UTSW |
7 |
96,975,155 (GRCm39) |
missense |
probably damaging |
1.00 |
R6454:Usp35
|
UTSW |
7 |
96,960,851 (GRCm39) |
nonsense |
probably null |
|
R6454:Usp35
|
UTSW |
7 |
96,960,767 (GRCm39) |
missense |
probably damaging |
0.98 |
R7142:Usp35
|
UTSW |
7 |
96,960,754 (GRCm39) |
missense |
probably damaging |
0.97 |
R7158:Usp35
|
UTSW |
7 |
96,975,171 (GRCm39) |
start codon destroyed |
probably null |
0.89 |
R7260:Usp35
|
UTSW |
7 |
96,969,286 (GRCm39) |
missense |
probably damaging |
0.98 |
R8270:Usp35
|
UTSW |
7 |
96,961,551 (GRCm39) |
missense |
probably benign |
|
R8795:Usp35
|
UTSW |
7 |
96,961,270 (GRCm39) |
missense |
probably benign |
|
R8795:Usp35
|
UTSW |
7 |
96,961,167 (GRCm39) |
missense |
possibly damaging |
0.92 |
R9198:Usp35
|
UTSW |
7 |
96,962,276 (GRCm39) |
missense |
probably damaging |
1.00 |
RF003:Usp35
|
UTSW |
7 |
96,971,303 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Predicted Primers |
PCR Primer
(F):5'- ATGATGCCAGCACTAGGTTC -3'
(R):5'- AGTGGGTTCTAGTCCAGGAG -3'
Sequencing Primer
(F):5'- GCACTAGGTTCAAAGCTTGC -3'
(R):5'- GGGCTTCCTGGAAGAAAGTG -3'
|
Posted On |
2020-07-28 |